This paper presents Integrated Information Theory (IIT) 4.0. IIT aims to account for the properties of experience in physical (operational) terms. It identifies the essential properties of experience (axioms), infers the necessary and sufficient properties that its substrate must satisfy (postulates), and expresses them in mathematical terms. In principle, the postulates can be applied to any system of units in a state to determine whether it is conscious, to what degree, and in what way. IIT offers a parsimonious explanation of (...) empirical evidence, makes testable predictions, and permits inferences and extrapolations. IIT 4.0 incorporates several developments of the past ten years, including a more accurate translation of axioms into postulates and mathematical expressions, the introduction of a unique measure of intrinsic information that is consistent with the postulates, and an explicit assessment of causal relations. By fully unfolding a system's irreducible cause-effect power, the distinctions and relations specified by a substrate can account for the quality of experience. (shrink)

The definitions and conceptualizations of health, and the management of healthcare have been challenged by the current global scenarios (e.g., new diseases, new geographical distribution of diseases, effects of climate change on health, etc.) and by the ongoing scholarship in humanities and science. In this paper we question the mainstream definition of health adopted by the WHO—‘a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity’ (WHO in Preamble to the constitution of (...) the World Health Organization as adopted by the international health conference, The World Health Organization, 1948)—and its role in providing tools to understand what health is in the contemporary context. More specifically, we argue that this context requires to take into account the role of the environment both in medical theory and in the healthcare practice. To do so, we analyse WHO documents dated 1984 and 1986 which define health as ‘coping with the environment’. We develop the idea of ‘coping with the environment’, by focusing on two cardinal concepts: adaptation in public health and adaptivity in philosophy of biology. We argue that the notions of adaptation and adaptivity can be of major benefit for the characterization of health, and have practical implications. We explore some of these implications by discussing two recent case studies of adaptivity in public health, which can be valuable to further develop adaptive strategies in the current pandemic scenario: community-centred care and microbiologically healthier buildings. (shrink)

Lean is a new open source theorem prover being developed at Microsoft Research and Carnegie Mellon University, with a small trusted kernel based on dependent type theory. It aims to bridge the gap between interactive and automated theorem proving, by situating automated tools and methods in a framework that supports user interaction and the construction of fully specified axiomatic proofs. Lean is an ongoing and long-term effort, but it already provides many useful components, integrated development environments, and a rich API (...) which can be used to embed it into other systems. It is currently being used to formalize category theory, homotopy type theory, and abstract algebra. We describe the project goals, system architecture, and main features, and we discuss applications and continuing work. (shrink)

Both physiological and evolutionary criteria of biological individuality are underpinned by the idea that an individual is a functionally integrated whole. However, a precise account of functional integration has not been provided so far, and current notions are not developed in the details, especially in the case of composite systems. To address this issue, this paper focuses on the organisational dimension of two representative associations of prokaryotes: biofilms and the endosymbiosis between prokaryotes. Some critical voices have been raised against the (...) thesis that biofilms are biological individuals. Nevertheless, it has not been investigated which structural and functional obstacles may prevent them from being fully integrated physiological or evolutionary units. By contrast, the endosymbiotic association of different species of prokaryotes has the potential for achieving a different type of physiological integration based on a common boundary and interlocked functions. This type of association had made it possible, under specific conditions, to evolve endosymbionts into fully integrated organelles. This paper therefore has three aims: first, to analyse the organisational conditions and the physiological mechanisms that enable integration in prokaryotic associations; second, to discuss the organisational differences between biofilms and prokaryotic endosymbiosis and the types of integration they achieve; finally, to provide a more precise account of functional integration based on these case studies. (shrink)

Eating is a fundamental behavior in which all organisms must engage in order to procure the material and energy from their environment that they need to maintain themselves. Since controlling eating requires procuring, processing, and assessing information, it constitutes a cognitive activity that provides a productive domain for pursuing cognitive biology as proposed by Ladislav Kováč. In agreement with Kováč, we argue that cognition is fundamentally grounded in chemical signaling and processing. To support this thesis, we adopt Cisek’s strategy of (...) phylogenetic refinement, focusing on two animal phyla, Porifera and Placozoa, organisms that do not have neurons, muscles, or an alimentary canal, but nonetheless need to coordinate the activity of cells of multiple types in order to eat. We review what research has revealed so far about how these animals gather and process information to control their eating behavior. (shrink)

Many factors contribute to the inappropriate use of medicines, including not only a lack of information but also inaccurate and misleading promotional information. This review examines how the promotion of pharmaceuticals directly affects the prescribing and use of medicines. We define promotion broadly as all actions taken directly by pharmaceutical companies with the aim of enhancing product sales. We look in greater detail at promotion techniques aimed at prescribers, such as sales representatives, pharmaceutical advertisements in medical journals and use of (...) key opinion leaders, along with the quality of information provided and the effects thereof. We also discuss promotion to the public, through direct-to-consumer advertising, and its effects. Finally, we consider initiatives to regulate promotion that come from industry, government and nongovernmental organizations. (shrink)

El texto se propone abordar el problema de la expresión en la filosofía de Merleau-Ponty bajo tres aspectos generales: 1. Hacia una ontología de lo sensible, 2. Expresión y diferencia corporal y 3. Cuerpo y expresión creadora. A partir de la noción de naturaleza se busca, con el primer apartado, destacar el carácter ontológico de la percepción, con el fin de comprender por qué la percepción es ya expresión. En segundo lugar, se pretende ahondar en la tesis del cuerpo como (...) expresión y de esta manera poder precisar su vínculo esencial con el lenguaje. A partir de la distinción entre el lenguaje hablante y el lenguaje hablado se precisa, finalmente, el carácter paradójico de la expresión, su sentido encarnado. (shrink)

To be usable in practice, interactive theorem provers need to provide convenient and efficient means of writing expressions, definitions, and proofs. This involves inferring information that is often left implicit in an ordinary mathematical text, and resolving ambiguities in mathematical expressions. We refer to the process of passing from a quasi-formal and partially-specified expression to a completely precise formal one as elaboration. We describe an elaboration algorithm for dependent type theory that has been implemented in the Lean theorem prover. Lean’s (...) elaborator supports higher-order unification, type class inference, ad hoc overloading, insertion of coercions, the use of tactics, and the computational reduction of terms. The interactions between these components are subtle and complex, and the elaboration algorithm has been carefully designed to balance efficiency and usability. We describe the central design goals, and the means by which they are achieved. (shrink)

Apresentação do Dossiê temático 'Bem-estar / Mal-estar do alunado e do professorado: saúde do corpo e da mente no ambiente formativo' - Parte 1: Discentes. Editorial do número 30, v. 1, Ano XVII, Jul-Dez, 2023. Artigos fluxo contínuo.

Nuestro punto de partida es la concepción de Merleau-Ponty del lenguaje como "habla". Sostenemos que esta, como experiencia corporal del lenguaje -como lenguaje "en" nosotros-, permite comprender el fenómeno de la /nter-culturalidad como un fenómeno esencialmente /ntra-cultural, en el sentido de una experiencia de la cultura "desde dentro", es decir, desde la experiencia que cada quien hace del lenguaje. Este carácter endógeno e individual de pensar la cultura pone en evidencia, sin embargo, un "entre-lazamiento" recíproco originario entre lo propio y (...) lo extraño que impide de entrada privilegiar ya sea una visión universalista o totalizante o bien individualista o regionalista de la cultura. En dos momentos doy cuenta de este planteamiento: 1. Mundo de la vida y diversidad cultural y 2. El habla como lugar de acceso a las culturas. Our starting point is the conception in Merleau Ponty of language as "speech". We support this concept as corporal experience of language -as language "in" us - allows to understand the phenomenon of ¿nter-culturality as an essentially ¿ntra-cultural phenomenon, in the sense of an experience of culture "from within", that is to say; from the experience that everyone does with the language. This endogenous and individual character of thinking about culture highlights, however, a reciprocal "entanglement" originated among one's own and the strange that initially prevents to privilege, even a universal or totalizing or either an individualistic or regionalist vision of culture. Two moments I take on this approach: 1. World of life and cultural diversity. 2. Speech as an access place to the cultures. (shrink)

Dispositivos da Formação Teórica Queer: contribuições de Michel Foucault e Jacques Derrida Resumo: O presente artigo busca discutir as contribuições de Michel Foucault e Jacques Derrida para a formulação da teoria queer, apresentando algumas de suas propostas teóricas que passeiam e incorporam movimentos políticos e acadêmicos, bem como corpos em constante construção de si, incorporados por enunciados de gênero, suas oposições, mas também por suas Diferanças. Para isso, apresentamos inicialmente os itinerários históricos dos movimentos políticos queer, ou seja, uma pragmática (...) que se dará ao longo da sua construção, base para o pensamento teórico. A seguir, apresentamos o pensamento desses autores como pressupostos para a potencialização, tanto dessa pragmática, como de dispositivos que compõem a analítica das normalizações dos gêneros e para além deles, constitutivas da Teoria Queer. Palavras-chave: Gênero; Teoria Queer; Michel Foucault; Jacques Derrida. Devices of Queer Theoretical Formation: contributions from Michel Foucault and Jacques Derrida Abstract: This article aims to discuss the contributions of Michel Foucault and Jacques Derrida to the formulation of queer theory, presenting some of their theoretical proposals that walk and incorporate political and academic movements, as well as bodies in constant construction of themselves, incorporated by statements of gender, its oppositions, but also for its Differances. For this, we initially present the historical itineraries of queer political movements, that is, a pragmatics that will take place throughout their construction, the basis for theoretical thinking. In sequence, we present the thought of these authors as presuppositions for the potentializing of both this pragmatics and devices that make up the analysis of the normalizations of genres and beyond them, which are constitutive of the Queer Theory. Keywords: Gender; Queer Theory; Michel Foucault; Jacques Derrida. Dispositivos de Formación Teórica Queer: aportes de Michel Foucault y Jacques Derrida Resumen: Este artículo busca discutir los aportes de Michel Foucault y Jacques Derrida a la formulación de la teoría queer, presentando algunas de sus propuestas teóricas que caminan e incorporan movimientos políticos y académicos, así como cuerpos en constante construcción de sí mismos, incorporados por declaraciones de género, sus oposiciones, pero también por sus Diferancias. Para eso, presentamos inicialmente los itinerarios históricos de los movimientos políticos queer, o sea, una pragmática que se irá dando a lo largo de su construcción, base del pensamiento teórico. La continuación, presentamos el pensamiento de estos autores como presupuestos para la potencialización tanto de esta pragmática como de los dispositivos que componen el análisis de las normalizaciones de géneros y más allá de ellos, que son constitutivos de la Teoría Queer. Palabras clave: Género; Teoría Queer; Michel Foucault; Jacques Derrida. Data de registro: 16/09/2021 Data de aceite: 19/01/2022. (shrink)

En su obra principal “Crítica de la razón pura”, Kant deja clara su intención de no solo investigar las cualidades epistemológicas del ser humano, sino también de fundamentar las ciencias naturales. Principalmente la física y las matemáticas. El libro “Fundamentaciones metafísicas de las ciencias naturales” continua este proyecto. En su prólogo se excluye aún más a ambas ciencias, al catalogarlas como las únicas portadoras de conocimientos sintéticos a priori. Los problemas surgen con la “Crítica del Juicio” y su apartado “Crítica (...) del Juicio teleológico”. Aquí, Kant intenta legitimar la biología como ciencia natural sin invadir el campo ocupado por la física matemática. El resultado es una biología que porta conocimientos necesarios pero que al mismo tiempo no puede brindarnos leyes constitutivas de la naturaleza. Esta nueva ciencia natural se torna irreconciliable con el sistema de las ciencias naturales que Kant mismo había planteado en sus libros anteriores. (shrink)

El caso del Movimiento Arcoíris en Chile permite ilustrar en dos ámbitos, los significados atribuidos a la naturaleza y las formas que adquiere la acción colectiva contemporánea, las derivas y tensiones que se presentan al intentar materializar el mundo anhelado. Esta investigación, se efectuó por medio de una etnografía (2009-2022) y diez entrevistas semiestructuradas analizadas desde un enfoque hermenéutico. Tuvo como resultados nueve prácticas sedimentadas -de las cuales se presentan tres- y un conjunto heterogéneo de significaciones para cada una de (...) ellas. A modo de discusión y conclusión se propone que este Movimiento expande un tipo de vínculo afectivo/espiritual con la naturaleza que rehúye del modo de producción industrial y que sus formas de acción colectiva privilegian la autonomía y la horizontalidad entre sus miembros. Ambas cuestiones encuentran límites en la espontaneidad de las acciones, el capitalismo verde, en las dificultades para arribar a acuerdos y/o su escaso cumplimiento. (shrink)

This paper investigates, in a simple risk-sharing framework, the extent to which the incompleteness of contracts could be attributed to the complexity costs associated with the writing and the implementation of contracts. We show that, given any measure of complexity in a very general class, it is possible to find simple contracting problems such that, when complexity costs are explicitly taken into account, the contracting parties optimally choose an incomplete contract which coincides with the ‘default’ division of surplus. Optimal contracts (...) with complexity costs are constrained efficient in our model. We therefore interpret our results as saying that, in the absence of a strategic role for complexity costs, their effect is entirely determined by their size relative to the size of payoffs. (shrink)

El presente artículo desea reflexionar, por un lado, sobre la necesidad de una formación integral de los agentes sanitarios, que contemple la dimensión espiritual; y, por otro lado, sobre la necesidad de una mejor preparación de los agentes religiosos que trabajan en hospitales y centros de salud, para que en sus intereses y preocupaciones por los enfermos, se eviten las dicotomías en nombre de la fe o en nombre de la razón. La promoción del diálogo entre razón y fe reduce (...) la distancia entre las ciencias y evita el divorcio entre la praxis de la fe y la praxis de la ciencia, revelando que, a pesar de ser distintas por sus grados de certeza, pueden estar próximas por el objeto: la búsqueda de la verdad que libera al ser humano de todas las formas de injusticia y opresión, generadoras de malestar y enfermedades sicosomáticas. This paper intends to reflect, on one hand, the need for an integral education of healthcare agents, that addresses the spiritual dimension; and, on the other hand, the need for a better preparation of religious agents that work in hopitals and health centers, so that, in the interest and concern for sick people, dichotomies in the name of faith or in the name of reason are prevented. The promotion of dialogue between reason and faith shortens the distance between sciences and avoids a divorce between praxis of faith and praxis of science, showing that, despite the different degrees of certainty, may be close by the object: the search for the truth that liberates human beings of all forms of injustice and oppression, disease generators and psychosomatic illnesses. (shrink)

Once hematopoiesis is established in the bone marrow, a continuous egress of hematopoietic stem cells (HSCs) to the periphery occurs at a low frequency. It has been proposed that this phenomenon is part of a regenerative homeostatic mechanism that ensures the maintenance of hematopoiesis through the life of the individual. The administration of certain cytotoxic drugs or cytokines can enhance the mobilization of hematopoietic progenitors to the periphery. During the past 15 years, granulocyte‐colony stimulating factor (G‐CSF) has been used as (...) a standard cytokine for mobilization protocols in experimental models and in humans. Despite extensive efforts by multiple groups, a definitive mechanism explaining its role in mobilization has not been provided. In a recent paper, Katayama et al.,1 through a series of clever associations supported by well‐defined experimental systems, proposed that signals through the sympathetic nervous system modify the activity of the hematopoietic niche, acting as regulators of the mobilization of hematopoietic progenitors. This surprising finding adds a new level of complexity to the cellular milieu responsible for generation and maintenance of the hematopoietic niche. BioEssays 28: 687–691, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

En el presente escrito, se da a conocer una interpretación _“personal”_, no por ello arbitraria, del texto _Sobre el concepto de historia _o _Tesis de filosofía de la historia_, _Über den Begriff der Geschichte_ de Walter Benjamín, leído de manera situada, una lectura cuya óptica pretende ser _desde_ América Latina. Se insistirá en la excepcionalidad crítica de la obra de Benjamín, sugiriendo que su propuesta alcanza una re-definición y transvaloración del concepto de historia, aquel que de manera habitual nos determina, (...) y que impide todo actuar, toda praxis revolucionaria, que para un tiempo como el nuestro, y que es ahora, se requiere más que nunca. (shrink)

RESUMENEn este trabajo se propone una física filosófica de causas como posible respuesta al problema del realismo que plantea la teoría de la ciencia actual. La clave de la respuesta estriba en la inactualidad y potencialidad de lo físico causal.PALABRAS CLAVESMETAFISICA – FISICA DE CAUSAS – REALISMOABSTRACTThe article defends a causal philosophical physics as a posible answer to the problema of realism set up by the current theory of science. The answers lies in the inactuality and potentiality of causal physics.KEYWORDSMETAPHYSICS (...) – CAUSAL PHYSICS – REALISM. (shrink)

Apresentamos um recorte da pesquisa realizada no âmbito do doutorado em Educação na Universidade Nacional de Córdoba, Argentina. Utilizamos partes de entrevistas realizadas em uma escola no Rio de Janeiro, BR e em Córdoba, AR. Trabalharemos com uma categoria criada e desenvolvida na tese a partir de interlocuções com a bibliografia e a posterior análise. Objetivamos analisar as condições materiais dos sentidos dos discursos de alunos da Educação de Jovens e Adultos de Brasil e Argentina sobre a categoria trabalho. Nos (...) fundamentamos em uma metodologia qualitativa. Tivemos como fulcro teórico a Análise de Discurso.A partir dos Recortes discursivos, observamos uma exaltação do trabalho. (shrink)

Edmund Husserl intentó excluir supuestos metafísicos y ajustarse a lo dado en la experiencia inmediata, con el fin de buscar una verdad primera e indubitable sobre la cual basar verdades ulteriores, teóricas. Pero, en la segunda etapa de su pensamiento, él abandonó ese camino para usar, sin tematizarlo, el supuesto subjetivista de René Descartes. Para reconducir la fenomenología al proyecto original de ir a las cosas mismas, eliminando supuestos y ateniéndose a la experiencia inmediata, el lósofo español Antonio González Fernández (...) propone la praxeología. Esta aproximación reemplaza el concepto de sujeto, que considera al ser humano como una cosa pensante, por el de persona, entendida como acto encarnado. Esta definición antropológica, coherente con la visión teológica del ser humano como imagen y semejanza de Dios, posibilita orientaciones éticas de las acciones en pro de la descosificación y dignificación del ser humano y el cuidado de la naturaleza. (shrink)

Bernardo de Monteagudo en su texto: Diálogo entre Atahualpa y Fernando VII en los Campos Eliseos, parte de una crítica a las atrocidades llevadas a cabo por los españoles contra los americanos en la Conquista –atrocidades que sobrepasan las llevadas a cabo por Napoleón contra Fernando VII–, para proponer una integración social y cultural que movilice a los pueblos latinoamericanos a la independencia del colonialismo español. Sin embargo, su propuesta no reivindica al indígena, sino que su imagen es usada por (...) el escritor como símbolo de una Latinoamérica que se limita a los criollos. Es decir, el indígena quedará, luego de las independencias latinoamericanas, en una situación similar a la colonial, sólo que ahora bajo el dominio de los criollos. De igual manera, esto nos puede suceder en nuestra realidad bogotana: pensar que Latinoamérica, y especialmente Colombia, se reduce a los Andes, a las ciudades del interior, excluyendo así al Caribe. (shrink)

La posición inicial de Einstein con respecto al éter electromagnético y su posterior eliminación del escenario de la relatividad especial resultaron profundamente alteradas por la relatividad general. En este artículo analizamos los diferentes argumentos de Einstein contra el éter electromagnético. Luego estudiamos las razones que lo llevaron a reintroducir el éter gravitatorio en la relatividad general. Después de comparar las propiedades y funciones del antiguo éter con las del nuevo éter relativista, concluimos que se ha producido un cambio conceptual y (...) que el término "éter" ha experimentado un cambio de significado. No obstante, mostramos que el nuevo éter retuvo algunas de las propiedades y funciones características del viejo éter electromagnético. Einstein's initial attitude towards electromagnetic ether in special relativity was deeply disrupted by general relativity. In this paper we analyze Einstein's different arguments against electromagnetic ether in the frame of special relativity. We then study his reasons for postulating a gravitatory ether in general relativity. After comparing the properties and functions of the traditional electromagnetic ether with those of the new relativistic ether, we conclude that a conceptual change has occurred, because the term "ether" has undergone a change of meaning. However, we also show that the new ether still retains many properties and functions characteristic of the old electromagnetic ether. (shrink)

Este trabajo surge de un diálogo interdisciplinario entre dos tesis doctorales, una de educación y otra de filosofía, que comparten un interés sobre formas emancipadoras y democráticas de pensar con otros y otras en la escuela pública latinoamericana. Desde una perspectiva crítica propia de la filosofía de la educación latinoamericana realizamos un análisis epistemológico sobre las distintas formas de habitar la pregunta dentro de una práctica filosófica con niños y niñas. Tomamos como objeto de estudio una experiencia específica de comunidad (...) de indagación realizada en 2022 en el sur de Mendoza, Argentina. Entramamos herramientas teóricas de Walter Kohan, Paulo Freire y Jacques Rancière con la intención de visibilizar diversas formas de habitar la producción de saberes dentro de dicha comunidad. Proponemos dos nudos problemáticos: por un lado, el orden explicador/embrutecedor a partir de Rancière y, por el otro,la pregunta como afirmación vital a partir de Kohan y Freire. Trabajamos una serie de disonancias en torno a la circulación y a la potencia de la pregunta en la escuela y la educación pública. Finalmente proponemos una síntesis de estas problemáticas en la postulación de una “pregunta niña” como potencia epistémica emancipadora que supone una intimidad con los otros y otras, con las cosas y el mundo abierta desde una igualdad política e intelectual radical. (shrink)

An atmosfere of fear seems to surround western culture in the last two or three decades. From it stems a new kind of fear, imaginarially expressed in the fear of collapse event. In this paper, we chart some manifestations of the new fear of collapse in the sphere of cinema and of intelectual academic writings. In the first case, with the emergence of collapse and zombie movies in cultural industry productions; in the second one, in the emergence of civilizational collapse (...) as a theme for historians, systems and complexity cientists, ecologists, peak-oil theorists, economists, social scientists etc. Some possible explanatory hipothesis for the emergency of this fenomenon are conjectured. (shrink)

Palabras de agradecimiento al promotor del Congreso Internacional y a los participantes en él. Asimismo, a la persona que ha trabajado en la labor de transcripción de mis escritos y a otros colaboradores míos. También a quienes han tomado en cuenta mis ideas para elaborar sus tesis doctorales, y a otros colegas cuyos planteamientos filosóficos distan de los míos. Como la filosofía es una actividad interminable, queda abierta la sucesiva investigación en mis propuestas.

Resumo Este artigo procura apresentar e discutir tentativas recentes em filosofia social de analisar e interpretar o capitalismo, a partir de uma perspectiva praxeológica. O practice turn em teoria social procurou superar o dualismo entre agência e estrutura, ou entre ação e sistema, por meio da noção de prática social. Seria possível então interpretar o capitalismo como um tipo especifico de prática social? Para tentar encaminhar essa questão, explicita-se brevemente, em um primeiro momento, em que consiste o practice turn em (...) teoria social. Num segundo momento, analisa-se e se discute a proposta de Rahel Jaeggi de conceber a economia como uma rede de práticas sociais. Em seguida, expõe-se e se avalia a tentativa de Christian Lotz em ver, no dinheiro, a chave para compreender aquilo que ele chama de esquema capitalista. Por fim, conclui-se, chamando a atenção para os potenciais e desafios ligados ao empreendimento de interpretar o capitalismo em função de uma teoria da prática, sugerindo que um aprofundamento na análise da imaginação especificamente capitalista, vinculando-a com a típica plasticidade e diversidade do capitalismo, possa ajudar a avançar nesse campo.This paper aims to present and discuss recent attempts in social philosophy to analyze and interpret capitalism from a praxeological perspective. The practice turn in social theory sought to overcome the dualism between agency and structure, or between action and system, through the notion of social practice. Is it then possible to interpret capitalism as a specific type of social practice? To try to address this question, I briefly introduce, in a first moment, the practice turn in social theory. In a second moment, I analyze and discuss Rahel Jaeggi’s proposal to conceive the economy as a network of social practices. I then explain and evaluate Christian Lotz’s attempt to see money as the key to understanding what he names as “the capitalist schema”. Finally, I conclude by drawing attention to the potentials and challenges of interpreting capitalism as a social practice, suggesting that a deeper analysis of specifically capitalist imagination, linking it with the typical plasticity and diversity of capitalism, may help to move forward in this field. (shrink)

Organization figures centrally in the understanding of biological systems advanced by both new mechanists and proponents of the autonomy framework. The new mechanists focus on how components of mechanisms are organized to produce a phenomenon and emphasize productive continuity between these components. The autonomy framework focuses on how the components of a biological system are organized in such a way that they contribute to the maintenance of the organisms that produce them. In this paper we analyze and compare these two (...) accounts of organization and argue that understanding biological organisms as cohesively integrated systems benefits from insights from both. To bring together the two accounts, we focus on the notions of control and regulation as bridge concepts. We start from a characterization of biological mechanisms in terms of constraints and focus on a specific type of mechanism, control mechanisms, that operate on other mechanisms on the basis of measurements of variables in the system and its environment. Control mechanisms are characterized by their own set of constraints that enable them to sense conditions, convey signals, and effect changes on constraints in the controlled mechanism. They thereby allow living organisms to adapt to internal and external variations and to coordinate their parts in such a manner as to maintain viability. Because living organisms contain a vast number of control mechanisms, a central challenge is to understand how they are themselves organized. With the support of examples from both unicellular and multicellular systems we argue that control mechanisms are organized heterarchically, and we discuss how this type of control architecture can, without invoking top-down and centralized forms of organizations, succeed in coordinating internal activities of organisms. (shrink)

Living organisms act as integrated wholes to maintain themselves. Individual actions can each be explained by characterizing the mechanisms that perform the activity. But these alone do not explain how various activities are coordinated and performed versatilely. We argue that this depends on a specific type of mechanism, a control mechanism. We develop an account of control by examining several extensively studied control mechanisms operative in the bacterium E. coli. On our analysis, what distinguishes a control mechanism from other mechanisms (...) is that it relies on measuring one or more variables, which results in setting constraints in the control mechanism that determine its action on flexible constraints in other mechanisms. In the most basic arrangement, the measurement process directly determines the action of the control mechanism, but in more complex arrangements signals mediate between measurements and effectors. This opens the possibility of multiple responses to the same measurement and responses based on multiple measurements. It also allows crosstalk, resulting in networks of control mechanisms. Such networks integrate the behaviors of the organism but also present a challenge in tailoring responses to particular measurements. We discuss how integrated activity can still result in differential, versatile, responses. (shrink)

ABSTRACT This paper aims at examining the way in which Rahel Jaeggi’s conception of forms of life as inert bundles of practices is connected to the problem of the possibility of an immanent critique of life forms, that is, of a kind of analysis that is both internal and transformative. In the first part, my contention will be that understanding practices in terms of conventions makes it difficult to admit of internal criticisms of them. Jaeggi’s account of immanent critique, as (...) argued in the second part, tries to differentiate practices from social conventions by maintaining that transformations of life forms can be seen as the result of episodes of crises ignited by the inability to cope with “second order” problems. I maintain that, unless one is willing to postulate something like an absolute telos dictating the historical sequence that forms of life must follow, the way in which forms of life solve second order problems displays some conventional features preventing any quick assimilation to the paradigm of immanent critique. This circumstance, as argued in the third section of my presentation, poses an obstacle to Jaeggi’s project of an immanent critique of life forms. (shrink)