Adapt to Translate – Adaptive Clinical Trials and Biomedical Innovation

European Journal of Analytic Philosophy 17 (2):(SI3)5-24 (2021)
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Abstract

The article presents the advantages and limitations of adaptive clinical trials for assessing the effectiveness of medical interventions and specifies the conditions that contributed to their development and implementation in clinical practice. I advance two arguments by discussing different cases of adaptive trials. The normative argument is that responsible adaptation should be taken seriously as a new way of doing clinical research insofar as a valid justification, sufficient understanding, and adequate operational conditions are provided. The second argument is historical. The development of adaptive trials can be related to lessons learned from research in cases of urgency and to the decades-long efforts to end the productivity crisis of pharmaceutical research, which led to the emergence of translational, personalized, and, recently, precision medicine movements.

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Daria Jadreškić
Alpen-Adria Universität Klagenfurt

Citations of this work

Bias as an epistemic notion.Anke Bueter - 2022 - Studies in History and Philosophy of Science Part A 91 (C):307-315.

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References found in this work

Making Medical Knowledge.Miriam Solomon - 2015 - Oxford: Oxford University Press.
Bias and values in scientific research.Torsten Wilholt - 2009 - Studies in History and Philosophy of Science Part A 40 (1):92-101.
Epistemic values and the argument from inductive risk.Daniel Steel - 2010 - Philosophy of Science 77 (1):14-34.

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