AimThe functional prognosis of patients after coma following either cardiac arrest or acute structural brain injury is often uncertain. These patients are associated with high mortality and disability. N20 and N70 somatosensory evoked potentials are used to predict prognosis. We evaluated the utility of SSEP as an early indicator of long-term prognosis in these patients.MethodsThis was a retrospective cohort study of patients admitted to the intensive care unit with a diagnosis of coma after CA or ABI. An SSEP study was (...) performed, including N20 and N70 at 24–72 h, after coma onset. Functional recovery was assessed 6–12 months later using the modified Glasgow scale. The study was approved by our local research ethics committee.ResultsIn the CA and ABI groups, the absence of N20 or N70 was a strong indicator of poor outcome. Conversely, the presence of N70 was an indicator of a good outcome.ConclusionSomatosensory evoked potentials are useful early prognostic markers with high specificity and sensitivity. Moreover, N70 has additional potential value for improving the prediction of good long-term functional outcomes.Clinical Trial Registration:[https://clinicaltrials.gov/], identifier [2018/01/001]. (shrink)

Edith Stein (1891-1942) is a clear example of a philosopher, since she dedicated her entire life and effort to the conquest of Truth, of Being. The path she follows begins with her personal experience and her desire to find an answer to the existence of man. In phenomenology, she will find a means of confronting reality, free of prejudices. During her intellectual and existential journey, she meets a God that becomes living experience and quenches her thirst for Truth. She completes (...) her contemplation of the philosophical being by means of a mystic contemplation of Being. Her philosophical activity is a road that leads “from finite being to eternal being”. (shrink)

Contemporary biological research has suggested that some host–microbiome multispecies systems (referred to as “holobionts”) can in certain circumstances evolve as unique biological individual, thus being a unit of selection in evolution. If this is so, then it is arguably the case that some biological adaptations have evolved at the level of the multispecies system, what we call hologenomic adaptations. However, no research has yet been devoted to investigating their nature, or how these adaptations can be distinguished from adaptations at the (...) species-level (genomic adaptations). In this paper, we cover this gap by investigating the nature of hologenomic adaptations. By drawing on the case of the evolution of sanguivory diet in vampire bats, we argue that a trait constitutes a hologenomic adaptation when its evolution can only be explained if the holobiont is considered the biological individual that manifests this adaptation, while the bacterial taxa that bear the trait are only opportunistic beneficiaries of it. We then use the philosophical notions of emergence and inter-identity to explain the nature of this form of individuality and argue why it is special of holobionts. Overall, our paper illustrates how the use of philosophical concepts can illuminate scientific discussions, in the trend of what has recently been called metaphysics of biology. (shrink)

Bourrat and Griffiths :33, 2018) have recently argued that most of the evidence presented by holobiont defenders to support the thesis that holobionts are evolutionary individuals is not to the point and is not even adequate to discriminate multispecies evolutionary individuals from other multispecies assemblages that would not be considered evolutionary individuals by most holobiont defenders. They further argue that an adequate criterion to distinguish the two categories is fitness alignment, presenting the notion of fitness boundedness as a criterion that (...) allows divorcing true multispecies evolutionary individuals from other multispecies assemblages and provides an adequate criterion to single out genuine evolutionary multispecies assemblages. A consequence of their criterion is that holobionts, as conventionally defined by hologenome defenders, are not evolutionary individuals except in very rare cases, and for very specific host-symbiont associations. This paper is a critical response to Bourrat and Griffiths’ arguments and a defence of the arguments presented by holobiont defenders. Drawing upon the case of the hologenomic basis of the evolution of sanguivory in vampire bats, I argue that Bourrat and Griffiths overlook some aspects of the biological nature of the microbiome that justifies the thesis that holobionts are evolutionarily different to other multispecies assemblages. I argue that the hologenome theory of evolution should not define the hologenome as a collection of genomes, but as the sum of the host genome plus some traits of the microbiome which together constitute an evolutionary individual, a conception I refer to as the stability of traits conception of the hologenome. Based on that conception I argue that the evidence presented by holobiont defenders is to the point, and supports the thesis that holobionts are evolutionary individuals. In this sense, the paper offers an account of the holobiont that aims to foster a dialogue between hologenome advocates and hologenome critics. (shrink)

The hologenome concept of evolution is a hypothesis about the evolution of animals and plants. It asserts that the evolution of animals and plants was partially triggered by their interactions with their symbiotic microbiomes. In that vein, the hologenome concept posits that the holobiont (animal host + symbionts of the microbiome) is a unit of selection. -/- The hologenome concept has been severely criticized on the basis that selection on holobionts would only be possible if there were a tight transgenerational (...) host-genotype-to-symbiont-genotype connection. As our current evidence suggests that this is not the case for most of the symbiont species that compose the microbiome of animals and plants, the opportunity for holobiont selection is very low in relation to the opportunity for selection on each of the species that compose the host microbiome. Therefore, holobiont selection will always be disrupted ‘from below’, by selection on each of the species that compose the microbiome. -/- This thesis constitutes a conceptual effort to defend philosophically the hologenome concept. I argue that the criticism according to which holobiont selection requires tight transgenerational host-genotype-to-symbiont-genotype connection is grounded on a metaphysical view of the world according to which the biological hierarchy needs to be nested, such that each new level of selection includes every entity from below. Applied to hologenomes, it entails that the hologenome is a collection of genomes, and selection of hologenomes is assumed to entail cospeciation of the host with the species that constitute its microbiome. -/- Against that interpretation, I propose the ‘stability of traits’ account, according to which hologenome evolution is the result of the action of natural selection in a non-nested hierarchical world. In that vein, hologenome evolution does not entail cospeciation, and thus it does not require tight transgenerational host-genotype-to-symbiont-genotype connection. By embracing a multilevel selection perspective, I argue that hologenome evolution results from the simultaneous action of natural selection on each of the lineages that compose the microbiome, and on the assemblage composed by the host genome plus the functional traits of its microbiome. Hologenome selection occurs when the evolution of the traits of the microbiome result from their effects on the fitness of the host, and it can take the form of multilevel selection 1, or multilevel selection 2. In both cases, hologenome selection entails the evolution of microbiome traits, as well as evolution of the host genome, rather than cospeciation of lineages. (shrink)

Automated decision-making takes up an increasingly significant place in the administrative state. This article presents a conception of discretion that is helpful for evaluating the proper place of algorithms in public decision-making. I argue that the algorithm itself is not a site of discretion. The threat is that automated decision-making alters the relationships between traditional actors in a way that can cut down discretion and human commitment. Algorithmic decision-makers can serve to fetter the discretion that the legislature and the populace (...) expect to be exercised. We must strive to maintain discretion, moral agency, deliberative ideals, and human commitment through the system that surrounds the use of an algorithm and to develop a new expertise that can retain and exercise the expected discretion. Backing this argument are traditional legal constraints, public expectations, and administrative law principles, tied together through the organizing principle of discretion. (shrink)

Aristotle's Ethics develops a complex theory of the qualities which make for a good human being and for several decades there has been intense discussion about whether Aristotle's theory of voluntariness, outlined in the Ethics, actually delineates what modern thinkers would recognize as a theory of moral responsibility. Javier Echeñique presents a novel account of Aristotle's discussion of voluntariness in the Ethics, arguing - against the interpretation by Arthur Adkins and that inspired by Peter Strawson - that he developed (...) an original and compelling theory of moral responsibility and that this theory has contributed in important ways to our understanding of coercion, ignorance and violence. His study will be valuable for a wide range of readers interested in Aristotle and in ancient ethics more broadly. (shrink)

Uno de los principales retos del transhumanismo lo encontramos en su antropología. Nos encontramos ante un reduccionismo en el que el cuerpo aparece despojado de su dignidad y el espíritu no existe. El ejemplo que más me llama la atención de esto es el de la endogénesis: no se valora el hecho de que el ser humano sea gestado dentro del vientre de otro ser humano; para ellos sería preferible tener una máquina que pudiese hacer la misma misión, en lugar (...) de que el embarazo sea un acto de amor que tiene impacto en toda la vida de la persona. Creo que este es el mayor obstáculo en el que nos encontraremos al valorar el transhumanismo, y es especialmente importante: la persona es un edificio de múltiples dimensiones inextricablemente ligadas. Es necesario reconocer la dignidad de nuestro cuerpo, que va más allá de ser sustrato material de nuestra consciencia. El cuerpo forma parte de nuestra naturaleza, en la que cuerpo, emoción, pensamiento y espíritu son dimensiones que están íntimamente ligadas. No podemos renunciar a nuestro cuerpo. Además, me gustaría proponer que dentro del cuerpo existen portales ante la trascendencia. no es lo mismo ser que parecer. Muchos defienden que pronto tendremos robots que estarán dotados de consciencia. Que podrán pasar el test de Turing. Además, la Inteligencia Artificial permite generar mensajes de manera sintética. En algunos casos, estos mensajes son relativamente simples, pero en otros casos, como los chatbots, resultan muy interesantes. Algunos autores estiman que, dentro de poco, estos chatbots podrían llegar a pasar el test de Turing. Una vez tengamos máquinas que pasen el test de Turing, ¿podremos decir que son conscientes? ¿Es lo mismo una máquina que pase el Test de Turing que una máquina consciente? Para algunos, la respuesta es «es indiferente». Yo digo que no, que no es lo mismo. (shrink)

Derek Parfit influentially defends reductionism about persons, the view that a person’s existence just consists in the existence of a brain and body, and the occurrence of a series of physical and mental events. Yet some critics, particularly Mark Johnston, have raised powerful objections to Parfit’s reductionism. In this paper, I defend reductionism against Johnston. In particular, I defend a radical form of reductionism that Buddhist philosophers developed. Buddhist reductionism can justify key features of Parfit’s position, such as the claims (...) that personal identity is not what matters and can also be indeterminate. Furthermore, Buddhist reductionism can avoid Johnston’s objections to Parfit’s reductionism. I conclude that reductionists have good reasons to favor Buddhist reductionism over Parfit’s version. (shrink)

The units or levels of selection debate concerns the question of what kind of biological systems are stable enough that part of their evolution is a result of the process of natural selection acting at their level. Traditionally, the debate has concerned at least two different, though related, questions: the question of the level at which interaction with the environment occurs, and the question of the level at which reproduction occurs. In recent years, biologists and philosophers have discussed a new (...) aspect of this debate, namely the possibility that certain multi-species consortia formed by a host and its microbiome may act as a unit of selection. This thesis, however, has not been without criticism, as it is doubtful that such consortia could meet the conditions required to achieve the degree of stability that would allow them to experience natural selection. The purpose of this paper is to systematically examine such criticisms and to defend the thesis that the holobiont/hologenome can act as a genuine level of selection both in the form of an interactor and in the form of a reproducer. To do so, it will be argued that the microbiome should be characterized in functional rather than taxonomic terms. (shrink)

Se presenta el descubrimiento de un zócalo pintado con almagra, decorado con motivos geométricos de lacería. El muro en que aparece pertenece a un salón alargado en el que se abrirían dos alcobas a cada extremo. El diseño está organizado en cuatro paños, enmarcados por trenza de lazos. Esta composición destaca por la conservación del trazo regulador, y también por el uso de filigranas que ocupan los espacios libres. La cronología de la pintura se establece al pertenecer a las estructuras (...) de una vivienda demolida en el año 1172 para construir la Aljama. Existen varios paralelos, como el ejemplar del patio del Yeso del Alcázar de Sevilla y el aparecido en la calle Imperial. (shrink)

Recently, there has been increasing theoretical and experimental interest in Popper's gedanken experiment. We calculate in this paper, using the path integral approach, the diffraction patterns predicted by quantum mechanics for this arrangement. The calculations confirm the narrowing of the width of the pattern in absence of the slit obtained experimentally by Kim and Shih (Y. Kim and Y. Shih, Found. Phys. 29, 1849 (1999)).

ABSTRACT:This paper analyzes how national institutional factors affect the adoption of the international environmental management standard ISO 14001, using a panel of 139 countries from 1996 to 2006. The analysis emphasizes that during the emerging phase of the standard, the potential lack of consensus within the constituents of the national institutional environment concerning the value of a new standard could send mixed signals to firms about the standard. The results show that in the early phase of adoption, regulative and normative (...) forces within the institutional environment can work against each other. Results also show that regulative or coercive forces play a relatively more important role in the early phase of adoption of the standard than in the subsequent phases of diffusion. In the later phases of diffusion of ISO 14001, normative forces, such as the diffusion of other management standards, as well as factors related to trade, play a more important role. Because of the similarities between environmental management standards and corporate social responsibility standards, this study can help identify some of the challenges for diffusion of ISO management standards in the area of social responsibility. (shrink)

This paper addresses the 1996 cloning of Dolly the sheep, locating it within a long-standing tradition of animal breeding research in Edinburgh. Far from being an end in itself, the cell-nuclear transfer experiment from which Dolly was born should be seen as a step in an investigative pathway that sought the production of medically relevant transgenic animals. By historicising Dolly, I illustrate how the birth of this sheep captures a dramatic redefinition of the life sciences, when in the 1970s and (...) 1980s the rise of neo-liberal governments and the emergence of the biotechnology market pushed research institutions to show tangible applications of their work. Through this broader interpretative framework, the Dolly story emerges as a case study of the deep transformations of agricultural experimentation during the last third of the twentieth century. The reorganisation of laboratory practice, human resources and institutional settings required by the production of transgenic animals had unanticipated consequences. One of these unanticipated effects was that the boundaries between animal and human health became blurred. As a result of this, new professional spaces emerged and the identity of Dolly the sheep was reconfigured, from an instrument for livestock improvement in the farm to a more universal symbol of the new cloning age. -/- . (shrink)

Fred Sanger, the inventor of the first protein, RNA and DNA sequencing methods, has traditionally been seen as a technical scientist, engaged in laboratory bench work and not interested at all in intellectual debates in biology. In his autobiography and commentaries by fellow researchers, he is portrayed as having a trajectory exclusively dependent on technological progress. The scarce historical scholarship on Sanger partially challenges these accounts by highlighting the importance of professional contacts, institutional and disciplinary moves in his career, spanning (...) from 1940 to 1983. This paper will complement such literature by focusing, for the first time, on the transition of Sanger’s sequencing strategies from degrading to copying the target molecule, which occurred in the late 1960s as he was shifting from protein and RNA to DNA sequencing, shortly after his move from the Department of Biochemistry to the Laboratory of Molecular Biology, both based in Cambridge (UK). Through a reinterpretation of Sanger’s papers and retrospective accounts and a pioneering investigation of his laboratory notebooks, I will claim that sequencing shifted from the working procedures of organic chemistry to those of the emergent molecular biology. I will also argue that sequencing deserves a history in its own right as a practice and not as a technique subordinated to the development of molecular biology or genomics. My proposed history of sequencing leads to a reappraisal of current STS debates on bioinformatics, biotechnology and biomedicine. (shrink)

Ante la crisis social de la intimidad en favor de la extimidad, en las neurociencias y su reducción a privacidad en el derecho, este artículo expone la idea orteguiana de la intimidad, destacando su carácter corporal. Esta noción corporal de la intimidad descubre el ámbito sentimental de la realidad, superando el cosismo y el subjetivismo, mediante el análisis del mecanismo de la metáfora y de la capacidad de ensimismamiento. El modo de realidad de la intimidad se revela como ejecutividad y (...) constituye una alternativa al idealismo, al objetivismo de la conciencia y a la introspección psicológica. (shrink)

Estudio de la noción «voz de la conciencia» en la obra de Xavier Zubiri, tras una contextualización histórica del tema, mostrando su importancia en las obras más tardías, así como su conexión con las fuentes más relevantes en el pensamiento contemporáneo, en especial, la Fenomenología y la Analítica existencial de Heidegger. Se destaca la aportación zubiriana del análisis noológico de la voz de la conciencia, que distingue la experiencia moral y la religiosa, pero que descubre, a su vez, una peculiar (...) conexión entre lo moral y lo religioso. (shrink)

In this paper we analyze some of the major difficulties of informed consent. We consider insufficient to base IC on the principle of autonomy. We must not forget that the patient may be in a situation of extreme vulnerability and the good doctor should assume a degree of commitment and responsibility with his/her decisions. Our aim is to introduce the ethics of responsibility of Levinas in practice and theory of IC in order to generate a beneficent medical practice in which (...) the supervision and overseeing of the patient do not undermine his/her autonomy. (shrink)

The aim of this paper is to provide a complete Natural Kind Semantics for an Essentialist Theory of Kinds. The theory is formulated in two-sorted first order monadic modal logic with identity. The natural kind semantics is based on Rudolf Willes Theory of Concept Lattices. The semantics is then used to explain several consequences of the theory, including results about the specificity (species–genus) relations between kinds, the definitions of kinds in terms of genera and specific differences and the existence of (...) negative kinds. First, I show under which conditions the Hierarchy principle, which has been subjected to counterexamples in the literature, holds. I also show that a different principle about the species–genus relations between kinds, namely Kant’s Law, follows from the essentialist theory. Second, I introduce two new operations for kinds and show that they can be used to provide traditional definitions of kinds in terms of genera and specific differences. Finally, I show that these operations of specific difference induce, for each kind, a uniquely specified contrary kind and a uniquely specified subcontrary kind, which can be used as semantic values for non-classical predicate negations of kind terms. (shrink)

On 26 June 2000, during the presentation of the Human Genome Project's first draft, Bill Clinton, then President of the United States, claimed that "today we are learning the language in which God created life".1 Behind his remarks lay a story of more than half a century involving the understanding of DNA as information. This paper analyses that story, discussing the origins of the informational view of our genes during the early 1950s, how such a view affected the research on (...) the genetic code (1950s and '60s) and the transformation of the information idea in the context of DNA sequencing and bioinformatics ('80s and '90s). I suggest that the concept of DNA as information reached a climax with the proposal of the Human Genome Project (HGP), but is currently facing a crisis coinciding with the questioning of the information society. Finally, I discuss the emergence of systems biology as an alternative paradigm. (shrink)

Ortega trasladó sus ideas pedagógicas a su quehacer como profesor universitario. Muchos de sus discípulos y colaboradores han dejado constancia de ello, como aquí se refiere. Fue para ellos, sobre todo ejemplo, ejemplo de vida, de orientación vital, de sinceridad intelectual en su quehacer filosófico. En este artículo no analizamos la filosofía de Ortega, lo que hemos hecho en otros textos, sino el impacto que causó la «persona» Ortega en sus colaboradores y discípulos. Aunque es algo estudiando, nunca se ha (...) presentado de esta forma sintética que muestra la envergadura del impacto que Ortega produjo en el mundo intelectual de la Edad de Plata de la cultura española. (shrink)

Este estudio es una aproximación al tema del trabajo desde el pensamiento sociológico de Zygmunt Bauman. Uno de los textos más conocidos de Bauman al respecto es Trabajo, consumismo y nuevos pobres; sin embargo, este es un tema que el sociólogo trata en otras obras. Aquí se pretende dar una visión en la que se tienen en cuenta la globalidad de sus escritos. Además, se dan unas claves que permiten comprender el enfoque que Bauman tiene del trabajo: se hace una (...) breve explicación de su perspectiva sociológica y de la importancia de la modernidad en su pensamiento. Por último, se expone cómo el trabajo cambia de sentido e importancia en la modernidad sólida y en la líquida. (shrink)

What is the so-called “question of ontology?” Is the question of ontology genuinely a question about “categories” (Lowe 2006), “structure” (Sider 2011), “existence” (Thomasson 2015), or rather “reality” (Fine 2009)? In this article, I defend the neo-Sellarsian approach to the question of ontology, a novel, naturalistic approach according to which the foundational question of ontology is about “understanding the manifest and the scientific images of the world, and their multiple relationships.” First, I argue for the thesis of Impure Eliminativism, a (...) form of constructive pluralism about the question of ontology by which the substantivity of questions of ontology which are not the neo-Sellarsian one is to be built upon certain relations with the neo-Sellarsian question of ontology. Second, I argue for the categorial plasticity of the two images and their relations in connection with the hypothesis of Weak Epistemic Factualism. Third, and lastly, I argue for a person-based ontology framed in terms of the crucial notions of “fact” and “understanding” in response to the eliminativist categorizations of the two images and their relationships proposed by substantialism and structuralism. (shrink)

The paper defends an interactive theory of the distinctiveness of criminal law. It argues that criminal law’s distinctive behavior can be connected to the interaction between five traits: it is an institutional practice administered by a large and special bureaucracy, playing a substantial role in authorizing the use of coercive police force, leading to a harsh sanctioning regime linked, at least in part, with core wrongs and notions of personal responsibility. Although none of these features is exclusive to criminal law, (...) their interaction leads to modes of behavior that set it apart from other institutions. The paper argues that putting attention on the effects of this interaction provides us with powerful tools to both understand and asses the value and problems of criminal law. (shrink)

Symbiosis plays a fundamental role in contemporary biology, as well as in recent thinking in philosophy of biology. The discovery of the importance and universality of symbiotic associations has brought new light to old debates in the field, including issues about the concept of biological individuality. An important aspect of these debates has been the formulation of the hologenome concept of evolution, the notion that holobionts are units of natural selection in evolution. This review examines the philosophical assumptions that underlie (...) recent proposal of the hologenome concept of evolution, and traces those debates back in time to their historical origins, to the moment when the connection between the topics of symbiosis and biological individuality first caught the attention of biologists. The review is divided in two parts. The first part explores the historical origins of the connection between the notion of symbiosis and the concept of biological individuality, and emphasizes the role of A. de Bary, R. Pound, A. Schneider and C. Merezhkowsky in framing the debate. The second part examines the hologenome concept of evolution and explores four parallelisms between contemporary debates and the debates presented in the first part of the essay, arguing that the different debates raised by the hologenome concept were already present in the literature. I suggest that the novelty of the hologenome concept of evolution lies in the wider appreciation of the importance of symbiosis for maintaining life on Earth as we know it. Finally, I conclude by suggesting the importance of exploring the connections among contemporary biology, philosophy of biology and history of biology in order to gain a better understanding of contemporary biology. (shrink)

Are properties universal or particular? According to Universalism, properties are universals because there is a certain fundamental tie that makes properties capable of being shareable by more than one thing. On the opposing side, Particularism is the view that properties are particulars due to the existence of a fundamental tie that makes properties incapable of being shared. My aim in this paper is to critically examine the connections between the notions of the fundamental tie and universality and particularity. I argue, (...) first, that universality and particularity can characterize a property if and only if there is a universalist or a particularist fundamental tie, and, second, that it is unclear that these should be the fundamental ties that connect ordinary and scientific properties to their respective bearers. Then I develop an alternative approach to properties and the fundamental tie, which is neutralist because it dispenses with universality and particularity as features of properties, and naturalist because it naturalizes the possession of properties by replacing metaphysical fundamental ties with a scientific one, in particular, a physical process. I show how this approach improves our understanding of properties and instantiation. (shrink)

Holobionts are symbiotic assemblages composed by a host plus its microbiome. The status of holobionts as individuals has recently been a subject of continuous controversy, which has given rise to two main positions: on the one hand, holobiont advocates argue that holobionts are biological individuals; on the other, holobiont detractors argue that they are just mere chimeras or ecological communities, but not individuals. Both parties in the dispute develop their arguments from the framework of the philosophy of biology, in terms (...) of what it takes for a “conglomerate” to be considered an interesting individual from a biological point of view. However, the debates about holobiont individuality have important ontological implications that have remained vaguely explored from a metaphysical framework. The purpose of this paper is to cover that gap by presenting a metaphysical approach to holobionts individuality. Drawing upon a conception of natural selection that puts the focus on the transgenerational recurrence of the traits and that supports the thesis that holobionts are units of selection, we argue that holobionts bear emergent traits and exert downward powers over the entities that compose them. In this vein, we argue, a reasonable argument can be made for conceiving holobionts as emergent biological individuals. (shrink)