Histone acetylation is an important regulatory mechanism that controls transcription and diverse nuclear processes. While great progress has been made in understanding how localized acetylation and deacetylation control promoter activity, virtually nothing is known about the consequences of acetylation throughout entire chromosomal regions. An increasing number of genes have been found to reside in large chromatin domains that are controlled by regulatory elements many kilobases away. Recent studies have shown that broad histone acetylation patterns are hallmarks of chromatin domains. The (...) purpose of this review is to discuss how such patterns are established and their implications for regulating gene expression. BioEssays 23:820–830, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

O texto apresenta um série de provocações diante da situação de obrigatoriedade do ensino de filosofia no nível médio da educação brasileira. A grande questão levantada é sobre a própria identidade da filosofia e do filosofar no ensino médio. A tensão entre a reflexão viva da filosofia e a tradição fica expressa na conturbada construção do lugar da filosofia no ensino médio brasileiro.

O trabalho é um exercício de pensamento referente ao lugar da filosofia no currículo do ensino médio. A investigação considera a recente presença da filosofia como disciplina obrigatória em todas as séries da escola média brasileira. Assim, a condição curricular, e o próprio lugar do docente são ainda uma lacuna a ser preenchida. Para essa “atividade” as provocações de Hannah Arendt e de Gilles Deleuze figuram como o solo conceitual da reflexão.O exercício intelectual de Arendt sobre o “vazio de pensamento” (...) e sua rigorosa análise sobre a faculdade de pensar articuladas com as provocações de Deleuze quanto a compreensão da filosofia como uma “produtora” e articuladora de conceitos, ditaram o caminho que sugere ser a filosofia, enquanto “disciplina”, um parar para pensar como forma de contrapor o pensar ao fluxo laboral de consumo de conteúdos da escola média. Aqui a filosofia enquanto disciplina é uma contemplação tão ativa quanto a ação. (shrink)

JOHN E. MURDOCH AND EDITH DUDLEY SYLLA INTRODUCTION Conferences and colloquia are held and their results often published, but very rarely is any account ...

I argue that there are such things as nomological probabilities—probabilities that play a certain explanatory role with respect to stable, long-run relative frequencies. Indeed, I argue, we should be willing to accept nomological probabilities even if they turn out to be metaphysically weird or even wholly sui generis entities. I then give an example of one way in which this argument should shape future work on the metaphysics of chance by describing a challenge to a common group of analyses of (...) objective probability—Humean analyses— understood as analyses of nomological probability. (shrink)

Subject of numerous interpretations and studies, the vicissitudes of the famous Frankfurt Institute for Social Research nevertheless still reserve some little-known pages, such as the human and scientific relationship that bound philosopher Max Horkheimer and economist Friedrich Pollock for over fifty years. Based on texts and letters translated here into English for the first time as well as some previously unpublished documents, the book reconstructs the crucial moments in the friendship between the two scholars with a narrative style and philological (...) accuracy. Nicola Emery accompanies us through the two friends and intellectuals' "nonconformism" and search for an alternative life-form that led to the birth of the Frankfurt critical theory. (shrink)

As with any proposal for institutional reform, and especially one that has gained so much ground in such a short amount of time, this paper asks whether diversity, equity, and inclusion (DEI) movement is good for corporations. Are businesses stronger with DEI practices and ideas or weaker? We believe that the DEI movement is asking the right questions: How do we create more just and equitable institutions? The challenge, however, is whether this movement is giving the right answers to such (...) questions. The main premise of our paper is that without deeper principles than DEI itself, these qualities of corporate life will be misunderstood, misused, and disordered in our increasingly fragmented and politicized culture. We propose in this essay that “subsidiarity” serves as one of those deeper principles that can order and enrich our understanding of DEI. It serves as a gift principle that begins to reveal the deepest nature of our work, namely, that our work allows us to exercise our gifts in serving others. (shrink)

The ability to imagine hypothetical events in one’s personal future is thought to involve a number of constituent cognitive processes. We investigated the extent to which individual differences in working memory capacity contribute to facets of episodic future thought. College students completed simple and complex measures of working memory and were cued to recall autobiographical memories and imagine future autobiographical events consisting of varying levels of specificity . Consistent with previous findings, future thought was related to analogous measures of autobiographical (...) memory, likely reflecting overlapping cognitive factors supporting both past and future thought. Additionally, after controlling for autobiographical memory, residual working memory variance independently predicted future episodic specificity. We suggest that when imagining future events, working memory contributes to the construction of a single, coherent, future event depiction, but not to the retrieval or elaboration of event details. (shrink)