Measurements of open chromatin in specific cell types are widely used to infer the spatiotemporal activity of transcriptional enhancers. How reliable are these predictions? In this review, it is argued that the relationship between the accessibility and activity of an enhancer is insufficiently described by simply considering open versus closed chromatin, or active versus inactive enhancers. Instead, recent studies focusing on the quantitative nature of accessibility signal reveal subtle differences between active enhancers and their different inactive counterparts: the closed silenced (...) state and the accessible primed and repressed states. While the open structure as such is not a specific indicator of enhancer activity, active enhancers display a higher degree of accessibility than the primed and repressed states. Molecular mechanisms that may account for these quantitative differences are discussed. A model that relates molecular events at an enhancer to changes in its activity and accessibility in a developing tissue is also proposed. (shrink)

We argue that the asymmetry between diverging and converging electromagnetic waves is just one of many asymmetries in observed phenomena that can be explained by a past hypothesis and statistical postulate (together assigning probabilities to different states of matter and field in the early universe). The arrow of electromagnetic radiation is thus absorbed into a broader account of temporal asymmetries in nature. We give an accessible introduction to the problem of explaining the arrow of radiation and compare our preferred strategy (...) for explaining the arrow to three alternatives: (i) modifying the laws of electromagnetism by adding a radiation condition requiring that electromagnetic fields always be attributable to past sources, (ii) removing electromagnetic fields and having particles interact directly with one another through retarded action-at-a-distance, (iii) adopting the Wheeler-Feynman approach and having particles interact directly through half-retarded half-advanced action-at-a-distance. In addition to the asymmetry between diverging and converging waves, we also consider the related asymmetry of radiation reaction. (shrink)

Detachment, Involvement, and Rationality: are we Essentially Rational Animals? Philosophers have long thought that what differentiates humans from mere animals is that humans are essentially rational. The rational nature of human beings lies in their ability to detach themselves from ongoing involvement and to ask for as well as give reasons for activity. According to the philosophical tradition, human action and perception generally should be understood in light of this ability. This essay examines a contemporary version of this conviction, one (...) promulgated by John McDowell. McDowell follows the tradition in suggesting that people are always able to step back and to ask as well as answer why questions about what they are doing, i.e., they always have reasons for their actions. This essay shows that people have no reasons for many of the things they do. They often, instead, simply respond to shifting situational fields of attraction and repulsion. These attractions and repulsions cannot be captured in propositional form—any attempt to describe, or even just name, them turns them into objects and robs them of their motivational force. The demands of the situation are not available as reasons, but exist only as embodied in actions. McDowell, consequently, errs in claiming that conceptual capacities are inextricably implicated in human activity. Nor is the detached, rational way of being any more essential to human life than is involved coping. (shrink)

Contemporary society needs the recognition of a moral middle ground, where human behavior can be evaluated as permissible, understandable, or even valuable. As a counterforce to polarization and divisive politics, an identity model is proposed in which individual and group identities are transcended by a human and ecological identity.

"This book provides a representative survey of early and more recent concerns in cognitively inspired lexical semantics.

Le present ouvrage propose une etude systematique de la conception de la condition humaine contenue dans Condition de l'homme moderne de H. Arendt. Il en eclaire l'orientation, a la fois par rapport a la tradition ancienne et classique de la philosophie et par rapport au contexte immediat de la phenomenologie et de l'existentialisme contemporains. Il met en evidence une structure de la condition humaine, un agencement des differentes conditions qui la composent et l'accent mis par Arendt sur un pluriel de (...) conditions de base plus que sur les traits generaux habituellement mis en avant (la finitude, la mortalite). Outre la triade bien connue des trois activites fondamentales, le travail, l'oeuvre, l'action, il explicite une triade d'activites mentales, l'intelligence, la connaissance et la pensee. Il examine le statut de la pensee dans la condition humaine et le paradoxe de sa capacite de retrait par rapport a elle. La conception arendtienne de la condition humaine, non depassee a ce jour, est une reference capitale pour l'humanite, aujourd'hui inquiete de l'avenir de son monde. La version allemande du livre de Arendt, remaniee par rapport a l'edition anglaise originale, est prise en compte. (shrink)

La 4e de couverture indique : "Les thèses de Lacan viennent de sa pratique, mais il avait articulé celles-ci dans un cadre théorique très élaboré. De Platon et Descartes jusqu'à Heidegger ou Wittgenstein, en passant par Kant et Hegel, Lacan a lu avec attention les grands philosophes. Le refondateur de la psychanalyse, à l'encontre des scolastiques de la psyché qu'il a sans cesse combattues, avait à faire à la vérité, à la vérité freudienne, celle des sujets qui s'analysent, mais aussi (...) aux articulations de savoir qui prennent une place primordiale dans l'élaboration de son immense séminaire qui constitue une des créations les plus puissantes de notre temps. Les grands philosophes y sont fréquemment interrogés dans leur pensée fondamentale et jusqu'à leur point de butée que Lacan nommait l'impossible et qu'il tentait de déborder à partir des (quatre) concepts fondamentaux de Freud et en posant avec l'objet a le registre du Réel et le primat de l'écriture.". (shrink)

The effectiveness of complaint handling and service recovery policies in customer retention has been the focus of both scholars and service organizations. In the past decade, Justice Theory has provided the basis of the dominant theoretical framework for complaint management and service recovery. However, it does not explicitly address unfair trade practices, which constitute an ethical issue. Favorable outcomes in complaint handling may not be able to restore the reputation of a company and the potential harm perceived by consumers. Using (...) face-to-face interviews, this study applies Fairness Theory to explore the psychological responses of consumers in the post-complaint phase, particularly in ethical judgment. The findings suggest that an unfavorable outcome in the post-complaint stage leads to counterfactual thinking by the consumer about the consumer's state of well-being. The complaint must be due to the discretionary actions of the service provider whose accountability is assessed. Those harmful actions are then judged against an ethical standard. Explanations can reduce blame, and their effectiveness is moderated by outcome favorability but not ethical judgment. Favorable outcome, captured by "Would Perception," has only limited influence on Perceived Potential Harm (PPH), which is an important determinant of ethical judgment. This study makes both theoretical and practical contributions. It is the first study to validate Fairness Theory empirically and apply it to complaint handling as a complement of Justice Theory in the information and communication technology (ICT) service context. The study indicates that customers may condemn a service provider because of PPH even though the outcome is favorable. Unfair trade practices are what make customers hate ICT service providers. (shrink)

Celem artykułu jest pogłębiona analiza przyczyn i konsekwencji rozdwojenia sejmiku wiszeńskiego w 1597 r. z naciskiem na relacje polityczno-społeczne obejmujące teren dawnego województwa ruskiego oraz głównych politycznych aktorów zdarzeń: Stanisława Stadnickiego z Łańcuta, Stanisława Żółkiewskiego i Jana Zamoyskiego. Pomimo stosunkowo obfitego materiału źródłowego w postaci listów, protestacji i sejmowych diariuszy jedyna poważna próba zbadania tego tematu podjęta przez Jana Rzońcę okazała się dalece niewystarczająca, zawężając temat rozbicia sejmiku jedynie do obszaru wpływu na późniejsze obrady sejmu oraz ogólną kondycję państwa. Przeprowadzona (...) w artykule krytyczna analiza zachowanych źródeł pozwoliła w dużym stopniu zrekonstruować obrady tytułowego sejmiku, ustalić dokładne przyczyny jego rozbicia oraz powiązać zaszłe na nim zdarzenia z politycznym przesileniem, do którego doszło w województwie ruskim pod koniec roku 1597 w postaci lokalnego sojuszu Jana Zamoyskiego ze Stanisławem Stadnickim z Łańcuta. Poznanie kulis zawarcia powyższego porozumienia oraz powodów jego fiaska pozwoliło natomiast lepiej zrozumieć mechanizmy funkcjonowania stronnictwa kanclerskiego pod koniec XVI w. i stanu, w jakim się wówczas znalazło. W artykule podjęta została ponadto próba rozwikłania problemu uczestnictwa w sejmiku żołnierzy kwarcianych/prywatnych oraz zbadania ich rzeczywistego wpływu na obrady sejmiku w Wiszni. Bezrefleksyjnie przyjmowana do tej pory teoria personalnie obarczająca winą za rozbicie sejmiku hetmana polnego Stanisława Żółkiewskiego wydaje się co najmniej przesadzona, zupełnie pomijając własnowolność służących w wojsku żołnierzy oraz przysługujące im jako szlachcie prawa do uczestnictwa w życiu publicznym Rzeczypospolitej. (shrink)

Perhaps the burning issue facing us today is how people from different cultural backgrounds can live together or in close proximity with one another and preserve their identities without destroying one another. This topic is important to me because I believe that new understandings about what we mean by the terms “speech” and “reality”' may contribute towards an improvement in our ability to work together with peoples of diverse backgrounds in order to create a more caring an humane planet. As (...) I approach my three score and ten years of life and think about the importance for future generations of the legacies of my teacher Eugen Rosenstock-Huessy, of Mikhail Bakhtin, Martin Buber and Franz Rosenzweig, two Christians and two Jews, whose lives and writings have also influenced my own life and thinking. I would single out their insights into speech and language as worthy of serious attention by future generations. When asked by students and colleagues if there is a single unifying theme that we should focus our energies on, without hesitation, I say: speech and reality. (shrink)

The creation and consolidation of a memory can rest on the integration of any number of disparate features and contexts. How is it that these bind together to form a coherent memory? This book offers an unrivalled overview of one of the most debated hotspots of modern memory research: binding, and will instigate innovative and pioneering ideas for future research.

In Fortführung einer postmodernen Geschichtsschreibung haben sich in den letzten zwei Jahrzehnten deutsche und angelsächsische Historiker verstärkt darum bemüht, eine virtuelle oder konjekturale Geschichtsforschung als den Königsweg zur Überwindung der Krise der Geschichtswissenschaft zu etablieren. Die Was wäre geschehen, wenn...?-Geschichtsschreibung wird vor allem von dem Althistoriker Alexander Demandt als eine erkenntnistheoretische Wunderwaffe, als ein Novum Organon der Geschichtswissenschaft, angepriesen. In diesem Buch wird gezeigt, daß die irreale oder virtuelle Geschichte sich nicht nur in logische und methodologische Widersprüche verstrickt, sondern geschichtstheoretisch (...) einen erheblichen Rückschritt darstellt. Neben der Kritik an dieser erkenntnisvermindernden Strategie in der Geschichtsforschung wird anhand von unterschiedlichen Interpretationen historischer Ereignisse und Entwicklungen gezeigt, daß von der Antike bis heute alternative Geschichtsinterpretationen das eigentliche Bemühen um größere Erklärungskraft der historischen Forschung darstellten. Auf dieser Grundlage werden Ansätze zu einer Methodologie der Geschichtswissenschaft erarbeitet, die die Erkenntnisse der modernen Wissenschaftstheorie dazu nutzen, um ein größeres Erklärungspotential für historische Interpretationen zu ermöglichen. Geschichtsforschung wird in diesem Sinne zu einer Sozialwissenschaft menschlichen Handelns und muß sich deshalb darum bemühen, die theoretischen Fortschritte anderer sozialwissenschaftlicher Fächer zu integrieren und zu verarbeiten. Dieses Buch ist deshalb ein Plädoyer für interdisziplinäre Zusammenarbeit, damit die Geschichtswissenschaft Anschluß findet an die methodisch fortgeschrittenen Wissenschaften. Deshalb müssen sich Historiker, Soziologen, Philosophen oder Politikwissenschaftler gleichermaßen mit diesen Problemen befassen. (shrink)

English summary: The authors of this conference volume describe and discuss various aspects of Popper's ethics, such as for example his contributions to freedom and responsibility, to objectivity and truth, to humanism and to metaphysics, from a critical-rational point of view. This is the first time that Popper's ethics have been brought face to face with the Christian faith. The lectures and the ensuing discussions between Protestant and Catholic theologians and advocates of critical rationalism deal with the question of whether (...) Popper's critiques of religion can be compatible with modern social ethics based on Christianity or whether theology can be a critical-rational science. One of the special attractions of this volume is the fact that it contains not only the revised talks but also the very animated discussions on the various subjects. German description: Karl Popper war nicht nur ein Mensch und Wissenschaftler mit klaren ethischen Grundsatzen, auch seiner Wissenschafts- und Erkenntnistheorie lagen ethische Pramissen zugrunde. Dieser Sachverhalt ist lange nicht erkannt worden, weil Popper selbst nicht daruber gesprochen hat und weil er diese ethischen Voraussetzungen in seinen Werken nicht systematisch dargelegt hat. Wenn es aber zutrifft, dass dem wissenschaftlichen Lebenswerk Poppers ein ethisches Forschungsprogramm zugrunde lag, dann wird es Zeit, sich damit zu befassen.Die Autoren dieses Bandes stellen verschiedene Aspekte von Poppers Ethik, wie z.B. seine Beitrage zur Freiheit und Verantwortung, zur Objektivitat und Wahrheit, zum Humanismus und zur Metaphysik, von einem kritisch-rationalen Standpunkt aus zur Diskussion. Erstmalig wird die Ethik Poppers mit dem christlichen Glauben konfrontiert. In den Beitragen sowie den anschliessenden Diskussionen zwischen evangelischen und katholischen Theologen mit Vertretern des kritischen Rationalismus geht es darum, ob Poppers religionskritische Darlegungen mit einer modernen Sozialethik auf christlicher Basis vereinbar sind, bzw. ob es eine Theologie als kritisch-rationale Wissenschaft geben kann.Ein besonderer Reiz dieses Bandes liegt darin, dass nicht nur die uberarbeiteten Referate, sondern auch die sehr lebhaften Diskussionen zu den verschiedenen Themen enthalten sind. Hier wird noch deutlicher, dass Poppers Philosophie von starken ethischen Voraussetzungen durchdrungen ist. (shrink)

The Rev’d Roland Allen’s grandson ventures to speculate on the attitudes his grandfather might be expected to have adopted regarding several of today’s controversial issues. After rehearsing briefly Roland’s published and unpublished work, Hubert Allen reviews, both on the basis of Roland’s expressed opinions and by inference from remarks made by him or by members of his immediate family, how he believes his grandfather would have reacted to six matters of current or recent controversy, namely: Modern Translations of the (...) Bible, The Role of Women in the Church, Homosexuality, Ecumenism, Inter-Faith Dialogue, and the proposed Anglican Covenant. (shrink)

The article discusses the connection between theory formation and historical research in the study of religion. It presupposes that the study of religion is conceived of as an empirical discipline. The empirical basis of theories is provided primarily by historical research, including research in the very recent past, that is, the present time. Research in the history of religions, therefore, is an indispensable part of the study of religion. However, in recent discussions on the methods, aims, and theoretical presuppositions of (...) the discipline, research in the history of religions largely is ignored. To shed some light on this blind spot, the article builds on the philosophy of science of Critical Realism. While the first part deals with the role of historical research in theoretical discourses of the discipline, the second part explains fundamental ontological and epistemological positions of Critical Realism and their implications for empirical research. On this basis, some methodological problems of theory formation in the study of religion are discussed in the third part. In particular, it is argued that it is impossible to validate empirically theories of religion that aim to explain what religion is. The concluding part sketches ways of theory formation in the study of religion that does not take religion as the explanandum but as the theoretical perspective that guides research. (shrink)

A Critique of Artificial Reason Hubert L. Dreyfus . HUBERT L. DREYFUS What Computers Still Can't Do Thi s One XZKQ-GSY-8KDG What. WHAT COMPUTERS STILL CAN'T DO Front Cover.