Interleukin 5 (IL‐5) is a kind of peptide hormone released from T lymphocytes of mammals infected with microorganisms or parasites. It is an acidic glycoprotein with a molecular mass of 40 to 50 kDa that consists of a homodimer of polypeptides. It controls hematopoiesis so that it increases natural immunity. In the mouse, IL‐5 acts on committed B cells to induce differentiation into Ig‐producing cells and on common progenitors for CD5+ pre‐B cells and CD5+ macrophages to support their survival. The (...) antibodies secreted by CD5+ B cells seem to be responsible for the primary protection against the infection with microorganisms or parasites. It also supports the growth and/or differentiation of eosinophil precursor and mature eosinophils, which can be effective for the removal of parasites in combination with the antibodies against them. Murine IL‐5 receptor (IL‐5R) consists of two different polypeptide chains; αL chain and β chain. The IL‐5R α chain is 60 kDa protein that binds IL‐5 with low affinity. The IL‐5R β chain is a 130 kDa protein which does not bind IL‐5 by itself but is necessary to form the high affinity IL‐5R. The β chain was identified by using one of the anti‐IL‐5R mAb and anti‐IL‐3R mAb as the IL‐3R homologue. This β chain is also used as the β chain of GM‐CSF receptor. This fact suggests that there is a common signaling mechanism among these cytokines and efficient cooperation among them. At the same time, these findings may explain the overlapping role of these cytokines in the development of granulocytes. (shrink)

Three multifunctional protein kinases, cyclic AMP‐dependent protein kinase, protein kinase C, and calmodulin‐dependent protein kinase II, are involved in signal transduction in response to their respective second messengers, cyclic AMP, diacylglycerol, and Ca2+. This review will summarize the key findings on calmodulin‐dependent protein kinase II.

Continuous deep sedation (CDS) has the effect of making the patient unconscious until death, and that it has this effect is clearly an undesirable aspect of CDS. However, some authors have recently maintained that many physicians do not intend this effect when practicing CDS. According to these authors, CDS is differentiated into two types; in what is called “gradual” CDS (or CDS as a result of proportionate palliative sedation), physicians start with low doses of sedatives and increase them only gradually, (...) whereas in “rapid” CDS (or palliative sedation to unconsciousness), physicians rapidly administer a heavy dose that clearly induces unconsciousness from the beginning. The claim is that the physicians intend permanent unconsciousness only if they rapidly administer a heavy dose, but they do not intend it when the unconsciousness is the result of a gradual increase of sedatives. This paper attempts to refute these claims based on a close examination of the protocol of gradual CDS. If my argument is valid, the doctrine of double effect would not be useful in justifying most, if not all, cases of CDS. (shrink)

We investigate the notion of classical negation from a non-classical perspective. In particular, one aim is to determine what classical negation amounts to in a paracomplete and paraconsistent four-valued setting. We first give a general semantic characterization of classical negation and then consider an axiomatic expansion BD+ of four-valued Belnap–Dunn logic by classical negation. We show the expansion complete and maximal. Finally, we compare BD+ to some related systems found in the literature, specifically a four-valued modal logic of Béziau and (...) the logic of classical implication and a paraconsistent de Morgan negation of Zaitsev. (shrink)

In this introduction to the special issue “40 years of FDE”, we offer an overview of the field and put the papers included in the special issue into perspective. More specifically, we first present various semantics and proof systems for FDE, and then survey some expansions of FDE by adding various operators starting with constants. We then turn to unary and binary connectives, which are classified in a systematic manner. First-order FDE is also briefly revisited, and we conclude by listing (...) some open problems for future research. (shrink)

In this introduction, we offer an overview of main systems developed in the growing literature on connexive logic, and also point to a few topics that seem to be collecting attention of many of those interested in connexive logic. We will also make clear the context to which the papers in this special issue belong and contribute.

In this paper we discuss the extent to which conjunction and disjunction can be rightfully regarded as such, in the context of infectious logics. Infectious logics are peculiar many-valued logics whose underlying algebra has an absorbing or infectious element, which is assigned to a compound formula whenever it is assigned to one of its components. To discuss these matters, we review the philosophical motivations for infectious logics due to Bochvar, Halldén, Fitting, Ferguson and Beall, noticing that none of them discusses (...) our main question. This is why we finally turn to the analysis of the truth-conditions for conjunction and disjunction in infectious logics, employing the framework of plurivalent logics, as discussed by Priest. In doing so, we arrive at the interesting conclusion that —in the context of infectious logics— conjunction is conjunction, whereas disjunction is not disjunction. (shrink)

This edited volume collects essays on the four-valued logic known as Belnap-Dunn logic, or first-degree entailment logic. It also looks at various formal systems closely related to it. These include the strong Kleene logic and the Logic of Paradox. Inside, readers will find reprints of seminal papers written by the fathers of the field: Nuel Belnap and Michael Dunn. In addition, the collection also features a well-known but previously unpublished manuscript of Dunn, an interview with Belnap, and a new essay (...) by Dunn. Besides the original, monumental papers, the book also includes research by leading scholars. They consider the extraordinary importance of Belnap-Dunn logic from several perspectives. They look at how, philosophically, it has served as a basic system of inconsistency-tolerant reasoning, as the core of underlying logics for theories based on dialetheism, and, more recently, for theories based on Buddhist philosophy. Coverage also explores its contributions to computer science, such as knowledge representation and information processing. This mix of seminal papers and insightful analysis by top scholars offers readers a comprehensive outlook on Belnap-Dunn logic and its related expansions, which have been agenda setting for the debate on philosophical logic as well as philosophy of logic. The book will also enhance further discussion on the philosophical issues related to nonclassical logics in general. (shrink)

One of the problems we face in many-valued logic is the difficulty of capturing the intuitive meaning of the connectives introduced through truth tables. At the same time, however, some logics have nice ways to capture the intended meaning of connectives easily, such as four-valued logic studied by Belnap and Dunn. Inspired by Dunn’s discovery, we first describe a mechanical procedure, in expansions of Belnap-Dunn logic, to obtain truth conditions in terms of the behavior of the Truth and the False, (...) which gives us intuitive readings of connectives, out of truth tables. Then, we revisit the notion of functional completeness, which is one of the key notions in many-valued logic, in view of Dunn’s idea. More concretely, we introduce a generalized notion of functional completeness which naturally arises in the spirit of Dunn’s idea, and prove some fundamental results corresponding to the classical results proved by Post and Słupecki. (shrink)

There is a relatively recent trend in treating negation as a modal operator. One such reason is that doing so provides a uniform semantics for the negations of a wide variety of logics and arguably speaks to a longstanding challenge of Quine put to non-classical logics. One might be tempted to draw the conclusion that negation is a modal operator, a claim Francesco Berto, 761–793, 2015) defends at length in a recent paper. According to one such modal account, the negation (...) of a sentence is true at a world x just in case all the worlds at which the sentence is true are incompatible with x. Incompatibility is taken to be the key notion in the account, and what minimal properties a negation has comes down to which minimal conditions incompatibility satisfies. Our aims in this paper are twofold. First, we wish to point out problems for the modal account that make us question its tenability on a fundamental level. Second, in its place we propose an alternative, non-modal, account of negation as a contradictory-forming operator that we argue is superior to, and more natural than, the modal account. (shrink)

A world is trivial if it makes every proposition true all at once. Such a world is impossible, an absurdity. Our world, we hope, is not an absurdity. It is important, nevertheless, for semantic and metaphysical theories that we be able to reason cogently about absurdities—if only to see that they are absurd. In this note we describe methods for ‘observing’ absurd objects like the trivial world without falling in to incoherence, using some basic techniques from modal logic. The goal (...) is to begin to locate the trivial world’s relative position in modal space; the outcome is that the less we assume about relative possibility, the more detail we can discern at the edge of reason. (shrink)

Dialetheism is the metaphysical claim that there are true contradictions. And based on this view, Graham Priest and his collaborators have been suggesting solutions to a number of paradoxes. Those paradoxes include Russell’s paradox in naive set theory. For the purpose of dealing with this paradox, Priest is known to have argued against the presence of classical negation in the underlying logic of naive set theory. The aim of the present paper is to challenge this view by showing that there (...) is a way to handle classical negation. (shrink)

We observe that Jc Beall’s shrieking and shrugging strategy gives us an opportunity to reflect on the Australian plan for negation in FDE, a basic subclassical logic that is used in Beall’s argument for subclassical logics. An implication of our observation is applied to a recent defense of the Australian plan for negation by Francesco Berto and Greg Restall.

Change of logic is typically taken as requiring that the meanings of the connectives change too. As a result, it has been argued that legitimate rivalry between logics is under threat. This is, in a nutshell, the meaning‐variance argument, traditionally attributed to Quine. In this paper, we present a semantic framework that allows us to resist the meaning‐variance claim for an important class of systems: classical logic, the logic of paradox and strong Kleene logic. The major feature of the semantics (...) is that the connectives have the same meanings in these systems, so that the meaning‐variance argument is straightforwardly blocked. We discuss the effects of this semantics for two uses of the argument of meaning variance, and also consider its impact on related issues. (shrink)

In one of his papers, JC Beall advanced a new and interesting interpretation of Weak Kleene logic, in terms of on-topic/off-topic. In brief, Beall suggests to read the third value as off-topic, whereas the two classical values are read as true and on-topic and false and on-topic. Building on Beall’s new interpretation, the aim of this paper is threefold. First, we discuss two motivations to enrich Beall’s interpretation, and offer an alternative semantic framework that reflects our motivations. Second, by making (...) use of our new framework, we will offer a new interpretation of the logic of Catuskoti which combines Beall’s proposal of having FDE as the correct logic with the on-topic/off-topic divide. Finally, we will offer a general result that will allow us to make sense of a family of infectious logics in terms of Beall’s on-topic/off-topic reading. (shrink)

We outline the rather complicated history of attempts at axiomatizing Jaśkowski’s discussive logic $$\mathbf {D_2}$$ D2 and show that some clarity can be had by paying close attention to the language we work with. We then examine the problem of axiomatizing $$\mathbf {D_2}$$ D2 in languages involving discussive conjunctions. Specifically, we show that recent attempts by Ciuciura are mistaken. Finally, we present an axiomatization of $$\mathbf {D_2}$$ D2 in the language Jaśkowski suggested in his second paper on discussive logic, by (...) following a remark of da Costa and Dubikajtis. We also deal with an interesting variant of $$\mathbf {D_2}$$ D2, introduced by Ciuciura, in which negation is also taken to be discussive. (shrink)

In a recent article, Mario Günther presented a conditional that is claimed to be connexive. The aim of this short discussion note is to show that Günther’s claim is not without problems.

In this paper, we generalize the ordered-pair semantics advanced by Matthew Clemens for the Logic of Paradox to n-tuple semantics, for each fixed n. Moreover, we show that the resulting semantics can accommodate not only LP, but also classical logic as well as strong Kleene logic depending on the set of designated values that one chooses. Building on the technical observations, we offer intuitively plausible readings for the semantics, and we also discuss some weaknesses of the original intuitive reading advanced (...) by Clemens. (shrink)

Intuitionism can be seen as a verificationism restricted to mathematical discourse. An attempt to generalize intuitionism to empirical discourse presents various challenges. One of those concerns the logical and semantical behavior of what has been called ' empirical negation'. An extension of intuitionistic logic with empirical negation was given by Michael De and a labelled tableaux system was there shown sound and complete. However, a Hilbert-style axiom system that is sound and complete was missing. In this paper we provide the (...) missing axiom system which is shown sound and complete with respect to its intended semantics. Along the way we consider some further applications of empirical negation. (shrink)

Connectives such as Tonk have posed a significant challenge to the inferentialist. It has been recently argued that the classical semanticist faces an analogous problem due to the definability of “nasty connectives” under non-standard interpretations of the classical propositional vocabulary. In this paper, we defend the classical semanticist from this alleged problem.

In several experimental conditions, neuronal excitation at the perirhinal cortex (PC) does not propagate to the entorhinal cortex (EC) due to a “wall” of inhibition, which may help to create functional coupling and un‐coupling of the PC and EC in the medial temporal lobe. However, little is known regarding the coupling control process. Herein, we propose that the deep layer of area 35 in the PC plays a pivotal role in opening the gate for coupling, thus allowing the activity in (...) the PC to propagate to the EC. Using voltage‐sensitive dye imaging for the brain slices of rodents, we show that a slowly inactivating potassium conductance in this area is essential to induce excitation overtaking the inhibitory control. This coupling between the distinct neural circuits persists for at least 1 h. We elucidate further implications of this network‐level plastic behavior and its mechanism. (shrink)

The two target articles agree that processes of cultural evolution generate richness and diversity in music, but neither address this question in a focused way. We sketch one way to proceed – and hence suggest how the target articles differ not only in empirical claims, but also in their tacit, prior assumptions about the relationship between cognition and culture.

ドゥルーズの「リゾーム」、フーコーの「脱中心化」、バタイユの「蕩尽」、デリダの「ディコンストラクション」。80年代のニューアカデミズム、ポストモダンとは何だったのか?世界を席捲した現代思想のキイ・ワー ドが、20年の歳月をへて、今よみがえる。新たに第5部を書き加えて、21世紀の思想状況に斬り込む「増補決定版」が、ここに登場!現代思想はいま、どの地点にまでたどりついたのか。.