It is probable that, increasingly, genome investigations are going to be based on statistical formalization. This review summarizes the state of art and potentiality of using statistics in microbial genome analysis. First, I focus on recent advances in functional genomics, such as finding genes and operons, identifying gene conversion events, detecting DNA replication origins and analysing regulatory sites. Then I describe how to use phylogenetic methods in genome analysis and methods for genome‐wide scanning for positively selected amino acids. I conclude (...) with speculations on the future course of genome statistical modeling. BioEssays 25:266–273, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

We discuss the role of perceptron (or threshold) connectives in the context of Description Logic, and in particular their possible use as a bridge between statistical learning of models from data and logical reasoning over knowledge bases. We prove that such connectives can be added to the language of most forms of Description Logic without increasing the complexity of the corresponding inference problem. We show, with a practical example over the Gene Ontology, how even simple instances of perceptron connectives are (...) expressive enough to represent learned, complex concepts derived from real use cases. This opens up the possibility to import concepts learnt from data into existing ontologies. (shrink)

Machiavelli is known chiefly for The Prince, but his main considerations on politics are in his most profound and later work Discourses on Livy, the complexity, length and style of which have often discouraged new readers and interpreters of Machiavelli, despite its historical and theoretical importance. For this reason, the Discourses has not been given the attention it deserves. This volume of newly commissioned essays by some of the world's leading experts on Machiavelli overcomes this gap. It is the first (...) collective volume dedicated specifically to this work, ranging over topics such as Machiavelli's republicanism, the relation between liberty and tyranny, the role of religion, his conception of history, his writing style, his view of society as a plural and conflictive body, his suggestion of how a free state should be organized, or his notions of the people and virtù. Contributors include: Jérémie Barthas, Thomas Berns, Alessandro Campi, J. Patrick Coby, Marie Gaille, Marco Geuna, Mark Jurdjevic, Cary J. Nederman, Gabriele Pedullà, Diogo Pires Aurélio, Fabio Raimondi, Andre Santos Campos, Miguel Vatter, and Camila Vergara. (shrink)

(English:) This contribution attempts a first non-normative approach to the problem of the classic, its definition and its meaning in an age of globalization. It reviews a series of common representations of the classic (and other analogous or contrary terms), stressing the programmatic-ideological aspect that generally characterizes them. Classic, actually, tends to be a foundational category, and therefore rests on delimitations that determine its exclusiveness as opposed to something else. This paper, in particular, criticizes the last boundary of the exclusivity (...) of the classic, that is, its normative opposition to fashion and actuality. On the contrary, it is argued that there is a substantial link between classic, actuality and fashion. On the basis of this connection, two deflationary definitions of the classic are proposed: the first regards it as part of the broader process of construction of historical identity by concrete individuals. The second, on the other hand, conceives it as a product of art, and, therefore, of a formative process of abilities, skills, taste, by which the classic becomes the object of technical, aesthetic and teleological judgments. -/- (Spanish:) En esta contribución se intenta una primera aproximación no normativa al problema del clásico, su definición y su significado en una era de globalización. Se revisa una serie de representaciones comunes sobre lo clásico (y otros términos análogos o contrarios), se destaca el aspecto programático-ideológico que por lo general las caracteriza. Clásico, en efecto, tiende a ser una categoría fundacional, por lo cual se apoya en delimitaciones que determinan su exclusividad por oposición a otra cosa. En este trabajo, en particular, se critica la última frontera de la exclusividad de lo clásico, es decir, su oposición normativa a la moda y la actualidad. Por el contrario, se argumenta que existe un vínculo sustancial entre el clásico, la actualidad y la moda. A partir de esta conexión, se proponen dos definiciones deflacionarias del clásico: la primera lo considera parte del proceso más amplio de construcción de la identidad histórica por parte de individuos concretos. El segundo, en cambio, lo concibe como un producto del arte, y, por tanto, de un proceso de formación de competencias, habilidades, gusto, por el cual el clásico se convierte en objeto de juicios técnicos, estéticos y teleológicos. (shrink)

Orthodox decision theory is fanatical in the way it treats small probabilities of enormous value, if unbounded utility functions are allowed. Some have suggested a fix, Nicolausian discounting, according to which outcomes with small enough probabilities should be ignored when making decisions. However, there are lotteries involving only small-probability outcomes, none of which should intuitively be ignored. So the Nicolausian discounter needs a procedure for distinguishing the problematic cases of small-probability outcomes from the unproblematic ones. In this paper, I present (...) a dilemma for Nicolausian discounting: the view must be coupled either with a procedure that delivers fanatical verdicts of its own, as bad as those of orthodox decision theory, or with one that entails intransitive cyclic preferences. (shrink)

The Handbook of Formal Argumentation is a community effort aimed at providing a comprehensive and up-to-date view of the state of the art and current trends in the lively research field of formal argumentation. The first volume of the Handbook is organised into five parts, containing nineteen chapters in all, each written by leading experts in the field. The first part provides a general and historical perspective on the field. The second part gives a comprehensive coverage of the argumentation formalisms (...) available in the literature at various levels of abstraction. The third part is devoted to cover some of the many dialogical aspects of argumentation, while the fourth one deals with algorithmic, computational and implementation issues. Finally, the fifth part provides some deeper analyses on the previously introduced topics. The Handbook of Formal Argumentation is an open-ended initiative of which the present volume is the first outcome. Further volumes are planned to cover topics not included in the present one and the initiative is conceived to grow by the support and feeding it receives from the community members. (shrink)

This paper presents a novel argumentation framework to support Issue-Based Information System style debates on design alternatives, by providing an automatic quantitative evaluation of the positions put forward. It also identifies several formal properties of the proposed quantitative argumentation framework and compares it with existing non-numerical abstract argumentation formalisms. Finally, the paper describes the integration of the proposed approach within the design Visual Understanding Environment software tool along with three case studies in engineering design. The case studies show the potential (...) for a competitive advantage of the proposed approach with respect to state-of-the-art engineering design methods. (shrink)

En la actualidad el pensamiento de Maquiavelo ha estado ligado a una praxis política que se juzga como mala desde el punto de vista ético. El secretario florentino, alejándose de la tradición estoica que marcó la filosofía política de la antigüedad y gran parte del medioevo, separa la política de la moral planteando un realismo político que evalúa los actos como eficientes o ineficientes, útiles o inútiles, fructíferos o infructíferos, tomando distancia de aquella calificación de bueno o malo. Sin embargo, (...) este simple acto, que no es más que la teorización y la explicitación de algo que se ha hecho desde siempre en la historia política, le valió ser tildado de hereje o que incluso su apellido se transformase en un término que hasta el día de hoy tiene una carga negativa en términos morales. Este artículo se adentra en aquellas interpretaciones, elementos históricos, teológicos y filosóficos del pensamiento de Maquiavelo, que con o sin intención, llevaron a que el secretario florentino fuera entendido como un pensador que hace apología de las malas praxis, acercándolo incluso a ideas heréticas. Palabras clave_: _Maquiavelo– Antimaquiavelismo - Realismo político – Herejía. (shrink)

Creating an integrated design space can be successful only if researchers agree on how to define and measure a certain phenomenon of interest. Adversarial collaborations and mathematical modeling can aid in reaching the necessary level of agreement when researchers depart from different theoretical perspectives.

This paper aims at comparing and relating belief revision and argumentation as approaches to model reasoning processes. Referring to some prominent literature references in both fields, we will discuss their (implicit or explicit) assumptions on the modeled processes and hence commonalities and differences in the forms of reasoning they are suitable to deal with. The intended contribution is on one hand assessing the (not fully explored yet) relationships between two lively research fields in the broad area of defeasible reasoning and (...) on the other hand pointing out open issues and potential directions for future research. (shrink)

This paper focuses on sections of Nietzsche's Twilight of the Idols that deal with Goethe, with the aim of reflecting on the anthropological ideal that Nietzsche outlines in his late period. I give particular attention to the way in which Nietzsche deals with concepts such as "German", "(good) European", and "free spirit", connecting them in a coherent picture. Finally, I argue that the Renaissance plays an important role in Nietzsche's anthropological project, for it helps to define the spiritual strength that (...) characterizes the healthy type of man whom Nietzsche thought destined to realize his late philosophy. (shrink)

Wilfrid Sellars’ denunciation of the Myth of the Given was meant to clarify, against empiricism, that perceptual episodes alone are insufficient to ground and justify perceptual knowledge. Sellars showed that in order to accomplish such epistemic tasks, more resources and capacities, such as those involved in using concepts, are needed. Perceptual knowledge belongs to the space of reasons and not to an independent realm of experience. Dan Hutto and Eric Myin have recently presented the Hard Problem of Content as an (...) ensemble of reasons against naturalistic accounts of content. In a nutshell, it states that covariance relations—even though they are naturalistically acceptable explanatory resources—do not constitute content. The authors exploit this move in order to promote their preferred radical enactivist and anti-representationalist option, according to which, basic minds—the lower stratum of cognition—do not involve content. Although it is controversial to argue that the Hard Problem of Content effectively dismisses naturalistic theories of representation, a central aspect of it—the idea that information as covariance does not suffice to explain content—finds support among the defenders of classical cognitive representationalism, such as Marcin Miłkowski. This support—together with the acknowledgment this remark about covariance is a point already made by Sellars in his criticism of the Myth of the Given—has a number of interesting implications. Not only is it of interest for the debates about representationalism in cognitive science, where it can be understood as an anticipatory move, but it also offers some clues and insights for reconsidering some issues along Sellarsian lines—a conflation between two concepts of representation that is often assumed in cognitive science, a distinction between two types of relevant normativities, and a reconsideration of the naturalism involved in such explanations. (shrink)

Reciprocal libertarianism is a version of left-wing libertarianism that combines self-ownership with an egalitarian distribution of resources according to reciprocity. In this paper, I show that reciprocal libertarianism is a coherent and appealing view. I discuss how reciprocal libertarians can handle conflicts between self-ownership and reciprocity, and I show that reciprocal libertarianism can be realised in a framework of individual ownership of external resources or in a socialist scheme of common ownership (libertarian socialism). I also compare reciprocal libertarianism with left-libertarian (...) approaches: I argue that a reciprocity-sensitive version of left-libertarianism (reciprocal left-libertarianism) is coherent and morally superior to traditional left-libertarianism, on grounds of incorporating a distinctively solidaristic and recognition-oriented aspect of equality. The policy implications of reciprocal libertarianism will differ depending on which rights people can have over external resources, but all reciprocal libertarian views acknowledge the existence of social rights that people have as co-operators. (shrink)

This paper investigates the relations between the concepts of moral harm and moral responsibility, arguing for a circularity between the two. On this basis the conceptual soundness of descriptivism, on which consequentialist and non-consequentialist arguments are often grounded, is questioned. In the last section a certain version of ascriptivism is defended: The circularity is relevant in order to understand how a restricted version of ascriptivism may in fact be well founded.

O objetivo deste artigo é mostrar a semântica da palavra Eros dentro da tradição cristã. Limita-se a algumas dessas significações. A reflexão mostra a limitação dessa expressão na língua portuguesa. Seu significado é muito mais rico na língua grega. Se a tradição cristã carregou esta palavra de forma negativa, outros Padres leram-na em sintonia com Ágape e com outros significados. A relação mística a interpreta como uma relação “erótica” entre homem e Deus. Esta intimidade procura explicar o aspecto do desejo (...) de Deus e da relação mútua entre aquele que ama e o amado, que tem sua raiz na busca mais íntima da humanidade. Negar por preconceitos palavras carregadas de desejos não divinos e nem dignos da humanidade, como na Antigüidade, é reduzir demais seu campo semântico na história. Esta palavra reflete o amor da alma para com Deus numa perspectiva mística, assume variações significativas, dentre tantas, como o amor de Jesus Cristo, como sinônimas de Ágape, do amor de Deus para com os homens, como amor individual ligado a Deus, o Eros como virtude e como castidade. A compreensão das dimensões do amor se realiza na capacidade de ver que todas elas são positivas e importantes para obtermos o equilíbrio da vida humana, numa harmonia destas dimensões constitutivas e importantes para a vida. Palavras-chave: Eros; Patrística; Amor; Alma; Mística; Virtude; Castidade e Ágape. ABSTRACT This article aims at demonstrating the semantics of the term Eros in Christian tradition, pointing out the limitations of the term in Portuguese. The scope of its meaning is much wider in Greek. If Christian tradition has charged the word with a negative feature, other priests have read it in tune with Agape and other meanings. The mystical perspective interprets it as an ‘erotic’ relationship between man and God. Such intimacy attempts to explain God’s desire and the mutual relation between the one who loves and the beloved, rooted in mankind’s most intimate longing. To deny, on account of prejudice, words charged with non-divine desires unworthy of humanity, as happened in antiquity, is to reduce their semantic field in history. That word reflects the soul’s love for God in a mystical perspective and assumes meaningful variations, among which Christ’s love, ‘Agape’ or God’s love for men, and individual love connected with God: ‘Eros’ as virtue and chastity. The comprehension of the dimensions of love takes place in the capacity to realize that they are all positive and relevant to human life’s balance, in the harmony of those dimensions that constitute life. Key words: Eros; Patristics; Love; Soul; The mystical; Virtue; Chastity; Agape. (shrink)

As François Lambert experimented with religious identity in his passage from the Franciscan Observance to Lutheran Reform, he presents a valuable witness to the processes of identity formation and self-understanding in a period of religious turmoil that was still open to many different solutions. From 1522 to 1530 his choices led him from Avignon to Genève, Lausanne, Bern, Zurich, Basel, Wittenberg, Metz, Strasbourg, Marburg, in a life marked by projects of reform and moments of fear, illusions and delusions, success and (...) failure. Lambert wrote a type of autobiography of this itinerary, which is traceable from his first work composed in Wittenberg until the very last letter that he wrote a few days.. (shrink)

Forty years ago, speaking of Peter of John Olivi’s commentaries on the Gospel of Matthew and the Gospel of John, Raoul Manselli affirmed that these texts prove that Olivi had “a vast knowledge of the exegetes who preceded him, a vivid perception of the role of the Bible within the contemporary life of the Church, and, last but not least, a vivid understanding of the complex significance and value of being Franciscan.”1 Undoubtedly, this judgment can also be extended to the (...) Lectura super Lucam, which Fortunato Iozzelli edited in 2010, thereby becoming the first of Olivi’s Gospel commentaries to be available in a modern edition.2 Iozzelli’s critical edition offers scholars a precious opportunity to better understand... (shrink)