We extend the construction of a global square sequence in extender models from Zeman [8] to a construction of coherent non-threadable sequences and give a characterization of stationary reflection at inaccessibles similar to Jensen’s characterization in L.

We present a construction of a global square sequence in extender models with λ-indexing.

This article proposes a new bi-directional way of understanding the convergence of biology and computing. It argues for a reciprocal interaction in which biology and computing have shaped and are currently reshaping each other. In so doing, we qualify both the view of a natural marriage and of a digital shaping of biology, which are common in the literature written by scientists, STS, and communication scholars. The DNA database is at the center of this interaction. We argue that DNA databases (...) are spaces of convergence for computing and biology that change in form, meaning, and function from the 1960s to the 2000s. The first part of the article shows how, in the 1980s, DNA sequencing shifted from passively incorporating computers to be increasingly modeled in digital coding and decoding. Information retrieval algorithms, reciprocally, were altered according to the peculiarities of DNA in the first sequence-storage databases. The second part of the article investigates the impact of these reciprocal interactions and globalization on the organization of research centers, ways of conducting big science, and scientific values. Through convergence and new technologies such as data mining, biology and computing were transformed technologically, institutionally, and culturally into a new bio-data enterprise called genomics. (shrink)

Versions of Laver sequences are known to exist for supercompact and strong cardinals. Assuming very strong axioms of infinity, Laver sequences can be constructed for virtually any globally defined large cardinal not weaker than a strong cardinal; indeed, under strong hypotheses, Laver sequences can be constructed for virtually any regular class of embeddings. We show here that if there is a regular class of embeddings with critical point κ, and there is an inaccessible above κ, then it is consistent for (...) there to be a regular class that admits no Laver sequence. We also show that extendible cardinals are Laver-generating, i.e., that assuming only that κ is extendible, there is an extendible Laver sequence at κ. We use the method of proof to answer a question about Laver-closure of extendible cardinals at inaccessibles. Finally, we consider Laver sequences for super-almost-huge cardinals. Assuming slightly more than super-almost-hugeness, we show that there are super-almost-huge Laver sequences, improving the previously known upper bound for such Laver sequences. We also describe conditions under which the canonical construction of a Laver sequence fails for super-almost-huge cardinals. (shrink)

Staphylococcus aureus ST45 is a major global MRSA lineage with huge strain diversity and a high clinical impact. It is one of the most prevalent carrier lineages but also frequently causes severe invasive disease, such as bacteremia. Little is known about its evolutionary history. In this study, we used whole-genome sequencing to analyze a large collection of 451 diverse ST45 isolates from 6 continents and 26 countries. De novo-assembled genomes were used to understand genomic plasticity and to perform coalescent (...) analyses. The ST45 population contained two distinct sublineages, which correlated with the isolates’ geographical origins. One sublineage primarily consisted of European/North American isolates, while the second sublineage primarily consisted of African and Australian isolates. Bayesian analysis predicted ST45 originated in northwestern Europe about 500 years ago. Isolation time, host, and clinical symptoms did not correlate with phylogenetic groups. Our phylogenetic analyses suggest multiple acquisitions of the SCCmec element and key virulence factors throughout the evolution of the ST45 lineage. (shrink)

The paper argues that new environmental values are needed as the advanced industrial economy becomes global. Reviewing a range of values from hunter-gatherer, agricultural and industrial societies, the paper suggests that environmental value systems should ideally satisfy three criteria. They should be consistent with scientific understanding of natural systems, they should lead to practical ethical and political proposals and, crucially, they should inspire aesthetic responses of pleasure and awe. Current global value systems fall short of this ideal: Gaia (...) has the potential to combine science and awe, but lacks humane decision criteria, while sustainable development is pragmatic but environmentally minimalist and lacks aesthetic inspiration. The short term need is to integrate different strands of current positions as Hinduism combined pre-existing views. A sequence of priorities is suggested: eliminating irreversible environmental change ; stabilising population change through more equitable trade; and reconsidering the boundaries, practical and aesthetic, between society and nature. (shrink)

Let M be a short extender mouse. We prove that if $E\in M$ and $M\models $ “E is a countably complete short extender whose support is a cardinal $\theta $ and $\mathcal {H}_\theta \subseteq \mathrm {Ult}(V,E)$ ”, then E is in the extender sequence $\mathbb {E}^M$ of M. We also prove other related facts, and use them to establish that if $\kappa $ is an uncountable cardinal of M and $\kappa ^{+M}$ exists in M then $(\mathcal {H}_{\kappa ^+})^M$ satisfies (...) the Axiom of Global Choice. We prove that if M satisfies the Power Set Axiom then $\mathbb {E}^M$ is definable over the universe of M from the parameter $X=\mathbb {E}^M\!\upharpoonright \!\aleph _1^M$, and M satisfies “Every set is $\mathrm {OD}_{\{X\}}$ ”. We also prove various local versions of this fact in which M has a largest cardinal, and a version for generic extensions of M. As a consequence, for example, the minimal proper class mouse with a Woodin limit of Woodin cardinals models “ $V=\mathrm {HOD}$ ”. This adapts to many other similar examples. We also describe a simplified approach to Mitchell–Steel fine structure, which does away with the parameters $u_n$. (shrink)

Morally supererogatory acts are those that go above and beyond the call of duty. More specifically: they are acts that, on any individual occasion, are good to do and also both permissible to do and permissible to refrain from doing. We challenge the way in which discussions of supererogation typically consider our choices and actions in isolation. Instead we consider sequences of supererogatory acts and omissions and show that some such sequences are themselves problematic. This gives rise to the following (...) puzzle: what problem can we have with a sequences of actions if each individual act or omission is itself permissible? In this paper, we develop a response to this question, by exploring whether solutions analogous to those proposed in the rational choice literature are available in the case of supererogatory sequences. Our investigation leads us to the view that making sense of the supererogatory requires accepting that there are global moral norms that apply to sequences of acts alongside the local moral norms that apply to individual acts. (shrink)

We study the influence of the individual behaviour of animals on predator-prey models. Populations of preys and predators are divided into sub-populations corresponding to different activity classes. The animals are assumed to do many activities all day long such as searching for food of different types. The preys are more vulnerable when doing some activities during which they are very exposed to predators attacks rather than for others during which they are hidden. We study activity sequences of the animals and (...) also the effect of a change in the average individual behaviour of the animals on Lotka-Volterra prey-predator interactions. Numerical simulations are realized for the whole sets of equations (governing the subpopulations) and are compared to the simulations of the reduced sets of equation (governing the populations). We look for the validity of the method with respect to a scaling factor which measures the differences between the two time scales associated to the fast-varying variables and to the slow-time varying global variables. It is shown that when the two time scales differ of about two orders of magnitude, the approximation is satisfying. (shrink)

We give the proof of a theorem of Jensen and Zeman on the existence of a global □ sequence in the Core Model below a measurable cardinal κ of Mitchell order ) equal to κ++, and use it to prove the following theorem on mutual stationarity at n.Let ω1 denote the first uncountable cardinal of V and set to be the class of ordinals of cofinality ω1.TheoremIf every sequence n m. In particular, there is such a model (...) in which for all sufficiently large m<ω, the class of measurables λ with oM≥ωm is, in V, stationary below m+2. (shrink)

We explore in this paper the relation between activities, communication channels and media, and common ground building in global teams. We define re-representation as a sequence of representations of the same concept using different communication channels and media. We identified the re - representation technique to build common ground that is used by team members during multimodal and multimedia communicative events in cross-disciplinary, geographically distributed settings. Our hypotheses are as follows: (1) Significant sources of information behind decisions and (...) request for actions are embedded within the fabric of communicative events in which participants use both informal and formal media to express their ideas. Capturing these information sources can facilitate common ground building and accelerate the execution of action requests. (2) Re-representations of concepts, i.e., sequences of representations using diverse media and communication channels, mediate and accelerate common ground building. (3) The use of intra- or interdisciplinary re-representations correlates with high team performance, i.e., effective team process and high product quality. We used AEC Global Teamwork course offered in 2008–2009 as the testbed for our study to validate our hypothesis. (shrink)

Comparing the relative sensitivity of direct and indirect measures of learning is proposed as the best way to provide evidence for unconscious learning when both conceptual and operative definitions of awareness are lacking. This approach was first proposed by Reingold & Merikle (1988) in the context of subliminal perception. In this paper, we apply it to a choice reaction time task in which the material is generated based on a probabilistic finite-state grammar (Cleeremans, 1993). We show (1) that participants progressively (...) learn about the statistical structure of the stimulus material over training with the choice reaction time task, and (2) that they can use some of this knowledge to predict the location of the next stimulus in a subsequent “generation” task. However, detailed partial correlational analyses of the correspondence between performance during the reaction time task and the statistical structure of the training material showed that large effects remained even when controlling for explicit knowledge as assessed by the generation task. Hence we conclude (1) that at least some of the knowledge expressed through reaction time performance can not be characterized as conscious, and (2) that even when associations are found at a global level of analysis, dissociations can still be obtained when more detailed analyses are conducted. Finally, we also show that participants are limited in the depth of the contingencies they can learn about, and that these limitations are shared by the Simple Recurrent Network model of Cleeremans & McClelland (1991). (shrink)

In this paper we introduce the Wholeness Axiom , which asserts that there is a nontrivial elementary embedding from V to itself. We formalize the axiom in the language {∈, j } , adding to the usual axioms of ZFC all instances of Separation, but no instance of Replacement, for j -formulas, as well as axioms that ensure that j is a nontrivial elementary embedding from the universe to itself. We show that WA has consistency strength strictly between I 3 (...) and the existence of a cardinal that is super- n -huge for every n . ZFC + WA is used as a background theory for studying generalizations of Laver sequences. We define the notion of Laver sequence for general classes E consisting of elementary embeddings of the form i :V β → M , where M is transitive, and use five globally defined large cardinal notions – strong, supercompact, extendible, super-almost-huge, superhuge – for examples and special cases of the main results. Assuming WA at the beginning, and eventually refining the hypothesis as far as possible, we prove the existence of a strong form of Laver sequence for a broad range of classes E that include the five large cardinal types mentioned. We show that if κ is globally superstrong, if E is Laver-closed at beth fixed points, and if there are superstrong embeddings i with critical point κ and arbitrarily large targets such that E is weakly compatible with i , then our standard constructions are E -Laver at κ . , there is an extendible Laver sequence at κ .) In addition, in most cases our Laver sequences can be made special if E is upward λ -closed for sufficiently many λ. (shrink)

Multiple sequence alignment is one of the major problems that can be encountered in the bioinformatics field. MSA consists in aligning a set of biological sequences to extract the similarities between them. Unfortunately, this problem has been shown to be NP-hard. In this article, a new algorithm was proposed to deal with this problem; it is based on a quantum-inspired cuckoo search algorithm. The other feature of the proposed approach is the use of a randomized progressive alignment method based (...) on a hybrid global/local pairwise algorithm to construct the initial population. The results obtained by this hybridization are very encouraging and show the feasibility and effectiveness of the proposed solution. (shrink)

Genomics is increasingly considered a global enterprise – the fact that biological information can flow rapidly around the planet is taken to be important to what genomics is and what it can achieve. However, the large-scale international circulation of nucleotide sequence information did not begin with the Human Genome Project. Efforts to formalize and institutionalize the circulation of sequence information emerged concurrently with the development of centralized facilities for collecting that information. That is, the very first databases (...) build for collecting and sharing DNA sequence information were, from their outset, international collaborative enterprises. This paper describes the origins of the International Nucleotide Sequence Database Collaboration between GenBank in the United States, the European Molecular Biology Laboratory Databank, and the DNA Database of Japan. The technical and social groundwork for the international exchange of nucleotide sequences created the conditions of possibility for imagining nucleotide sequences as a “global” objects. The “transnationalism” of nucleotide sequence was critical to their ontology – what DNA sequences came to be during the Human Genome Project was deeply influenced by international exchange. (shrink)

Since the first phase of the formal effort to sequence the human genome, geneticists, social scientists and other scholars of race and ethnicity have warned that new genetic technologies and knowledge could have negative social effects, from biologizing racial and ethnic categories to the emergence of dangerous forms of genetic discrimination. Early on in the Human Genome Project, population geneticists like Luigi Luca Cavalli-Sforza enthusiastically advocated for the collection of DNA samples from global indigenous populations in order to (...) track the history of human ancestry, migration, and languages, while social scientists like Troy Duster insisted that the new genetics was in danger of ushering in insidious practices of eugenics. The Human Genome Diversity Project's 1991 proposal to archive human genetic variation around the world quickly came under intense scrutiny by indigenous peoples and advocacy groups who worried that such measures could exploit indigenous groups as research populations and even resurrect racist taxonomies from the nineteenth century. (shrink)

Cet article vise à contribuer à l’élaboration d’une théorie critique du capitalisme global. Il s’appuie pour ce faire, d’une part, sur une relecture serrée des deux ouvrages cosignés par Sandro Mezzadra et Brett Neilson, La Frontière comme méthode (2013) et The Politics of Operations (2019). Il esquisse d’autre part un diagnostic historique de la séquence enclenchée par la crise de 2008. L’article se développe en trois temps, l’un sur le « multivers capitaliste », où sont considérées les dimensions spatio-temporelles (...) de la dynamique capitaliste, le second de critique de la violence politique nécessaire à la reproduction élargie du capital, le troisième ouvrant sur des problèmes de stratégie politique sous le prisme d’une reproblématisation actualisée des « soviets » et du « double pouvoir ». (shrink)

Political globalization is one dimension of a process that is multidimensional (not just economic), historical (in millennial proportions), and transformative (in changing planetary institutional structures). Conceiving of political globalization in evolutionary terms (as one centered on innovative sequences of search-and-selection) makes it possible to construct a time-table for global politics, and to derive from it an agenda of priority global problems. The following questions will be addressed on that basis: Where in that process are we situated at the (...) present time? (a time that is one of palpable uncertainty); What global problems does this analysis point to, and what does it tell us about where we are heading? These are not forecasts but rather elements of an "institutional" framework of orientation for the discussion of the next several decades of global organization. (shrink)

The article comprises a conceptual framework to analyze the strengths and weaknesses of a global health convention. The analyses are inspired by Lawrence Gostin's suggested Framework Convention on Global Health. The analytical model takes a starting-point in events tentatively following a logic sequence: Input (global health funding), Processes (coordination, cooperation, accountability, allocation of aid), Output (definition of basic survival needs), Outcome (access to health services), and Impact (health for all). It then examines to what degree binding (...) international regulations can create order in such a sequence of events. We conclude that a global health convention could be an appropriate instrument to deal with some of the problems of global health. We also show that some of the tasks preceding a convention approach might be to muster international support for supra-national health regulations, negotiate compromises between existing stakeholders in the global health arena, and to utilize WHO as a platform for further discussions on a global health convention. (shrink)

This report describes the rationale, approaches, organization, and resource development leading to a large-scale deletion bin map of the hexaploid wheat genome. Accompanying reports in this issue detail results from chromosome bin-mapping of expressed sequence tags representing genes onto the seven homoeologous chromosome groups and a global analysis of the entire mapped wheat EST data set. Among the resources developed were the first extensive public wheat EST collection. Described are protocols for sequencing, sequence processing, EST nomenclature, and (...) the assembly of ESTs into contigs. These contigs plus singletons were used for selection of distinct sequence motif unigenes. Selected ESTs were rearrayed, validated by 5′ and 3′ sequencing, and amplified for probing a series of wheat aneuploid and deletion stocks. Images and data for all Southern hybridizations were deposited in databases and were used by the coordinators for each of the seven homoeologous chromosome groups to validate the mapping results. Results from this project have established the foundation for future developments in wheat genomics. (shrink)

This study examines the system-deciding principle of economic rationality for its logical soundness and effects in global practice. Analysis demonstrates the fallacious structure of the underlying assumptions of homo economicus across theories and institutions, and explains how cumulative destruction of global economic, social, and ecological life systems follows from its life-blind mechanism. Higher-order concepts of life-capital, life-value efficiency, and life-good supply and demand are then defined to bring economic rationality into coherence with terrestrial and human life requirements.

Understanding the functional mechanisms underlying genetic signals associated with complex traits and common diseases, such as cancer, diabetes and Alzheimer's disease, is a formidable challenge. Many genetic signals discovered through genome‐wide association studies map to non‐protein coding sequences, where their molecular consequences are difficult to evaluate. This article summarizes concepts for the systematic interpretation of non‐coding genetic signals using genome annotation data sets in different cellular systems. We outline strategies for the global analysis of multiple association intervals and the (...) in‐depth molecular investigation of individual intervals. We highlight experimental techniques to validate candidate (potential causal) regulatory variants, with a focus on novel genome‐editing techniques including CRISPR/Cas9. These approaches are also applicable to low‐frequency and rare variants, which have become increasingly important in genomic studies of complex traits and diseases. There is a pressing need to translate genetic signals into biological mechanisms, leading to prognostic, diagnostic and therapeutic advances. (shrink)

Who gets to practice and participate in science? Research teams in Puerto Rico and New Zealand have each sequenced the genomes of parrot populations native to these locales: the iguaca and kākāpō, respectively. In both cases, crowdfunding and social media were instrumental in garnering public interest and funding. These forms of Internet-mediated participation impacted how conservation science was practiced in these cases and shaped emergent social roles and relations. As citizens “follow,” fund, and “like” the labor of conservation, they create (...) new relational possibilities for and with science. For example, the researchers became newly engaged and engaging by narrating and displaying the parrots via an Internet-inflected aesthetic. The visibility of online modalities shifted accountabilities as researchers considered whom this crowdfunded work answered to and how to communicate their progress and results. The affordances of the Internet allowed researchers from the peripheries of the scientific establishment to produce genomic knowledge for globally dispersed audiences. The convergence of genomic and Internet technology here shaped scientific practice by facilitating new modes of participation—for laypeople in science but also for scientists in society. (shrink)

Comparing the relative sensitivity of direct and indirect measures of learning is proposed as the best way to provide evidence for unconscious learning when both conceptual and operative definitions of awareness are lacking. This approach was first proposed by Reingold & Merikle (1988) in the context of subliminal perception. In this paper, we apply it to a choice reaction time task in which the material is generated based on a probabilistic finite-state grammar (Cleeremans, 1993). We show (1) that participants progressively (...) learn about the statistical structure of the stimulus material over training with the choice reaction time task, and (2) that they can use some of this knowledge to predict the location of the next stimulus in a subsequent “generation” task. However, detailed partial correlational analyses of the correspondence between performance during the reaction time task and the statistical structure of the training material showed that large effects remained even when controlling for explicit knowledge as assessed by the generation task. Hence we conclude (1) that at least some of the knowledge expressed through reaction time performance can not be characterized as conscious, and (2) that even when associations are found at a global level of analysis, dissociations can still be obtained when more detailed analyses are conducted. Finally, we also show that participants are limited in the depth of the contingencies they can learn about, and that these limitations are shared by the Simple Recurrent Network model of Cleeremans & McClelland (1991). (shrink)

Two priming experiments demonstrated exogenous attentional persistence to the fundamental auditory dimensions of frequency (Experiment 1) and time (Experiment 2). In a divided-attention task, participants responded to an independent dimension, the identification of three-tone sequence patterns, for both prime and probe stimuli. The stimuli were specifically designed to parallel the local–global hierarchical letter stimuli of [Navon D. (1977). Forest before trees: The precedence of global features in visual perception. Cognitive Psychology, 9, 353–383] and the task was designed (...) to parallel subsequent work in visual attention using Navon stimuli [Robertson, L. C. (1996). Attentional persistence for features of hierarchical patterns. Journal of Experimental Psychology: General, 125, 227–249; Ward, L. M. (1982). Determinants of attention to local and global features of visual forms. Journal of Experimental Psychology: Human Perception and Performance, 8, 562–581]. The results are discussed in terms of previous work in auditory attention and previous approaches to auditory local–global processing. (shrink)

Proteins are targeted to plastids by N‐terminal transit peptides, which are recognized by protein import complexes in the organelle membranes. Historically, transit peptide properties have been defined from vascular plant sequences, but recent large‐scale genome sequencing from the many plastid‐containing lineages across the tree of life has provided a much broader representation of targeted proteins. This includes the three lineages containing primary plastids (plants and green algae, rhodophytes and glaucophytes) and also the seven major lineages that contain secondary plastids, “secondhand” (...) plastids derived through eukaryotic endosymbiosis. Despite this extensive spread of plastids throughout Eukaryota, an N‐terminal transit peptide has been maintained as an essential plastid‐targeting motif. This article provides the first global comparison of transit peptide composition and summarizes conservation of some features, the loss of an ancestral motif from the green lineages including plants, and modifications to transit peptides that have occurred in secondary and even tertiary plastids. BioEssays 29:1048–1058, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Because a large number of molecular mechanisms involved in gene regulation have been described during the last decades, it is now becoming possible to address questions about the global structure of gene regulatory networks, at least in the case of some of the best-characterized organisms.This paper presents a global characterization of the transcriptional regulation in Escherichiacoli on the basis of the current data. The connectivity of the corresponding network was evaluated by analyzing the distribution of the number of (...) genes regulated by a given regulatory protein, and the distribution of the number of regulatory genes regulating a given regulated gene. The mean connectivity found (between 2 and 3) shows a rather loosely interconnected structure. Special emphasis is given to circular sequences of interactions (“circuits”) because of their critical dynamical properties. Only one-element circuits were found, in which negative autoregulation is the dominant architecture. These global properties are discussed in light of several pertinent theoretical approaches, as well as in terms of physiological and evolutionary considerations. BioEssays 20:433–440, 1998. © 1998 John Wiley & Sons Inc. (shrink)

Because a large number of molecular mechanisms involved in gene regulation have been described during the last decades, it is now becoming possible to address questions about the global structure of gene regulatory networks, at least in the case of some of the best-characterized organisms.This paper presents a global characterization of the transcriptional regulation in Escherichiacoli on the basis of the current data. The connectivity of the corresponding network was evaluated by analyzing the distribution of the number of (...) genes regulated by a given regulatory protein, and the distribution of the number of regulatory genes regulating a given regulated gene. The mean connectivity found (between 2 and 3) shows a rather loosely interconnected structure. Special emphasis is given to circular sequences of interactions (“circuits”) because of their critical dynamical properties. Only one-element circuits were found, in which negative autoregulation is the dominant architecture. These global properties are discussed in light of several pertinent theoretical approaches, as well as in terms of physiological and evolutionary considerations. BioEssays 20:433–440, 1998. © 1998 John Wiley & Sons Inc. (shrink)

Because a large number of molecular mechanisms involved in gene regulation have been described during the last decades, it is now becoming possible to address questions about the global structure of gene regulatory networks, at least in the case of some of the best-characterized organisms.This paper presents a global characterization of the transcriptional regulation in Escherichiacoli on the basis of the current data. The connectivity of the corresponding network was evaluated by analyzing the distribution of the number of (...) genes regulated by a given regulatory protein, and the distribution of the number of regulatory genes regulating a given regulated gene. The mean connectivity found (between 2 and 3) shows a rather loosely interconnected structure. Special emphasis is given to circular sequences of interactions (“circuits”) because of their critical dynamical properties. Only one-element circuits were found, in which negative autoregulation is the dominant architecture. These global properties are discussed in light of several pertinent theoretical approaches, as well as in terms of physiological and evolutionary considerations. BioEssays 20:433–440, 1998. © 1998 John Wiley & Sons Inc. (shrink)

The problem of threat to international politics and global peace has undermined the effectiveness of the power of dialogue. The world seems to be in the condition of will to power derivable from the mutually assured destructive tendencies. Is it possible to extend global peace? How can this be achieved? In this paper, we posit that dialogue is a fundamental medium for conflict resolution and peaceful coexistence in a diverse world. We contend that monologue in international politics understood (...) in terms of might is right undermines the effectiveness of dialogue and often leads to violent conflicts within and between countries. Our world today is at a crossroads. Dialogue, however, foregrounds the medium of conflict resolution and the social consciousness of human communication. We present a hermeneutic understanding of dialogue that follows from relevant works of Hans Georg Gadamer and Jűrgen Habermas. This paper espouses the power of dialogue as a basis for the normative foundation of an emancipated social global order. The dialogical sequence has a cobweb of social interconnectedness and the ethics of global peace. We present a literal and philosophical understanding of dialogue and a contextual understanding of dialogue within the hermeneutic tradition. (shrink)

American Academy of Pediatrics (AAP) and American College of Medical Genetics (ACMG) recently provided two recommendations about predictive genetic testing of children. The Clinical Sequencing Exploratory Research Consortium's Pediatrics Working Group compared these recommendations, focusing on operational and ethical issues specific to decision making for children. Content analysis of the statements addresses two issues: (1) how these recommendations characterize and analyze locus of decision making, as well as the risks and benefits of testing, and (2) whether the guidelines conflict or (...) come to different but compatible conclusions because they consider different testing scenarios. These statements differ in ethically significant ways. AAP/ACMG analyzes risks and benefits using best interests of the child and recommends that, absent ameliorative interventions available during childhood, clinicians should generally decline to order testing. Parents authorize focused tests. ACMG analyzes risks and benefits using the interests of the child and other family members and recommends that sequencing results be examined for additional variants that can lead to ameliorative interventions, regardless of age, which laboratories should report to clinicians who should contextualize the results. Parents must accept additional analysis. The ethical arguments in these statements appear to be in tension with each other. (shrink)

La période est à la transgression. Transgresser est en effet la nécessité même de l'ordre. Tel est le principe de base de tout pouvoir dès lors qu'il se proclame souverain. Autrement dit, il n'est de pouvoir que transgresseur. Telle est aussi l'énigme de la puissance attribuée à l'État depuis son élaboration principielle par Jean Bodin jusqu'aux énoncés de Carl Schmitt dont la formule "est souverain celui qui décide de la situation exceptionnelle", a permis au XXe siècle de donner un autre (...) contenu, dictatorial, à la question de la souveraineté. L'évolution récente de cette notion prise au piège de la fondation des grands ensembles plurinationaux telle l'Union européenne, réactualise la question de l'adéquation de la souveraineté avec la nation. C'est dans cette logique qu'une archéologie de cette notion paraît indispensable pour évaluer sa double évolution dont la première, transcendante et de type vertical, la fait descendre de la toute-puissance divine jusqu'à son incarnation populaire à travers ses séquences ecclésiales (le souverain pontife), royales, nationales et populaires. Une seconde évolution à partir de la Révolution française, que l'on peut qualifier d'horizontale, l'instaure sur le versant de son incarnation imaginée au sein de la nation, souveraineté nationale, ou au plan de l'universalité des citoyens, souveraineté populaire. Qu'elle soit fondée sur une représentation imaginée collective de soi, la nation, ou sur une identité citoyenne étendue à tous, le peuple, la question de la souverainetén'est soluble que dans cette double identité, nationale et populaire à travers la question de la démocratie qui apparaît ici fondamentale pour restituer au souverain-peuple la légitimité des choix qu'il opère au travers de la délégation de ses compétences aux représentants qu'il se donne. En fin de compte, la souveraineté est avant tout toute-puissante, et ainsi, il n'y a de puissance politique que découlant d'elle. (shrink)

Amit's Hebbian model risks being overexplanatory, since it does not depend on specific physiological modelling of cortical ANNs, but concentrates on those phenomena which are modelled by a large class of ANNs. While offering a strong demonstration of the presence of Hebb's “cell assemblies,” it does not offer an equal account of Hebb's “phase sequence” concept.

Included in the acute response of lowlanders exposed to reduced oxygen availability is an elevated red blood cell count due to increased erythropoietin (Epo) synthesis. According to current thinking, hypoxia is “sensed” by hydroxylases that permit Hypoxia Inducible Factor 1α (HIF‐1α) to complex with HIF‐1β to form a transcriptional activator (HIF‐1) that drives expression of hypoxia‐sensitive genes (such as EPO) under hypoxic conditions. In altitude‐adapted Andean natives, the Epo hypoxic response may be blunted; however, our data indicate that the DNA (...) sequences of the genes encoding Epo (including the 3′ regulatory region) and HIF‐1α appear to be conserved. Hence, adaptive changes in the Andean hypoxic response are not a consequence of changes in the primary sequence of these proteins or of known transcriptional regulatory domains of EPO. These results suggest that the altered erthropoietic response in Andean natives reflects adaptations in hypoxia sensing, rather than hypoxia response, mechanisms. BioEssays 25:515–519, 2003. © 2003 Wiley Periodicals, Inc. (shrink)