The health crisis caused by COVID-19 has resulted in the physical and emotional deterioration of health personnel, especially nurses, whose emotional state is affected by the high risk of contagion, the high demands of health services, and the exhausting working hours. The objective of this research was to determine the relationship between fear, anxiety, and fatigue of nurses caring for patients with COVID-19 in a second level public hospital in Peru. This study presents a quantitative approach and correlational level, cross-sectional, (...) and non-experimental design. The sample consisted of 145 nurses who attended patients with COVID-19 in health care areas. The results show a significant relationship between fear of contagion and physical-cognitive fatigue and a significant relationship between generalized anxiety and physical-cognitive fatigue. It is concluded that in this context, both fear of contagion and generalized anxiety are related to physical-cognitive fatigue. (shrink)

En la obra de Enrique Buenaventura, se funden el teatro culto y el teatro de tradición popular. Una de las obras dramáticas en las que se puede apreciar esta fusión, es en la diestra de Dios Padre. Es una pieza dramática, situada en la tradición del teatro popular de corte religioso y en las obras burlescas de las festividades del carnaval. De un lado, es una obra cercana al auto sacramental, pero, de otro lado, es una parodia que se debe (...) leer como un texto carnavalesco, atravesado por la risa y su poder desactivador (es un mundo al revés). En el siguiente ensayo se analizarán los mecanismos de la parodia, la recursividad popular y los móviles que marcan el desarrollo de la trama en la obra de Enrique Buenaventura. (shrink)

Without doubt, in modern society -specially within the European and Northeamerican boundaries- the formalistic doctrine of Dewey, Piaget, Kohlberg, Popper, Reed, Rest, Apel, Habermas and rorty has a deep influence at all levels: personal, social, political, and cultural. This study recognices the moral interest of the so called "consensus ethics", but points out important shortcomings of this approach.

In dealing with the radical politicization of psychoanalysis from a geopolitical standpoint, this essay argues that psychoanalysis has to be capable to rethink and reembody itself with every contingent and immanent dislocations of its transcendental horizons. Through a reading of Slavoj Žižek and Alain Badiou on Mao Tse-Tung, we can think about the notion of dislocation and localization of the Idea. We will argue that this has historically happened in psychoanalysis in the transition from Freud to Lacan; however, the issue (...) is that this dislocation has undergone a retroactivity of necessity which makes a vanishing mediator out of the contingent scrap of reality that it initially relied on—and this forms the quilting point of the contemporary Lacanian ideology. Through Gabriel Tupinambá›s _The Desire of Psychoanalysis_, we will inspect the notion of generic psychoanalysis. We will insist that while generic psychoanalysis is crucial for the refiguring of psychoanalytic politics in a dislocative matter, we need to take this outlook to the end onto a psychoanalysis that is willing to impurify itself through localization as this is the only psychoanalysis worthy of the name. (shrink)

mRNA synthesis in all organisms is performed by RNA polymerases, which work as nanomachines on DNA templates. The rate at which their product is made is an important parameter in gene expression. Transcription rate encompasses two related, yet different, concepts: the nascent transcription rate, which measures the in situ mRNA production by RNA polymerase, and the rate of synthesis of mature mRNA, which measures the contribution of transcription to the mRNA concentration. Both parameters are useful for molecular biologists, but they (...) are not interchangeable and they are expressed in different units. It is important to distinguish when and where each one should be used. We propose that for functional genomics the use of nascent transcription rates should be restricted to the evaluation of the transcriptional process itself, whereas mature mRNA synthesis rates should be employed to address the transcriptional input to mRNA concentration balance leading to variation of gene expression. (shrink)

Angiogenesis plays an essential role in tumor growth, invasion and metastasis. After initial pessimism about the usefulness of the antiangiogenic therapeutic approach for cancer, interest has increased in the development of antiangiogenic compounds after the first clinical approval of an antiangiogenic therapy. The anti‐vascular endothelial growth factor (VEGF) antibody bevacizumab has recently been approved for use in combination with chemotherapy for the treatment of metastatic colorectal and non‐small cell lung cancer patients. However, no survival benefit has been demonstrated in anti‐VEGF (...) monotherapy trials, probably due to the high complexity of tumor angiogenesis regulation. Experimental and clinical data, including the approval of the multitargeted drugs sunitinib and sorafenib, indicate that exciting results, including tumor regression, can be expected from the combined targeting of different pathways in the tumor angiogenesis scenario. Several obstacles, including the high cost of new molecular targeted drugs make this therapeutic approach difficult. BioEssays 29:1159–1168, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

This book explores the epistemic side of racial and sexual oppression. It elucidates how social insensitivities and imposed silences prevent members of different groups from listening to each other.