This book demonstrates how and why vitalism—the idea that life cannot be explained by the principles of mechanism—matters now. Vitalism resists closure and reductionism in the life sciences while simultaneously addressing the object of life itself. The aim of this collection is to consider the questions that vitalism makes it possible to ask: questions about the role and status of life across the sciences, social sciences, and humanities and questions about contingency, indeterminacy, relationality and change. All have special importance now, (...) as the concepts of complexity, artificial life and artificial intelligence, information theory, and cybernetics become increasingly significant in more and more fields of activity. (shrink)

Using C. Wright Mills' book The Sociological Imagination as a touchstone for its discussion, this article addresses the relations between the sociological problem, relevance and experience as they are and could potentially be understood within sociology. Beginning with the historical relation between sociology, science and literature — a relation which has been productively but differently complicated by poststructuralist and postconstructivist theories — this article asks: to what extent does the empirical offer a referent for the sociological problem? To what is (...) sociology obliged to be relevant? Arguing for the continued relevance of relevance, particularly in the light of recent reforms in higher education in the UK and the USA, the article explores how the sociological problem might be transformed — and perhaps, more importantly, might be transformative — if the basic commitments of a research project were not to historical social structures but to virtual structures. (shrink)

This article addresses the relations between ‘nature’ and ‘culture’ (and those characteristics associated with ‘the natural’ and ‘the cultural’) in the context of the debates about Prozac. Following Marilyn Strathern, I focus specifically on the contested issue of enablement - that is, on what Prozac does or does not enable, and on the relation between enablement and enhancement, normality and pathology. I argue that the implications of the model of the brain that accompanies explanations of Prozac are such that commentators (...) are obliged to address not only the nature of normality but also the nature of nature itself. Through a close analysis of these debates, I suggest that critiques of Prozac should be understood not as objections to reductionism - to a biology that closes things down - but rather to one that opens things up: that opens up the relations between nature, culture, biology and the individual, relations that are now cross-cut and thrown about by artificiality. Objections to Prozac, then, might be characterized as an attempt to put these concepts back into their ‘proper’ positions, to re-establish the relationality between them. In conclusion, I argue that the biology put forward by proponents of psychopharmacology, regardless of the desirability of the latter, challenges not only the frequent assumptions that are made about the claims of materialist science, but also some of the terms and concepts that are commonly deployed in the social sciences. (shrink)

In the context of the question of the extent to which science studies is able to mount an adequate critique of contemporary developments in science and technology, and in view of the proliferating interest in ethics across the social sciences, this article has two aims. Firstly to address some of the implications for ethics of Bruno Latour's, and to a lesser extent Alfred North Whitehead’s, conceptions of reality, both of which have a bearing on the long-standing dichotomy between facts and (...) values. Drawing on Whitehead's work, it also, secondly, seeks to make a positive argument for ethics and to ask again, in the light of this discussion, where the ethical dimensions of Latour's work might be located. Towards the end of the article, I suggest that Latour's concept of exteriority obliges him to pursue a politics of reality which is the special providence of ‘moralists’, rather than a politics of virtual reality in which all entities, human and non-human, are engaged. (shrink)

This article considers the grounds on which distinctions are drawn between the identities of gender, sexuality, `race' and class and explores the implications of these distinctions in relation to different kinds of identity politics and, in particular, to the politics implied by Judith Butler's theory of performativity. I argue that what is often taken to be the key site of much queer theory and activism - that is, the reappropriation of signifiers of difference - is problematic in the light of (...) a close analysis of subjectivities which are informed by `race', gender and class. More specifically, it may be that struggles which are frequently linked to issues of visibility are problematic in the context of subjectivities - class subjectivities - that are both enabled and constrained by a particular, and a particularly uneasy, relation to recognition and representation. (shrink)

This article addresses the serotonin hypothesis of depression, as it was formulated in clinical and laboratory experiments during the 1950s. In the first instance I argue that the `challenge' posed by patients' subjectivities in clinical investigations into the potentially anti-depressant drug iproniazid was not solely due to the tensions generated by the subject/object dichotomy, but to an excess that exceeds the properties of the objects of the experiment, as well as its requirements and conditions. I then suggest that the serotonin (...) hypothesis too is possessed of an excess, and that this can be understood in terms of a real (actual and virtual) existence in duration. By exploiting the notions of the event and of duration, I offer an under-standing of the hypothesis that pertains not to reduction, reproducibility and sameness, but to differentiation, innovation and creation. (shrink)

Trust is a key component in delivering quality and respectful care within health care systems. However, a growing lack of confidence in health care, particularly among specific subgroups of the population in the United States, could further widen health disparities. In this essay, we explore one approach to building trust and reaching diverse communities to promote health: engaging community‐based organizations (CBOs) as trusted community messengers. We present case studies of partnerships in health promotion, community education, and outreach that showcase how (...) CBOs’ programs build and leverage trust in health care systems through their workforce, services, and engagement with the community. (shrink)

Endo‐exonucleases from E. coli to man, although very different proteins, are multifunctional enzymes with similar enzymatic activities. They probably have two common but opposing biological roles. On the one hand, they promote survival of the organism by acting in recombination and recombinational DNA repair to diversify and help preserve the genome intact. On the other hand, they degrade the genomic DNA when it is damaged beyond repair. This ensures elimination of heavily mutagenized cells from the population.

The introduction to this special issue addresses the production of intimacy in the labour of research. It explores the sensory, emotional and affective relations which form an integral, if often invisible, part of the process through which researchers engage with, produce, understand and translate `research'. The article argues that these processes inform the making of knowledge, shape power relations and enable or constrain the practical negotiation of ethical problems. These issues are not, however, often foregrounded in debates on methods or (...) methodology and are frequently erased from researchers' own accounts of their work. The article explores some of the possible reasons for this, which include institutional and cultural conventions of academic practice, the historical legacies with which disciplines often struggle, and the difficult issues and decisions that individual researchers face as they try to negotiate the relations between scholarly research and personal relationships across time, and between scholarly research and, for example, creativity, fiction, or sensationalism. The article concludes with a review of the main themes in the special issue, focusing in particular on the ways in which the contributors use the concept of intimacy to challenge the boundaries between creativity and analysis; spatial and temporal proximity and distance; freedom and censorship; subjects and objects. (shrink)

This article is based on a performance piece, Thought Conductor # 2, by the artist Bruce Gilchrist. In a live-art context, the signals generated by an individual hooked up to an EEG are converted into passages of musical notation and played by a string quartet. What is happening here, or rather what kind of happening is taking place, is the focus of this article. The article explores the relations between the author, the score, and the sound in Thought Conductor # (...) 2 as well in John Cage’s 4’33”, the landmark work that inspired the Thought Conductor pieces, and which has been described as one of the first happenings in America. These key elements offer clues to the different kinds of ‘presences’ that the performances embody, and the different notions of ‘life’ to which they refer. The sound of TC2 is the sound of an event. (shrink)

This article explores representations of the artist Willem de Kooning who, during the last few years of his creative life, produced a large number of paintings at the same time as he was thought to be suffering from Alzheimer's disease. My focus is on the way that these representations mobilize themes which Jane Goodall identifies as belonging to a discourse of anxiety. In a bid to suggest that the artist is uniquely positioned to adapt to the progression of the disease, (...) commentators betray a particular concern with the relation between will and intuition. This relation is negotiated, first, by privileging the hand of the artist as a body part possessed of a brain and a will of its own and, second, by drawing on neurological explanations of the nervous system which have the effect of removing `will' from the sphere of voluntarism. Although these representations go some way to refigure conventional notions of artistic identity and creative processes, the reliance on neurology supports an elitism which justifies the exclusion of certain figures (the insane, the naive, the computer) not just from the subject-position `artist', but also from the category `human'. (shrink)

This paper is situated in the context of feminist poststructuralist debates around identity. In it, I argue that anti-essentialist accounts of identity, while they may displace, or at least call into question, the foundations of subjectivity, are no less likely to invoke a series of presuppositions with respect to the self than those who seek to maintain them in some form. In particular, these presuppositions often cohere around the materiality of the body. And yet, paradoxically, this accent on materiality refers (...) to a very particular kind of body - one that seems to have very little relation to the biological body. Using psychopharmacology as an example, I suggest that the Gilles Deleuze's ethology offers one way through which both to engage seriously with the 'biological' body while at the same time resisting either an essentialist or biological determinist position. (shrink)

The authors explore how the multi-media artist Farniyaz Zaker uses words to establish connections between different kinds of materials in her work, and how her work makes words material. Zaker’s conception of dress as ‘microcosmic dwelling places’ enables the authors to think about veiling practices, Islams and gender not only in relation to the familiar domains of state, piety, subjectivity, consumption, capitalism, public and private, but also with regard to some less self-evidently relevant contexts. Light, architecture and cinema, as well (...) as walls, windows, curtains, coffins, tents and screens, are among them. It is by way of these multiple refractions that the authors are able to return to those debates that conceive of Islamic veiling in terms of embodied, material practices and to support and develop further reasons for an understanding of that most exceptionally charged piece of material, the veil, as more than a sign of …. (shrink)