The dependence on history of both present and future dynamics of life is a common intuition in biology and in humanities. Historicity will be understood in terms of changes of the space of possibilities as well as by the role of diversity in life’s structural stability and of rare events in history formation. We hint to a rigorous analysis of “path dependence” in terms of invariants and invariance preserving transformations, as it may be found also in physics, (...) while departing from the physico-mathematical analyses. The idea is that the invariant traces of the past under organismal or ecosystemic transformations contribute to the understanding of present and future states of affairs. This yields a peculiar form of unpredictability in biology, at the core of novelty formation: the changes of observables and pertinent parameters may depend also on past events. In particular, in relation to the properties of synchronic measurement in physics, the relevance of diachronic measurement in biology is highlighted. This analysis may a fortiori apply to cognitive and historical human dynamics, while allowing to investigate some general properties of historicity in biology. (shrink)

Recently, a time-honored assumption has resurfaced in some parts of the free will debate: if past divine beliefs or past truths about what we do depend on what we do, then these beliefs and truths are, in a sense, up to us; hence, we are able to act otherwise, despite the existence of past truths or past divine beliefs about our future actions. In this paper, I introduce and discuss a novel incompatibilist argument that rests on. This argument is (...) interesting in itself, for it is independent of a number of assumptions about the nature of God that have played an essential role in the classical defense of incompatibilism about divine foreknowledge and human free will. Moreover, the argument enables us to identify a difficulty compatibilists encounter when employing to block incompatibilism. (shrink)

According to the safety account of knowledge, one knows that p only if one’s belief in p could not easily have been false. In the literature, most objections to the safety account rely on intuition of knowledge that could be easily denied by the safety theorists. In this paper, an objection to the safety account which does not make use of such intuition is raised. It is argued that either there are instances of unsafe knowledge or the safety account has (...) an implausible implication that one’s epistemic status might depend on what happens in the future. (shrink)

This article aims to show that the so-called ‘Ockhamist’ solution to the determinist challenge was a commonplace among Parisian scholastics around 1200. On the ‘Ockhamist’ view, some propositions about the past do not fall under the necessity of the past, since their truth-value depends on the future. The paper focuses on two puzzles involving Abraham’s belief in the future Incarnation. The author discusses the ‘Ockhamist’ strategies adopted by theologians of the period, including Simon of Tournai, Peter of Poitiers, (...) Praepositinus of Cremona, Stephen Langton, Geoffrey of Poitiers, and William of Auxerre. Langton draws an analogy between Abraham’s faith and Christ’s statement “Thou shalt deny me thrice” and suggests that past movements of faith are counterfactually flexible with regard to content. In order to interpret Langton’s statements, the author sketches a model of empty slots in the supernatural layer of the past, retrospectively infused with grace. (shrink)

Early twelfth-century logicians invoked past-tensed statements with future-oriented contents to undermine the assumption that every proposition ‘about the past’ is determinate. In the second half of the century, the notion of future-dependence was used to restrict the scope of necessity per accidens. At some point, this idea began to be applied in theology to solve puzzles surrounding predestination, prescience, prophecy, and faith. In the mid-1160s, Magister Udo quotes some thinkers who insisted that the principle of the necessity (...) of the past should exclude dicta that ‘relate to the future’, such as that he has been predestined. Peter of Poitiers adopted this ‘Ockhamist’ strategy around 1170. We find similar accounts in Simon of Tournai and Alan of Lille, who invoked it in other contexts as well. By the time of Praepositinus of Cremona, Hubert of Pirovano, and Stephen Langton, the restricted principle became something of a common view at Paris. (shrink)

Trenton Merricks, among others, has recently championed in a series of papers what he takes to be a novel and simple solution to an age-old problem concerning the compatibility of divine omniscience and human freedom. The solution crucially involves the thesis that God’s beliefs about the future actions of human persons asymmetrically depend on the future actions of those persons. I show that Merricks’s defense of this thesis is inadequate and that the prospects for improving his defense of (...) it would require him to enter the fray of articulating and defending a view about the mechanics whereby divine foreknowledge is achieved—something he and other advocates of the strategy he advances had hoped to avoid. (shrink)

It is often said that, according to common sense, there is a fundamental asymmetry between the past and future; namely, that the past is closed and the future is open. Eternalism in the ontology of time is often seen as conflicting with common sense on this point. Here I argue against the claim that common sense is committed to this fundamental asymmetry between the past and the future, on the grounds that facts about the past often depend (...) on facts about the future.1. (shrink)

ABSTRACT In his innovative and thought-provoking Why Worry About Future Generations? Samuel Scheffler argues that the value of many of our present-day projects depends upon the existence of future generations, and this gives us one major reason to care about their fate. I raise questions about this ‘Value Dependence Thesis’ by comparing an imminent human extinction scenario to the case of imminent individual death. If an imminently dying individual can still find much value in their remaining life, (...) then why should it be any different for humanity facing imminent extinction? Scheffler anticipates this kind of argument; I respond to his objection to this analogy. I also raise a concern about the value of meliorative projects as providing reason in favor of continued human existence. While meliorative projects have instrumental value contingent on the existence of future generations, this value does not count in favor of their existing. Despite raising these concerns, I agree with Scheffler that many of our actual activities presuppose the survival of humanity and that we are antecedently interested in and committed to their survival. Moreover, Scheffler’s novel approach offers us a creative, sophisticated, and rich resource for developing the ethics of future generations. (shrink)

Following on from the target article, which presented a new model of procedural skill memory development, in this response I will reflect on issues raised by invited commentators and further expound attributes of the model. Discussion will focus on: evidence against sleep-dependent memory processing, definitions of memory stages and memory systems, and relationships between memory enhancement, sleep-stages, dreaming, circadian time, and sleep-disorders.

In response to criticism of the impairment argument for the immorality of abortion, Bruce Blackshaw and Perry Hendricks appeal to Don Marquis’s future-like-ours (FLO) account of the wrongness of killing to explain why knowingly causing fetal impairments is wrong. I argue that wedding the success of the impairment argument to FLO undermines all claims that the impairment argument for the immorality of abortion is novel. Moreover, I argue that relying on FLO when there are alternative explanations for the wrongness (...) of causing FAS begs the question. I conclude, therefore, that the impairment argument remains unsuccessful. (shrink)

Starting from the early 2000s, paired associative stimulation protocols have been used in humans to study brain connectivity in motor and sensory networks by exploiting the intrinsic properties of timing-dependent cortical plasticity. In the last 10 years, PAS have also been developed to investigate the plastic properties of complex cerebral systems, such as the frontal ones, with promising results. In the present work, we review the most recent advances of this technique, focusing on protocols targeting frontal cortices to investigate connectivity (...) and its plastic properties, subtending high-order cognitive functions like memory, decision-making, attentional, or emotional processing. Overall, current evidence reveals that PAS can be effectively used to assess, enhance or depress physiological connectivity within frontal networks in a timing-dependent way, in turn modulating cognitive processing in healthy and pathological conditions. (shrink)

For the last thirty years or so, there has been a search underway for a theory that can accommodate our intuitions in regard to moral duties to future generations. The object of this search has proved surprisingly elusive. The classical moral theories in the literature all have perplexing implications in this area. Classical Utilitarianism, for instance, implies that it could be better to expand a population even if everyone in the resulting population would be much worse off than in (...) the original. The main problem has been to find an adequate population theory, that is, a theory about the moral value of states of affairs where the number of people, the quality of their lives, and their identities may vary. Since, arguably, any reasonable moral theory has to take these aspects of possible states of affairs into account when determining the normative status of actions, the study of population theory is of general import for moral theory. A number of theories have been proposed in the literature that purport to avoid counterintuitive implications such as the one mentioned above. The suggestions are diverse: introducing novel ways of aggregating welfare into a measure of value, revising the notion of a life worth living, questioning the way we can compare and measure welfare, counting people’s welfare differently depending on the temporal location or the modal features of their lives, and challenging the logic of axiological and normative concepts. We investigate the concepts and assumptions involved in these theories as well as their implications for population theory. In our discussion, we propose a number of intuitively appealing and logically weak adequacy conditions for an acceptable population theory. Finally, we consider whether it is possible to find a theory that satisfies all of these conditions. We prove that no such theory exists. (shrink)

Ainslie's target article provides a map of distinct mechanisms relevant to self-control, potentially providing needed precision to the field. He also breaks new ground in characterizing the symbiotic relationship between suppression and resolve. In this commentary, I argue that one behaviorism-based feature of his framework, present-state independence, is unjustified and unnecessary for the broader claims of the theory.

The idea that some of God's past beliefs depend on our future actions has a long history, going back to Origen in the third century CE. However, it is not always clear what this idea amounts to, since it is not always clear what kind of dependence is at issue. This paper surveys five different interpretations of dependence and, in each case, considers the implications for the debate over theological fatalism. Along the way, we discuss a number (...) of related issues, including the nature of explanation, the scope of metaphysical grounding, and the possibility of backward causation. (shrink)

Aging populations have become a major concern in the developed world and are expected to require novel care strategies. Public policies, health-care regimes and technology developers alike stress the need for a more individualized care to meet the increased demand for care services in response to demographic change. Increasingly, care services are offered to individuals with diseases and or disabilities in their homes by means of Personalized Health-Monitoring (PHM) technologies. PHM-based home care is typically portrayed as the key to a (...) cost-effective future care that better can accommodate the needs of an aging population and promote care recipients’ independence. In light of the emerging technology-based home care, this article sets forth to investigate the significance and implications of a strong emphasis on independence in relation to this novel care form. Notions of independence as used by care planners, care providers and technology developers are examined in relation to ICT-based home care and the reasonableness of independence as an aim for future health-care is critically discussed. In conclusion, the need for a shift from a strong emphasis on independence to a right to healthy dependence is advocated. (shrink)

Unfit for the Future argues that the future of our species depends on radical enhancement of the moral aspects of our nature. Population growth and technological advances are threatening to undermine the conditions of worthwhile life on earth forever. We need to modify the biological bases of human motivation to deal with this challenge.

In the current paper, I enter into debate with Marcin Tkaczyk and the chosen Anglo-Saxon analytic philosophers of religion to discuss the theological version of the problem of future contingents. I take into consideration some varieties of Ockhamism (retroactivism)—the position denying the temporal necessity (non-determination) of all past events and allowing some form of retroactivity. Strong Ockhamism postulates real retroactive causation, moderate Ockhamism limits it to the meanings of physical and psychical events, and weak Ockhamism replaces the notion of (...) retroactive causation with that of retroactive dependence. I compare different forms of retroactivism with eternalism (of Boethius, St. Anselm of Canterbury, and St. Thomas Aquinas) to show that the latter has significant advantage. At the same time, I point out that eternalism in its presentist and relativist version (proposed by Brian Leftow) avoids the objections put forward against it, and that, within such eternalism, the problem of future contingents does not arise. (shrink)

There is an old and powerful argument for the claim that divine foreknowledge is incompatible with the freedom to do otherwise. A recent response to this argument, sometimes called the “dependence response,” centers around the claim that God’s relevant past beliefs depend on the relevant agent’s current or future behavior in a certain way. This paper offers a new argument for the dependence response, one that revolves around different cases of time travel. Somewhat serendipitously, the argument also (...) paves the way for a new reply to a compelling objection to the dependence response, the challenge from prepunishment. But perhaps not so serendipitously, the argument also renders the dependence response incompatible with certain views of providence. (shrink)

This article addresses three questions about well-being. First, is well-being future-sensitive? I.e., can present well-being depend on future events? Second, is well-being recursively dependent? I.e., can present well-being depend on itself? Third, can present and future well-being be interdependent? The third question combines the first two, in the sense that a yes to it is equivalent to yeses to both the first and second. To do justice to the diverse ways we contemplate well-being, I consider our thought (...) and discourse about well-being in three domains: everyday conversation, social science, and philosophy. This article’s main conclusion is that we must answer the third question with no. Present and future well-being cannot be interdependent. The reason, in short, is that a theory of well-being that countenances both future-sensitivity and recursive dependence would have us understand a person’s well-being at a time as so intricately tied to her well-being at other times that it would not make sense to consider her well-being an aspect of her state at particular times. It follows that we must reject either future-sensitivity or recursive dependence. I ultimately suggest, especially in light of arguments based on assumptions of empirical research on well-being, that the balance of reasons favors rejecting future-sensitivity. (shrink)

"This volume is concerned with how we ought to evaluate the individual and collective actions on which the existence, numbers and identities of future people depend - discussed here as the "problem of contingent future persons." For it seems that those future persons who are brought into existence by such actions cannot benefit from or be harmed by them in any conventional sense. This is a relatively novel problem in ethics and as yet there is simply no (...) consensus on how we ought to evaluate such actions or, indeed, on whether we can. However, the pursuit of a solution to the problem has been interestingly employed by moral philosophers to press the limits of ethics and to urge a reconsideration of the nature and source of value at its most fundamental level. Intended for professional ethicists, policy researchers, and graduate students, this volume explores the theological implications of the problem and advances the investigation of it both philosophical and in theological terms." --Book Jacket. (shrink)

I foreground the principle of epistemic dependence. I isolate that relation and distinguish it from other relations and note what it does and does not entail. In particular, I distinguish between dependence and necessitation. This has many interesting consequences. On the negative side, many standard arguments in epistemology are subverted. More positively, once we are liberated from the necessary and sufficient conditions project, many fruitful paths for future epistemological investigation open up. I argue that that not being (...) defeated does not make for knowledge. And I argue for the multiple realization of epistemic properties in non-epistemic properties. (shrink)

This paper is about the opposite of judgement and calculation. This opposition has been a traditional anchor of critiques concerned with the rise of AI decision making over human judgement. Contrary to these approaches, it is argued that human judgement is not and cannot be replaced by calculation, but that it is human judgement that contextualises computational structures and gives them meaning and purpose. The article focuses on the epistemic structure of algorithms and artificial neural networks to find that they (...) always depend on human judgement to be related to real life objects or purposes. By introducing the philosophical concept of judgement, it becomes clear that the property of judgement to provide meaning and purposiveness is based on the temporality of human life and the ambiguity of language, which quantitative processes lack. A juxtaposition shows that calculations and clustering can be used and referred to in more or less prejudiced and reflecting as well as opaque and transparent ways, but thereby always depend on human judgement. The paper clearly asserts that the transparency of AI is necessary for their autonomous use. This transparency requires the explicitness of the judgements that constitute these computational structures, thereby creating an awareness of the conditionality of such epistemic entities. (shrink)

In the literature on free will, fatalism, and determinism, a distinction is commonly made between temporally intrinsic (‘hard’) and temporally relational (‘soft’) facts at times; determinism, for instance, is the thesis that the temporally intrinsic state of the world at some given past time, together with the laws, entails a unique future (relative to that time). Further, it is commonly supposed by incompatibilists that only the ‘hard facts’ about the past are fixed and beyond our control, whereas the ‘soft (...) facts’ about the past needn’t be. A substantial literature arose in connection with this distinction, though no consensus emerged as to the proper way to analyze it. It is time, I believe, to revisit these issues. The central claim of this paper is that the attempts to analyze the hard/soft fact distinction got off on fundamentally the wrong track. The crucial feature of soft facts is that they (in some sense) depend on the future. Following recent work on the notion of dependence, however, I argue that the literature on the soft/hard distinction has failed to capture the sense of dependence at stake. This is because such attempts have tried to capture softness in terms of purely modal notions like entailment and necessitation. As I hope to show, however, such notions cannot capture the sort of asymmetrical dependence relevant to soft facthood. Arguing for this claim is the first goal of this paper. My second goal is to gesture towards what an adequate account of soft facthood will really look like. (shrink)

Don Marquis’s “future-like-ours” argument against the moral permissibility of abortion is widely considered the strongest anti-abortion argument in the philosophical literature. In this paper, I address the issue of whether the argument relies upon controversial metaphysical premises. It is widely thought that future-like-ours argument indeed relies upon controversial metaphysics, in that it must reject the psychological theory of personal identity. I argue that that thought is mistaken—the future-like-ours argument does not depend upon the rejection of such a (...) theory. I suggest, however, that given a widely-accepted view about contraception and abstinence, the argument is committed to contentious metaphysics after all, as it relies upon a highly controversial assumption about mereology. This commitment is not only relevant for those who are inclined to endorse the argument but reject the mereological view in question, but in addition entails dialectical and epistemological liabilities for the argument, which on some views will be fatal to the argument’s overall success. (shrink)

In this paper, I examine the syntax-semantics of subjunctive clauses in (Modern) Greek. These clauses are headed by the particle na and contain a dependent verbal form with no formal mood features: the perfective nonpast (PNP). I propose that the semantics of na is temporal: it introduces the variable now (n) into the syntax. This is necessary because the apparent present tense in the PNP cannot introduce n. The PNP, instead, contains a dependent time variable. This variable cannot be interpreted (...) as a free variable – hence it cannot be identified with the utterance time of the context. This analysis relies on two premises. One is the (quite influential) idea that pronouns and tenses are analogous creatures (Partee 1973, 1984, Heim 1998, Kratzer 1998, and others). The other premise is that at least some polarity items are expressions that contain variables that cannot be interpreted deictically (Giannakidou 1998, 2001). In the present work I suggest to enlarge the domain of phenomena that can receive a unified treatment across individuals, worlds, and tenses, and treat the subjunctive mood as a non-deictic time, thus an instance of a polarity dependency of the temporal kind. It is my hope that the analysis proposed here for the PNP can be used to analyze verbal subjunctives in Romance languages, and perhaps also infinitival forms in English, but investigation of this question will have be left for the future. (shrink)

The adaptive significance of temperature‐dependent sex determination (TSD) in reptiles remains unknown decades after TSD was first identified in this group. Concurrently, there is growing concern about the effect that rising temperatures may have on species with TSD, potentially producing extremely biased sex ratios or offspring of only one sex. The current state‐of the‐art in TSD research on sea turtles is reviewed here and, against current paradigm, it is proposed that TSD provides an advantage under warming climates. By means of (...) coadaptation between early survival and sex ratios, sea turtles are able to maintain populations. When offspring survival declines at high temperatures, the sex that increases future fecundity (females) is produced, increasing resilience to climate warming. TSD could have helped reptiles to survive mass extinctions in the past via this model. Flaws in research on sex determination in sea turtles are also identified and it is suggested that the development of new techniques will revolutionize the field. (shrink)

It is easy to envision marked progress in biological and physiological approaches to emotion, due to technological advances in imaging and other recording techniques. The future of social-constructionism appears more hazy: Progress will likely depend as much on new ideas as on new empirical discoveries. The most fruitful breeding ground for new ideas is where disciplines meet. Hence, the contributors to this special section represent diverse disciplines: biology, computer science, and the arts, as well as areas more traditionally associated (...) with the social construction of emotion, for example, interpersonal relations, cultural influence, and individual development. (shrink)

This article explores the ethical implications of the goal of functional independence for persons with disabilities. Central to independence is protection against the fear and uncertainty of future dependency and assurance of a level of social status. Moreover, independence reflects individualism, autonomy and control of decisions about one's life. Dependency, in contrast, implies the inability to do things for oneself and reliance on others to assist with tasks of everyday life. The ethics of independence are explored within the context (...) of the medical and social constructionist models of disability and contrasted against the ethics of support that underscores self-regulated dependency. Self-regulated dependency gives emphasis to the need for support created through relationships, choices and the management of resources. Finally, the article concludes with a challenge to meaningfully translate the principles of ethics to the multiplicity of adapted physical activity contexts. (shrink)

In this article, we take into consideration two semantics of the future tense: linearism, according to which future-tense sentences are interpreted on a single history, and universalism, according to which they are evaluated by universally quantifying on the plurality of future histories that radiate from the present instant. Specifically, we focus on a objection advanced against universalism: if universalism were correct semantics of _will_, negated future-tense sentences of natural language should have two readings, depending on the (...) scope of negation with respect to the universal quantifier on histories. However, since natural language does not show this difference, one may conclude that there is no universal quantifier in the interpretation of these sentences. We show that this conclusion is premature. First, _will_ has clear scope interactions with indefinite nouns phrases, contrary to what linearism predicts. Second, it is possible to extend the treatment of vague predicates as partial predicates to _will_: Since partial predicates have no scope interactions with negation, this can account for the scopelessness of _will_. The partiality of truth conditions is not restricted to _will_ but also pertains to counterfactuals and generics and probably is part of a general tendency to maximize contraries. (shrink)

The future of public philosophy is already being practiced, developed, molded, and critiqued on the ground through the act of doing and writing about public philosophy. Thus, given the astute framings of the future of public philosophy in prior chapters, the author's contribution is going to engage two shifts that she want to emphasize: Increasing the inclusivity of who counts as a public philosopher and providing more experience‐building in public philosophy through educating and mentoring philosophers in public philosophy (...) practice. The future of public philosophy is also dependent upon experience‐building in public philosophy. Engaging in experience‐building in public philosophy with students, faculty, and the broader public has the potential to mitigate the harms that could occur. (shrink)

Recent findings suggest that our capacity to imagine the future depends on our capacity to remember the past. However, the extent to which episodic memory is involved in our capacity to think about what could have happened in our past, yet did not occur , remains largely unexplored. The current experiments investigate the phenomenological characteristics and the influence of outcome valence on the experience of past, future and counterfactual thoughts. Participants were asked to mentally simulate past, future, (...) and counterfactual events with positive or negative outcomes. Features of their subjective experiences during each type of simulation were measured using questionnaires and autobiographical interviews. The results suggest that clarity and vividness were higher for past than future and counterfactual simulations. Additionally, emotional intensity was lower for counterfactual simulations than past and future simulations. Finally, outcome valence influenced participants’ judgment of probability for future and counterfactual simulations. (shrink)

In my essay, Why abortion is immoral, I criticised discussions of the morality of abortion in which the crucial issue is whether fetuses are human beings or whether fetuses are persons. Both argument strategies are inadequate because they rely on indefensible assumptions. Why should being a human being or being a person make a moral difference? I argued that the correct account of the morality of abortion should be based upon a defensible account of why killing children and adults is (...) wrong. I claimed that what makes killing us wrong is that our premature deaths deprive us of our futures of value, that is, the goods of life we would have experienced had we survived. This account of the wrongness of killing explains why killing is one of the worst of crimes and how killing greatly harms the victim. It coheres with the attitudes of those with cancer or HIV facing premature death. It explains why we believe it is wrong to kill infants. It does not entail that it wrongs a human being to end her life if she is in persistent vegetative state or if her future must consist only of unbearable physical suffering and she wants to die. This account of the wrongness of killing implies that abortion is immoral because we were fetuses once and we know those fetuses had futures of value. Mark Brown claims that this potential future of value account is unsound because it implies that we have welfare rights to what we need to stay alive that most people would reject. I argue that Brown is incorrect in two ways: a welfare right to what we need to stay alive is not directly implied by my account and, in addition, most of us do believe that dependent human beings have substantial welfare rights to what they need to stay alive. Brown argues that depriving us of a future of value of which we have mental representations both is a better explanation of the wrongness of killing and does not imply that abortion is immoral. I reply that if Brown's arguments against my view were sound, those arguments could be easily adapted to show that his view is unsound as well and Brown's view is both ambiguous and unsound on any interpretation. The most popular class of pro-choice argument strategies appeals to the view that some or all fetuses lack either a mental state or function or a capacity for a mental state or function necessary for possession of the right to life. Desires, interests, sentience, various concepts, moral agency, and rationality have all been suggested as candidates for this crucial mental role. Brown's analysis is one member of this class of strategies. I believe that it is possible to show that none of these strategies is reasonable. However, there are so many of these strategies that the required argument demands something more like a book and less like a short essay. The argument of the following essay is a piece of this larger argument. (shrink)

Recent findings suggest that multiple event properties contribute to shape the phenomenology of episodic future thoughts, but the specific role of each property is not yet fully understood. This study shows that different phenomenological features are predicted by distinct event properties. The vividness of an episodic future thought largely depends on the familiarity of its constitutive elements , while the visual perspective adopted is instead related to the temporal distance of the imagined event. Cognitive feelings such as the (...) sense of pre-experiencing the future depend on sensory–perceptual qualities, and are further modulated by the personal importance attributed to the event. These findings suggest that the essence of episodic future thought—the sensation of mentally visiting one’s personal future—lies, in part, in the relevance of imagined events with respect to personal goals. (shrink)

This article argues that current civilizational analysis as exemplified by the work of Shmuel N. Eisenstadt still shares the strengths and weaknesses of the original approach as developed by Marcel Mauss (and Émile Durkheim) a century ago. Eisenstadt’s approach basically relies on a particular understanding of path dependency which immediately raises the question how civilizational patterns are reproduced after the crucial turning point of the Axial Age. This problem of civilizational persistence, however, remains largely unresolved and will not even be (...) resolved in the future as long as civilizational analysis relies on mostly culturalist premises. Only a combination of arguments from the field of political sociology and the sociology of religion — as suggested by Johann P. Arnason — promises to explain how civilizations are able to reproduce their patterns over and over again. (shrink)

Matrix population models provide a natural tool to analyse state-dependent life-history strategies. Reproductive value and the intrinsic rate of natural increase under a strategy, and the optimal life-history strategy can all be easily characterised using projection matrices. The resultant formulae, however, are not directly comparable with the corresponding formulae for age structured populations such as Lotka's equations and Fisher's formula for reproductive value. This is because formulae involving projection matrices lose track of what happens to an individual over its lifetime (...) and are only concerned with expected numbers of descendants one time step in the future. In contrast the usual age-dependent formulae explicitly followed a single individual through from birth to death.In this paper I show how the state-dependent formulae can be rewritten to be directly comparable with the standard age-structured formulae. Although the formulae are intuitively obvious the decomposition into current and future reproductive success differs from that previously given and is, I suggest, a more natural definition. The derivation of appropriate equations for optimal life-histories relies on results from dynamic programming theory; and is much more general and easier than previous derivations. (shrink)

Three studies tested the conditions under which people judge utilitarian harm to be authority dependent (i.e., whether its right or wrongness depends on the ruling of an authority). In Study 1, participants judged the right or wrongness of physical abuse when used as an interrogation method anticipated to yield useful information for preventing future terrorist attacks. The ruling of the military authority towards the harm was manipulated (prohibited vs. prescribed) and found to significantly influence judgments of the right or (...) wrongness of inflicting harm. Study 2 established a boundary condition with regards to the influence of authority, which was eliminated when the utility of the harm was definitely obtained rather than forecasted. Finally, Study 3 replicated the findings of Studies 1–2 in a completely different context—an expert committee’s ruling about the harming of chimpanzees for biomedical research. These results are discussed as they inform ongoing debates regarding the role of authority in moderating judgments of complex and simple harm. (shrink)

Extant discussions of subjectivism about reasons for action have concentrated on presentist versions of the theory, on which reasons for present actions are grounded in present desires. In this article, I motivate and investigate the prospects of futurist subjectivism, on which reasons for present actions are grounded in present or future desires. Futurist subjectivism promises to answer Parfit's Agony Argument, and it is motivated by natural extensions of some of the considerations that support subjectivism in general. However, it faces (...) a problem: because which desires one will have in the future can depend on what one does now, it must tell us which of one's possible future desires give one reasons to promote their satisfaction. I argue that the most natural solutions to this problem are unsatisfactory: they either fail to answer the Agony Argument or have unacceptable implications elsewhere. Then, I propose a more promising solution. Moreover, I argue that a closely analogous problem arises for an important class of idealizing subjectivist views and that this problem admits of a similar solution. (shrink)

Passage through the cell cycle requires the successive activation of different cyclin‐dependent protein kinases (CDKs). These enzymes are controlled by transient associations with cyclin regulatory subunits, binding of inhibitory polypeptides and reversible phosphorylation reactions. To promote progression towards DNA replication, CDK/cyclin complexes phosphorylate proteins required for the activation of genes involved in DNA synthesis, as well as components of the DNA replication machinery. Subsequently, a different set of CDK/cyclin complexes triggers the phosphorylation of numerous proteins to promote the profound structural (...) reorganizations that accompany the entry of cells into mitosis. At present, much research is focused on elucidating the links between CDK/cyclin complexes and signal transduction pathways controlling cell growth, differentiation and death. In future, a better understanding of the cell cycle machinery and its deregulation during oncogenesis may provide novel opportunities for the diagnostic and therapeutic management of cancer and other proliferation‐related diseases. (shrink)

The early part of the twentieth century was as revolutionary in the domain of ethical ideas as in other realms. An ethical culture inherited from the preceding century was to all appearance destroyed. This culture, the high-bourgeois culture of the nineteenth century, had emerged gradually from years of revolution and counter-revolution, and seemed then to be developing steadily and expanding its reach towards the end of the century and up to the first world war. Yet what followed it, and in (...) fact overlapped with it, being already presaged well before the war, was quite other: the mainly 20th century phase we call ‘Modernism’, acutely fragmented not only in aesthetic but also in ethical terms, marked in politics by nationalist, collectivist and populist clashes. However, Modernism too, and in particular, many of the ideas in ethics which were characteristic of it, now belongs to history. That much has for some time been clear; the change is complicated, confused, hard to outline; discernibly though, we're in a new period and have been for perhaps a third of a century—quite how long depends on which aspect of change one considers, and on how one interprets its character. (shrink)

The problem of future contingents is one of the most ancient and debated puzzles in Western philosophy, and Supervaluationism is, today, one of the most prominent solutions to the problem. Recently, John MacFarlane has carried a well-known criticism to Supervaluationism and put forward a new solution of the problem of future contingents, which is known as Double Time Reference Theory. Here, we compare DTRT with Supervaluationist semantics, and we show that the success of MacFarlane's criticism crucially depends on (...) the expressivity of the language adopted. Once a reasonable expressive power is granted, however, MacFarlane's criticism no longer applies. (shrink)

Work on global ethics looks at ethical connections on a global scale. It should link closely to environmental ethics, recognizing that we live in unified social-ecological systems, and to development ethics, attending systematically to the lives and interests of contemporary and future poor, marginal and vulnerable persons and groups within these systems and to the effects on them of forces around the globe. Fulfilling these tasks requires awareness of work outside academic ethics alone, in other disciplines and across disciplines, (...) in public debates and private agendas. A relevant ethics enterprise must engage in systematic description and understanding of the ethical stances that are expressed or hidden in the work of influential stakeholders and analysts, and seek to influence and participate, indeed embed itself, in the expressed and hidden choice-making involved in designing and conducting scientific research and in policy analysis and preparation; it will contribute in value-critical and interpretive policy analysis. It will explore how the allocation of attention and of concern in research and policy depend on perceptions of identity and of degrees of interconnection, and are influenced by the choice or avoidance of humanistic interpretive methodologies. The paper illustrates these themes with reference to the study of climate change. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Future Directions for Oversight of Stem Cell Research in the United StatesCynthia B. Cohen (bio) and Mary A. Majumder (bio)Human pluripotent stem cell research, meaning research into cells that can multiply indefinitely and differentiate into almost all the cells of the body, has become a minefield in which science, ethics, and politics have collided over the last decade in the United States. President Barack Obama entered this highly (...) charged territory when he indicated during his campaign that once in office he would issue an executive order expanding federally funded human embryonic stem cell (hESC) research and introduce rigorous oversight of it (Obama 2008a & b). Candidate Obama stated that he would require that the hESC lines involved were derived with donor consent from early embryos that otherwise would be discarded following in vitro fertilization (IVF) treatment. However, in contrast with the policy of President George W. Bush, he would do so without regard to the date of their derivation. He added that he would call upon the director of the National Institutes of Health (NIH) to develop guidelines for federally funded hESC and other pluripotent stem cell research that would draw from the guidelines developed in 2005 by the National Academies of Science (NAS) for privately funded research (National Research Council 2005).A similar policy was written into the 2008 version of the Stem Cell Research Enhancement Act, which reiterates the policy enunciated in earlier versions of this bill, passed twice by the Congress but vetoed by President Bush each time (House of Representatives, 110th Congress 2008).1 Depending on how one reads the 2008 version of the act, it could also apply in certain respects to hESC research that is not federally funded. We proceed on the assumption that the act applies at least to federally funded stem cell research. Therefore, it appears that the president or the Congress, or both, will approve of an expanded policy of federal funding of hESC research, as well as other forms of human pluripotent stem cell research. [End Page 79]This policy would make the guidelines developed by a committee appointed by NAS, a prestigious private body of American scientists and related experts, the primary basis for the development of new federal guidelines for oversight of hESC research in the United States. This would have certain advantages in that those familiar with the relevant scientific issues are likely to address them accurately and stem cell investigators are apt to accept restrictions on their research written by fellow scientists and ethics and policy experts whom they perceive as strong supporters of stem cell research. However, it also would have certain disadvantages. Chief among these is that the NAS committee appointed to write guidelines for this research, in its concern to see stem cell science move forward after a period in which many scientists and others maintained that it had been unduly restricted, might have overlooked or deferred consideration of some pressing ethical and policy issues. We maintain that this is the case—although we also maintain that the NAS guidelines provide a responsible foundation for developing NIH guidelines for stem cell research. Consequently, we propose that an NIH task force charged by the director of NIH with writing new guidelines for hESC and other stem cell research should revise and expand the NAS guidelines in ways that we propose below, as well as others that it considers necessary, and make it obligatory for those seeking federal funding of such research to follow these new guidelines.We highlight certain areas in which an ethical case can be made for strengthening the existing NAS guidelines and certain areas in which more fundamental ethical reflection—and building on that, additional guideline/policy development—seems warranted. Among the sections of the NAS guidelines that need clarification and reworking, we include those regarding consent to embryo donation, which provide one of their central focuses, and the development of human-nonhuman chimeras, which they address relatively briefly. In addition, we maintain that new guidelines need to be written to address the nascent ethical and policy issues raised by the possibility that human gametes will be induced from pluripotent stem cells in the next few years and that... (shrink)

The nuclear community frequently refers to the concept of “future generations” when discussing the management of high-level radioactive waste. However, this notion is generally not defined. In this context, we have to assume a wide definition of the concept of future generations, conceived as people who will live after the contemporary people are dead. This definition embraces thus each generation following ours, without any restriction in time. The aim of this paper is to show that, in the debate (...) about nuclear waste, this broad notion should be further specified and to clarify the related implications for nuclear waste management policies. Therefore, we provide an ethical analysis of different management strategies for high-level waste in the light of two principles, protection of future generations—based on safety and security—and respect for their choice. This analysis shows that high-level waste management options have different ethical impacts across future generations, depending on whether the memory of the waste and its location is lost, or not. We suggest taking this distinction into account by introducing the notions of “close future generations” and “remote future generations”, which has important implications on nuclear waste management policies insofar as it stresses that a retrievable disposal has fewer benefits than usually assumed. (shrink)

Putnam’s argument aims to prove that future is as real as present. His argument is based on the equation present = real. Is real what exists now. Is real what is part of observer-independent reality. What exists now depends on an observer—it is not real. It is then shown that Special Relativity is not only a physical theory, it has also a philosophical dimension in that it questions our very understanding of reality and requires a clear distinction between reality (...) and its representation. (shrink)

Local item dependence is one of the most critical assumption in the Rasch model when it comes to the validity of a test. As the field of vocabulary assessment is calling for more clarity and validity for vocabulary tests, such assumption becomes more important than ever. The article offers a Rasch-based investigation into the issue of LID with the focus on the two popular formats of Vocabulary Levels Tests : multiple-choice and matching. A Listening Vocabulary Levels Test and an (...) Updated Vocabulary Levels Test were given to a single cohort of 311 university students in an English as a Foreign Language context. The analyses of raw score and standardized residuals correlations were conducted. The findings found no relationship between the 4-option, multiple-choice format of the LVLT and item local dependence. However, results from score and standardized residuals correlations analyses showed a strong link between the 3-item-per-cluster, matching format and item local dependence. The study calls for greater attention to the format of future vocabulary tests and support the use of meaning-recall formats in vocabulary testing. (shrink)

In this paper, I defend the view that within a rights-based ethical framework, the moral status of future generations is best understood as that of present rightsholders. I argue that in this way it can be justified that we have obligations towards future generations. This justification in turn is of great relevance for many issues in moral theory and applied ethics. In the first part of the paper, I argue that the fact that future persons will have (...) rights in the future cannot fully account for present obligations. The missing link in this argument cannot be provided by approaches that infer those obligations mediately. In the second part of the paper, I argue that existing is not a necessary condition for being a rightsholder. First, our own future selves should be said to have rights even though they do not exist at present. Second, even at present, uncertainty challenges the relationship between rightsholders and obligation bearers: often enough, obligations depend on presuppositions or suspicions about other persons’ existence. In light of these cases, we should conceive of rightsholders as place holders, that is, sets of (actual) individuals whose existence or identity can be unknown or indetermined, with specific properties. Therefore, future generations can coherently be said to have rights now that correspond to our present obligations towards them. (shrink)

In this paper I examine some of the significant moral concerns inherent in cases of treatment refusal involving patients with psychotic disorders. In particular, I explore the relevance of the principle of autonomy in such situations. After exploring the concept of autonomy and explaining its current and historical significance in a health care setting, I argue that because autonomous choice depends for its existence upon certain human functions such as the ability to reason, judge, and assess consequences, patients cannot be (...) said to be making free and autonomous decisions if these capacities are compromised. I contend further that because psychotic disorders have the potential to compromise these functions in the future, it is appropriate, in some limited cases, to coerce patients with psychotic disorders to undergo treatment in order to preserve their future decision-making capacities and to protect their ability to recognize and respect the autonomy of others. (shrink)

While writing this thesis, there were many things I wanted to get right. I wanted to get the data right. I wanted to get my analysis of the data right. I certainly wanted to get all my citations right, which can get pretty tricky when one is trying to finish a chapter at 2am. But if an error did creep in somewhere in the body of the thesis, that is not a disaster. Sooner or later, I will get a chance (...) to correct it in a future publication. However, this part of the thesis, which sits right at the beginning but was among the last to be written, is different. I only have one opportunity to express, in print, how thankful I am to the people whose assistance was so important to me over the past years. Which is unfortunate, since if I were to truly elaborate all I am thankful for, these acknowledgements would be the lengthiest chapter of the thesis. But I hope this brief version will suffice in its stead. (shrink)