An Institute of Medicine panel charged with reviewing the system for overseeing research involving children concluded in 2004 that Institutional Review Boards, institutions engaged in research, and study sponsors should “adopt explicit written policies on acceptable and unacceptable types and amounts of payments related to [children’s] research participation.” We previously reported data on practices and policies in the U.S. regarding payments to children who participate in research and their parents. Here, we report additional results from our study and identify some (...) of the decisions that must be made in developing payment plans and on which payment policies will be expected to offer guidance. We conclude that further conceptual analysis and empirical research are necessary before IRBs, institutions, and sponsors can develop specific rules on numerous aspects of payment. Nevertheless, payment policies that promote the ethical treatment of children in research and their parents can be developed. We propose a structure for such policies. (shrink)

How is a terminally ill patient treated by the surrounding people in the U.S. and Japan? How does a terminally ill patient decide on his or her own treatment? These questions will be examined in a study of intensive medical care, received by a terminally ill Japanese cancer patient in the U.S. and Japan. This casereflects the participant observation by a Japanese anthropologist for about 8 years in the United States and Japan on one patient who was hospitalized in both (...) countries on and off for about eight years. The objective of this study is to illuminate the different concept of personhood between the U.S. and Japan that appeared in different cultural practices of both countries and in the subject’s own decision making process. The significant differences appeared between theU.S. and Japan in the concepts of (1) science, (2) suffering, (3) Power of Attorney and Doisho (Consent Form), and (4) organized care. The interpretation of such differences indicates that seemingly universal practices across countries suggest cultural specific concepts and their management. Therefore, ethical norms appeared differently accordingly to each country. (shrink)

Moral appraisals are found to be associated with a person’s individual differences (e.g., political ideology), and the effects of individual differences on language use have been studied within the framework of the Moral Foundations Theory (MFT). However, the relationship between one’s moral concern and the use of language involving morality on social media is not self-evident. The present exploratory study investigated that relationship using the MFT. Participants’ tweets and self-reported responses to the questionnaire were collected to measure the degree of (...) their appraisals according to the five foundations of the MFT. The Japanese version of the Moral Foundations Dictionary (J-MFD) was used to quantify the number of words in tweets relevant to the MFT’s five moral foundations. The results showed that endorsement of the Fairness and Authority foundations predicted the word frequency in the J-MFD across all five foundations. The findings suggest that the trade-off relationship between the Fairness and Authority foundations plays a key role in online language communication. The implications and future directions to scrutinize that foundation are discussed. (shrink)

Shweder et al. (1997) proposed the three domains of morality: Autonomy, Community, and Divinity. This study used situation sampling to explore how people from Japan and the U.S. interpret moral transgressions provided in their own and another cultural context. Specifically, the analysis tested whether participants with one cultural background recognize culturally congruent moral transgressions as violations more frequently and feel more harshly towards them than culturally incongruent domains. Furthermore, the extent of evocation caused by the home and another culture was (...) investigated. This study asked 102 Japanese and 168 U.S. participants to judge which domain would be primarily involved in each transgression and to rate their wrongness. Participants showed a higher perceived magnitude of transgressions in culturally valued domains provided by in-group than outside members. Cross-cultural differences in morality and future directions are discussed. (shrink)

The moral foundations theory (MFT) proposes that there are five moral foundations that work as the standard to make moral judgments. Among them, the purity foundation is a complex concept. It is considered to be a distinctive foundation compared with the other ones partly because it involves religious beliefs. The assumption underlying the purity foundation is Christian beliefs, so the MFT was developed and made prevalent mostly in the Western cultures. However, because of that assumption, cultural differences in perceiving the (...) purity foundation should be observed with a non-Western sample, such as Japan. It would be important to discuss and clarify the Japanese unique aspect of their orientation toward the pure and impure. We constituted a scale to measure people's tendency toward purity orientation–pollution avoidance (POPA), based on the purity/sanctity subscale of the MFT. For validation, we administered several scales along with POPA. In Study 1, we developed the scale and measured the relationship between the degree of one's POPA, disgust, and animism. We identified four factors as POPA subscales. In Study 2, we investigated the test–retest reliability of POPA and conducted questionnaire surveys to measure attitudes toward paranormal phenomena and the degree of concern for each of the moral foundations. The results showed the validity of the scale, based on the moderate correlations with other scales. The POPA can be a promising tool to better understand the phenomena involving the purity foundation in a Japanese context. (shrink)

Machine learning, deep learning and neural networks are extensively applied for the development of many fields. Though their technologies are improved greatly, they are often said to be opaque in terms of explainability. Their explainable neural functions will be essential to realization in the networks. In this paper, it is shown that the bio-inspired networks are useful for the explanation of tracking and classification of features. First, the asymmetric network with nonlinear functions is created based on the bio-inspired retinal network. (...) They have orthogonal properties useful for the tracking of features compared with the conventional symmetric networks, which is also proposed on the biological functions. Next, the analysis for the independence of the subspaces between the Fourier bases and the asymmetric network bases is performed. It was that the asymmetric networks have better performances in the classification compared with the symmetric ones. Further, the layered asymmetric networks generate the higher dimensional orthogonal bases that improve the classification accuracies by the replacements of bases. Finally, we classified Reuters collections data applying the explainable processing steps, which consist of the linear discriminations and the sparse coding with nearest neighbor relation for classification. (shrink)

AimTo examine the association of body mass index (BMI) [kg/m2] and its classifications (underweight [BMI < 18.5], normal [18.5 ≤ BMI < 25], overweight [25 ≤ BMI < 30], and obese [BMI ≥ 30]) with brain structure in individuals with a wide range of BMI group.Materials and methodsThe participants included 382 right-handed individuals (mean age: 46.9 ± 14.3 years, 142 men and 240 women). The intelligence quotient was assessed using the Japanese Adult Reading Test. Voxel-based morphometry (VBM) and diffusion tensor (...) imaging (DTI) were performed to analyze the association of BMI and its classifications with gray and white matter structures, respectively.ResultsAccording to VBM, BMI was significantly and negatively correlated with the bilateral cerebellum exterior volumes. In group comparisons, the right cerebellum exterior volume was significantly lower in the overweight or obese group than in the underweight or normal group, while the bilateral cuneus and calcarine cortex, left cuneus, and left precuneus volume was significantly lower in the underweight group than in the non-underweight group. Sex-related stratification analyses for VBM revealed that BMI was significantly and negatively correlated with the bilateral cerebellum exterior volumes only in women. In group comparisons, the left cerebellum exterior volume was significantly lower in obese women than in non-obese women. The left thalamus proper and the right cerebellum exterior volumes were significantly lower in overweight or obese group than in underweight or normal group in men and women, respectively. The bilateral cuneus and calcarine cortex, left cuneus and carcarine cortex, and bilateral cuneus volume was significantly lower in underweight men than in non-underweight men. In contrast, there were no notable findings on DTI.ConclusionOur results suggest association of continuous BMI, being overweight or obese, and being underweight with decreased gray matter volume in individuals with a wide range of BMI group. Furthermore, sex-related differences are seen in the association of BMI and its classifications with regional gray matter volume reductions. Abnormally high or low BMIs may have a negative influence on regional gray matter volumes. (shrink)

In recent years, neural networks have attracted much attention in the machine learning and the deep learning technologies. Bio-inspired functions and intelligence are also expected to process efficiently and improve existing technologies. In the visual pathway, the prominent features consist of nonlinear characteristics of squaring and rectification functions observed in the retinal and visual cortex networks, respectively. Further, adaptation is an important feature to activate the biological systems, efficiently. Recently, to overcome short-comings of the deep learning techniques, orthogonality for the (...) weights in the networks has been developed for the signal propagation and the efficient optimization of the learning. In this paper, bio-inspired asymmetric networks with nonlinear characteristics are proposed, which are derived from the retinal networks in the biological visual pathway. The asymmetric network proposed here was verified to detect the movement of the object, efficiently in our previous studies. This paper shows a new characteristic of the adaptive orthogonality in the asymmetric networks. First, it is shown that the asymmetric network with nonlinear characteristics is effective for generating orthogonality. Second, the proposed asymmetric network with Gabor filters is compared with the conventional energy model from the point of the orthogonality characteristics. Finally, the asymmetric networks with nonlinear characteristics can generate the extended orthogonal bases in independent subspaces, which are useful for classification and efficient learning. (shrink)

This study aimed to investigate whether the effect of mental practice can be enhanced by providing neurofeedback based on transcranial magnetic stimulation -induced motor evoked potentials. Twenty-four healthy, right-handed subjects were enrolled in this study. The subjects were randomly allocated into two groups: a group that was given correct TMS feedback and a group that was given randomized false TMS feedback. The subjects imagined pushing the switch with just timing, when the target circle overlapped a cross at the center of (...) the computer monitor. In the Real-FB group, feedback was provided to the subjects based on the MEP amplitude measured in the trial immediately preceding motor imagery. In contrast, the subjects of the Sham-FB group were provided with a feedback value that was independent of the MEP amplitude. TMS was applied when the target, moving from right to left, overlapped the cross at the center of the screen, and the MEP amplitude was measured. The MEP was recorded in the right first dorsal interosseous muscle. We evaluated the pre-mental practice and post-mental practice motor performance in both groups. As a result, a significant difference was observed in the percentage change of error values between the Real-FB group and the Sham-FB group. Furthermore, the MEP was significantly different between the groups in the 4th and 5th sets. Therefore, it was suggested that TMS-induced MEP-based neurofeedback might enhance the effect of mental practice. (shrink)

Dysfunctional attentional control is observed in patients with mental disorders. However, there is no established neurophysiological method to assess attention in such patients. We showed a discrepancy in alpha-band power in the tasks that evoked internal and external attention event-related alpha-band power changes in healthy subjects during self-reflection and working memory tasks in a preliminary study. In this study, we aimed at elucidating event-related alpha-band power changes in healthy subjects during the tasks, addressing the shortcomings of the previous study. Sixteen (...) healthy volunteers were examined for the event-related power change during the tasks. The results demonstrated the discrepancy of alpha-band ERpow at 8, 10, and 12 Hz in the parieto-occipital area between the WM and SR tasks for a period between a target stimulus and a command stimulus, where a participant switched to internal attention from external attention according to the SR task and remained at external attention according to the WM task. The results suggest that alpha-band ERpow in this area is associated with the direction of attention in response to cognitive stimuli, indicating that the findings of ERpow during the two tasks would potentially aid in the clarification of the pathophysiology of the dysfunctional change in attention in patients with psychiatric disorders. (shrink)

PurposeThis study aimed to investigate whether oxygenated hemoglobin generated during a motor imagery task is associated with the motor learning level of the task.MethodsWe included 16 right-handed healthy participants who were trained to perform a ball rotation task. Hemodynamic brain activity was measured using near-infrared spectroscopy to monitor changes in oxy-Hb concentration during the BR MI task. The experimental protocol used a block design, and measurements were performed three times before and after the initial training of the BR task as (...) well as after the final training. The BR count during training was also measured. Furthermore, subjective vividness of MI was evaluated three times after NIRS measurement using the Visual Analog Scale.ResultsThe results showed that the number of BRs increased significantly with training. VAS scores also improved with training. Furthermore, oxy-Hb concentration and the region of interest showed a main effect. An interaction was confirmed, and it was ascertained that the change in oxy-Hb concentrations due to training was different for each ROI. The most significant predictor of subjective MI vividness was supplementary motor area oxy-Hb concentration.DiscussionHemodynamic brain activity during MI tasks may be correlated with task motor learning levels, since significant changes in oxy-Hb concentrations were observed following initial and final training in the SMA. In particular, hemodynamic brain activity in the SMA was suggested to reflect the MI vividness of participants. (shrink)

In this paper I argue that the concept of pilgrimage provides a unifying trope for the otherwise seemingly unfocused travel accounts of Bashō’s Narrow Road to the Interior and Alexander von Humboldt and Aimé Bonpland’s Voyage aux régions equinoxiales du Nouveau Continent. I begin with a brief description of debates regarding the notion of pilgrimage. After that I show how pilgrimage as trope may be applied to the texts of these authors. This is followed by an application of the classical (...) stages of pilgrimage to particular phases of Bashō’s and Humboldt’s recounted experiences. I conclude that pilgrimage offers an illuminating new way to understand the travel accounts of these two writers. (shrink)

This article explores how the notion ofordinary aestheticscan stem, as well as the one ofordinary ethics, from thatrevolution of the ordinarystarted by Wittgenstein and further developed by philosophers like Cavell and Diamond. The idea ofordinary ethicsemphasizes the importance of everyday life and the particular details of our experiences. This concept can be extended to aesthetics, forming the basis of a modality of aesthetic appreciation that recognize values and importance in the details and nuances of everyday experience. One example of suchordinary (...) aestheticscan be found in thehaikupoetry of Bashō. Bashō’s poetry often focuses on the ordinary and mundane aspects of life, such as the changing of seasons, the sound of rain, or the sight of a bird in flight, but also on that lower world made of insects, rotten foliage, and excrements. Bashō conveys in poetry the core ofZenphilosophy, emphasizing the interconnectedness of all things and the value of living in the present moment. This approach to aesthetics offers an alternative to more traditional modes of aesthetic appreciation, which tend to prioritize grandeur, spectacle, and formal perfection. Ultimately, the concept of ordinary aesthetics invites us to find the intrinsic importance in the simple things that surround us and to cultivate a deeper appreciation for the richness of our everyday lives. (shrink)

> この道や行く人なしに秋の暮れ Matsuo Basho 16941 The surface is asymmetrical, the pigment flecked and uneven. Looking close, what seems at a distance to be smooth is actually covered in tiny gentle indentations and irregularities. On one edge, there are a series of fine lines—evidence of past damage, and repair. It is obviously old. But its age is part of its specialness. It is simple, one of a kind, beautiful. The above is a description of a Japanese stoneware tea bowl, like (...) the one in figure 1, embodying an aesthetic dating back to at least the 16th century called wabi-sabi (侘び寂び). Figure 1 Wabi-sabi tea bowl. ottmarliebert.com from Santa Fe, Turtle Island, CC BY-SA 2.0 via Wikimedia Commons. Wabi-sabi is famously difficult to translate, but derives from the words wabi 侘– indicating austerity, simplicity, the quiet life and sabi 寂—indicating maturity, solitude, naturalness. Wabi-sabi refers to the aesthetic appreciation of natural imperfection and impermanence.2 It is embodied in a tradition of handmade pottery, sometimes including repair of past breaks with gold inlay (kintsugi). But it is also reflected in stone gardens, in bonsai, in haiku, and some forms of the Japanese tea ceremony. What, you might ask, does this have to do with medicine? Pottery and aesthetics seem a long way from pathology and medical ethics. First, some …. (shrink)

This paper critically analyses the strongly subjectivist approach to exploitation theory proposed by Matsuo on this journal, in general convex economies with heterogeneous agents. It is proved that the Fundamental Marxian Theorem is not preserved and that no meaningful subjectivist exploitation index can be constructed. A minimal objectivism is necessary in exploitation theory, whereby subjective preferences do not play a direct, definitional role. An objectivist approach related to the ‘New Interpretation’ is proposed which captures the core intuitions of exploitation (...) theory, provides appropriate indices of individual and aggregate exploitation, and preserves the Fundamental Marxian Theorem in general economies. (shrink)