How are data science systems made to work? It may seem that whether a system works is a function of its technical design, but it is also accomplished through ongoing forms of discretionary work by many actors. Based on six months of ethnographic fieldwork with a corporate data science team, we describe how actors involved in a corporate project negotiated what work the system should do, how it should work, and how to assess whether it works. These negotiations laid the (...) foundation for how, why, and to what extent the system ultimately worked. We describe three main findings. First, how already-existing technologies are essential reference points to determine how and whether systems work. Second, how the situated resolution of development challenges continually reshapes the understanding of how and whether systems work. Third, how business goals, and especially their negotiated balance with data science imperatives, affect a system’s working. We conclude with takeaways for critical data studies, orienting researchers to focus on the organizational and cultural aspects of data science, the third-party platforms underlying data science systems, and ways to engage with practitioners’ imagination of how systems can and should work. (shrink)

Recent studies indicate that mammalian chromosomes contain discretecis‐acting loci that control replication timing, mitotic condensation, and stability of entire chromosomes. Disruption of the large non‐coding RNA gene ASAR6 results in late replication, an under‐condensed appearance during mitosis, and structural instability of human chromosome 6. Similarly, disruption of the mouse Xist gene in adult somatic cells results in a late replication and instability phenotype on the X chromosome. ASAR6 shares many characteristics with Xist, including random mono‐allelic expression and asynchronous replication timing. (...) Additional “chromosome engineering” studies indicate that certain chromosome rearrangements affecting many different chromosomes display this abnormal replication and instability phenotype. These observations suggest that all mammalian chromosomes contain “inactivation/stability centers” that control proper replication, condensation, and stability of individual chromosomes. Therefore, mammalian chromosomes contain four types ofcis‐acting elements, origins, telomeres, centromeres, and “inactivation/stability centers”, all functioning to ensure proper replication, condensation, segregation, and stability of individual chromosomes. (shrink)

The extant manuscripts of Nicholas of Cusa’s private library are not only a unique testimony to the reading world of one of the most important philosophers of the 15th century. They also document the material context of a specific literary activity by their reader: as is well known, Cusanus frequently annotated his books, noting his thoughts in the margins. This paper focuses on Cusanus’ marginalia as an object of research and edition. In a first step, the essay reconstructs the 20th-century (...) editorial history of this special textual tradition and embeds it in the developments of the modern philological and historiographical work on Nicholas of Cusa. In a second step, it offers an interpretation of Cusanus’ marginalia as a coherent textual corpus and investigates the reading and writing practices to which this corpus bears witness. Finally, against this background, the paper presents a case for the scientific relevance of a continuation and re-conception of the critical edition of Cusanus’ marginalia, which began in 1941 with the first volume of the series Cusanus-Texte III. Marginalien and has remained unfinished to date. (shrink)

In a recent publication in the European Journal for Philosophy of Science, Romero and Pérez claim to reveal new trouble for the already difficult life of presentism in relativistic spacetimes. Their argument purports to demonstrate the impossibility of postulating a viable present in the presence of black holes, in particular the Schwarzschild geometries. I argue that their argument is flawed, and that the Schwarzschild geometries they consider offer no novel threats to presentism. However, if we consider more general black holes, (...) different and more potent threats may be lurking in the dark. I discuss these threats and sketch how a presentist may respond, thus painting a more balanced picture of the way the existence of black holes might impact presentist metaphysics. At present there is no decisive verdict from black holes, but it turns out a close scrutiny of the developments in the relevant physics will be needed to see whether their import will remain so inconclusive. (shrink)

A historical investigation of the exclusion of Africa and Asia from modern histories of philosophy.

This volume contains 3 papers published here for the first time as well as 13 studies from the years 1979-2001 in revised and in part expanded form.

The general picture of the history of Dutch Catholicism is that of a unified, hierarchic, ultra-montane subculture between 1870-1960 that was replaced for a liberal, open-minded, world-oriented identity after Vatican II. But in daily life, contrary to the official declarations, the Church and its members gradually adapted to modern society already after 1920. With the help of rational choice theory on religion, this shift from ‘sect’ to ‘church’ in this period will be highlighted. Catholics became ordinary citizens, changed their position (...) towards the national state and Catholic intellectuals introduced modern developments in the Catholic social organizations. By 1960, Catholics could no longer be discerned as different from the rest of society. The article therefore makes a plea to re-evaluate the period 1920-1960 from this perspective, also from an international perspective. (shrink)

Der erste Teil1 dieses Forschungsberichts gab einen Überblick über die philologisch-philosophische Erschließung der Schriften des Nikolaus von Kues durch Editionen und Übersetzungen. Die Fortsetzung behandelt: die historische Forschung zur Lebensgeschichte und Interpretationsversuche und vergleichende Studien.

Diese Monographie über Nikolaus von Kues (1401-1464) stellt auf der Grundlage der historischen Forschung des letzten Jahrhunderts im ersten Teil das Leben des Kardinals und einflussreichen römischen Kirchenpolitikers dar. Sie skizziert im zweiten Teil das Werk seiner philosophisch-theologischen, kirchen- und staatspolitischen sowie der mathematischen und naturwissenschaftlichen Schriften in Einzeldarstellungen, um im dritten Teil die Lehre unter systematisierenden Aspekten nach thematischen Gesichtspunkten darzulegen. Im vierten Teil geht der Autor auf der Grundlage einer jahrzehntelangen Arbeit mit historisch-kritischer Quellen- und Wirkungsgeschichte der Nachwirkung (...) dieser Lehre im Umkreis des Nikolaus von Kues und deren Fortwirken vom 16. bis ins 20. Jahrhundert nach. Alle Teile werden durch umfangreiche bibliographische Verzeichnisse im Sinn einer "bibliographie raisonnée" erschlossen, die auch die aus Anlass des 600. Geburtstags und des 550. Todestags weltweit erschienene umfangreiche Literatur zu Leben, Werk und Lehre in historischer Einordnung berücksichtigt. (shrink)

Mit der Erfindung des Buchdrucks war die Zeit handschriftlicher Überlieferung von Texten noch lange nicht vorbei. Trotz der rapiden Verbreitung des neuen Druckmediums stand der Zugang zu ihm nur wenigen offen. Schriften anerkannter Autoritäten wurden im 15. und 16. Jahrhundert postum gedruckt, auch solche einflußreicher Multiplikatoren, vielfältig auch die Kunst der Holzschneider und Kupferstecher. Die Schriften derer, die weniger Anerkennung gefunden hatten, auf Skepsis gestoßen oder verurteilt worden waren, hatten verständlicherweise kaum eine Chance, gedruckt zu werden. Dennoch wäre es ganz (...) falsch, in allen Fällen handschriftlicher Textüberlieferung des 16., 17. und 18. Jahrhunderts auf eine geringere Bedeutung des nach traditioneller Art tradierten Autors zu schließen. Auch Schriften anerkannter, gar ‘kanonisierter' Autoren, deren Werke in einer Edition oder in mehreren Ausgaben bereits gedruckt vorlagen, wurden noch handschriftlich aus Manuskripten, aber auch aus Drucken kopiert. Nach Beispielen dafür braucht man nicht lange zu suchen. Beispiele aus der Cusanus-Überlieferung habe ich früher schon verzeichnet. (shrink)

Vaesen infers unique properties of mind from the appearance of specific cultural innovation – a correlation without causal direction. Shifts in habitat, population density, and group dynamics are the only independently verifiable incentives for changes in cultural practices. The transition from Acheulean to Late Stone Age technologies requires that we consider how population and social dynamics affect cultural innovation and mental function.

The first English translation of Fichte’s second set of 1804 lectures on the Wissenschaftslehre.

v. 1. Nicomachean ethics. Politics. The Athenian Constitution. Rhetoric. On Poetics.--v. 2. Logic.--v. 3. Physics. Metaphysics. On the soul. Short physical treaties.--v. 4. On the heavens. On generation and corruption. Meteorology. Biological treatises.

The posterior parietal cortex (PPC) is the most likely site where egocentric spatial relationships are represented in the brain. PPC cells receive visual, auditory, somaesthetic, and vestibular sensory inputs; oculomotor, head, limb, and body motor signals; and strong motivational projections from the limbic system. Their discharge increases not only when an animal moves towards a sensory target, but also when it directs its attention to it. PPC lesions have the opposite effect: sensory inattention and neglect. The PPC does not seem (...) to contain a “map” of the location of objects in space but a distributed neural network for transforming one set of sensory vectors into other sensory reference frames or into various motor coordinate systems. Which set of transformation rules is used probably depends on attention, which selectively enhances the synapses needed for making a particular sensory comparison or aiming a particular movement. (shrink)

Orthologic is defined by weakening the axioms and rules of inference of the classical propositional calculus. The resulting Lindenbaum-Tarski quotient algebra is an orthoimplication algebra which generalizes the author's implication algebra. The associated order structure is a semi-orthomodular lattice. The theory of orthomodular lattices is obtained by adjoining a falsity symbol to the underlying orthologic or a least element to the orthoimplication algebra.

Providing an original and systematic treatment of foundational issues in philosophy of religion, J. L. Schellenberg's new book addresses the structure of..

According to realist structuralism, mathematical objects are places in abstract structures. We argue that in spite of its many attractions, realist structuralism must be rejected. For, first, mathematical structures typically contain intra-structurally indiscernible places. Second, any account of place-identity available to the realist structuralist entails that intra-structurally indiscernible places are identical. Since for her mathematical singular terms denote places in structures, she would have to say, for example, that 1 = − 1 in the group (Z, +). We call this (...) the identity problem and conclude that nominalism is presently the safest route for the structuralist. (shrink)

Ned Block argues that the higher-order (HO) approach to explaining consciousness is ‘defunct’ because a prominent objection (the ‘misrepresentation objection’) exposes the view as ‘incoherent’. What’s more, a response to this objection that I’ve offered elsewhere (Weisberg 2010) fails because it ‘amounts to abusing the notion of what-it’s-like-ness’ (xxx).1 In this response, I wish to plead guilty as charged. Indeed, I will continue herein to abuse Block’s notion of what-it’s-like-ness. After doing so, I will argue that the HO approach accounts (...) for the sense of what-it’s-like-ness that matters in a theory of consciousness. I will also argue that the only incoherence present in the HO theory is that generated by embracing Block’s controversial notion of what-it’s-like-ness, something no theorist of any stripe ought to do. Block is famous for (among other things) having introduced the notion of ‘phenomenal consciousness’ into contemporary philosophy of mind (Block 1995). This term is widely employed in the philosophical literature and it even appears in the empirical literature. But wide-speared usage has brought about divergent interpretations of the term. We can distinguish a ‘moderate’ and a ‘zealous’ reading of ‘phenomenal consciousness’. On the moderate reading, ‘phenomenal consciousness’ just means ‘experience’. Many people have embraced this sense of the term and use it to roughly pick out conscious experience involving sensory quality (states like conscious visual experiences or conscious pains, for example).2 On the zealous reading, however, phenomenal consciousness is held to be ‘distinct from any cognitive, intentional, or functional property’ (Block 1995: 234). That is, any explanation of phenomenal consciousness in exclusively cognitive, intentional, or functional terms will fail to capture, without remainder, what is really distinctive about phenomenal consciousness. Block, of course, is fully clear about embracing the zealous reading; indeed, his initial introduction of the notion is in those terms. The same ambiguity occurs with the much-used (and abused) idea of ‘what-it’s-like-ness’.. (shrink)