Over the past several years, discoveries from mouse genetics have had direct impact on our understanding of vitamin A metabolism. Although the metabolism of vitamin A in the mouse does have some special features (for example very large stores of liver and pulmonary retinyl esters), the ability to construct knockout and transgenic mouse models has yielded an impressive amount of information directly relevant to understanding the general principles of vitamin A transport, storage and degradation. We discuss below the metabolism of (...) vitamin A through a number of genetically engineered mouse strains with alterations in genes that affect this metabolism. The novelty of this experimental approach is evidenced by the fact that the oldest of these strains was first reported only eight years ago.1) BioEssays 23:409–419, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

When confronted with an ethical dilemma, most of us like to think we would stand up for our principles. But we are not as ethical as we think we are. In Blind Spots, leading business ethicists Max Bazerman and Ann Tenbrunsel examine the ways we overestimate our ability to do what is right and how we act unethically without meaning to. From the collapse of Enron and corruption in the tobacco industry, to sales of the defective Ford Pinto, the downfall (...) of Bernard Madoff, and the Challenger space shuttle disaster, the authors investigate the nature of ethical failures in the business world and beyond, and illustrate how we can become more ethical, bridging the gap between who we are and who we want to be. Explaining why traditional approaches to ethics don't work, the book considers how blind spots like ethical fading--the removal of ethics from the decision--making process--have led to tragedies and scandals such as the Challenger space shuttle disaster, steroid use in Major League Baseball, the crash in the financial markets, and the energy crisis. The authors demonstrate how ethical standards shift, how we neglect to notice and act on the unethical behavior of others, and how compliance initiatives can actually promote unethical behavior. They argue that scandals will continue to emerge unless such approaches take into account the psychology of individuals faced with ethical dilemmas. Distinguishing our "should self" from our "want self", the authors point out ethical sinkholes that create questionable actions. Suggesting innovative individual and group tactics for improving human judgment, Blind Spots shows us how to secure a place for ethics in our workplaces, institutions, and daily lives. (shrink)

When confronted with an ethical dilemma, most of us like to think we would stand up for our principles. But we are not as ethical as we think we are. In Blind Spots, leading business ethicists Max Bazerman and Ann Tenbrunsel examine the ways we overestimate our ability to do what is right and how we act unethically without meaning to. From the collapse of Enron and corruption in the tobacco industry, to sales of the defective Ford Pinto, the downfall (...) of Bernard Madoff, and the Challenger space shuttle disaster, the authors investigate the nature of ethical failures in the business world and beyond, and illustrate how we can become more ethical, bridging the gap between who we are and who we want to be. Explaining why traditional approaches to ethics don't work, the book considers how blind spots like ethical fading--the removal of ethics from the decision--making process--have led to tragedies and scandals such as the Challenger space shuttle disaster, steroid use in Major League Baseball, the crash in the financial markets, and the energy crisis. The authors demonstrate how ethical standards shift, how we neglect to notice and act on the unethical behavior of others, and how compliance initiatives can actually promote unethical behavior. They argue that scandals will continue to emerge unless such approaches take into account the psychology of individuals faced with ethical dilemmas. Distinguishing our "should self" from our "want self", the authors point out ethical sinkholes that create questionable actions. Suggesting innovative individual and group tactics for improving human judgment, Blind Spots shows us how to secure a place for ethics in our workplaces, institutions, and daily lives. (shrink)

Across the Euro-Atlantic world, political leaders have been mobilizing their bases with nativism, racism, xenophobia, and paeans to “traditional values,” in brazen bids for electoral support. How are we to understand this move to the mainstream of political policies and platforms that lurked only on the far fringes through most of the postwar era? Does it herald a new wave of authoritarianism? Is liberal democracy itself in crisis? In this volume, three distinguished scholars draw on critical theory to address our (...) current predicament. Wendy Brown, Peter E. Gordon, and Max Pensky share a conviction that critical theory retains the power to illuminate the forces producing the current political constellation as well as possible paths away from it. Brown explains how “freedom” has become a rallying cry for manifestly un-emancipatory movements; Gordon dismantles the idea that fascism is rooted in the susceptible psychology of individual citizens and reflects instead on the broader cultural and historical circumstances that lend it force; and Pensky brings together the unlikely pair of Tocqueville and Adorno to explore how democracies can buckle under internal pressure. These incisive essays do not seek to smooth over the irrationality of the contemporary world, and they do not offer the false comforts of an easy return to liberal democratic values. Rather, the three authors draw on their deep engagements with nineteenth–and twentieth–century thought to investigate the historical and political contradictions that have brought about this moment, offering fiery and urgent responses to the demands of the day. (shrink)

John McCormick's ‘democratic’ interpretation of Machiavelli depends on the view that Machiavelli unequivocally endorses the people's moral and political wisdom over that of princes and the elite alike. Leo Strauss's interpretation of Machiavelli offers a means for appraising the anthropological basis of this reading, which is yet to appear in the scholarship. Strauss argues that Machiavelli reduces human nature to the mere desire to stay alive. The people will therefore choose whatever political option stands to offer them the best chance (...) for survival, and, this being equivocal to them, they are just as likely to opt for democracy as they are to raise up a tyrant. From this anthropology also emerges a strand of intellectual elitism in Machiavelli, which is incompatible with what McCormick considers to be Machiavelli's staunch anti-elitism. This article therefore uses Strauss to challenge McCormick's reading of Machiavelli as a populist, arguing that McCormick exaggerates Machiavelli's populist partisanship. (shrink)

Heidegger, M. Andenken an Max Scheler.--Gadamer, H.-G. Max Scheler, der Verschwender.--Plessner, H. Erinnerungen an Max Scheler.--Kuhn, H. Max Scheler als Faust.--Dempf, A. Schelers System christlicher Geistphilosophie als Grundlage einer religiösen Erneuerung.--Scheler, M. Neun Briefe an Karl Muth.--Rombach, H. Die Erfahrung der Freiheit.--Landgrebe, L. Geschichtsphilosophische Perspektiven bei Scheler und Husserl.--Theunissen, M. Wettersturm und Stille.--Good, P. Anschauung und Sprache.--Welsch, W. Mit Scheler.--Avé-Lallement, E. Die phänomenologische Reduktion in der Philosophie Max Schelers.--Gehlen, A. Rückblick auf die Anthropologie Max Schelers.--Schoeps, H. J. Die Stellung des (...) Menschen im Kosmos.--Ströker, E. Der Tod im Denken Max Schelers.--Wyss, D. und Huppmann, G. Die Bedeutung Max Schelers für die Medizinische Anthropologie.--Lieber, H.-J. Bemerkungen zur Wissenssoziologie Max Schelers.--Fetscher, I. Max Schelers Auffassung von Krieg und Frieden.--Bochenski, J. M. Ist die Sprache Schelers in eine analytische übersetzbar? (shrink)

Major depressive disorder is a highly prevalent psychiatric disorder, and recurrent depression is associated with severe and chronic impairment. Identifying markers of risk is imperative to i...

Collaboration requires agents to coordinate their behavior on the fly, sometimes cooperating to solve a single task together and other times dividing it up into sub‐tasks to work on in parallel. Underlying the human ability to collaborate is theory‐of‐mind (ToM), the ability to infer the hidden mental states that drive others to act. Here, we develop Bayesian Delegation, a decentralized multi‐agent learning mechanism with these abilities. Bayesian Delegation enables agents to rapidly infer the hidden intentions of others by inverse planning. (...) We test Bayesian Delegation in a suite of multi‐agent Markov decision processes inspired by cooking problems. On these tasks, agents with Bayesian Delegation coordinate both their high‐level plans (e.g., what sub‐task they should work on) and their low‐level actions (e.g., avoiding getting in each other's way). When matched with partners that act using the same algorithm, Bayesian Delegation outperforms alternatives. Bayesian Delegation is also a capable ad hoc collaborator and successfully coordinates with other agent types even in the absence of prior experience. Finally, in a behavioral experiment, we show that Bayesian Delegation makes inferences similar to human observers about the intent of others. Together, these results argue for the centrality of ToM for successful decentralized multi‐agent collaboration. (shrink)

Nous sommes des êtres à la fois spirituels et corporels. Mon poids est un attribut corporel, tandis que ma capacité d'imaginer un paysage marin relève d'un attribut mental. Or, une fois admise cette dualité des attributs, comment concevoir l'interaction entre le corps et l'esprit? Face aux doctrines dualistes qui échouent à répondre à cette question, Max Kistler défend ici une variante du matérialisme réductionniste qui fait droit à la notion d'émergence : corps et esprit se logent au sein d'une hiérarchie (...) de niveaux de réalité. Les personnes - exclusivement composées, comme tout autre objet matériel, d'atomes - ont des propriétés émergentes que ne possède aucune de leurs composantes. L'auteur développe ainsi une nouvelle conception de l'émergence qui la rend compatible avec la réduction. Une personne peut penser tandis qu'aucune partie de son corps ne le peut : en ce sens, la capacité de penser émerge au niveau de la personne. Mais il est en principe possible d'expliquer cette capacité en termes des parties physiologiques de la personne. Une telle intégration dans la conception scientifique du monde ne prive notre esprit ni de réalité ni d'efficacité : lorsque je raconte ma rêverie à un ami, ma rêverie et le désir de la partager figurent parmi les causes de la vibration de mes cordes vocales..."--Page 4 of cover. (shrink)

Adolescence is a crucial time for social development, especially for helping and compassionate behaviors; yet brain networks involved in adolescent prosociality and compassion currently remain underexplored. Here, we sought to evaluate a recently proposed domain-general developmental network model of prosocial cognition by relating adolescent functional and structural brain networks with prosocial and compassionate disposition. We acquired resting state fMRI and diffusion MRI from 95 adolescents along with self-report questionnaires assessing prosociality and compassion. We then applied the Network-Based Statistic to inductively (...) investigate whether there is a significant subnetwork related to prosociality and compassion while controlling for age and sex. Based on the Do-GooD model, we expected that this subnetwork would involve connectivity to the ventromedial prefrontal cortex from three domain-general networks, the default mode network, the salience network, and the control network, as well as from the DMN to the mirror neuron systems. NBS revealed a significant functional subnetwork related to prosociality and compassion connecting 31 regions, showing DMN and DLPFC connectivity to the VMPFC; DMN connectivity to mirror neuron systems; and connectivity between the DMN and cerebellum. These findings largely support and extend the Do-GooD model of prosocial cognition in adolescents by further illuminating network-based relationships that have the potential to advance our understanding of brain mechanisms of prosociality. (shrink)

Launched in 1982, the so-calledBerliner Wissenschaftsladen e. V.(WILAB) belonged to the scattered West-German ventures in “counter-science”. This article situates the origins of the “Laden” (~ workshop)—an “alternative” spin-off of sorts, spawned from the Technical University of Berlin—in the context of contemporary advances in regional science policy. In this connection, the ailing, de-industrializing “island city” arguably even played a certain pioneering role: elements of its multipronged “innovation offensive”, which peaked in the early-to-mid 1980s, were visible beyond city limits, including the trade (...) showBIG TECHand, notably, theBerlin Center for Innovation and New Enterprises(BIG), the FRG’s first start-up “incubator”, which opened in 1983.In other words, politically-minded scientists in tendency now had to deal with conditions that were less and less conducive to dreams of a “socially engaged” and “non-alienated” (counter-)science. Indeed, while hardly opposed to the new gospel of innovation, it’s not surprising that ventures such as WILAB, committed as they were to the production of “socially useful” science, found themselves increasingly marginalized. It’s as such a marginal venture, my argument goes, that WILAB’s prima facie hopeless attempt to initiate a different, more “humane” information technology sheds an instructive light on the emergence of “entrepreneurial” science in the FRG during the 1970s and 1980s. (shrink)

Apparsa in versione integrale nel 1916, l’opera che qui offriamo al lettore in una nuova traduzione, accompagnata peraltro dal testo originale e da un esteso indice analitico che per la prima volta, in edizione italiana, restituisce la ricchezza del lessico fenomenologico (e le integrazioni editoriali apportate nel tempo al testo - fino all’ultima edizione tedesca, l’ottava), costituisce l’opus magnum di Max Scheler e, nell’ambito della ragione pratica, un modello di pensiero mai disgiunto dalla vita, capace di guidare, nel sentire e (...) nei corrispondenti giudizi di valore, i nostri passi nel mondo: il nostro volere e il nostro agire. Muovendo da una concezione olistica della percezione assiologica, in linea con i più influenti orientamenti del pensiero filosofico e scientifico contemporaneo, Il formalismo nell’etica e l’etica materiale dei valori presenta una teoria dei valori che sfugge finalmente alla cieca alternativa del relativismo e dell’assolutismo etico e indica con precisione i criteri di correttezza dei giudizi di valore. Nel sottotitolo – Nuovo tentativo di fondazione di un personalismo etico – il volume tradisce, inoltre, l’intento più ambizioso di Scheler, quello di rifondare il classico personalismo declinandolo, appunto, nei termini di una personologia laica che, rivelando all’essere umano un possibile accesso alla propria identità personale e alla propria vocazione, tenta di strapparlo al destino. (shrink)

Digital Earth applications provide a common ground for visualizing, simulating, and modeling real-world situations. The potential of Digital Earth applications has increased significantly with the evolution of artificial intelligence systems and the capacity to collect and process complex amounts of geospatial data. Yet, the widespread techno-optimism at the root of Digital Earth must now confront concerns over high-risk artificial intelligence systems and power asymmetries of a datafied society. In this commentary, we claim that not only can current debates about data (...) governance and ethical artificial intelligence inform development in the field of Digital Earth, but that the specificities of geospatial data, together with the expectations surrounding Digital Earth applications, offer a fruitful lens through which to examine current debates on data governance and artificial intelligence ethics. In particular, we argue that for the implementation of ethical artificial intelligence and inclusive approaches to data governance, Digital Earth initiatives need to involve stakeholders and communities at the local level and be sensitive to social, legal, cultural, and institutional contexts, including conflicts that might arise within those contexts. (shrink)

The concept of mass is one of the most fundamental notions in physics, comparable in importance only to those of space and time. But in contrast to the latter, which are the subject of innumerable physical and philosophical studies, the concept of mass has been but rarely investigated. Here Max Jammer, a leading philosopher and historian of physics, provides a concise but comprehensive, coherent, and self-contained study of the concept of mass as it is defined, interpreted, and applied in contemporary (...) physics and as it is critically examined in the modern philosophy of science. With its focus on theories proposed after the mid-1950s, the book is the first of its kind, covering the most recent experimental and theoretical investigations into the nature of mass and its role in modern physics, from the realm of elementary particles to the cosmology of galaxies.The book begins with an analysis of the persistent difficulties of defining inertial mass in a noncircular manner and discusses the related question of whether mass is an observational or a theoretical concept. It then studies the notion of mass in special relativity and the delicate problem of whether the relativistic rest mass is the only legitimate notion of mass and whether it is identical with the classical mass. This is followed by a critical analysis of the different derivations of the famous mass-energy relationship E = mc2 and its conflicting interpretations. Jammer then devotes a chapter to the distinction between inertial and gravitational mass and to the various versions of the so-called equivalence principle with which Newton initiated his Principia but which also became the starting point of Einstein's general relativity, which supersedes Newtonian physics. The book concludes with a presentation of recently proposed global and local dynamical theories of the origin and nature of mass.Destined to become a much-consulted reference for philosophers and physicists, this book is also written for the nonprofessional general reader interested in the foundations of physics. (shrink)

What, in essence, characterizes the mind? According to Searle, the potential to be conscious provides the only definitive criterion. Thus, conscious states are unquestionably "mental"; "shallow unconscious" states are also "mental" by virtue of their capacity to be conscious (at least in principle); but there are no "deep unconscious mental states" - i.e. those rules and procedures without access to consciousness, inferred by cognitive science to characterize the operations of the unconscious mind are not mental at all. Indeed, according to (...) Searle, they have no ontological status - they are simply ways of describing some interesting facets of purely physiological phenomena. (shrink)