Recent advances in spatially resolved transcriptomics have greatly expanded the knowledge of complex multicellular biological systems. The field has quickly expanded in recent years, and several new technologies have been developed that all aim to combine gene expression data with spatial information. The vast array of methodologies displays fundamental differences in their approach to obtain this information, and thus, demonstrate method‐specific advantages and shortcomings. While the field is moving forward at a rapid pace, there are still multiple challenges presented to (...) be addressed, including sensitivity, labor extensiveness, tissue‐type dependence, and limited capacity to obtain detailed single‐cell information. No single method can currently address all these key parameters. In this review, available spatial transcriptomics methods are described and their applications as well as their strengths and weaknesses are discussed. Future developments are explored and where the field is heading to is deliberated upon. (shrink)

Kunst als Projektionsfläche, Kunst als Ausdruck, Kunst als Gesellschaftskritik: Die Beitragenden dieses Bandes reflektieren unterschiedliche Dimensionen und Spannungslinien des Verhältnisses von Kunst und Kritik und untersuchen dabei das künstlerische Gestaltungs- und Inszenierungspotenzial aus interdisziplinärer Perspektive. Mit der Verflechtung von wissenschaftlichen Beiträgen und Kunstperformances erschliessen sie eine Bandbreite an unterschiedlichen Bedeutungszusammenhängen und Entwicklungsdynamiken von zentralen Diskursen der Kunstlandschaft unter Berücksichtigung u.a. architektonischer, philosophischer, kunsthistorischer, musikwissenschaftlicher und aktionistischer Aspekte"--Back cover.

While the technical aspects of engineering are emphasized in education and industry, the ethical aspects are, in some ways, just as vital. Engineering instructors should teach undergraduates about their ethical responsibilities in the realm of engineering. Students would then be more likely to grasp their responsibilities as professionals. For many students, undergraduate study is a time of growth and change, with their ethical development just beginning to take shape. In this study, we aim to understand the progression of ethical development (...) for engineering undergraduate students and identify key factors that may contribute to their development. To help us assess ethical development, we deployed in Fall 2020 a survey to undergraduate engineering students at two universities; the survey entailed the Defining Issues Test-2 (DIT-2). The DIT-2 evaluates ethical development based on Kohlberg’s theory of moral development; the test recognizes three levels of morality—preconventional, conventional, and postconventional. This study evaluates the associations between students’ university and class year and their Personal Interest, Maintaining Norms, and N2 scores. We utilized the results of a multivariate analysis of variance (MANOVA) to address the following research question: _Is a student’s ethical development associated with their university and class year?_ The results of the analysis reveal that students’ ethical development appear to differ between universities and to lie along a continuum, changing from first-year students to seniors of engineering undergraduate study. (shrink)

I argue for an account of grasping, or understanding that, on which we grasp via a higher-order mental act of Husserlian fulfillment. Fulfillment is the act of matching up the objects of our phenomenally presentational experiences with those of our phenomenally representational thought. Grasping-by-fulfilling is importantly different from standard epistemic aims, in part because it is phenomenal rather than inferential. (I endorse Bourget’s 2017 arguments to that effect.) I show that grasping-by-fulfilling cannot be a species of propositional knowledge or belief, (...) and that it is not essentially connected to justification. I motivate a revisionary epistemology on which achieving propositional knowledge and coming to grasp are dual epistemic aims. My account makes sense of a common occurrence—that we are often unmoved to act on our beliefs until we come to phenomenally experience them in some way. It also explains puzzling features of human inquiry. (shrink)

I explore the view that metaphysics is essentially imaginative. I argue that the central goal of metaphysics on this view is understanding, not truth. Metaphysics-as-essentially-imaginative provides novel answers to challenges to both the value and epistemic status of metaphysics.

The purpose of this paper is to advance research on CSR beyond the stalemate of economic versus ethical models by providing an alternative perspective integrating existing views and allowing for more shared dialog and research in the field. It is suggested that we move beyond making a normative case for ethical models and practices of CSR by moving beyond the question of how to manage organizational self-interest toward the question of how accurate current conceptions of the organizational self seem to (...) be. Specifically, it is proposed that CSR is not a question of how self-interested the corporation should be, but how this self is defined. Economic and ethical models of CSR are not models of opposition but exist on a continuum between egoic and post-egoic, illusory and authentic conceptions of the organizational self. This means that moving from one to the other is not a question of adopting different paradigms but rather of moving from illusion and dysfunction to authenticity and functionality, from pathology to health. (shrink)

I first quickly outline what I think grasping is, and suggest that it is both among our basic aims of inquiry and not essentially tied to belief, justification, or knowledge. Then, I briefly look at some places in the metaphysics of science in which it looks like our aim of grasping and our aim in knowing—or perhaps more specifically in knowing the explanations for things—might seem to conflict. I will use this conflict to support a broader view: sometimes, we might (...) develop philosophical views or theories—and even endorse them—in order to better grasp them, regardless of whether we genuinely believe them, or are justified in so doing. At other times, we may be aiming at propositional knowledge. These aims can come apart, and perhaps even systematically come apart. A pluralism about the value of those aims doesn’t entail an “anything goes” attitude with respect to how we think about what philosophical views to put forward, defend, or endorse, however—far from it. Instead, it suggests that what counts as a virtue of a philosophical theory depends on our aims in espousing it. If philosophers have distinct aims at the meta-level, it will be hard for them to engage in joint theory evaluation at the first-order level. At least all three of theoretical virtues, evaluative judgments of philosophical views, and what attitudes we ought to have towards the views we ourselves espouse will vary according to our guiding metaphilosophical aims. (shrink)

Many philosophers take purportedly logical cases of ground ) to be obvious cases, and indeed such cases have been used to motivate the existence of and importance of ground. I argue against this. I do so by motivating two kinds of semantic determination relations. Intuitions of logical ground track these semantic relations. Moreover, our knowledge of semantics for first order logic can explain why we have such intuitions. And, I argue, neither semantic relation can be a species of ground even (...) on a quite broad conception of what ground is. Hence, without a positive argument for taking so-called ‘logical ground’ to be something distinct from a semantic determination relation, we should cease treating logical cases as cases of ground. (shrink)

Logical realism is the view that there is logical structure in the world. I argue that, if logical realism is true, then we are deeply ignorant of that logical structure: either we can’t know which of our logical concepts accurately capture it, or none of our logical concepts accurately capture it at all. I don’t suggest abandoning logical realism, but instead discuss how realists should adjust their methodology in the face of this ignorance.

Abstract‘Logical Realism’ is taken to mean many different things. I argue that if reality has a privileged structure, then a view I call metaphysical logical realism is true. The view says that, first, there is ‘One True Logic’; second, that the One True Logic is made true by the mind‐and‐language‐independent world; and third, that the mind‐and‐language‐independent world makes it the case that the One True Logic is better than any other logic at capturing the structure of reality. Along the way, (...) I discuss a few alternatives, and clarify two distinct kinds of metaphysical logical realism. (shrink)

Using an ethnographic case study based in a UK state school for 11- to 18-year-olds, this paper explores the tensions that arose when the senior leadership team (SLT) introduced a justice-based ethic-of-care that prioritized good grades and equal treatment for all pupils over a feminist ethic-of-care (preferred by most teachers in non-leadership roles) that accentuated individual pupil need and placed greater emphasis on a broader social education. Through highlighting the tensions between a feminist ethic-of-care and a more ‘masculine’ style, justice-based (...) approach to care-ethics, the paper extends the organisational care-ethics literature. We emphasise that such tensions occurred whether the different ethics were enacted by men, women, or non-binary individuals. In order to better understand the tensions between these two ethical approaches, we draw upon the theoretical work of Donald Winnicott, which highlights the importance both of maternal and paternal roles during infancy. We update Winnicott’s ideas, noting how maternal and paternal caring roles can be undertaken by people of varied gender identities. Building on Winnicott’s theory, we propose a new ‘Parentalist’ ethic-of-care, which has the potential to balance and hold together ideas of both a feminist ethic-of-care, and a justice-based ethic. A Parentalist ethic-of-care could support teachers yet recognize the context of the contemporary neo-liberal environment, where most children need to attain formal qualifications in a marketized world, and where such measures of success are highly valued. (shrink)

This article explores the emerging intersections between the shift towards higher quality food consumption in China and Chinese investment in overseas farmland. Based on an ethnographic study of a Chinese company acquiring one of Australia’s largest dairy farms, the article argues that the linkage between imported Australian milk and perceptions of safety and quality has served as a powerful driver of Chinese investment in overseas farmland—a linkage that has largely been overlooked by literature on China’s role in the global land (...) rush. Drawing on the notion of ‘quality imaginaries’, the paper shows how images of Australian farmland as natural, pure, and geographically isolated have been mobilized by the investor company to position itself as provider of fresh, premium milk in the Chinese market. While such place-based qualities constitute a prized advantage, ironically, they also present a looming risk as the investor company struggles to reconcile fresh milk’s perishability with the farm’s location at the ‘edge of the world’. Thus, the case study not only demonstrates how cultural meanings tied to food and eating shape the ways in which investors imagine land’s affordances and possibilities but also draws attention to land’s materiality as a factor that both facilitates and destabilizes investment in farmland. (shrink)

I argue that, in order for us to be justified in believing that two theories are metaphysically equivalent, we must be able to conceive of them as unified into a single theory, which says nothing over and above either of them. I propose one natural way of precisifying this condition, and show that the quantifier variantist cannot meet it. I suggest that the quantifier variantist cannot meet the more general condition either, and argue that this gives the metaphysical realist a (...) way to rule out theses like quantifier variance without appealing to fundamentality, grounding, or "levels" of reality. (shrink)

In Koriat's paper ''The Feeling of Knowing: Some Metatheoretical Implications for Consciousness and Control,'' he asserts that the feeling of knowing straddles the implicit and explicit, and that these conscious feelings enter into a conscious control process that is necessary for controlled behavior. This assertion allows him to make many speculations on the nature of consciousness itself. We agree that feelings of knowing are produced through a monitoring of one's knowledge, and that this monitoring can affect the control of behavior (...) such as whether or not to search memory for an answer. Further, we believe that monitoring of performance with a strategy can also affect cognition control and strategy selection; however, we also believe that frequently this monitoring and control occurs without conscious awareness. Feeling of knowing has received an inordinate amount of attention because it lies behind the highly recognizable tip-of-the-tongue phenomenon that represents one of the rare cases of conscious monitoring. There are other feelings of knowing which are much more common and are not accompanied by conscious awareness. These are evident in the early selection of a strategy for answering a problem. In our view, the research on feeling of knowing will not resolve the question of whether consciousness is merely epiphenomenal. (shrink)

In his Heretical Essays, Jan Patočka introduces the concept of the solidarity of the shaken. He argues that it emerges in the conditions of political violence—the frontline experience. Moreover, Patočka brings into discussion the puzzling concepts of day, night, metanoia and sacrifice, which only further problematise the idea. Researching how other thinkers have examined the phenomenon of the frontline experience, it becomes obvious that Patočka did not invent the obscure vocabulary ex nihilo. Concepts such as frontline experience, sacrifice and the (...) metaphors of the day and night were commonly used by thinkers in the inter-war and post-war eras in their examination of community. This study aims to reconstruct the idea of the solidarity of the shaken as contextualized within a broader scholarly debate on the concept of community. Through the critical dialogue between Patočka’s works and the works of Ernst Jünger and Pierre Teilhard de Chardin, this study will portray how Patočka, in his discourse on the frontline experience, follows the usual pattern of overcoming one’s individuality, transcending and opening up to the constitution of solidarity. This paper will argue that Patočka defined the solidarity of the shaken in an attempt to revive the positive aspects of a community and break with the regressive uses to which it was put in the twentieth century. (shrink)

In his two works from the 1970s, Patočka proposes a very personal way that the spiritual crisis, which manifests itself as a techno-scientific reality of Gestell, can be overcome. Patočka argues that the only way to escape spiritual decline is through sacrifice. This study examines how the ethical is represented in Patočka’s philosophy. It focuses on his two main concepts of sacrifice and care for the soul and explores the relationship between them. Through a close reading of Plato and Europe, (...) ‘Four Seminars’, and his essay ‘The dangers of technicization’, this study reveals how Patočka proposes that the ethical can be implemented within the realm of the political. Drawing a parallel between Socrates’ and Patočka’s lives and fates, this study points to the significance of ethics in political life – both in the ancient Greek polis of Socrates’ time and in communist Czechoslovakia in Patočka’s time. This approach highlights the influence that the philosophy of Socrates had on Patočka’s thinking. (shrink)

The present article deals with specific normative concepts of Spinoza’s ethical system and compares them to certain aspects of the theory of ethics of social consequences. At first, a way to approach the problem of normativity in Spinoza is presented, concentrating on the obligatory character of rational - or intellectual - motives. Then, theoretical evidence is presented which links Spinoza to normative-ethical consequentialism. The basis for a consequentialist model of Spinoza’s ethics is the concept of perfection, and on this basis (...) it seems possible to consider its compatibility with non-utilitarian forms of consequentialism, such as ethics of social consequences. Conclusively, the paper’s aim is to present the possibility of considering Spinozian consequentialism as a non-utilitarian consequentialism, while considering ethics of social consequences as a contemporary form of Spinozian consequentialism. (shrink)

As the crisis around Covid-19 evolves, it becomes clear that there are numerous negative side-effects of the lockdown strategies implemented by many countries. Currently, more evidence becomes available that the lockdowns may have more negative effects than positive effects. For instance, many measures taken in a lockdown aimed at protecting human life may compromise the immune system, and purpose in life, especially of vulnerable groups. This leads to the paradoxical situation of compromising the immune system and physical and mental health (...) of many people, including the ones we aim to protect. Also, it is expected that hundreds of millions of people will die from hunger and postponed medical treatments. Other side effects include financial insecurity of billions of people, physical and mental health problems, and increased inequalities. The economic and health repercussions of the crisis will be falling disproportionately on young workers, low-income families and women, and thus exacerbate existing inequalities. As the virus outbreak and media coverage spread fear and anxiety, superstition, cognitive dissonance reduction and conspiracy theories are ways to find meaning and reduce anxiety. These behavioral aspects may play a role in the continuance of lockdown decisions. Based on theories regarding agnotology (i.e. the ways ignorance or doubt about certain topics is created by means of withholding or presenting information in a certain way), social influence, superstition and stress and coping, I seek to explain the social and behavioral aspects of human behavior in times of crises. Both the Covid-19 crisis itself as well as the resulting economic and (mental) health crisis are global problems that may require global solutions. I present a model of drivers and outcomes of lockdown behaviors and offer suggestions and a tool to counteract the negative psychological effects by means of online life crafting therapeutic writing interventions. (shrink)

Bidirectional deep brain stimulation (DBS) platforms have enabled a surge in hours of recordings in naturalistic environments, allowing further insight into neurological and psychiatric disease states. However, high amplitude, high frequency stimulation generates artifacts that contaminate neural signals and hinder our ability to interpret the data. This is especially true in psychiatric disorders, for which high amplitude stimulation is commonly applied to deep brain structures where the native neural activity is miniscule in comparison. Here, we characterized artifact sources in recordings (...) from a bidirectional DBS platform, the Medtronic Summit RC + S, with the goal of optimizing recording configurations to improve signal to noise ratio (SNR). Data were collected from three subjects in a clinical trial of DBS for obsessive-compulsive disorder. Stimulation was provided bilaterally to the ventral capsule/ventral striatum (VC/VS) using two independent implantable neurostimulators. We first manipulated DBS amplitude within safe limits (2–5.3 mA) to characterize the impact of stimulation artifacts on neural recordings. We found that high amplitude stimulation produces slew overflow, defined as exceeding the rate of change that the analog to digital converter can accurately measure. Overflow led to expanded spectral distortion of the stimulation artifact, with a six fold increase in the bandwidth of the 150.6 Hz stimulation artifact from 147–153 to 140–180 Hz. By increasing sense blank values during high amplitude stimulation, we reduced overflow by as much as 30% and improved artifact distortion, reducing the bandwidth from 140–180 Hz artifact to 147–153 Hz. We also identified artifacts that shifted in frequency through modulation of telemetry parameters. We found that telemetry ratio changes led to predictable shifts in the center-frequencies of the associated artifacts, allowing us to proactively shift the artifacts outside of our frequency range of interest. Overall, the artifact characterization methods and results described here enable increased data interpretability and unconstrained biomarker exploration using data collected from bidirectional DBS devices. (shrink)

Aufgrund der Dominanz eines okonomistisch verengten Rationalitatsideals wird Vertrauen zunehmend als Reputationskalkul oder quasi-vertragliche Kreditbeziehung definiert. MIchaela I. ABdelhamid zeigt: Was hier als "Vertrauen" bezeichnet wird, soll vielmehr der Wertschopfung sowie der Legitimation strategischer Entscheidungen, Sanktionen und Abhangigkeitsverhaltnisse dienen. MIt verstandlichen Analysen und Begriffsscharfungen bietet sie die Grundlage, um die Probleme solcher Inszenierungen erkennen oder auch die Gegenstande sogenannter Vertrauenskrisen reflektieren zu konnen.

Aufgrund der Dominanz eines ökonomistisch verengten Rationalitätsideals wird Vertrauen zunehmend als Reputationskalkül oder quasi-vertragliche Kreditbeziehung definiert. Michaela I. Abdelhamid zeigt: Was hier als »Vertrauen« bezeichnet wird, soll vielmehr der Wertschöpfung sowie der Legitimation strategischer Entscheidungen, Sanktionen und Abhängigkeitsverhältnisse dienen. Mit verständlichen Analysen und Begriffsschärfungen bietet sie die Grundlage, um die Probleme solcher Inszenierungen erkennen oder auch die Gegenstände sogenannter Vertrauenskrisen reflektieren zu können.

Daniel Dennett’s compatibilism based on redefining free will via broadening the concept of self to include unconscious processes seems to disappoint certain intuitions. As Sam Harris points out, it changes the subject from the free will we seem to intuitively care about – conscious free will. This compatibilism is untenable since conscious will seems to be an illusion. However, if we take Dennett’s idea of “atmosphere of free will” and view conscious will as an important concept or “user illusion” which (...) is one of the atmosphere’s building blocks, we can see how a new compatibilism could be reached. Although from the point of view of scientific thinking conscious will seems illusory, inspired by Wilfrid Sellars’s conception of manifest and scientific images we can start to understand free will as existing on its own conceptual level. The confusion stems from mixing the two frameworks. Kompatibilismus Daniela Dennetta, založený na redefinování svobodné vůle skrze rozšíření konceptu „já“ o nevědomé procesy, se zdá být v nesouladu s jistými intuicemi. Jak upozorňuje Sam Harris, vyhýbá se té svobodné vůli, o kterou nám zřejmě intuitivně jde – vědomé svobodné vůli. Tento kompatibilismus je neudržitelný, protože vědomá vůle se zdá být iluzí. Když ale přijmeme Dennettovu myšlenku „atmosféry svobodné vůle“ a nahlédneme vědomou vůli jako důležitý koncept nebo „uživatelskou iluzi“, která je součástí této atmosféry, můžeme najít cestu k novému kompatibilismu. Ačkoliv se z vědeckého pohledu zdá být vědomá vůle iluzí, inspirováni koncepcí zjevného a vědeckého obrazu Wilfrida Sellarse můžeme porozumět svobodné vůli jako existující na své vlastní konceptuální úrovni. Zmatení přichází právě s mícháním zmiňovaných dvou rámců. (shrink)

Minimal counterintuitiveness and its automatic processing has been suggested as the explanation of persistence and transmission of cultural ideas. This purported automatic processing remains relatively unexplored. We manipulated encoding strategy to assess the persistence of memory for different types of expectation violation. Participants viewed concepts including two types of expectation violation or no violation under three different encoding conditions: in the shallow condition participants focused on the perceptual attributes of the concepts, a deep condition probed their semantic meaning, and intentional (...) remembering condition. Participants’ recall was tested immediately as well as 2 weeks later. Our findings showed the greatest memory enhancement for schema-level violations regardless of the encoding condition, while the memory for domain-level violations improved over time. These results suggest two distinct memory patterns for different types of violations, and illustrate the importance of elaborative processes in memory consolidation especially for violations to our expectations. (shrink)

In einer Mixed-Methods-Studie werden elf neu zugewanderten Schüler*innen in der Jahrgangsstufe Einführungsphase am Gymnasium im Rahmen einer Unterrichtsreihe Texte in Easy-to-Read-Versionen (Deutsch: Leichte Sprache) vorgelegt und sowohl sprachliche/fachliche als auch emotionale/soziale Auswirkungen auf die Lernenden untersucht. Außerdem wird ein auf die Zielgruppe angepasstes, zweifach gestuftes Regelwerk für die Erstellung solcher Textversionen entwickelt und Rahmenbedingungen für dessen Einsatz konkretisiert. Ziel ist es, dass neu zugewanderten Schüler*innen, die u.U. wenig oder kaum Englisch können, aber aufgrund ihres Alters in eher fortgeschrittene Englischlerngruppen eingegliedert (...) werden, dennoch die Möglichkeit haben, sich im Englischunterricht einzubringen und mit der peer group zu lernen. Dabei übernimmt das Easy-to-Read eine Brückenfunktion, bis dem Englischunterricht auf Regelniveau gefolgt werden kann. Die AutorinMichaela Quast ist seit 2016 abgeordnete Studienrätin in der fachdidaktischen Abteilung des Englischen Seminars I der Universität zu Köln. (shrink)

Issued by the Schelling-Kommission der Bayerischen Akademie der Wissenschaften.

This article investigates Madison Smartt Bell’s Haitian trilogy as a neocaptivity narrative that combines in new ways the conventions of the slave narrative and the Barbary captivity narrative. Furthermore, it examines the culture-crossing of the character of Doctor Hébert in the course of the successful slave uprising of Saint Domingue. Captivity, I argue, constitutes the central theme and structuring device and also triggers Hébert’s culture-crossing in a reversed Hegelian master-slave dialectic that needs to be read together with Riau’s enslavement. Lacking (...) the social recognition of a free subject, Riau attains his independent self-consciousness through physical resistance and Saint-Domingue’s distinct black culture. Whereas Hébert learns to actively resist slavery as he crosses over into the Haitian society. In their struggles, both undergo the three phases of rites of passage. (shrink)