This dissertation explores the influence of time constraints on different research practices. The first two parts present case studies, which serve as a basis for discussing the epistemological and ethical implications of temporal limitations in scientific research. Part I is a case study on gravitational wave research, conducted by the LIGO Scientific Collaboration. This exemplifies fundamental research – without immediate societal applications, open-ended in terms of timeline and in terms of research goals. It is based, in part, on qualitative interviews (...) conducted with gravitational wave physicists. I show that considerations about time and speed play a role in every stage of research: goal setting, method design, and the evaluation and communication of results. Part II provides a case study on translational medicine, an approach explicitly dedicated to accelerating research in order to develop and implement new therapies. This epitomizes applied research with high social stakes, motivated by non-epistemic goals. Here, epistemic trade-offs between speed and reliability intersect with ethical trade-offs between different types of harms. In Part III, the insights from both of these case studies are used as the basis for a more general discussion concerning the pragmatic aspects of epistemic practices, especially in relation to current debates centered on the role of values in science. A particular focus is on the value of speed and the ability to generate reliable results, either via choice of methods, or via decisions about which goals to set, as well as decisions about when to stop further testing. The primary thesis of the dissertation is that pragmatic considerations stemming from limitations of resources are a necessary feature of the pursuit of epistemic aims, and that the epistemic is thus inherently pragmatic. (shrink)

I examine the role of time-sensitivity in science by drawing on a discussion between Kevin Elliott and Daniel McKaughan and Daniel Steel, on the role of non-epistemic values in theory assessment and the epistemic status of speed of inference. I argue that: 1) speed supervenes on ease of use in the cases they discuss, 2) speed is an epistemic value, and 3) Steel’s account of values doesn’t successfully distinguish extrinsically epistemic from non-epistemic values. Finally, I propose an account of time-sensitivity.

The article presents the advantages and limitations of adaptive clinical trials for assessing the effectiveness of medical interventions and specifies the conditions that contributed to their development and implementation in clinical practice. I advance two arguments by discussing different cases of adaptive trials. The normative argument is that responsible adaptation should be taken seriously as a new way of doing clinical research insofar as a valid justification, sufficient understanding, and adequate operational conditions are provided. The second argument is historical. The (...) development of adaptive trials can be related to lessons learned from research in cases of urgency and to the decades-long efforts to end the productivity crisis of pharmaceutical research, which led to the emergence of translational, personalized, and, recently, precision medicine movements. (shrink)

Practical reasoning is a domain of concerns that deal with our most intimate views on what should be done, every day, in facing the world. Unlike theoretical reasoning which forms only beliefs, practical reasoning forms intensions and sets ground for actions. It deals mostly with the notion of reason, broadly understood as a term that acquires both rationality and motivation for our actions. Bernard Williams in “Internal and external reasons” introduced a strong and influential distinction, the distinction between internal and (...) external reasons. Williams explicitly argues in favour of internalism, excluding the existence of external reasons and placing the burden of proof on the externalists. In this paper I will reconsider his views drawing on John Skorupski’s insights on Williams in “Internal Reasons and the Scope of Blame” and Skorupski’s cognitive internalism. I will criticise both of their internalistic accounts and argue for an Aristotelian framing of their main arguments which I believe is a fairer deal in their contribution to the practical reasoning issues. (shrink)

У статті автор аналізує місце й роль учених вірменського походження в Арабському халіфаті в період мусульманського завоювання Вірменії з використанням відомостей арабо-мусульманських історико-біографічних словників. Автор показує, що вірменські лікарі поряд із грецькими й сирійськими лікарями відіграли значну роль у справі ознайомлення народів арабського халіфату з давньогрецькою медичною літературою.

This paper studies systems of explicit mathematics as introduced by Feferman [9, 11]. In particular, we propose weak explicit type systems with a restricted form of elementary comprehension whose provably terminating operations coincide with the functions on binary words that are computable in polynomial time. The systems considered are natural extensions of the first-order applicative theories introduced in Strahm [19, 20].

The improvement of modern computer technology to achieve fundamentally new indicators can be carried out on the basis of various approaches. One of such approaches is the application of methods of physical informatics. Therefore, this paper considers the support of ensuring “digital immortality” based on physical computer science methods. On the basis of Wiener random processes, measures are proposed to ensure the security of computer nodes to ensure “digital immortality”. The calculated ratios from physical informatics adapted to determine the requirements (...) for the design of information systems to ensure the digitalization of the brain are given. (shrink)

This paper is a direct successor to 12. Its aim is to introduce a new realisability interpretation for weak systems of explicit mathematics and use it in order to analyze extensions of the theory PET in 12 by the so-called join axiom of explicit mathematics.

Since the mid-90’s the figure of Peter Lombard and his Book of Sentences has regained the importance in scholarly world and been studied from both historical-theological and historical-philosophical perspectives. But some aspects of his thinking, encapsulated in the written form, which was to become the material basis for the thirteenth- through the fifteenth-century theological projects, remained somewhat insufficiently researched. Therefore this article analyzes the select parts of the Book of Sentences with the purpose of looking at how Peter Lombard handled (...) the issue of God’s knowledge. The article shows that for Peter Lombard God’s knowledge is God’s awareness of everything knowable. It has no causal power which belongs to the divine will. Nevertheless, this knowledge is able to function in two different modes: it can be either a purely cognitive act as awareness alone, or a double cognitive and voluntary act as awareness and simultaneous volition in the form of approbation. Hence, God’s knowledge in general is not causative, but God’s knowledge of the good must be causative because he simultaneously knows and wills what is good. The article reasonably suggests that Lombard’s logic implies the compatibility of God’s (fore)knowledge and voluntary activity, on the one hand, and the contingency of the created order and the rational creatures’ free will, on the other hand. But the details of this conception remain unrevealed as Lombard’s presentation of the problem is to be declared underdeveloped. (shrink)

У статті аналізується книга Ю. Гордера «Світ Софії» та визначається її місце у філософії для дітей як сфери гуманітарного знання. Філософія для дітей у «класичній» моделі представлена як методика Р4С. Автор знайомить аудиторію з головними положеннями методики Р4С та порівнює «Світ Софії» з класичними творами М. Ліпмана. Спільними рисами цих творів є: цільова аудиторія, «сократівський діалог», наявність творчої уяви. Проте книга Ю. Гордера вирізняється літературним способом викладу та проблематикою. «Світ Софії» має такі ознаки Р4С: філософська настанова, «сократівський діалог», інтерактивна взаємодія, (...) саморефлексія. Як підсумок автор надає рекомендації щодо особливості викладання твору «Світ Софії» у школі та визначає компетенції, які книга може розвинути в учнів. (shrink)

The article is devoted to identifying the specifics of Russian philosophy through the analysis of F. M. Dostoevsky and L.N. Shestov’s texts. The stylistic features of the two philosophers have been considered, their ways of philosophizing and denying of the cult of reason have been examined. The analysis is carried out using additional literature of French existentialism. To date, there are many researches in which study features of Russian philosophy. It is noted, that one of them are imagery, inseparable connection (...) between philosophy and faith and criticism of rationalism. The excessive cult of reason leads to such problems in the history as the creation of the hydrogen bomb, the environmental crisis and so on. The revolt against reason and the state of groundlessness are a response to the processes of modern rationalization and technocratization, an attempt to go beyond the limits of the usual paradigm, to get out of the closed subjectivity. Thus, it’s necessary to define the limits of the reason and develop a new way of philosophizing, for this reason it is proposed to consider the concept of groundlessness in the philosophy of L.N. Shestov, which makes the attempt to construct a philosophy, avoiding strict logic and excessive rationality. (shrink)

The Divine source and end of the Imago Dei -- The image of God and its perfection -- The grace of the Holy Spirit -- The incarnation and participation in the Divine nature -- Charity in the Summa theologiae -- Wisdom, charity, and Christ -- Deification in the Summa theologiae.

The global Peter Lombard research reinaugurated in 1990s has resulted in a number of recent publications, but the Master of the Sentences’ theology proper is partially underresearched. In particular, a more detailed exposition of the distinctions 35-41 of his Book of Sentences is needed in order to clarify his doctrine of God’s knowledge and its relation to the human free will. The article builds on the earlier established evidence that, for Peter Lombard in distinctions 35-38, God’s knowledge, in general, is (...) not causative, although some causative power has to be ascribed to God’s knowledge of the good. The last part of distinction 38 and the content of distinction 39 further analyze the capacities and functionalities of the divine omniscience and explain how it interacts with acts of human will. The key question here deals with the problem of alternative states of affairs: whether something may be otherwise than God foreknew. As it is shown, Master Peter agrees that it is possible for created things and events to be otherwise than they are, but insists that God’s knowledge must be in any case exhaustive and infallible. He uses a number of logical tools to defend the thesis about God’s perfect knowledge and the possibility of things happening otherwise, but lacks a strict definition of the notion of “possibility” used here. The study concludes that in few cases Lombard’s posse could mean a potency or a simple logical possibility, or the diachronic contingency, but the overall theological statement is clear: potentially, God’s knowledge can be different or include alternative state of affairs but it cannot change. (shrink)

The article treats the doctrine of transubstantiation or the Eucharistic change as formulated by Thomas Aquinas in his Summa theologiae, Question 75, against its double conceptual (Christian religious vs. Aristotelian philosophical), as well as double linguistic (Latin vs. translated Greek), background. The doctrine is presented and analyzed as a philosophical-theological theory that can be explicated and assessed using the concept of philosophical untranslatable(s), recently discovered and brought to the fore by the proponents of the “translational turn” in continental philosophy. It (...) is argued on the basis of careful study of Aquinas’ text that the notion of transubstantiation should be identified as a conceptual untranslatable. -/- Here the term “untranslatable” means a unique reinterpretation of Aristotelian language of being and change, which results in a conceptual innovation that has some inherent problems as well as creative and promising inventions. The usage of such a concept is justified by the fact that the reconceptualization that Aquinas did to a number of Peripatetic ideas creates a few untranslatable notions, which do not have much meaning outside the peculiarly Thomistic Latin vocabulary. Despite some criticisms they are not necessarily to be regarded as contradictions, but rather as thomistic untranslatables. (shrink)

The purpose of this study is to discover, present and analyze the key ideas of Anselm of Canterbury concerning the notions of knowledge, will and mode of divine-human relations in the context of this “knowledge-will” framework which is important due to (a) somewhat insufficient attention to the medieval insights on the issue and (b) the peculiarity that Anselm’s intuitions have. More specifically, the object of the given paper is Anselmian understanding of relations between God’s foreknowledge and will, on the one (...) side, and human free will, on the other side, as it is presented in the work entitled De Concordia. In this treatise Anselm of Canterbury partially uses and further elaborates some ideas of Augustine and Boethius, while integrating, updating and synthesizing them in a creative manner, and partially develops a number of thoughts of his own. As a result, there is a set of the well-formulated and comprehensive theses concerning (i) different types of (metaphysical) necessity, (ii) a proper definition of freedom of choice and will, (iii) the nature of will per se, and, finally, (iv) unique relation of “simultaneity” that exists between God’s knowledge, God’s will and the creature’s rational will. These ideas are presented and explicated in the article along with detailed exposition and analytical examination of the main line of argumentation found in the De Concordia. (shrink)

Cette étude vise à reconstruire la fonction dramatique des interjections attestées dans la première partie des Euménides (ὠή, ἰοὺ ἰοὺ, πυπάξ, ὢ πόποι, ἰώ), afin de montrer les effets que peuvent produire dans le texte les emplois ou les contre-emplois d’une interjection donnée.

This article continues the author's research devoted to the study of the problem of choreographic interpretations of literary works, in particular, John Neumeier's ballet "Anna Karenina". In this work, the identification of expressive staging means and choreographic elements used by Neumeier in the production of duets by Anna Karenina and Alexei Vronsky is carried out in order to determine the place of these choreographic fragments in the performance, as well as their significance for the author's interpretation of the images of (...) the main characters of the novel by Leo Tolstoy. In the course of the research, the author applied comparative-historical, ideological-artistic and analytical methods, as well as the method of included observation. In the course of the source analysis, video materials from the archives of the Hamburg Ballettzentrum and the Moscow Bolshoi Theater were used, as well as lectures conducted by Neumeier before the Moscow premiere of Anna Karenina. A detailed analysis of the dance score of three duets by Anna and Vronsky revealed traditional and innovative author's solutions related to the new research results. So, Neumeier uses such staging means as the compilation of Tchaikovsky and Schnittke's music; the inclusion of symbolic images in the choreographic canvas; the appearance of other characters; the use of stage lighting to accentuate the transition from reality to the sphere of the subconscious; active choreographic development based on a technically saturated duet dance, replete with high supports in the neoclassical style, as well as acrobatic elements; semantic use of plastic quotations. It can be concluded that in order to develop the images and relationships of Anna Karenina and Alexey Vronsky, the choreographer chooses a duet as the dominant musical and choreographic form. Moreover, in his version of Anna Karenina, Neumeier makes three duets of the main characters a key component of the performance and the author's interpretation of the images of the main characters. (shrink)

У статті розглянуто основні педагогічні метафори, які побутували в Антіохійській школі патристики. Дослідження засноване, насамперед, на матеріалі гомілій свт. Іона Золотоуста De inani gloria, Adversus oppugnatores vitae monasticae, In Matthaeum, Ad populum Antiochenum, а також на окремих творах Феодорита Кирського і Северіана Габальського. Ці твори проаналізовано крізь призму теорії метафори П. Рікера, докладені Н. Райтом та Р. Хейзом до вивчення життєсвіту релігійних громад. Такий аналіз допоміг виявити у творах Золотоуста та інших антіохійців співіснування двох основних педагогічних метафор різного походження. Метафора (...) чистого аркушу, що походить з трактату Аристотеля De anima, розглядає процес освіти в категоріях активного формування педагогом ментальності вихованця. У Золотоуста ця метафора набуває вигляду складного палімпсесту, де первинний текст постійно записується новими шарами, редагується і відновлюється знову. До цього процесу взаємного навчання і редагування свт. Іоан закликає усіх своїх слухачів. Натомість метафора фортеці, укорінена в Павловій антропології і в Платоновій теорії анамнезису, імплікуючи значно більшу самодостатність особистості, застерігає від надмірного педагогічного конструктивізму. Ця парадигма представляє людський ум як храм або місто, збудоване за Божим задумом, що розвивається за законами, закладеними Творцем. Завдання педагога в такому сценарії – радше оберігати тонкий і складний внутрішній світ дитини від примітивної логіки оточення, щоб не перешкоджати її природному розвитку за Божим задумом. У Золотоуста, Феодорита та інших антіохійців співіснують обидві метафори, але метафора чистого аркушу – переосмисленого як палімпсест – докладається радше до просвіти дорослих християн, тоді як метафора фортеці застосовується стосовно виховання дітей. (shrink)

The last thirty years of scholarship in western medieval philosophical historiography have seen a number of reflections on the methodological paradigms, schools, trends, and dominant approaches in the field. As a contribution to this ongoing assessment of the existing methods of studies in medieval philosophy and theology and a supplement to classifications offered by M. Colish, J. Inglis, C. König-Pralong, J. Marenbon, A. de Libera, and others, the article offers another explanatory tool. Here is a description of an imaginary system (...) of methodological coordinates that systematizes the current tendencies by placing them in a three-dimensional system of axes. Every axis corresponds to a certain aspect of the historical and systematic research in medieval thought and symbolizes a possible movement between two extremes representing opposite methodological values and directions. The methods and approaches practiced in recent studies in medieval philosophy and theology might be schematically located inside this general system of argumentational, focal (or objectival), and (con)textual axes with their intersection identified with what some scholars call the “integral” model of study. This explanatory tool allows one to see how current approaches and methods form a panoply of axes that belong together in one complex grid and helps to visualize the tapestry of existing approaches in medieval philosophical historiography. (shrink)

Cette étude vise à reconstruire la fonction dramatique des interjections attestées dans la première partie des Euménides (ὠή, ἰοὺ ἰοὺ, πυπάξ, ὢ πόποι, ἰώ), afin de montrer les effets que peuvent produire dans le texte les emplois ou les contre-emplois d’une interjection donnée.

The rural general, work, polytechnic school holds a prominent place in the life of the modern socialist village. As one of the sources from which collective and state farms get trained personnel, equipment operators, for example, the rural school is meant to train a comprehensively developed younger generation capable of creatively applying to its work the latest achievements of science, engineering, and progressive technology and of presenting models of a communist attitude toward work.

У статті розглянуто вплив візантійської антропології на думку Григорія Сковороди і преп. Паїсія Величковського. За допомогою порівняльно-історичного методу та методу історії традиції простежено застосування українськими богословами XVIIІ ст. візантійської патристичної спадщини. Доповнюючи нещодавнє дослідження М.Ґ.Бартоліні, присвячене розробці Сковородою ідей Александрійської школи патристики, стаття аналізує мотиви, позичені ним у Антіохійської школи. Це, зокрема, своєрідна філософія дозвілля та християнський епікуреїзм, що відлунює вчення Йоана Золотоуста про легкість і природність християнського способу життя. Порівняння містичної антропології двох богословів показало відмінність шляхів їхньої інтроспекції, яка (...) у Сковороди присвячена, передусім, самопізнанню, а в Паїсія – автентичному пошуку Іншого: Бога, наставника, подвижницької громади. (shrink)

This paper delves into the nuances of ‘fashion’ in recommender systems and social media analytics, which shape and define an individual’s perception and self-relationality. Its aim is twofold: first, it supports a different perspective on privacy that focuses on the individual’s process of identity construction considering the social and personal aspects of ‘fashion’. Second, it underlines the limitations of computational models in capturing the diverse meaning of ‘fashion’, whereby the algorithmic prediction of user preferences is based on individual conscious and (...) unconscious associations with fashion identity. I test both of these claims in the context of current concerns over the impact of algorithmic personalisation systems on individual autonomy and privacy: creating ‘filter bubbles’, nudging the user beyond their conscious awareness, as well as the inherent bias in algorithmic decision-making. We need an understanding of privacy that sustains the inherent reduction of fashion identity to literal attributes and protects individual autonomy in shaping algorithmic approximations of the self. (shrink)

This work presents a thorough derivation of the full-wave transmission-line equations on the basis of Maxwell’s theory. The multiconductor system is assumed to be composed of nonuniform thin wires. It is shown that the mixed potential integral equations are equivalent to generalized telegrapher equations. Novel, exact, and compact expressions for the multiconductor transmission-line parameters are derived, and their connection to radiation effects is shown. Iteration and perturbation procedures are proposed for the solution of the generalized transmission-line equations.

The purpose of the study is to reveal the contextual features of the actualization of the ancient heritage, in particular, the figure of Aristotle in German thought in the first half of the twentieth century, in particular, in the work of Werner Jaeger. The article examines the relationship between classical philology and philosophy in the academic environment, as well as the influence on the philosophy from the poetic circle of Stefan George. The scientific novelty lies in the identification of non-philosophical (...) factors determining scientific research at the beginning of the twentieth century, which contributed to the appeal to the ancient heritage in Germany. As a result, authors identify the main stages that German humanitarian thought went through from classical philology to its own historical and philosophical studies of antiquity, in particular, the figure of Aristotle. (shrink)

The problem of wasteful clinical trials has been debated relentlessly in the medical community. To a significant extent, it is attributed to redundant trials – studies that are carried out to address questions, which can be answered satisfactorily on the basis of existing knowledge and accessible evidence from prior research. This article presents the first evaluation of the potential of the EU Clinical Trials Regulation 536/2014, which entered into force in 2014 but is expected to become applicable at the end (...) of 2021, to prevent such trials. Having reviewed provisions related to the trial authorisation, we propose how certain regulatory requirements for the assessment of trial applications can and should be interpreted and applied by national research ethics committees and other relevant authorities in order to avoid redundant trials and, most importantly, preclude the unnecessary recruitment of trial participants and their unjustified exposure to health risks. (shrink)

The metaphor of the labyrinth in the second half of the XX century becomes an iconic model of the postmodern world order. In musical culture, the phenomenon of the labyrinth has acquired the meaning of a symbol of intertextuality, a game with cultural codes and musical heritage of the past, multivariance, variability, uncertainty. The ballet "Labyrinths" by Alfred Schnittke is an example of the embodiment of the labyrinth paradigm and is the object of research. The subject of the study is (...) the peculiarity of the implementation of the idea of the labyrinth at the compositional and dramatic level of the ballet cycle. In the light of the author's individual interpretation, the labyrinth model takes the form of a "macrolabirint" and a "microlabiint", where the macrostructure is the construction of the whole, and the microstructure is the last, fifth part. The novelty of the research lies in the consideration of the compositional and dramatic features of the ballet "Labyrinths" in the context of the metaphor of the labyrinth. The concept of the "macrolabyrint" contributed to the relief display of the principles of symmetry and centralization inherent in the labyrinth of the classical Cretan type. Symmetry in the ballet cycle found expression in the structure of the extreme parts, in their author's division into sections, the presence of a reprise in Maestoso and Meno mosso, a single tonal organization interspersed with modal episodes, the assertion of the third c–e in the intonation system of the parts. Centralization of the Cretan labyrinth was reflected in the endowment of the fourth part with the properties of the culmination point, characterized by an increase in sonorous qualities, an abundance of cluster verticals, and heterogeneous stratified tissue. The concept of "microlabirint" contributed to the depiction of the multivariance of the maze-confusion in the fifth part of the ballet. The nonlinear movement of the characters along the branched labyrinth model was carried out by the interaction of contrasting sections correlated with deviation into various emotional states. The conducted research allowed us to conclude about a new interpretation of the labyrinth paradigm in ballet in the light of Schnittke's individual author's handwriting. (shrink)

The mutual interest between embodied cognitive sciences, in particular enactivism, and phenomenological psychopathology has significantly increased in the last 15 years. Gipps's article contributes to this field of research by defining ego boundaries in an enactivist framework to explain how the distinction self-other emerges and is maintained in ordinary healthy conditions, and how it is weakened and impaired in cases of schizophrenia. Gipps's first tenet is: The ego-boundary is enacted equiprimordially with experience, that is, it...

The purpose of the study is to consider the main provisions of the system approach to product quality management at the enterprise and to formulate the need for a comprehensive assessment of product quality. The scientific novelty lies in the step-by-step consideration of all factors, principles and aspects of quality management that affect the quality of products, and the formulation of priority areas of activity on the basis of them on the way to the development of a quality management system. (...) As a result of the study, the technical, economic, organizational and other types of measures that allow improving the quality of the product at each stage of its creation are considered, and the aspects that contribute to the development of a quality management system and the fundamental principles of its construction are identified. (shrink)