Cell division is an universal process the aim of which is the equitable distribution of subcellular organelles from single cells to their daughters. The extraordinary accuracy with which the genetic material is partitioned requires a complex machinery involving many gene products. Genetic approaches can be used to identify the relevant components and processes, and mutational analysis of loci essential for cell division has been carried out in several eukaryotes, in particular fungi and mammalian cells in culture. Recently, this type of (...) analysis has been extended to Drosophila, an ideal eukaryote for genetic studies. We will review here the genetic dissection of mitosis in Drosophila melanogaster, discussing recent findings of interest and the methodological problems that have been encountered. (shrink)

José Manuel Giménez Amaya; Sergio Sánchez Migallón: De la Neurociencia a la Neuroética. Narrativa científica y reflexión filosófica, Pamplona: EUNSA 2010, 172 pp.

Este trabajo indaga las resemantizaciones del mito de Venus en tres poetas latinoamericanos: Julián del Casal, Rubén Darío y José Lezama Lima teniendo en cuenta la intertextualidad y las poéticas correspondientes. This paper analyses the Venus myth appropiation into the poetry of Julián del Casal, Rubén Darío and José Lezama Lima considering their poetry and intertextuality.

Este trabajo indaga las resemantizaciones del mito de Venus en tres poetas latinoamericanos: Julián del Casal, Rubén Darío y José Lezama Lima teniendo en cuenta la intertextualidad y las poéticas correspondientes. This paper analyses the Venus myth appropiation into the poetry of Julián del Casal, Rubén Darío and José Lezama Lima considering their poetry and intertextuality.

To the sceptic's contention that I don't know that I have hands because I don't know that there is an external world, the Moorean replies that I know that there is an external world because I know that I have hands. Crispin Wright has argued that the Moorean move is illegitimate, and has tried to block it by limiting the applicability of the principle of the transmission of knowledge by inference—the principle that recognising the validity of an inference from known (...) premises generates knowledge of the conclusion. I argue that, in the presence of some plausible assumptions, blocking the Moorean move does not require limiting the applicability of the transmission principle. Then I argue against Jim Pryor's contention that the Moorean argument transmits evidential support from its premises to its conclusion. (shrink)

While in agreement with Miranda Fricker’s context-sensitive approach to hermeneutical injustice, this paper argues that this contextualist approach has to be pluralized and rendered relational in more complex ways. In the first place, I argue that the normative assessment of social silences and the epistemic harms they generate cannot be properly carried out without a pluralistic analysis of the different interpretative communities and expressive practices that coexist in the social context in question. Social silences and hermeneutical gaps are misrepresented if (...) they are uniformly predicated of an entire social context, instead of being predicated of particular ways of inhabiting that context by particular people in relation to particular others. I contend that a more nuanced—polyphonic—contextualization offers a more adequate picture of what it means to break social silences and to repair the hermeneutical injustices associated with them. In the second place, I argue that the particular obligations with respect to hermeneutical justice that differently situated subjects and groups have are interactive and need to be determined relationally. That is, whether individuals and groups live up to their hermeneutical responsibilities has to be assessed by taking into account the forms of mutual positionality, relationality, and responsivity (or lack thereof) that these subjects and groups display with respect to one another. The central argument is developed through an examination of what in race theory and in contemporary epistemologies of ignorance has been termed “white ignorance”; that is, the kind of hermeneutical inability of privileged white subjects to recognize and make sense of their racial identities, experiences, and social positionality. (shrink)

The paper deals with the interpretation of Wittgenstein's views on the power of occurrent mental states to sort objects or states of affairs as in accord or in conflict with them, as presented in the rule-following passages of the Philosophical Investigations. I shall argue first that the readings advanced by Saul Kripke and John McDowell fail to provide a satisfactory construal of Wittgenstein's treatment of a platonist account of this phenomenon, according to which the sorting power of occurrent mental states (...) is to be explained by reference to the mind's ability to grasp universals. I contend that the argument that Kripke extracts from Wittgenstein's discussion doesn't succeed in undermining the platonist position. Then I argue that McDowell's reading exhibits a more serious shortcoming: the position that he ascribes to Wittgenstein is indistinguishable from the platonist account. Then I put forward a proposal as to how to articulate the relationship between Wittgenstein's views and the platonist position. (shrink)

An introduction to the basic concepts and results of contemporary logic, including a discussion of the basic mathematical tools needed to master the technical aspects of the subject.

The paper develops an account of semantic notions which occupies a middle ground between antirealism and traditional forms of realism, using some ideas from the work of John McDowell. The position is based on a contrast between two points of view from which we might attempt to characterize our linguistic practices from the cosmic exile s point of view and from the midst of language as a going concern. The contrast is drawn in terms of whether our characterization of our (...) linguistic practices is taken to result from engagement in the very same practices that we are trying to characterize. The position takes realism to be correct when understood as an account from the internal perspective, but incorrect when taken as an account from the external perspective. However, the intelligibility of the question as to what our practices would look like from the cosmic exile s point of view is presented as problematic. (shrink)

I use some ideas of Keith DeRose's to develop an (invariantist!) account of why sceptical reasoning doesn't show that I don't know that I'm not a brain in a vat. I argue that knowledge is subject to the risk-of-error constraint: a true belief won’t have the status of knowledge if there is a substantial risk of the belief being in error that hasn’t been brought under control. When a substantial risk of error is present (i.e. beliefs in propositions that are (...) false in nearby worlds), satisfying the constraint requires bringing the risk under control. This is achieved either by sensitivity, i.e. you wouldn’t have the belief if it were false, or by identifying evidence for the proposition. However, when the risk of error is not substantial (i.e. beliefs in propositions that are not false in nearby worlds), the constraint is satisfied by default. My belief that I am not a brain in a vat is insensitive and I have no evidence for it, but since it is not false in nearby worlds, it satisfies the constraint by default. (shrink)

Reliabilist accounts of knowledge are widely seen as having the resources for blocking sceptical arguments, since these arguments appear to rely on assumptions about the nature of knowledge that are rendered illegitimate by reliabilist accounts. The goal of this book is to assess the main arguments against the possibility of knowledge, and its conclusions challenge this consensus. The book articulates and defends a theory of knowledge that belongs firmly in the truth-tracking tradition, and argues that although the theory has the (...) resources for blocking the main standard lines of sceptical reasoning, there is a sceptical argument against which the theory offers no defence, as it doesn’t rely on any assumptions that the theory would render illegitimate. The book ends with the suggestion that the problem might have a metaphysical solution—that although the sceptical argument may make no illegitimate epistemological assumptions, it does rest on a questionable account of the nature of cognition. (shrink)

There is a question that has not been raised in the literature on Japan's regionalism: Why does it have a strong tendency toward making the boundary of the proposed East Asian community fluid? By looking back beyond the Greater East Asia Co-Prosperity Sphere of the 1940s, a method hitherto untried, the paper shows that this Japanese propensity was also present in the first half of the twentieth century, especially in the 1920s and 1930s. Moreover, both then and now, Japan did (...) not and does not have a firm adherence to an ideology. These are two similarities between the pre-World War II period and the present (from the 1960s). On the other hand, Japan's present international situation is very different from its pre-World War II position. The paper uses the logic of the comparative method, which states that in two cases that are different in most aspects but the same in some, one or some of the similarities may explain the other similarity or similarities. It concludes that in both periods, the lack of a firm commitment to an ideology explains Japan's prejudice toward boundary fluidity. This explanation has the potential to contribute to a more comprehensive, if not yet a general theory of Japan's approach to regionalism because it applies not only to the present, but to the past as well. And it has to be stressed, the past refers not only to the Greater East Asia Co-Prosperity Sphere of the 1940s but also to the decades before. (shrink)

An account of predicate reference is presented which attempts to steer a middle course between reductionism, which construes the notion in terms of speakers' inclinations, and {transcendent) realism, which construes the notion in terms of properties. It is first introduced in the context of a discussion of the accounts of length (distance) advanced by Hans Reichenbach, Adolf Grünbaum and Hilary Putnam. A general account of predicate reference is then developed that explains the notion in terms of speakers' inclinations, while rejecting (...) the idea that this explanation should take the form of a reduction. The view is presented as a vindication of extreme nominalism, as it explains predicate reference solely in terms of the notion of qualia introduced by C.I. Lewis and developed by Nelson Goodman, which, it is argued, is definable in terms of speakers' classificatory propensities. Some connections are explored between the position that is presented and the views of Michael Dummett, John McDowell, Mark Johnston and Hilary Putnam, among others. (shrink)

In this paper I assess the two central ingredients of Laurence BonJour’s position on empirical knowledge that have survived the transition from his earlier coherentist views to his current endorsement of the doctrine of the given: his construal of the problem of the epistemic regress and his rejection of an internalist solution to the problem. The bulk of the paper is devoted to a critical assessment of BonJour’s arguments against externalism. I argue that they fail to put real pressure on (...) externalism, as they rely on a highly questionable conception of epistemic rationality and responsibility. Then, more briefly, I take issue with BonJour’s endorsement of the irrelevance thesis—the claim that even if externalism were true it would not offer a satisfactory solution to the epistemic regress problem. I contend that he is not entitled to subscribe this thesis unless he is prepared to abandon his construal of the problem. (shrink)

Replies to contributions to a symposium on the book, Scepticism and Reliable Belief.

Revised and enlarged edition. The first edition was in 1957.

Corporate America is institutionalizing ethics through a variety of structures, systems, and processes. This study sought to identify managerial perceptions regarding the institutionalization of ethics in organizations. Eighty-six corporate level marketing and human resource managers of American multi-national corporations responded to a mail survey regarding the various implicit and explicit ways by which corporations institutionalize ethics. The results revealed that managers found ethics to be good for the bottom line of the organizations, they did not perceive the need for additional (...) formalization of ethics, and that they perceived implicit forms of institutionalizing ethics (e.g., leadership, corporate culture, top management support) to be more effective than the explicit forms of institutionalizing ethics (e.g., ethics ombudspeople, ethics committees, ethics newsletters). Implications of the survey and future research directions conclude the paper. (shrink)

Ariel es un ensayo publicado por el uruguayo José Enrique Rodó en 1900 y considerado como una de las obras de mayor influencia en el campo de la cultura y la política latinoamericanas. Es un texto breve compuesto de seis partes. Se caracteriza por su contenido filosófico y su tono pedagógico. Está dirigido principalmente a la juventud hispanoamericana, como señala el autor, para advertirles contra el utilitarismo y contra lo que él llama la nordomanía. Utiliza los personajes de La (...) tempestad de William Shakespeare: Próspero, Ariel y Calibán. (shrink)

Robert Kilwardby on the Human Soul examines Kilwardby’s role in conciliating Aristotelian and Augustinian views on the soul, soul-body relation, and cognition.

Este texto se escribió y se publicó como parte de las celebraciones del 80 aniversario del Departamento de Filosofía de la Universidad Iberoamericana, Ciudad de México.

Normative systems have been advocated as an effective tool to regulate interaction in multi-agent systems. The use of deontic operators and the ability to represent defeasible information are known to be two fundamental ingredients to represent and reason about normative systems. In this paper, after introducing a framework that combines standard deontic logic and non-monotonic logic programming, deontic logic programs (DLP), we tackle the fundamental problem of equivalence between normative systems using a deontic extension of David Pearce’s Equilibrium Logic and (...) its monotonic basis, the logic of Here-and-There. We also show how deontic logic programs can be used to represent and reason about normative systems, and establish a strong connection with input-output logic. (shrink)

Social sustainability is in its early stages in hospitality and tourism supply chains, especially in developing countries. This research draws on institutional and stakeholder theories to identify the adopted social sustainability practices in Egypt and to determine the factors affecting their implementation. A mixed-method research approach is followed involving interviews of hotel managers and a literature-based questionnaire answered by a total of 187 practitioners from hospitality and tourism supply chains in Egypt. The interviews revealed that social sustainability practices in the (...) two hotels' supply chains are adopted but limited to legal requirements and brand policies. Statistical analysis indicated that local suppliers boost the adoption of social practices. All the studied barriers show very weak correlation with the adoption of social sustainability practices; according to the interviews, this does not imply barriers inexistence, but rather reflects lack of awareness regarding social rights in a culture that tend to preserve social conservatism. The enablers explained significant variations in many social sustainability practices (53 out of 62). This study is unique since it offers a novel approach by linking institutional and stakeholder theories to recognize weaknesses in tourism supply chain social sustainability, thereby providing directions for the future design of sustainable tourism policies. (shrink)