This paper offers a framework for consciousness of internal reality. Recent PET experiments are reviewed, showing partial overlap of cortical activation during self-produced actions and actions observed from other people. This overlap suggests that representations for actions may be shared by several individuals, a situation which creates a potential problem for correctly attributing an action to its agent. The neural conditions for correct agency judgments are thus assigned a key role in self/other distinction and self-consciousness. A series of behavioral experiments (...) that demonstrate, in normal subjects, the poor monitoring of action-related signals and the difficulty in recognizing self-produced actions are described. In patients presenting delusions, this difficulty dramatically increases and actions become systematically misattributed. These results point to schizophrenia and related disorders as a paradigmatic alteration of a ''Who?'' system for self-consciousness. (shrink)

The construct of moral intensity, proposed by Jones (1991), was used to predict the extent to which individuals were able to recognize moral issues. We tested for the effects of the six dimensions of moral intensity: social consensus, proximity, concentration of effect, probability of effect, temporal immediacy and magnitude of consequences. A scenario-based study, conducted among business individuals in Singapore, revealed that social consensus and magnitude of consequences influenced the recognition of moral issues. The study provided evidence for the effects (...) of temporal immediacy. There was marginal support for the impact of proximity and probability of effect but no evidence that concentration of effect influenced recognition of moral issues. The paper concludes with a discussion of the implications of these results for researchers and organisational practitioners. (shrink)

We consider two-sorted theories of vector spaces and prove a criterion for the assertion that such a theory allows elimination of quantifiers over vector variables.

The article is devoted to the problem of time in modern science, where in recent years there have been major changes related to the latest discoveries in the field of the foundations of quantum theory. The author refers to works of K.-F. von Weizsacker (which works are not well-known in Russian-speaking field). Weizsacker deploys a large-scale program of building modern physics, while starting (not only as a physicist, but also a professional philosopher) with questions of philosophical interpretation of postulates of (...) modern physics, especially quantum mechanics. His key thesis is that time in physics is fundamentally distinct, which represents the whole physics as an integral scientific discipline. Weizsacker comes from physical and philosophical reflections, that give a special value to his work. Analyzing the conclusions of theoretical physics, namely the issues of substantiation of statistical mechanics, thermodynamics, and, above all, quantum mechanics, Weizsacker comes to the key idea of the structure of time in the substantiation of physical theory. The author in this conclusion disagrees with the opinion of most modern physicists that time has a subjective character, and the modus of the past, present and future reflects its essential character. The allocation of the time structure requires special logic. Such a logic is temporal and quantum. Starting from temporal logic, introducing the concept of possibility and probability, he comes to the substantiation of quantum mechanics. Being modal logic, it is based on the concept of possibility and probability. Key concept for Weizsacker is a binary alternative (Uralternative), closely related to the principle of superposition in quantum mechanics. By introducing the concept of certain alternatives, essentially actualized alternatives, Weizsacker shows how one can get the theory of relativity with its space-time structure. Further, he shows that based on its structure, you can get the theory of relativity. The space-time structure in this case is secondary, relational, as understood by Leibniz, Mach, and Einstein. (shrink)

There are very significant conceptual links between theories of social macroevolution and theories of the World System development. It is shown that the growth of the World System complexity and integrity can be traced through a system of phase transitions of macroevolution. The first set of phase transition is connected with the agrarian, industrial, and information-scientific revolutions (that are interpreted as changes of “production principles”). The second set consists of phase transitions within one production principle. These phase transitions are analyzed (...) on the basis of the World System urbanization dynamics, but they can be traced with respect to the other (cultural, economic, technological, demographic, political, etc.) dimensions of the World System development. (shrink)

The relation between Kant’s philosophy and the “philosophy of balance” as it is described in the report Come on! Capitalism, Short-termism, Population and the Destruction of the Planet, delivered to the Club of Rome in 2018, requires some analysis. The authors of the report consider Kant to be a philosopher of European Enlightenment which laid the foundations of the modern world, but also proved to be the source of global problems. The report characterises the philosophy of the Enlightenment as lop-sided (...) rationalism which dismisses everything that does not possess desirable properties. In exchange, the authors offer a philosophy of balance, described in several points as the balance between conflicting values. The overarching problem of the philosophy of balance is the restraining of egoism. For this reason I first examine the relationship between duty and human inclinations in Kant’s ethics. I then demonstrate that the topic of political forecasts and the recommendations which Kant prescribes both in his philosophy of history and in his reflections on politics, right and justice, essentially boils down to three points of the philosophy of balance: the balance between development and justice (Kantian republicanism), between the speed and stability of development (external policy, the Kantian peace project), and between the short-term and long-term perspectives (reform policy). I then touch upon the problem of the implementation of Kantian principles in politics in the light of the reception of Kant in the modern theories of social conflicts, the communication theory of J. Habermas and the justice theory of J. Rawls. The overall conclusion is that Kant’s philosophy is not a philosophy of exclusion, capitalist values and utilitarianism and is not their ideological basis. (shrink)

The paper presents the reflection on philosophical foundations of contemporary physical concepts of global history and global structure of Universe. It shows that Democritus's dualism of "matter and void" is changed now in dualism of "matter and energy" in the frame of the strings theory, where anything what looks like "a void" is absent. At the same time the Poincare-Perelman's theorem calls to rethink Democritus's philosophy in the light of "space and hole" discourse and call it to come back. On (...) the level of philosophy doctrines for contemporary fundamental physics it in necessary to combine dialectically the concept of "matter and void/hole" and the concept "matter and energy" (or "matter and singular conditions"). It is possible to do on the way of rethinking of H. Bergson's ideas presented in his book "Matter and memory". The conclusion is that fundamental dualism consists the relation "visible matter - invisible historical memory" inside of Universe. (shrink)

Terminally differentiating stratified squamous epithelial cells assemble a specialized protective barrier structure on their periphery termed the cornified cell envelope (CE). It is composed of numerous structural proteins that become cross‐linked by several transglutaminase enzymes into an insoluble macromolecular assembly. Several proteins are involved in the initial stages of CE assembly, but only certain proteins from a choice of more than 20 different proteins are used in the final stages of CE reinforcement, apparently to meet tissue‐specific requirements. In addition, a (...) variable selection of proteins may be upregulated in response to genetic defects of one of the CE proteins or tissue injury, in an effort to maintain an effective barrier. Additionally, in the epidermis and hair fiber cuticle, a layer of lipids is covalently attached to the proteins, which provides essential water barrier properties. Here we describe our current understanding of CE structure, a possible mechanism of its assembly, and various disorders that cause a defective barrier. BioEssays 24:789–800, 2002. Published 2002 Wiley Periodicals, Inc. (shrink)

The paper aims to formulate theoretical and methodological foundations as well as basic research questions for studying intervention of artificial intelligence in everyday life of medical and life sciences in the 21 century. It is an invitation for professional philosophical, theoretical and methodological discussion about the necessity and reality of artificial intelligence in contemporary medical/life sciences and medicine. The authors commence with a proposition of their definitions of ‘artificial intelligence’ (AI) and ‘artificial sociality’ (AS). The next section of the paper (...) deals with a review of basic trends in medical/life sciences and medicine. In what follows the authors debate two problems related to incorporation of AI in reality of current medicine. The first is the potential revision of the principles developed in western medicine; the second is the alteration of the contents and forms of medical education. The authors theorize the dynamic interplay between structural expansion and cultural contraction of medicine and life sciences in current practices of higher education and explore how this introduces an essential tension between the necessity and reality for medical professionals to work with AI. The paper shows that attending to institutional dynamics serves as a critical and timely extension of disciplinary/cross/anti-disciplinary critiques of science and medicine, not only since the current inclusion agenda of the AI in medicine may do little to address the real concerns of a medical profession in the XXI century but also because it may inadvertently undermine the institutional recognition and epistemic acceptance of new anti-disciplinary vista for studying AI per se. In conclusion the authors underline basic outcomes of the discussion and propose further routes for inquiry and research. (shrink)

In this paper we prove that any Δ30 degree has an increasing η -representation. Therefore, there is an increasing η -representable set without a strong η -representation.

The starting point of my study is Kant’s remark to the effect that Garve in his treatise on the connection between morality and politics presents arguments in defence of unjust principles. Recognition of these principles is, according to Kant, an inadvisable concession to those who are inclined to abuse it. I interpret this judgement by making a detailed comparison of the texts of the two treatises. I demonstrate that Garve’s work is an eclectic attempt to combine in one concept the (...) lessons of historical experience with the ideas drawn from British empiricism and German rationalism. These ideas were criticised by Kant in his “critical” period. There is a consensus among researchers that Garve condoned the expansionist policy of Frederick II of Prussia, totally denied that legality in international relations was possible and in general deserved the reputation of an conservative. From that point of view the key values for Garve were the security and well-being of the state. I offer an alternative interpretation of Garve’s position because I believe that the value of political stability plays an important role in it. Such an interpretation makes it possible to treat Garve’s narrative as it was assessed by Kant, i.e. as a concession to the common principles of political practice as a result of a failure to find the guiding theory. My study has established that the role of Garve’s work in the writing of Kant’s treatise Toward Perpetual Peace was more significant than Kant’s own words suggest. Besides, I show that it was under Garve’s influence that Kant turned to the problem of excessive complexity of the principles involved in the search for concrete political decisions. Garve obviously laments this complexity and yet makes these principles still more complex. Kant offers a simpler solution of the problem on the basis of his theory of morals and right. (shrink)

This study provides a critical examination of biopolitics and the process of the subjectification of Russia, Ukraine, Georgia, and Estonia. The authors analyze multiple overlapping regimes of belonging, performativity, and debordering.

The abilities to attribute an action to its proper agent and to understand its meaning when it is produced by someone else are basic aspects of human social communication. Several psychiatric syndromes, such as schizophrenia, seem to lead to a dysfunction of the awareness of one’s own action as well as of recognition of actions performed by other. Such syndromes offer a framework for studying the determinants of agency, the ability to correctly attribute actions to their veridical source. Thirty normal (...) subjects and 30 schizophrenic patients with and without hallucinations and/or delusional experiences were required to execute simple finger and wrist movements, without direct visual control of their hand. The image of either their own hand or an alien hand executing the same or a different movement was presented on a TV-screen in real time. The task for the subjects was to discriminate whether the hand presented on the screen was their own or not. Hallucinating and deluded schizophrenic patients were more impaired in discriminating their own hand from the alien one than the non-hallucinating ones, and tended to misattribute the alien hand to themselves. Results are discussed according to a model of action control. A tentative description of the mechanisms leading to action consciousness is proposed. (shrink)

Introduction. The article analyzes one of the qualitative states of culture, called the cultural gap, which is a phenomenon of ambivalent properties, on the one hand, generating most of the destruc- tive conflicts in the history of mankind, and on the other hand, in constructive overcoming of contra- dictions, prompting creative transformations. The purpose of the study is to give a definition of a cultural gap with the allocation of significant distinctive features found when analyzing any empirically fixed manifestations of (...) it, for subse- quent understanding at the ultimate general level of reflection. Methods. Philosophical-anthropological, systemic, axiological, historical-philosophical and dialectical approaches are used as the methodological basis of the research, making it possible to consider the phenomenon of cultural gap in various aspects. Scientific novelty of the research. An analysis of the main directions of scientific discourse in the subject area under consideration makes it possible for us to conclude that the phenomenon of a cul- tural gap is studied within the framework of social and humanitarian knowledge, but mainly in relation to the analysis of conflict situations and turning points in history. The phrase “cultural gap” itself is beginning to be introduced into scientific circula- tion, however, often outside the established con- ceptual apparatus, in a narrow context and without meaningful disclosure, which makes it scientifically necessary to address the emerging subject field of studying the phenomenon and determining the meaning of the corresponding term. Results. As a result of the study, the author identifies significant signs of the phenomenon of a cultural gap, consisting in the loss of the integrity of certain areas of culture due to the heterogene- ous development of its parts, a critically significant interruption at the level of structure and content of the universals of culture in the deep value and semantic relationships provided by it, supporting mutual understanding and conflict-free coexistence of people. As no less significant signs, one can also designate the polarization and absolutization of cultural contradictions that result in antagonistic relations between representatives of sociocultural communities, separated by the interruption of these relationships Conclusions. The definition of a cultural gap, formed on the basis of existing options for inter- preting and comprehending this phenomenon, its essential and contextual features, is due to the ontological and semantic ambiguity of some of its aspects, due to which it goes beyond a strict defini- tion and is partly projective in nature, containing significant research potential. The realization of this potential through the functional capabilities of philosophical anthropology and philosophy of culture will make it possible to determine the main approaches to identifying, preventing and overcom- ing cultural gaps, including the formation of new worldview meanings and values that can ensure harmonious coexistence between people of differ- ent cultures in modern conditions. (shrink)

Andrey Tashchian | : Chez saint Augustin le numerus sert de principe ontologique de la beauté finie en révélant l’ascension métaphysique du sensible vers l’intelligible. De plus, se divisant en sphères objective et subjective, le numerus s’avère être une totalité, « l’idée ». Toutefois, comme une forme de la culture antique, ce concept n’est pas connu comme une contradiction réelle, et ainsi les numeri éternels ne sont pas postulés comme un processus où la subjectivité finie, le moi, deviendrait nécessaire (...) pour la substance infinie. Donc, dans la doctrine de saint Augustin, l’essence de la science de la musique n’a pas la valeur de l’activité humaine consciente de soi. | : In St. Augustine’s doctrine of rhythm numerus manifests the metaphysical ascent from sensuousness to rationality and is the ontological root of finite beauty. Moreover, numerus is differentiated into the objective and subjective spheres, proving to be a totality, the “idea.” Meanwhile, as a formation of antique culture, this concept is not known as a real contradiction, and thereby eternal numeri are not posited as a process in which finite subjectivity, I would be a necessity for the infinite substance. So, in St. Augustine’s doctrine the essence of the science of music has not the value of man’s self-conscious activity. (shrink)

A study of the relationship of trends towards specialization and universalization of scientific knowledge is most fruitful when sociological and epistemological methods are compared. Sociological methods describe the growth of scientific knowledge quantitatively as an increase in volume, whereas epistemological methods do it qualitatively in terms of an increase in the level of generalization. The sociological explanation of the specialization of researchers is based on the limited resources of the study time, the epistemological explanation of the differentiation of disciplines is (...) in the ontological differences of the objects of research. On the contrary, epistemological universalization – the formulation of generalizing theories is conditioned by the social need to ensure the connectivity of the network of technical practices. The history of the development of natural sciences shows a tendency towards absorption of the less developed paradigms by more developed ones. In other words, scientific knowledge increases cumulatively both in quantitative and qualitative terms. (shrink)

One cannot be responsible for a generic truth, argues Badiou in his critical rejoinder to Sartre; one can only be its militant. Challenging Badiou’s formulation, I propose that his plea for a new stage of the communist hypothesis, which unfolds in the wake of subjective decomposition of the Left, must draw upon the Sartrean notion of collective responsibility to affirm interminable inscription of the egalitarian axiom in a novel political sequence without forcing a violent realisation of equality. Encapsulated in an (...) enigmatic formula, ‘one and one make one,’ Sartrean ethics of the Same compel the Badiouian militant subject to heed the excluded demands of the new proletariat insofar as the latter occupies ‘a point of exile where it is possible that something, finally, might happen.’. (shrink)

Gene transcription in eukaryotes is associated with conformational changes of a large area of chromatin adjacent to a gene. This rearrangement may involve the whole loop (topological domain) to which a given gene belongs.Regulatory events associated with activation or inactivation of transcription are found to act through relatively short nucleotide sequences, often located several thousand base pairs apart from gene. These sequences, termed enhancers may act independently on their distance from or orientation with respect to the gene.Both long‐range conformational rearrangements (...) of chromatin and any long distance effects of enhancers may be associated with elastic torsional strain in DNA, arising in transcriptionally active chromatin loops. Enhancer effects, in particular, may be associated with conformational transitions in DNA competing for the energy deposited in the elastic spring of the DNA. (shrink)

The typology of rationality is one of major issues of modern philosophy. In an attempt to provide a typology to Oriental materials, a researcher faces additional problems. The diversity of the Orient as such poses a major challenge. When we say “Oriental,” we mean several cultures for which we cannot find a common denominator. The concept of “Orient” involves Arabic, Indian, Chinese, Turkish and other cultures, and the only thing they share is that they are “non-Western.” Moreover, even if we (...) focus just on Islamic culture and look into rationality in this context, we have to deal with a conglomerate of various trends, which does not let us define, with full confidence, a common theoretical basis and treat them as a unity. Nevertheless, we have to go on trying to find common directions in thought development, so as to draw conclusions about types of rationality possible in Islamic culture. A basis for such a typology of rationality in the context of the Islamic world was recently suggested in A.V. Smirnov’s logic of sense theory. However, actual empiric material cannot always fit theoretical models, and the cases that do not fit the common scheme are interesting per se. On the one hand, examination of such cases gives an opportunity to specify certain provisions of the theory and, on the other hand, to define the limits of its applicability. (shrink)

In this article, I present a sociological approach to the problem of meaningful work that dwells on its broad social and cultural sources, as opposed to the focus on subjective and organizational factors currently prevailing in the field. Specifically, I consider two sociological perspectives, those of community and autonomy, as important conceptual tools for understanding the ambivalent character of modern culture in providing individuals with a sense of meaningfulness of their activities. I also review some of the existing research on (...) meaningful work and interpret it through this conceptual distinction, both to show the latter’s relevance for the field and to identify the gaps it might help fill. As a result, based on the sociological perspectives, I propose a general conceptual model and discuss five directions to further advance the theoretical comprehension of meaningful work, and I suggest some implications of these perspectives for normative business ethics. (shrink)

Today a natural ball lightning (BL) phenomenon has not yet correct physical and philosophical explanation. This article is directed on a new exotic version of the occurrence and behavior of ball lightning. BL consists of a bulk air mixture—neutral air molecules, negative and positive aero ions. BL arise on linear lightning tracks due to the primary ionization of the atmosphere and the secondary effects of atmospheric light aero ions arisen. The emerging electrostatic surface tension forces form a volumetric gas drop, (...) in which the significant electrical energy of the “ball capacitor” is concentrated. The long lifetime of aero ions provides time stability of gas ball. As a rule, a BL gradually discharges and disappears due to recombination processes, emitting a weak cold glow. The explosion of BL occurs with an external destabilizing effect on its structure. First of all, this is contact with a source of free electrons—any conductive objects and surfaces, including the human body. The impulse powerful discharge of “ball capacitor” is very dangerous for human. Some other properties of BL are also discussing in this philosophical note. (shrink)

: I reformulate and elaborate on important claims relevantly put for debate by the commentators, i.e., counterfactuals are a form of observable experience rather than a plurality of ….

Dienes & Perner's (D&P's) target articles proposes an analysis of explicit knowledge based on a progressive transformation of implicit into explicit products, applying this gradient to different aspects of knowledge that can be represented. The goal is to integrate a philosophical concept of knowledge with relevant psychophysical and neuropsychological data. D&P seem to fill an impressive portion of the gap between these two areas. We focus on two examples where a full synthesis of theoretical and empirical data seems difficult to (...) establish and would require further refinement of the model: action representation and the closely related consciousness of action, which is in turn related to self-consciousness. (shrink)

Multidrug resistance (MDR) is developed in a population of somatic mammalian cells in vivo or in vitro when they are selected for resistance to each of a large group of drugs (colchicine, adriamycin, actinomycin D, etc.). It is produced by the amplification of some unknown gene(s) whose product(s) evidently change(s) the plasma membrane permeability of a cell to a selective agent and to other unrelated compounds. A large specific genomic region (150–250 kbp) undergoes amplification in MDR cells selected for the (...) resistance to different drugs. Amplified DNA is located in homogeneously staining regions of chromosomes, double minute chromosomes and small chromatin bodies – episome‐like structures that replicate out of the S‐phase of a cell cycle. The selection of MDR cell variants is accompanied by regular karyotypic evolution specific for this type of drug resistance. (shrink)

Este artigo busca expor as críticas de Bernardo de Claraval às superfluidades humanas no texto da Apologia, especialmente aquelas referentes à arte arquitetural. Em segundo lugar, procura analisar as implicações estéticas do ascetismo cisterciense e bernardiano. As críticas de Bernardo exercem uma influência decisiva na ornamentação e fazem nascer uma nova arquitetura. This paper is to expose the criticism of human superfluities at Bernard of Clairvaux in the text of the Apology, especially those related to architectural art. Secondly, analyzes the (...) aesthetic implications of cistercian and bernardian asceticism. Criticism of Bernard exercise a decisive influence on ornamentation and give birth to a new architecture. (shrink)

Este artigo busca expor as críticas de Bernardo de Claraval às superfluidades humanas no texto da Apologia , especialmente aquelas referentes à arte arquitetural. Em segundo lugar, procura analisar as implicações estéticas do ascetismo cisterciense e bernardiano. As críticas de Bernardo exercem uma influência decisiva na ornamentação e fazem nascer uma nova arquitetura.

This edited collection of original research represents the first substantial English-language overview of the current in late Soviet philosophy known as the 'activity approach'.

This note is part of the implementation of a programme in foundations of mathematics to find exact threshold versions of all mathematical unprovability results known so far, a programme initiated by Weiermann. Here we find the exact versions of unprovability of the finite graph minor theorem with growth rate condition restricted to planar graphs, connected planar graphs and graphs embeddable into a given surface, assuming an unproved conjecture : ‘there is a number a>0 such that for all k≥3, and all (...) n≥1, the proportion of connected graphs among unlabelled planar graphs of size n omitting the k-element circle as minor is greater than a’. Let γ be the unlabelled planar growth constant . Let P be the following first-order arithmetical statement with real parameter c: “for every K there is N such that whenever G1,G2,…,GN are unlabelled planar graphs with Gishrink)

In this article we find some sufficient and some necessary ${\Sigma^1_1}$ -conditions with oracles for a model to be resplendent or chronically resplendent. The main tool of our proofs is internal arguments, that is analogues of classical theorems and model-theoretic constructions conducted inside a model of first-order Peano Arithmetic: arithmetised back-and-forth constructions and versions of the arithmetised completeness theorem, namely constructions of recursively saturated and resplendent models from the point of view of a model of arithmetic. These internal arguments are (...) used in conjunction with Pabion’s theorem that ensures that certain oracles are coded in a sufficiently saturated model of arithmetic. Examples of applications are provided for the theories of dense linear orders and of discrete linear orders. These results are then generalised to other ω-categorical theories and theories with a unique countable recursively saturated model. (shrink)

The paper introduces a conceptually important, but previously unknown essay by the Russian poet, theologian and philosopher Aleksey Khomyakov. This essay, “The Slavic and Orthodox Christian Population of Austria,” was discovered in two versions: an original, previously unpublished manuscript and a later anonymous 1845 text. The author reveals an aesthetic function that certain structural elements perform in Khomyakov’s essay, encouraging the interaction between historiosophical ideas and literary creativity. The essay is emphatically philosophical in its style, as its very composition embraces (...) the classic Hegelian triad of “Being—Nothing—Becoming.” This notion overlaps with Khomyakov’s historiosophical idea of the European Slavdom that flourished in the first millennium B.C., and that then lost its sovereignty being under German rule, and finally enjoyed a renaissance in the 19th century. The paper also shows that the distinctive feature of Khomyakov’s poetry is its prophetism. The contrastive analysis was carried out to identify the affinity between the thematic-figurative patterns of Khomyakov’s early poetry and his essay on the Austrian Slavs, which revealed how the poetic thought had been accumulating and what aspect it had taken on within a philosophical and historical discourse. The author of the article puts forward the hypothesis that the difference in depicting Peter the Great in the two versions of Khomyakov’s essay can be attributed to his dispute with Konstantin Aksakov’s poem “To Peter.” This polemic between two fellow-Slavophils was driven by their diverging approaches to the problem of the ethical dilemma of ends and means. (shrink)

In this paper we prove general exact unprovability results that show how a threshold between provability and unprovability of a finite well-quasi-orderedness assertion of a combinatorial class is transformed by the sequence-construction, multiset-construction, cycle-construction and labeled-tree-construction. Provability proofs use the asymptotic pigeonhole principle, unprovability proofs use Weiermann-style compression techniques and results from analytic combinatorics.

Стаття присвячена аналізу складного і суперечливого процесу демократизації арабського суспільства, який відбувається вже багато років. Сучасні глобалізаційні процеси торкнулися і арабського світу, де спостерігається зіткнення цивілізаційних парадигм. Разом з тим наголошується, що існуючі соціальні конфлікти та елементи суспільно-політичної нестабільності, які торкнулися ряду арабських країн, частково є результатом західного впливу і нав'язування інститутів, не властивих арабської соціокультурної традиції. З іншого боку, всі ці феномени цілком можливо розглядати як етап своєрідної демократизації арабського соціуму, який потрібен як важлива складова відповідного процесу.