La nature de la conscience est au centre de la discussion actuelle sur la personne humaine. Bien que certains philosophes fassent de la conscience la clef fondamentale et de toute l'épistémologie, la plupart des scientifiques la réduisent aux intéractions complexes du cerveau. Le présent article tire sa matière de l'analyse que saint Thomas d'Aquin fait de cette notion dans son De Veritate . Il caractérise la conscience en termes de connaissance et d'application de la connaissance à l'agir. L'A. cherche à (...) donner une définition pour montrer que la conscience dépend directement d'un syllogisme pratique. (shrink)

I first characterize a moral mistake in coercion. The principle of independence with which I criticize coercion seems also to condemn exchange. I propose an account of exchange from which it follows that exchange upholds independence after all. In support of that account I argue that, of the accounts of exchange that occur to me, only this one has the consequence that, on general assumptions, a person can take part in exchange while acting, intending, and believing with sufficient reason. I (...) argue that the hiring of very poor people by very rich people for labor from which the rich draw a substantial surplus does not give rise to an exchange of this kind. These instances of the wage labor relation resemble coercion insofar as they violate independence. (shrink)

Ecologists use a remarkable range of methods and techniques to understand complex, inherently variable, and functionally diverse entities and processes across a staggering range of spatial, temporal and interactive scales. These multiple perspectives make ecology very different to the exemplar of science often presented by philosophers. In Philosophical Foundations for the Practices of Ecology, designed for graduate students and researchers, ecology is put into a new philosophical framework that engages with this inherent pluralism while still placing constraints on the ways (...) that we can investigate and understand nature. The authors begin by exploring the sources of variety in the practice of ecology and how these have led to the current conceptual confusion. They argue that the solution is to adopt the approach of constrained perspectivism and go on to explore the ontological, metaphysical, and epistemological aspects of this position and how it can be used in ecological research and teaching"--Provided by publisher. (shrink)

It is often said that knowledge is power, but more often than not relevant knowledge is not used when political decisions are made. This book examines how political decisions relate to scientific knowledge and what factors determine the success of scientific research in influencing policy. The authors take a comparative and historical perspective and refer to well-known theoretical frameworks, but the focus of the book is on three case studies: the discourse of racism, Keynesianism, and climate change. These cases cover (...) a number of countries and different time periods. In all three the authors see a close link between 'knowledge producers' and political decision makers, but show that the effectiveness of the policies varies dramatically. This book will be of interest to scientists, decision makers and scholars alike. (shrink)

The article presents the sociology of knowledge approach to discourse (SKAD). SKAD, which has been in the process of development since the middle of the 1990s, is now a widely used framework among social scientists in discourse research in the German-speaking area. It links arguments from the social constructionist tradition, following Berger and Luckmann, with assumptions based in symbolic interactionism, hermeneutic sociology of knowledge, and the concepts of Michel Foucault. It argues thereby for a consistent theoretical and methodological grounding of (...) a genuine social sciences perspective on discourse interested in the social production, circulation and transformation of knowledge, that is in social relations and politics of knowledge in the so-called ‘knowledge societies’. Distancing itself from Critical Discourse Analysis, Linguistics, Ethnomethodology inspired discourse analysis and the Analysis of Hegemonies, following Laclau and Mouffe, SKAD’s framework has been built up around research questions and concerns located in the social sciences, referring to public discourse and arenas as well as to more specific fields of (scientific, religious, etc.) discursive struggles and controversies around problematizations (Foucault). (shrink)

With great sympathy for Roman Ingarden and his work, Edith Stein edited his book project The Literary Work Of Art. In the letters she exchanges with him shereflects on relationship between reality and ideality: she writes that those who do not see the world as a reality must be fools. The political events in the 1930s had an impact on phenomenology. While Edmund Husserl dissociates himself from his protégé Martin Heidegger with regard to the content of his philosophy as well (...) as with regard to his ideology, Edith Stein distances herself more and more from the phenomenological method, seeing it as removed from reality, and she eventually become a Carmelite nun. Roman Ingarden, on the other hand, reconsiders interpreting phenomenology as aesthetic theory. Literature and film are being re-analysed in terms of phenomenological mediality and as factors of human communication. (shrink)

A Estrela da Redenção de Franz Rosenzweig estabelece uma conexão clara entre a questão do Tempo e a questão acerca da Experiência e da Linguagem como atributos fundamentais do ser humano. Tanto do ponto de vista metódico como do ponto de vista do conteúdo, o pensamento do tempo de Rosenzweig distingue-se do de Martin Heidegger, malgrado a sua aparente proximidade. Para Rosenzweig, a caducidade das coisas e a mortalidade do ser humano não são pensados a partir de uma ontologia da (...) finitude, antes se interpretam à luz da leitura judaica do acontecimento salvífico. Ora isto significa que, para Rosenzweig, o ser humano como indivíduo tem a partir da experiência do seu próprio tempo participação nos acontecimentos da Criação, da Revelação e da Redenção. Mais ainda, isto quer também dizer que para o pensador judeu o tempo está sempre de forma inusitada correlacionado com a Eternidade. Ou seja, segundo esta visão, o ser humano transforma-se a si mesmo graças ao acontecimento de salvação em concomitância com a sua própria relação em processo de transformação no que se refere ao tempo e à eternidade. Segundo o autor do artigo, a chave para esta nova compreensão do tempo está numa nova sistemática filosófica, cujo método possibilita a transformação de diferentes tempos, para lá do uso apropriado que Rosenzweig faz da simbologia matemática em ordem a fornecer uma interpretação filosófica da Criação. /// Franz Rosenzweig's Star of Redemption connects the question of time with the question about the experience and the language proper of the human being. In terms of both method and content, Rosenzweig's thinking about time is quite different from the heideggerian approach regardless of the fact that both thinkers also give the impression of being close to one another. But the truth is that Franz Rosenzweig thinks the caducity of things and the mortality of the human being not in terms of an ontology of finitude, but rather interprets them in the light of the Jewish understanding of the event of salvation. This means that for Rosenzweig the human being as individual situated in the midst of time has a direct part in the events of Creation, Revelation and Salvation. In each one of these instances time is shown as being imbedded with eternity, what in each case happens in a very special way. The human being transforms itself in this event of salvation together with his process of relation to time and eternity. The key for this new understanding of time is a philosophical systematic and method that makes possible the transformation of different times, not to mention the characteristic use of mathematical symbology made by Rosenzweig in order to give a philosophical interpretation of Creation. (shrink)

Keine ausführliche Beschreibung für "Reflexion und Gefühl" verfügbar.

This paper puts forward a theoretical framework for the analysis of expertise and experts in contemporary societies. It argues that while prevailing approaches have come to see expertise in various forms and functions, they tend to neglect the broader historical and societal context, and importantly the relational aspect of expertise. This will be discussed with regard to influential theoretical frameworks, such as laboratory studies, regulatory science, lay expertise, post-normal science, and honest brokers. An alternative framework of expertise is introduced, showing (...) the limitations of existing frameworks and emphasizing one crucial element of all expertise, which is their role in guiding action. (shrink)

According to the acousmatic thesis defended by Roger Scruton and others, to hear sounds as music is to divorce them from the source or cause of their production. Non-acousmatic experience involves attending to the worldly cause of the sound; in acousmatic experience, sound is detached from that cause. The acousmatic concept originates with Pythagoras, and was developed in the work of 20th century musique concrète composers such as Pierre Schaeffer. The concept yields important insights into the nature of musical experience, (...) but Scruton's version of the acousmatic thesis cannot overcome objections arising from timbral and spatial aspects of music, which seem to relate sounds to the circumstances of their production. These objections arise in part from music's status as a performing art rooted in human gesture and behaviour. Hence I defend a two-fold thesis of "hearing-in", which parallels Richard Wollheim's concept of "seeing-in": both acousmatic and.. (shrink)

Am Leitfaden des Begriffs Malum oeconomicum fuhrt das Buch seine Leser in einen Dialog mit klassischen und zeitgenossischen Denkern uber die abgrundigen Seiten der Wirtschaft und ihre Spiegelungen in der Seele. In der Wirtschaft erscheinen Menschen tendenziell fureinander als blosse Werkzeuge ihrer Bedurfnisbefriedigung, andererseits wird wirtschaftliche Leistung mit Bedeutungen aufgeladen, die an das Heil in der religiosen Sphare gemahnen. Im Kapitalismus der Moderne entfaltet sich aus der Wechselwirkung zwischen einer entfesselten Produktion und den Antrieben des Innenlebens eine zuvor unbekannte Dynamik. (...) Ist diese in liberalen Theorien ein Anlass, das Malum oeconomicum fur verschwunden zu erklaren, so machen Fundamentalkritiker des globalen Kapitalismus geltend, dass dieser illusionare Bedurfnisse weckt und unversohnliche Gegensatze zwischen Arm und Reich hervorruft, deren Sprengkraft jeden sozialen Zusammenhalt gefahrdet. Aus der Lekture von Platon, Aristoteles, Thomas Hobbes, Bernard Mandeville, Adam Smith, Thomas Robert Malthus, Karl Marx, Max Weber, Georg Simmel, John Maynard Keynes, Martin Heidegger, Herbert Marcuse, John Rawls und Amartya Sen ergeben sich Aussichten auf das Wirtschaftsgeschehen, die uber die Engfuhrungen heutiger Debatten weit hinausweisen. (shrink)

Pathogenic variants occurring in protein‐coding regions underlie human genetic disease through various mechanisms. They can lead to a loss of function (LOF) such as in recessive conditions or in dominant conditions due to haploinsufficiency. Dominant‐negative (DN) effects, counteracting the activity of the normal gene‐product, and gain of function (GOF) are also mechanisms driving dominance. Here, I discuss a few papers on these specific mechanisms. In short, there is accumulating evidence pointing to differences between LOF versus non‐LOF variants (DN and GOF). (...) The latter are thought to have milder effects on protein structure and, as expected, DN variants are enriched at protein interfaces. This tendency to cluster in 3D space can help improve the ability of computational tools to predict the pathogenicity of DN variants, which is currently a challenging issue. More recent results support the hypothesis whereby cotranslational assembly of macromolecular complexes can buffer deleterious consequences of variants that would otherwise lead to DN effects (DNEs). Indeed, subunits the variants of which are responsible for DNEs tend to elude cotranslational assembly, thus poisoning complexes involving wild‐type subunits. The constraints explaining why the buffering of DNEs is not universal require further investigation. (shrink)

Testis determination in most mammals is regulated by a genetic hierarchy initiated by the SRY gene. Early ovarian development has long been thought of as a default pathway switched on passively by the absence of SRY. Recent studies challenge this view and show that the ovary constantly represses male‐specific genes, from embryonic stages to adulthood. Notably, the absence of the crucial ovarian transcription factor FOXL2 (alone or in combination with other factors) induces a derepression of male‐specific genes during development, postnatally (...) and, even more interestingly, during adulthood. Strikingly, in the adult, targeted ablation of Foxl2 leads to a molecular transdifferentiation of the supporting cells of the ovary, which acquire cytological and transcriptomic characteristics of the supporting cells of the testes. These studies bring many answers to the field of gonadal determination, differentiation and maintenance, but also open many questions. (shrink)

Expression of most genes is regulated by the interaction of multiple transcription factors with cis‐regulatory sequences. Many studies have focused on how changes in promoters and enhancers alter gene expression and phenotype. Recently, Hare et al., using elegant wet and computational approaches uncovered a series of enhancers driving the expression of the even‐skipped gene in scavenger flies (Sepsidae).1 Despite the strong sequence divergence between the enhancers in sepsids and drosophilids, they lead to remarkably similar patterns of gene expression in transgenic (...) Drosophila embryos. This can be explained by the existence of intra‐enhancer compensatory mutations and the presence of overlapping/near binding sites for activators and repressors. BioEssays 30:1052–1057, 2008. © 2008 Wiley Periodicals, Inc. (shrink)