The present study had two goals: to test the validity of Planned Happenstance Career Inventory in the Italian context and to explore the relations between PHC skills and vocational identity processes within a sample of 472 undergraduate students attending university in the southern of Italy. Moreover, we examined relations between the PHCI and measures of vocational identity processes. With regard to the first goal, results show that for the Italian version of the instrument was confirmed the multifactor structure of the (...) original version. The multi-group analyses showed that invariance between genders is supported. Convergent validity and divergent validity of the measure were reported. Concerning the second goal, the skills of planned happenstance show different associations with Vocational Identity Dimensions. As hypothesized, the exploration and commitment dimensions of vocational identity status are positive related to Planned Happenstance Skills. These findings suggest implications for career guidance and counseling. (shrink)

Le but de cet article est de contribuer au débat sur la relation entre les pratiques prédictives et l’orthodoxie religieuse, telle qu’elle est exposée dans le Liber introductorius de Michel Scot. Au cœur de ce travail se trouve l’étude de la discussion de l’interprétation des signes inhabituels et des événements inattendus par Michel Scot, à la fois dans le Liber quatuor distinctionum et le Liber particularis. L’analyse de nouvelles preuves textuelles, jusque là passées inaperçues, permettra par ailleurs la réévaluation de (...) la réception de Michel Scot en tant qu’autorité dans le domaine des pratiques prédictives. (shrink)

Attempts to understand visual attention have produced models based on location, in which attention selects particular regions of space, and models based on other visual attributes . Previous studies of inattentional blindness have contributed to our understanding of attention by suggesting that the detection of an unexpected object depends on the distance of that object from the spatial focus of attention. When the distance of a briefly flashed object from both fixation and the focus of attention is systematically varied, (...) detection appears to have a location-based component. However, the likelihood that people will detect an unexpected event in sustained and dynamic displays may depend on more than just spatial location. We investigated the influence of spatial location on inattentional blindness under precisely controlled, sustained and dynamic conditions. We found that although location-based models cannot fully account for the detection of unexpected objects, spatial location does play a role even when displays are visible for an extended period. (shrink)

People acquire new beliefs in various ways. One of the most important of these is that new beliefs are acquired as a response to experiencing events that one did not expect. This involves a form of inference distinct from both deductive and inductive inference: abductive inference. The concept of abduction is due to the American pragmatist philosopher C. S. Peirce. Davies and Coltheart elucidated what Peirce meant by abduction, and identified two problems in his otherwise promising account requiring solution if (...) that account were to become fully workable. Here we propose solutions to these problems and offer an explicit cognitive model of how people derive new beliefs from observations of unexpected events, based on Peirce's work and Sokolov's ideas about prediction error triggering new beliefs. We consider that this model casts light not only upon normal processes of belief formation but also upon the formation of delusional beliefs. (shrink)

Background -/- Innovative neurosurgical treatments present a number of known risks, the natures and probabilities of which can be adequately communicated to patients via the standard procedures governing obtaining informed consent. However, due to their novelty, these treatments also come with unknown risks, which require an augmented approach to obtaining informed consent. -/- Objective -/- This paper aims to discuss and provide concrete procedural guidance on the ethical issues raised by serious unexpected complications of novel deep brain stimulation treatments. (...) -/- Approach -/- We illustrate our analysis using a case study of the unexpected development of recurrent stereotyped events in patients following the use of deep brain stimulation (DBS) to treat severe chronic pain. Examining these unexpected complications in light of medical ethical principles, we argue that serious complications of novel DBS treatments do not necessarily make it unethical to offer the intervention to eligible patients. However, the difficulty the clinician faces in determining whether the intervention is in the patient's best interests generates reasons to take extra steps to promote the autonomous decision making of these patients. -/- Conclusion and recommendations -/- We conclude with clinical recommendations, including details of an augmented consent process for novel DBS treatment. (shrink)

ABSTRACTInattentional blindness occurs when observers fail to detect unexpected objects or events. Despite the adaptive importance of detecting unexpected threats, relatively little research has examined how stimulus threat influences IB. The current study was designed to explore the effects of stimulus threat on IB. Past research has also demonstrated that individuals with elevated negative affectivity have an attentional bias towards threat-related stimuli; therefore, the current study also examined whether state and trait levels of negative affectivity predicted IB for (...) threat-related stimuli. One hundred and eleven participants completed an IB task that included both threat-related and neutral unexpected stimuli, while their eye movements were tracked. Participants were significantly more likely to detect the threatening stimulus than the neutral stimulus p =.035, odds ratio = 4.0, 95% confidence interval OR [1.13, 14.17]. Neither state nor trait... (shrink)

P3 is the most prominent of the electrical potentials of the human electroencephalogram that are sensitive to psychological variables. According to the most influential current hypothesis about its psychological significance [E. Donchin's], the “context updating” hypothesis, P3 reflects the updating of working memory. This hypothesis cannot account for relevant portions of the available evidence and it entails some basic contradictions. A more general formulation of this hypothesis is that P3 reflects the updating of expectancies. This version implies that P3-evoking stimuli (...) are initially unexpected but later become expected. This contradiction cannot be resolved within this formulation. The alternative “context closure” hypothesis retains the concept of “strategic information processing” emphasized by the context updating hypothesis. P3s are evoked by events that are awaited when subjects deal with repetitive, highly structured tasks; P3s arise from subjects' combining successive stimuli into larger units. The tasks in which P3s are elicited can accordingly be classified in terms of their respective formal sequences of stimuli. P3 may be a physiological indicator of excess activation being released from perceptual control areas. (shrink)

Much of the fascination that Petronius' Satyricon holds for its readers originates in the work's gleeful violation of traditional categories of classical genres. Critical terminology makes explicit the issue of unconventionality, as it is reduced to the neutral word ‘work’ in describing the Satyricon, which, as far as we can tell, belongs to no single category , but appropriates elements from many sources in both poetry and prose. Perhaps if we had more evidence with which to compare the work, such (...) as a greater selection of Menippean satire or proto-novels from antiquity, we might be able to identify it more accurately. But the suspicion remains that the intense variety of its evocations, allusions, and parodic passages differentiates it clearly from its component genres without allowing it to settle firmly in any one established genre. A certain amount of ‘Kreuzung der Gattungen’ is, of course, typical of both Alexandrian and consequently Roman texts. But the Satyricon seems to revel in its generic instability; it plays with the notion of ‘literariness’ by revealing impulses from non-literary forms such as mime and subliterary prose fiction, raising this material to an unfamiliar level of literary sophistication even as it debases other traditional genres through parodic techniques. One of the results of this open experimentation with style and decorum is an extremely dense fabric of literary allusion which some would label ‘literary opportunism’. The reader quickly learns to expect intertextual pyrotechnics, swift changes from the sublime to the ridiculous, and humorous incongruities in plot and form, as the stylistic disorder of the text reflects the topsyturvy Petronian world. The modern reader's response to this profusion of referents is to explore the recognizable categories and sources embedded in the work, to tease out the familiar elements in the hope of gaining a better understanding of the whole. Since a great deal of the allusion in the Satyricon functions parodically, there is yet another step necessary in the interpretation, namely taking into account the effect of the decontextualization of language and events from the source material and their recombination and transformation into the new text. (shrink)

Purpose of the study is to find out the interdependence of the event as a factor of transformations in the established areas of human life and everyday routine as a way of existence of social being, which cover various types of human activity. Theoretical basis of the research is based on understanding of everyday routine as a form of social reality, a complex and multidimensional object that is constantly evolving, includes new forms of reality, and is influenced by various (...) social changes. The main function of everyday routine is the survival of individual and society, therefore the stable foundations of human existence play a dominant role in every life. In turn the event serves as a way of being existence, has a singular character, an individual expression, identifies elements that do not fit into the usual framework of everyday life. Originality of the obtained results lies in understanding event as the opposition of the phenomena world to the out of experience world of being, unexpected innovation that leads to the emergence of behaviours and structures that are new and unusual for everyday life. Event is not identical to empirical facticity, does not correspond to the usual understanding of phenomena and processes, and leads to a break from the everyday life, as it causes significant changes in human life on the individual and social levels. Unexpected change in everyday life caused by event is a traumatic collision with another dimension of being for an individual, as a result of it new meanings may open. Conclusions. On the background of everyday life, which is able to be in different states, function in a variety of relationships, to be manifested in numerous structures, junctions and connections, the event assumes the prospect of a new reality, contrary to previous representations. From existential point of view, event is always an interruption of everyday life, as for example, love or religious conversion. A large-scale event causes shocks that affect most or all individuals and communities that use multiple ways to react to an event – interpretation, selection, glorification, silence, valuations adjustment, phenomena, facts, celebration of holidays, rituals that are periodically repeated. (shrink)

In the Briefe über die Ästhetische Erziehung des Menschen, the focus of this article, Schiller’s ostensible aim – to complete Kant’s aesthetic theory – is progressively abandoned. The article examines the reasons for this abandonment. On the one hand, Schiller’s original purpose was overtaken by events in France. Schiller found that he could no longer sustain confidence in reason’s capacity to build a durable political republic. On the other hand, the alternative path he favours involves him in the expounding of (...) an anthropology he did not set out to undertake. The Ästhetische Briefe, for this reason, finds itself adumbrating an “unexpected science” with little remaining reference to Kant – an account of the human being whose desirable future state, that of morality, can only be made secure by passage through the aesthetic state. A by-product of this argument, and perhaps its chief consequence, is that it finally settles the quarrel of the ancients and the moderns (in favour of the moderns). (shrink)

Though we often “fear the worst”, worrying that unexpectedly bad things will happen, there are times when we “hope for the best”, imagining that unexpectedly good things will happen, too. The paper explores how the valence of the current situation influences people's imagining of unexpected future events when participants were instructed to think of “something unexpected”. In Experiment 1, participants (N = 127) were asked to report unexpected events to everyday scenarios under different instructional conditions (e.g., asked (...) for “good” or “bad” unexpected events), and manifested a strong negativity bias in response to non-valenced instructions (i.e., being asked to “think of the unexpected” with no valence given). They mainly reported quite “predictable” unexpected outcomes that were negative; however, a post-test (N = 31) showed that the scenarios used were predominantly positive. In Experiment 2 (N = 257), when participants were instructed to think of “something unexpected and bizarre”, under the same instructional manipulations as Experiment 1, this negativity bias was replicated. In Experiment 3, using a design in which positive/negative materials were matched (verified by a pre-test, N = 60), it was found that when participants (N = 102) were given negative scenarios, they reported more positive events than they do when they are given positive scenarios. Though responding still retained an overwhelming negative bias, this result provided some evidence for a weaker valence-countering strategy; that is, where a negative scenario can lead to positive unexpected events being mentioned, and a positive scenario leads to negative unexpected events being reported. The implications of these results for people's projections of unexpected futures in their everyday lives is discussed. (shrink)

This article explores a number of questions about the relationship between intimacy and research that were bought into sharp focus for me by a disturbing event: my unexpected encounter with Iris Murdoch's archived brain. In considering how very intimate experiences such as these are both constructed and narrated to wider audiences, I begin by exploring the nature of intimacy itself. Here I argue that intimacy is the product of not only social but spatial relations, relations that may, in (...) contrast to popular conceptions, be `stretched out' to create what I call here `distributed spaces of intimacy'. In exploring the role that material artefacts can play as objects that create essential points of interface between individuals and communities that are geographically and socially distant, I also draw attention to the necessarily partial and relational nature of intimacy. In the final section of the article I turn to consider the impact that intensely personal experiences may have on research methodologies and the vexatious question of how, if at all, it is possible to speak of, or report them, without transgressing important social, moral and ethical conventions. (shrink)

The trials of life can wear us down. Unexpected events force us to face a new reality and unanswered prayers lead us to a growing frustration about why God doesn't intervene. We wonder if anything good can come out of this painful, dark, winter season. Grace Wabuke Klein knows that there is purpose in our darkest days and seasons of waiting. In Flourish, Grace meets the reader in their heartache, disappointment, and pain and gives encouragement and a fresh perspective (...) on the winter seasons we all go through, as well as practical steps to not just survive but to find purpose in the unknown and unexpected. Drawing insight from her own winter seasons, Grace reveals the divine purpose in each season of our lives. She explains how: -Fall is a time of release-a necessary season of letting go of offenses, unhealthy relationships, hurts, bad habits, toxic friendships, pride, unforgiveness and other heart issues before we can ever move on to the next season -Winter is a time of unexpected challenges and unknown futures-yet lessons learned in life's storms are deep and full of growth to shape us and makes us stronger. -Spring is a time of new things that require us to be open to new experiences, people, ideas, and perspective-stepping out into the unknown and uncomfortable. -Summer is a time when everything is flourishing-we clearly see how each season cultivated a deeper level of faith and spiritual muscles, developing our character and perseverance. Grace discovered there is value and unseen gifts in each season, but only in the hard seasons and storms of life are vital spiritual disciplines developed. Flourish connects with the reader in the tension and storms of life to bring a word of hope. (shrink)

The article attempts to comprehend the phenomenon of an event in the religious dimension. An event is considered as a phenomenon characterized by a singularity, that is, an individual character of expression, belongs to the sphere of non everyday life, does not coincide with the usual framework of understanding of the world and does not correspond to empirical factual. The need for a more active philosophical and religious discourse of the correlation between everyday and non everyday life in (...) the realm of religion led to the necessity of address to this problem. Thus, the purpose of the article is to find out the ontological status of the event, the religious context of which manifests itself as an opposition to everyday life and leads to a transformation of the established way of life of the believer. Everyday being is characterized by features of sacredness, demonstrates the attraction to the transcendent. For this reason, the obvious and justified is the combination of the phenomena of everyday empirical world with the values ​​of another dimension of being. The presence of non everyday in everyday life is evidenced, in particular, by elements of cult practice, since they are an expression of sacral time and space, as well as a way of incarnation of eternal values. The sphere of non everyday life includes the relationship between human and God described in the Gospels, prophecies, revelation, and vision as non everyday manifestations of religious experience. Event is the opposition of the world of phenomena to beyond the exquisite world of being, the transformation, which leads to the emergence of new orders and structures. Implementation of the event contradicts the previous ideas, therefore meeting the event with standard reality is accompanied by a transformation of everyday life. Establishing the rootedness of an event into being or its transcendental origin allows us to determine the causes of an event. In a secularized world, human, for the most part, demonstrates his willingness to recognize as significant events, including those in the universe, which correspond to scientific knowledge. This happens even when the fact of the event calls into question the fundamental postulates of science. Given this discovery in science, situations in politics, art, personal life are perceived as large-scale events. Moreover, the moment of meeting with the event can be described, for example, with a poetic language that expresses certain symbols of human existence and appears as a means of objectivizing the event as an unexpected innovation. Instead, the believer perceives events of a supernatural nature as an interference of the otherworldly reality in the usual way of life. Thus, the reception of religious experience is accompanied by the transformation of the individual's everyday life. The basis of the mystical experience of the religious tradition is the experience of meeting with the Divine, which results in a change in the believer's self-consciousness, transformation of its values, senses and meanings. That is, the awareness of an event that does not belong to an established order implies the prospect of new reality emersion, which contradicts previous notions. One of the forms of gaining religious experience is the process of conversion, which results in the transformation of the ideological orientation of a person, which enables the knowledge of their own hidden depths of consciousness. Conversion, the acquisition of grace and faith express the sudden or gradual process by which the individual achieves internal harmony, awareness of his righteousness, a sense of happiness, finds support in believing in the reality of what he has discovered in religious experiences. (shrink)

A formal, logical, theory of events is developed and used as the basis for a definition of causation and to provide a pragmatics for causal counterfactuals. The theory begins with with a logical formalization of events as represented in the planner strips. The resulting inertial theories include a common sense law of inertia and their pragmatics is based on the principle of chronological minimization. The theory of events is then developed by removing some of the simplifying assumptions of the strips (...) representation. To begin with the assumption that events always succeed, given that their preconditions are true when they occur, is dropped. Instead a common sense law of change is introduced with the effect that events normally succeed but may fail if some qualification (some unusual or unexpected condition) arises. The pragmatics of the resulting causal theories is provided by refining the pragmatics of inertial theories. In particular, where there is a conflict between change and inertia, preference is given to change. The resulting defeasibility of events makes it possible to remove the strips assumption that only one event occurs at any given time; as conflicting events now result in failure rather than inconsistency. However it is desirable to provide a means for adjudicating between conflicting events. Consequently the theory is extended so that qualification preferences can be specified and the pragmatics are refined accordingly. A further strips assumption is that the effects of an event are invariant. In order to remove this assumption a distinction is drawn between primary events, events of the kind described above, and secondary events. Secondary events are invoked by primary events in appropriate contexts, they are causally dependent on primary events and when successful produce the additional, variant, effects of the primary events which invoke them. As a result, both the context-dependent effects of events (their ramifications) and non-deterministic events (events whose outcome is uncertain) can be represented. The theory of primary and secondary events is then used as the basis for a definition of causation which can be seen as providing a formal account of Mackie's definition of a cause as an inus condition. A major theme of this paper is the conflict between the opposite but complementary principles of change and inertia. For much of the paper the emphasis is on restricting the effects of inertia and favouring change. The resulting imbalance becomes unnatural when considering the combined effects of several events. However the definition of causation makes it possible to state a law of change and inertia, which is used to regulate change and inertia and thus ensure a proper balance between them: while caused change is preferred to inertia, inertia is preferred to uncaused change. The theory is then used to provide a pragmatics for causal counterfactuals, thereby extending the representation of actual causal reasoning to counterfactual causal reasoning. This is illustrated by the use of causal counterfactuals in order to obtain explanations. (shrink)

How the insights of an 18th century economist can help us live better in the 21st century. Adam Smith became famous for The Wealth of Nations, but the Scottish economist also cared deeply about our moral choices and behavior--the subjects of his other brilliant book, The Theory of Moral Sentiments (1759). Now, economist Russ Roberts shows why Smith's neglected work might be the greatest self-help book you've never read. Roberts explores Smith's unique and fascinating approach to fundamental questions such as: (...) - What is the deepest source of human satisfaction? - Why do we sometimes swing between selfishness and altruism? - What's the connection between morality and happiness? Drawing on current events, literature, history, and pop culture, Roberts offers an accessible and thought-provoking view of human behavior through the lenses of behavioral economics and philosophy. (shrink)

This article undertakes a dual task. The first is to argue that the various positions of major Marxist thinkers on revolution may be gathered under the common framework of kairós, understood as a resolutely temporal term relating to the critical time, the opportune moment that appears unexpectedly and must be seized. The second task is to question the nature of kairós in terms of its biblical, class and economic residues. An investigation of the use of the term in classical Greece (...) reveals that it refers to both time and place, designating primarily what is in the right time and correct place. Given the class identifications of the Greek writers who deal with kairós and their subtle defences of their propertied, ruling class status, the term becomes problematic in light of these associations that trail behind it. In response, I seek to develop the political implications of the true opposite of kairós, namely ákairos, what is ill-timed and in the wrong place. (shrink)

Linguistic predictions may be generated from and evaluated against a representation of events and referents described in the discourse. Compatible with this idea, recent work shows that predictions about novel noun phrases include their definiteness. In the current follow-up study, we ask whether people engage similar prediction-related processes for definite and indefinite referents. This question is relevant for linguistic theories that imply a processing difference between definite and indefinite noun phrases, typically because definiteness is thought to require a uniquely identifiable (...) referent in the discourse. We addressed this question in an event-related potential (ERP) study (N = 48) with preregistration of data acquisition, preprocessing, and Bayesian analysis. Participants read Dutch mini-stories with a definite or indefinite novel noun phrase (e.g., “het/een huis,” the/a house), wherein (in)definiteness of the article was either expected or unexpected and the noun was always strongly expected. Unexpected articles elicited enhanced N400s, but unexpectedly indefinite articles also elicited a positive ERP effect at frontal channels compared to expectedly indefinite articles. We tentatively link this effect to an antiuniqueness violation, which may force people to introduce a new referent over and above the already anticipated one. Interestingly, expectedly definite nouns elicited larger N400s than unexpectedly definite nouns (replicating a previous surprising finding) and indefinite nouns. Although the exact nature of these noun effects remains unknown, expectedly definite nouns may have triggered the strongest semantic activation because they alone refer to specific and concrete referents. In sum, results from both the articles and nouns clearly demonstrate that definiteness marking has a rapid effect on processing, counter to recent claims regarding definiteness processing. (shrink)

The coronavirus pandemic has had some unexpected benign effects (including a large drop in air pollution and levels of nitrogen oxides in UK and elsewhere, and a smaller drop in global carbon emissions), which raises the problem of how to sustain and build on these unexpected gains. These gains could easily be lost when economies and road transport return to something like their previous condition. But if governments and industries are inspired to reduce automobile emissions to match the (...) levels of the spring of 2020, gains such as these could become recurrent, and many more lives could be saved. Further, if (with greater effort) carbon emissions could remain reduced, then future generations could be saved from sea-level rise, extreme weather events, and even from the spread of tropical diseases. Such a prevention of disease would be an ironic but welcome gain from a pandemic. (shrink)

The subject of intercultural exchange is complex and demands that we keep the basic issues that shape our views of the world in mind. And one of these basic issues is what we mean by “European identity.” The ideological concerns over the norms of identity became necessarily entangled in the post-1989 interests and agendas of Europe’s various nations. So the great challenge for us as academics as well as for the policymakers in Brussels and Strasburg is to focus on these (...) dialectics. European identity is too varied to be a unitary and homogenous thing; indeed, one of the battles within it is between the advocates of a unitary identity and those who see the whole as a complex that is irreducible to a unified identity. In this article I explore how the theatre, in the aftermath of the Second World War, served as a laboratory for the investigation, analysis, and constuction of dramatic models that became a means of transcultural communication. As attested by the continuing success of the experimental approaches of Brecht, Grotowski, La Mama, and Suzuki, this endeavour reflected the struggle of people from different cultural backgrounds to understand and accept each other. One of the reasons the theatre continues to have the potentiality to promote transcultural integration is that it deals in concrete particulars with universal resonances. As I will demonstrate with examples from my own work in various countries, the production and directing of plays by these and other dramatists shows that it is only in the performance—by transforming the familiar into the unfamiliar, by making the habitual and customary seem strange and unexpected—that the motives, relationships, and events enclosed in the written play are released so as to stimulate the audience to re-examine their own contemporary realities. Transcultural theatre thus creates dramatic experiences that are adequate and responsive to the changing world of migration and mobility in which both practitioners and audiences actually live. As such it offers the kind of transcultural education that promotes communication and understanding and that fosters an open-eyed and open-hearted attitude to the changing realities of Europe. (shrink)

A modular analysis of spontaneous language use provides support for the existence of an identifiable step in language evolution, protolanguage. Our suggestion is that a grammarless form of expression would have evolved to signal unexpected events, a behavior still prevalent in our species. Words could not be so specific as to refer to whole, non-recurring, situations. They referred to elements such as objects or locations, and the communicated event was inferred metonymically. Compositionality was achieved, without syntax, through multi-metonymy, (...) as words referring to elements of the same situation were concatenated into proto-utterances. (shrink)

A modular analysis of spontaneous language use provides support for the existence of an identifiable step in language evolution, protolanguage. Our suggestion is that a grammarless form of expression would have evolved to signal unexpected events, a behavior still prevalent in our species. Words could not be so specific as to refer to whole, non-recurring, situations. They referred to elements such as objects or locations, and the communicated event was inferred metonymically. Compositionality was achieved, without syntax, through multi-metonymy, (...) as words referring to elements of the same situation were concatenated into proto-utterances. (shrink)

ABSTRACT The purpose of this article is to show how William James's thought can help to construct a critical approach to the conceptualization of unexpected destructive events and suggest modes of conceptualization that reduce social injustice. I draw on several interrelated themes in James's thought, including, but not limited to: metaphysical and moral relationalism, the tragedy of choice, and the psychology of selective attention. Specifically, I argue that James provides resources for mounting a criticism of a kind of essentialist (...) thinking about unexpected events; for showing how this essentialism can create social injustice by obfuscating social choices and causing marginalized groups to bear a disproportionate share of social costs; for helping to construct a pluralistic approach to unexpected events that makes transparent the tragic choices laying behind them; and for putting this approach to use in ways that mitigate social injustice. (shrink)

Recent findings position the eukaryotic translation initiation factor eIF4E as a novel modulator of mRNA splicing, a process that impacts the form and function of resultant proteins. eIF4E physically interacts with the spliceosome and with some intron‐containing transcripts implying a direct role in some splicing events. Moreover, eIF4E drives the production of key components of the splicing machinery underpinning larger scale impacts on splicing. These drive eIF4E‐dependent reprogramming of the splicing signature. This work completes a series of studies demonstrating eIF4E (...) acts in all the major mRNA maturation steps whereby eIF4E drives production of the RNA processing machinery and escorts some transcripts through various maturation steps. In this way, eIF4E couples the mRNA processing‐export‐translation axis linking nuclear mRNA processing to cytoplasmic translation. eIF4E elevation is linked to worse outcomes in acute myeloid leukemia patients where these activities are dysregulated. Understanding these effects provides new insight into post‐transcriptional control and eIF4E‐driven cancers. (shrink)

For action systems, the critical task is to predict what will happen next. In language, however, the critical task is not to predict the next auditory event but to extract meaning. Reducing language to an action system, and putting prediction at center, mistakenly marginalizes our core capacity to communicate the novel and unpredictable.

Past research has repeatedly documented the close relationship between visual attention and awareness. Most recently, research exploring change blindness, inattentional blindness, repetition blindness, and the attentional blink has converged on the conclusion that attention to one aspect of a scene or event may lead to a highly circumscribed awareness of only the specific information attended, while other information, even that which is spatially or temporally nearby can go completely unnoticed. In the present report, we extend these observations to the (...) dynamic allocation of attention during a well-structured meaningful event. In two experiments, subjects viewed brief videos of simple events and were told to pay close attention to them. During the events, an unexpected disruption consisting of a brief low spatial frequency motion field occurred. Despite intensive questioning and opportunities for recognition, the majority of subjects reported no awareness of 200, 400, or 600 ms disruptions. In a second experiment, blank-screen disruptions were added, and these resulted in no increase in detection. We conclude that visual attention may result in far more transitory awareness of visual information than previously appreciated. (shrink)

Previous studies have found differences in the cognitive and neural mechanisms between cognitive reappraisal and expression suppression in the regulation of various negative emotions and the recognition of regulated stimuli. However, whether these differences are valid for sadness remains unclear. As such, we investigated the effect of cognitive reappraisal and expression suppression on sadness regulation and the recognition of sad scenes adopting event-related potentials. Twenty-eight healthy undergraduate and graduate students took part in this study. In the regulation phase, the (...) participants were asked to down-regulation, expressive suppression, or maintain their sad emotion evoked by the sad images, and then to perform an immediately unexpected recognition task involving the regulated images. The behavioral results show that down-regulation reappraisal significantly diminished subjective feelings of sadness, but expressive suppression did not; both strategies impaired the participants’ recognition of sad images, and expressive suppression had a greater damaging effect on the recognition of sad images than down-regulation reappraisal. The ERP results indicate that reappraisal and expressive suppression significantly reduced the late positive potential induced by sadness. These findings suggest that down-regulation reappraisal and expression suppression can effectively decrease sadness, and that down-regulation reappraisal is a more effective regulation strategy for sadness. Both strategies impair the recognition of sad scenes, and expression suppression leads to relatively greater impairment in the recognition of sad scenes. (shrink)

This essay examines the scratch as it relates to garbage, scores, and the event. Garbage is that which is cast aside as social systems form themselves, and, as such, is always destined to return. Scores are both methodological maps and experimental artistic methods. And the event, in this context, is the opening that enables both the determination of form and the emergence of the unexpected.

EVENTAL AESTHETICS RETROSPECTIVE 1. LOOKING BACK AT 10 ISSUES OF EVENTAL AESTHETICS.

BackgroundReconciling results obtained using different types of sensory measures is a challenge for autism sensory research. The present study used questionnaire, psychophysical, and neurophysiological measures to characterize autistic sensory processing in different measurement modalities.MethodsParticipants were 46 autistic and 21 typically developing 11- to 14-year-olds. Participants and their caregivers completed questionnaires regarding sensory experiences and behaviors. Auditory and somatosensory event-related potentials were recorded as part of a multisensory ERP task. Auditory detection, tactile static detection, and tactile spatial resolution psychophysical thresholds (...) were measured.ResultsSensory questionnaires strongly differentiated between autistic and typically developing individuals, while little evidence of group differences was observed in psychophysical thresholds. Crucially, the different types of measures appeared to be largely independent of one another. However, we unexpectedly found autistic participants with larger auditory Tb ERP amplitudes had reduced hearing acuity, even though all participants had hearing acuity in the non-clinical range.LimitationsThe autistic and typically developing groups were not matched on cognitive ability, although this limitation does not affect our main analyses regarding convergence of measures within autism.ConclusionOverall, based on these results, measures in different sensory modalities appear to capture distinct aspects of sensory processing in autism, with relatively limited convergence between questionnaires and laboratory-based tasks. Generally, this might reflect the reality that laboratory tasks are often carried out in controlled environments without background stimuli to compete for attention, a context which may not closely resemble the busier and more complex environments in which autistic people’s atypical sensory experiences commonly occur. Sensory questionnaires and more naturalistic laboratory tasks may be better suited to explore autistic people’s real-world sensory challenges. Further research is needed to replicate and investigate the drivers of the unexpected association we observed between auditory Tb ERP amplitudes and hearing acuity, which could represent an important confound for ERP researchers to consider in their studies. (shrink)

Our contributors explore a rich variety of aesthetic problems that bring about the self-reflexive re-evaluation of ideas.

In lieu of an abstract, here is a brief excerpt of the content:Kennedy Institute of Ethics Journal 11.2 (2001) 165-168 [Access article in PDF] UPMC Presbyterian Policy and Procedure Manual Guidelines for Disclosure and Discussion of Conditions and Events with Patients, Families and Guardians* I. Introduction and Background In the course of hospital care, an extensive amount of clinical information is generated. It includes diagnostic findings, treatment options, responses to interventions, and professional opinions. The information can be positive or negative. (...) Clinical events may or may not be caused by clinicians and consequently may be iatrogenic (caused by medical treatment), nosocomial (occurring in the hospital) or natural events.In accordance with the informed consent policy (#4011), Patients' Bill of Rights (# 0154, Section II H), and the Guidelines on Forgoing Life Sustaining Treatment (#4007), patients have the right to information regarding their condition and care. Physicians and other caregivers are obligated to provide accurate information as expeditiously as possible. While it is usually easy to provide positive information, negative information is more difficult to disclose, especially when the cause is iatrogenic."Therapeutic privilege" has been invoked to explain why certain negative information might be withheld. By invoking therapeutic privilege, the physician refrains from full disclosure to protect the patient from the effects of receiving the information itself. The use of therapeutic privilege is increasingly being called into question because it decreases patient autonomy and reduces trust.The following recommendations are provided to clinicians to help guide delivery of sensitive information, positive and negative. Specific recommendations [End Page 165] are provided for situations where the information is about an unfavorable or adverse event, or where the information might best be characterized as "bad news." II. Definitions Unfavorable event or unfavorable condition. For the purposes of these guidelines, an unfavorable condition is an occurrence or diagnosis that results in or is likely to result in a significant negative outcome, and/or a significant alteration in the care plan.An unfavorable event in this context is not the same as a sentinel event, which in policy #4025 is defined as, "a serious, unexpected, adverse patient event which has resulted in, or if repeated would have a significant probability of resulting in, loss of life or serious physical or psychological injury, that is judged to be a warning of an underlying problem involving hospital facilities, policies, procedures, systems or personnel."Adverse Event. An unfavorable event for the purposes of these guidelines is also distinguished from the FDA definition of the term "adverse event", which is a reportable negative effect of a drug or device potentially resulting in death, hospitalization, or medical or surgical intervention. (See policy #4022 Safe Medical Device Act.)Examples of unfavorable events or conditions for the purpose of these guidelines include a new diagnosis of cancer, a perioperative myocardial infarction, or unintended delivery of an incorrect medication that results in clinical change.Examples of events not covered by these guidelines are intravenous saline infiltration and medication dosing errors that have no clinical impact on care.Iatrogenic. Event caused by the treatment of a healthcare provider. III. Guidelines and Principles It is appropriate that UPMC Presbyterian support basic principles for patient and family notification regarding all clinical events and conditions, including unfavorable ones. Physicians must be honest because that is a cornerstone of the patient-physician relationship, and because it fosters patient autonomy.UPMC Presbyterian supports the following AMA position regarding patient information: [End Page 166] It is a fundamental ethical requirement that a physician should at all times deal honestly and openly with patients. Patients have a right to know their past and present medical status and to be free of any mistaken beliefs concerning their conditions. Situations occasionally occur in which a patient suffers significant medical complications that may have resulted from the physician's mistake or judgement. In these situations, the physician is ethically required to inform the patient of all the facts necessary to ensure understanding of what has occurred. Only through full disclosure is a patient able to make informed decisions regarding future medical care. Ethical responsibility includes informing patients of changes in their diagnoses... (shrink)

In her book, Vibrant Matter, Jane Bennett thinks through what ontological, political, and ecological questions would look like if humans could admit that matter and nonhuman things are living, creative agents; the contributors to this issue of Evental Aesthetics begin to think through what aesthetic questions would look like.

This issue is dedicated to thinking about art and current aesthetic perspectives through Hegelianism.

In this special issue on animals and aesthetics, contributors explore encounters with animals in art and thought.

In this issue, our contributors demonstrate how art in the city, art “about” the city, art compared to the city, can bring to attention the insidious forces underlying every city’s gleaming, wide-awake veneer.

In "Aesthetic Histories" our contributors’ shared concern is the inspiring and confounding, healthy and uncomfortable and above all inevitable relationship between history and aesthetic praxis.

A hijacking is a violent takeover, a misappropriation of something for a purpose other than its intended one, by parties other than those for whom the thing was meant. This issue explores the aesthetic practices and consequences of unauthorized repurposing.

This issue profiles various attempts, both successful and fraught, to engage the divide between asceticism and opulence, between materialism and poverty.

Is aesthetics a product of evolution? Are human aesthetic behaviors in fact evolutionary adaptations? The creation of artistic objects and experiences is an important aesthetic behavior. But so is the perception of aesthetic phenomena qua aesthetic. The question of evolutionary aesthetics is whether humans have evolved the capacity not only to make beautiful things but also to appreciate the aesthetic qualities in things. Are our near-universal love of music and cute baby animals essential to our species’ evolutionary development, which took (...) place over thousands of years? In other words, do aesthetic practice and appreciation help people to survive or reproduce? Do aesthetic behaviors help to propel natural selection? If so, what does that tell us about ourselves as human beings? What does it tell us about art, our other aesthetic practices, and aesthetic experience? (shrink)

Scheduling has been an important research field in Artificial Intelligence. Because typical scheduling problems could be modeled as a Constraint Satisfaction Problem, several constraint satisfaction techniques have been proposed. In order to handle the different levels of importance of the constraints, solving a problem as a Weighted Maximal Constraint Satisfaction Problem is an promising approach. However, there exists the case where unexpected events are added and some sudden changes are required, i.e., the case with dynamic changes in scheduling problems. (...) In this paper, we describe such dynamic scheduling problem as a Dynamic Weighted Maximal Constraint Satisfaction Problem in which constraints would changes dynamically. Generally, it is undesirable to determine vastly modified schedule even if re-scheduling is needed. A new schedule should be close to the current one as much as possible. In order to obtain stable solutions, we propose the methodology to maintain portions of the current schedule using the provisional soft constraints, which explicitly penalize the changes from the current schedule. We have experimentally confirmed the efficacy of re-scheduling based on our method with provisional constraints. In this paper, we construct the nurse scheduling system for applying the proposed scheduling method. (shrink)

This essay introduces a cluster of articles titled “Devalued Currency: An Elegiac Symposium on Paradigm Shifts.” Eagleton's piece addresses, from a perspective indebted to Walter Benjamin, the notion of Thomas Kuhn that “shifts” in the controlling paradigms of disciplines and practices are entirely transformative not only of their futures but also of their pasts. Benjamin argued that a work of art is a set of potentials that may or may not be realized in the vicissitudes of its afterlife. The true (...) significance of works might be said, therefore, to emerge only after some as-yet-unexpected event or upheaval makes their significance apparent. In this sense, we might argue that historical events make full sense only in the light of “judgment day”; until then, history remains an incoherent chronicle. But the totality that will one day be revealed cannot be anticipated. The past is open-ended because the present is, and meanwhile, the meaning of history is in our hands to change. Since we have that power, Eagleton suggests that we recycle figures of the past as characters in a comedy rather than tragedy. Still, it is never possible to say which figures of the past and which works are ultimately important and which are not, because we cannot say which mutations will result in major developments to come. No work or person is important or peripheral in itself or himself; it is the critic and historian who render them so. (shrink)

The phenomenon of shared intention has received much attention in the philosophy of mind and action. Margaret Gilbert (1989, 2000c, 2014b) argues that a shared intention to do A consists in a joint commitment to intend to do A. But we need to know more about the nature of joint commitments to know what exactly this implies. While the persistence of joint commitments has received much attention in the literature, their impersistence has received very little attention. In this paper, we (...) shed light on the impersistence of joint commitments by showing how joint commitments can be dissolved by unexpected events. (shrink)