This paper extends a stochastic theory for buffer fill distribution for multiple “on‘ and “off‘ sources to a mobile environment. Queue fill distribution is described by a set of differential equations assuming sources alternate asynchronously between exponentially distributed periods in “on‘ and “off‘ states. This paper includes the probabilities that mobile sources have links to a given queue. The sources represent mobile user nodes, and the queue represents the capacity of a switch. This paper presents a method of analysis which (...) uses mobile parameters such as speed, call rates per unit area, cell area, and call duration and determines queue fill distribution at the ATM cell level. The analytic results are compared with simulation results. (shrink)

With the advent of modern technology, the way society handles and performs monetary transactions has changed tremendously. The world is moving swiftly towards the digital arena. The use of Automated Teller Machine cards has led to a “cash-less society” and has fostered digital payments and purchases. In addition to this, the trust and reliance of the society upon these small pieces of plastic, having numbers engraved upon them, has increased immensely over the last two decades. In the past few years, (...) the number of ATM fraud cases has increased exponentially. With the money of the people shifting towards the digital platform, ATM skimming has become a problem that has eventually led to a global outcry. The present review discusses the serious repercussions of ATM card cloning and the associated privacy, ethical and legal concerns. The preventive measures which need to be taken and adopted by the government authorities to mitigate the problem have also been discussed. (shrink)

Ataxia‐telangiectasia (A‐T) is a pleiotropic recessive disorder characterized cerebellar ataxia, immunodeficiency, specific developmental defects, profound predisposition to cancer and acute radiosensitivity. Functional inactivation of single gene product, ATM, accounts for this compound phenotype. We suggest that ATM acts as a sensor of reactive oxygen species and/or oxidative damage cellular macromolecules, including DNA. In turn, ATM induces signalling through multiple pathways, thereby coordinating acute phase stress responses with cell cycle checkpoint control and repair of oxidative damage. Absence of ATM is proposed (...) to limit the repair of insidious oxidative damage that can occur under normal physiological conditions, ultimately leading to apoptosis of particularly sensitive cells, such as neurons and thymocytes. (shrink)

The ATM protein kinase is centrally involved in the cellular response to ionizing radiation (IR) and other DNA double‐strand‐break‐inducing insults. Although it has been well established that IR exposure activates the ATM kinase domain, the actual mechanism by which ATM responds to damaged DNA has remained enigmatic. Now, a landmark paper provides strong evidence that DNA‐strand breaks trigger widespread activation of ATM through changes in chromatin structure.1 This review discusses a checkpoint activation model in which chromatin perturbations lead to the (...) conversion of inactive ATM domains to phosphorylated, active ATM monomers. The new findings underscore the critical importance of epigenetic events in genome function and surveillance in mammalian cells. BioEssays 25:627–630, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

This paper describes the design of a control and management network (orderwire) for a mobile wireless Asynchronous Transfer Mode (ATM) network. This mobile wireless ATM network is part of the Rapidly Deployable Radio Network (RDRN). The orderwire system consists of a packet radio network which overlays the mobile wireless ATM network, each network element in this network uses Global Positioning System (GPS) information to control a beamforming antenna subsystem which provides for spatial reuse. This paper also proposes a novel Virtual (...) Network Configuration (VNC) algorithm for predictive network configuration. A mobile ATM Private Network-Network Interface (PNNI) based on VNC is also discussed. Finally, as a prelude to the system implementation, results of a Maisie simulation of the orderwire system are discussed. (shrink)

This research concentrates on the design and analysis of an algorithm referred to as Virtual Network Configuration (VNC) which uses predicted future states of a system for faster network configuration and management. VNC is applied to the configuration of a wireless mobile ATM network. VNC is built on techniques from parallel discrete event simulation merged with constraints from real-time systems and applied to mobile ATM configuration and handoff. Configuration in a mobile network is a dynamic and continuous process. Factors such (...) as load, distance, capacity and topology are all constantly changing in a mobile environment. The VNC algorithm anticipates configuration changes and speeds the reconfiguration process by pre-computing and caching results. VNC propagates local prediction results throughout the VNC enhanced system. The Global Positioning System is an enabling technology for the use of VNC in mobile networks because it provides location information and accurate time for each node. This research has resulted in well defined structures for the encapsulation of physical processes within Logical Processes and a generic library for enhancing a system with VNC. Enhancing an existing system with VNC is straight forward assuming the existing physical processes do not have side effects. The benefit of prediction is gained at the cost of additional traffic and processing. This research includes an analysis of VNC and suggestions for optimization of the VNC algorithm and its parameters. (shrink)

This study aims to identify the electronic banking services in Palestine from the point of view of the customers of the banks, where researchers used the descriptive analytical method, through a questionnaire distributed electronically to the sample of beneficiaries of the electronic banking services provided by banks operating in Palestine. The study reached a number of results, the most important of which are: There is a moderate degree of efficiency of electronic banking services provided in banks operating in Palestine from (...) the point of view of bank customers. Where the total score of electronic banking services received a relative weight of (64.37%), the results of the study confirmed that the ranking of electronic banking services as follows: Internet banking services ranked first with a relative weight (66.68%), a medium percentage, while ATM services came in Second place with a relative weight (64.30%), and mobile application services got the third and last place with a relative weight (62.12%). The results also showed that there are statistically significant differences between banks operating in Palestine according to the bank variable from the beneficiaries' point of view in favor of Bank of Palestine. The results showed that there were no statistically significant differences between banks operating in Palestine according to the variable number of years of dealing with the bank from the point of view of beneficiaries. The study made a number of recommendations, the most important of which are: The need for banks to enhance the use of electronic banking services and upgrade them. Conduct awareness campaigns on the importance of electronic banking services and give appropriate incentives to beneficiaries who deal with them. Direct customers use electronic banking services instead of traditional methods. Attention to quickly respond to customer problems sent via the website. (shrink)

Accelerating Turing machines have attracted much attention in the last decade or so. They have been described as “the work-horse of hypercomputation” (Potgieter and Rosinger 2010: 853). But do they really compute beyond the “Turing limit”—e.g., compute the halting function? We argue that the answer depends on what you mean by an accelerating Turing machine, on what you mean by computation, and even on what you mean by a Turing machine. We show first that in the current literature the term (...) “accelerating Turing machine” is used to refer to two very different species of accelerating machine, which we call end-stage-in and end-stage-out machines, respectively. We argue that end-stage-in accelerating machines are not Turing machines at all. We then present two differing conceptions of computation, the internal and the external, and introduce the notion of an epistemic embedding of a computation. We argue that no accelerating Turing machine computes the halting function in the internal sense. Finally, we distinguish between two very different conceptions of the Turing machine, the purist conception and the realist conception; and we argue that Turing himself was no subscriber to the purist conception. We conclude that under the realist conception, but not under the purist conception, an accelerating Turing machine is able to compute the halting function in the external sense. We adopt a relatively informal approach throughout, since we take the key issues to be philosophical rather than mathematical. (shrink)

Credentials play an important role in all modern societies, but the analysis of their nature and function has thus far been neglected by social philosophers. We present a view according to which the function of credentials is certify the identity and the institutional status (including the rights) of individuals. More importantly, credentials enable rights-holders to exercise their rights, so that for a particular right to be exercisable the right-holder should possess, carry and sometimes show to an authority (or QR code (...) scanner) a document of a specific kind. Driving licenses, identity cards, passports, boarding passes, library passes, credit cards, ATM cards, health insurance cards are all examples of credentials in this sense. Credentials have in every case a bearer, and the bearer should be able to carry them easily on his or her person. Credentials should also be inspectable – not least because credentials can be forged. The authors analyse several historical and contemporary examples of credentials, focusing on the credentials carried by the pilgrims of the Way of Saint James. (shrink)

How chromatin bridges are detected by the abscission checkpoint during mammalian cell division is unknown. Here, we discuss recent findings from our lab showing that the DNA topoisomerase IIα (Top2α) enzyme binds to catenated (“knotted”) DNA next to the midbody and forms abortive Top2‐DNA cleavage complexes (Top2ccs) on chromatin bridges. Top2ccs are then processed by the proteasome to promote localization of the DNA damage sensor protein Rad17 to Top2‐generated double‐strand DNA ends on DNA knots. In turn, Rad17 promotes local recruitment (...) of the MRN protein complex and downstream ATM‐Chk2‐INCENP signaling to delay abscission and prevent chromatin bridge breakage in cytokinesis. (shrink)

Increasing global competition has intensified the use of informal sector workforce worldwide. This phenomenon is true with regard to India, where 92% of the workers hold precarious jobs. Our study examines the dynamics of workplace dignity in the context of Indian security guards deployed as contract labour by private suppliers, recognising that security guards’ jobs were marked by easy access, low status, disrespect and precariousness. The experiences of guards serving bank ATMs were compared with those working in large reputed organisations. (...) The former reported loss of dignity though their inherent self-worth remained partially intact, whereas the latter reclaimed dignity despite the precarious working conditions and the absence of unions. Guards from large reputed organisations evolved strategies by which they took advantage of the client’s vulnerabilities, developed ‘thick’ relationships at work and immersed themselves in 'doing dignity work' to ensure that they are not disposable. ‘Doing dignity work’ was a visible device which involved actions that met or went beyond the norms laid down by the client and was used by security guards to limit the extent of their precariousness. Since the opportunity to reclaim dignity was facilitated by large reputed clients’ adherence to legal regulations, we see implications of the study for the moral economy. (shrink)

A hypothetical reasoning, which can find an explanation for a given set of observation by assuming some hypothetical sets, is a useful knowledge processing framework because of its theoretical basis and usefulness for practical problems such as diagnostics, scheduling, and design. It is, however, known to be computationally very expensive for large problems because it must deal with incomplete knowledge. Predicate-logic allows powerful and compact knowledge representation compared to propositional-logic. Efficient methods to proceed reasoning have been developed for propositional-logic. However (...) it would be desirable to develop similar methods for predicate-logic, but this has so far proved difficult. “KICK-HOPE” is one of hypothetical reasoning systems for predicate-logic. KICK-HOPE, which is based on a deductive database technique called the QSQR method and a basic fast hypothetical reasoning system called ATMS, made advances in the speed of reasoning. However, for a practical knowledge base, ‘the inconsistent process’ and ‘the subsumption process’ still consume much calculation time. In this paper, we investigate an e.cient method of the inconsistent and subsumption processes of KICK-HOPE. First, we show most of these processes are vain and omissible. Second, to omit vain processes, we introduce bit-vector to represent what hypotheses include in hypothetical sets. And, we improve that vain processes will be reduced to check the check-vector. Finally, we examine the proposed system with two examples, a diagnostic problem of a logic circuit and a scheduling problem. It is shown to be more efficient than the original KICK-HOPE for all problems. (shrink)

Ekonomik ilişkiler ve fetihler sonucu çok geniş bir coğrafyaya yayılan ve bunun bir sonucu olarak da birçok farklı kültürle karşılaşan Müslümanlar, özellikle Bizans (Helen/Yunan), İran ve kısmen Hint kültürleriyle temasları sonucunda bu kültürlere karşı büyük bir ilgi ve merak duymuşlardır. Özellikle İskenderiye, Harran ve Cündişâpûr gibi şehirlerin fethedilmesinin ve bu şehirlerdeki ilmî geleneğin Müslümanlar üzerinde önemli etkileri olmuştur. Nitekim bu fetihler akabinde Müslümanlar, sadece dinî ilimlerle yetinmemiş, bunun yanında antik düşünce geleneğini ve kadim kültürleri tanımak amacıyla o kültürlere ait eserleri (...) Arapçaya çevirmek üzere harekete geçmişler, yani ilk tercüme faaliyetlerine başlamışlardır. İslam medeniyeti ve bilim tarihi açısından son derece önemli olan bu ilk tercüme faaliyetleri, bugüne kadar pek çok çalışmaya konu olmuştur. Ancak yapılan çalışmalar sırasında genellikle tercüme yapılan eserlerin isminin, yapıldığı alanların ve bu tercümeleri yapan mütercimlerin zikredilmekle yetinildiği görülmektedir. Bu çalışmada ise İslam Bilim Tarihi’ndeki ilk tercüme faaliyetleri ve yapıldığı alanlar yanında, tercüme faaliyetlerinden önce Müslümanların bu alanlardaki bilgi ve birikimlerinin ne olduğu ve tercüme faaliyetlerinin bu alanlardaki gelişim veya değişime olan katkısı, yazmış olduğu eserler Batı’da da tanınan farklı yüzyıllardaki Müslüman bilim adamlarından örnekler verilmek suretiyle ortaya konulmaya çalışılacaktır. Bu bağlamda Müslümanlar açısından bilim ve teknolojide II. (VIII.) ile V. (XI.) yüzyıllar arasında yaşanan parlak zaman ve bu zaman dilimi içerisinde yapılan bazı önemli bilimsel faaliyetler; bilgiyi elde etme, bilgiyi sistemleştirme ve özgün bilgi üretme dönemi olmak üzere üç ana bölümde incelenecektir.Özet: Bilim, medeniyetin ve insanlık tarihinin en önemli ortak miraslarından biridir. Bu mirasta en çok katkısı olanlar ise yaşadıkları toplumda bilime, bilimsel çalışmalara ve bilim insanlarına gereken önemi gösterenlerdir. İlk emri “Oku” olan bir dinin müntesipleri olan Müslümanlar da, bilime değer veren ve bunun için önemli çalışmalar altına imza atan toplumlar arasında saygın bir yere sahiptir.Ekonomik ilişkiler ve fetihler sonucu çok geniş bir coğrafyaya yayılan ve bunun bir sonucu olarak da birçok farklı kültürle karşılaşan Müslümanlar, özellikle Bizans (Helen/Yunan), İran ve kısmen de Hint kültürleriyle temasları sonucunda bunlara karşı büyük bir ilgi ve merak duymuşlardır. Özellikle İskenderiye, Harran ve Cündişâpûr gibi şehirlerin fethedilmesinin ve bu şehirlerdeki ilmî geleneğin Müslümanlar üzerinde önemli etkileri olmuştur. Nitekim bu fetihler akabinde Müslümanlar, sadece dinî ilimlerle yetinmemiş, bunun yanında antik düşünce geleneğini ve kadim kültürleri tanımak amacıyla o kültürlere ait eserleri Arapçaya çevirmek üzere harekete geçmişler, yani tercüme faaliyetlerine başlamışlardır.İslam medeniyeti ve bilim tarihi açısından son derece önemli gördüğümüz bu çalışmada, tercüme faaliyetlerinin bilgi üretimine katkısı ele alınacaktır. Bu bağlamda Müslümanlar açısından bilim ve teknolojide VIII. ile XI. yüzyıllar arasında yaşanan parlak zaman ve bu zaman dilimi içerisinde yapılan bazı önemli bilimsel faaliyetler; bilgiyi elde etme, bilgiyi sistemleştirme ve özgün bilgi üretme dönemi olmak üzere üç ana bölümde incelenecektir.İslâm dininin iki ana kaynağı olarak kabul ettiğimiz Kur’ân-ı Kerîm ve Hz. Peygamber’in hadisleri ilmi öven ve teşvik eden pek çok emir ve tavsiye içermektedir. Hatta bu ayet ve hadislere göre ilmin ya da bilimin rolü dinin ve böylece de bütün bir insan hayatının asıl itici gücü olarak öne sürülmüştür de diyebiliriz. Bundan dolayı Hz. Muhammed’in peygamber olarak görevlendirilmesiyle Mekke’de başlayan ve Medine’de devam eden ilmî faaliyetler, Hulefâ-i Raşidîn döneminde de artarak devam etmiştir. Özellikle ilk İslâm fetihleri Müslümanların, Bizans ve İran başta olmak üzere pek çok farklı medeniyetle tanışmalarına, bu medeniyetlerin meydana getirmiş olduğu eserlerden faydalanmalarına, Emevîler ve Abbasîler dönemlerinde de yoğun bir tercüme faaliyetine girişmelerine vesile olmuştur. Bu sayede Müslümanlar, dinî ilimler yanında sosyal bilimler, fen ve sağlık bilimleri alanlarında da ilerlemeye başlamışlardır. Bu anlamda Müslümanların ilk yapmaya çalıştığı şey var olan bilgi birikimini tanımaya ve anlamaya çalışmak, sonrasında ise geliştirmek ve dünyanın istifadesine sunmak olmuştur.Araştırmamızda bilgiyi elde etme dönemi olarak adlandırdığımız dönem; İskenderiye, Harran ve Cündişâpûr gibi şehirlerin fethedilmesinin ve ardından bu şehirlerdeki ilmî geleneğin Müslümanlar üzerindeki önemli etkilerinin bir tezahürü olarak ilk tercüme faaliyetlerinin başladığı dönemdir. Bu dönemde bilim nerede olursa olsun gidip alma çabası hakim olup; amaç, bilgiyi üreten, ister Yunan, ister Hint, ister Farisî olsun onu elde etmek ve Arapçaya çevirmektir. Bilgiyi sistemleştirme dönemi ise hem tercüme faaliyetlerinin artarak devam ettiği hem de tercüme faaliyetleri neticesinde elde edilen bilginin sistematik hale getirilmeye başlandığı bir süreçtir. Bu süreçte amaç, bilgiyi üreterek, kullanılabilir hale dönüştürmek ve toplumun hizmetine sunmak olmuştur. Yine bu süreçte, bilim hem takdir ve teşvik edilme ayrıcalığını kazanmış, hem de dönemin yöneticileri ve ilim meraklıları, bilginin ışığıyla tüm sorunların çözülebileceği yaklaşımı içinde olmuşlar ve bu yönde adımlar atmışlardır. Beytülhikmeler ve rasathaneler, bu sürecin birer meyvesi olarak ortaya çıkmış kurumlardır. Bu dönemde yapılan tercümeler Müslümanlar arasında derin bir ilgi ve etki meydana getirerek onların bilgi ve kültürünü zenginleştirmiştir; ancak hiçbir zaman özgün kimliklerini kaybetmelerine sebep olmamıştır. Bilakis Müslüman âlimler, kendilerinden önce yaşamış bilginlerin çalıştıkları farklı alanlarla ilgili eserleri inceleyerek istifade etmişler; fakat hiçbir zaman onları mutlak bir otorite olarak görmeyip, yeri geldiğinde eksik ve yanlışlarını ortaya koymuşlar, sonunda da kendi gözlem, deney ve düşüncelerini ortaya koymak suretiyle özgün eserler üretmişlerdir.Özgün bilgi üretme süreci olarak adlandırdığımız bu dönemde ise, yaşadığı yüzyılda ön plana çıkmış ve sonrasında Avrupa bilim dünyası tarafından da tanınmış bazı ilim adamlarından ve çalışma yaptıkları alanlardan hareket etmek suretiyle dönemin ilmî anlamda nasıl bir gelişmişlik seviyesine ulaştığı ortaya konmaya çalışılacaktır. Söz konusu bu dönem Fezârî (ö. 190/806), Câbir b. Hayyân (ö. 200/815), Hârizmî (ö. 232/847), Fergânî (ö. 247/861), Ali b. Rabben et-Taberî (ö. 247/861), Ebû Bekir Râzî (ö. 313/925), Bettânî (ö. 317/929), Ebü’l-Vefâ Bûzcânî (ö. 388/998), İbn Sînâ (ö. 428/1037), Ali b. Îsâ el-Kehhâl (ö. 430/1039), İbnü’l-Heysem (ö. 432/1040) ve Bîrûnî (ö. 453/1061) gibi bilim adamı ve düşünürlerin zirvede olduğu bir zaman dilimidir. Bu dönemde bir taraftan tercüme faaliyetleri tüm hızıyla devam ederken (VIII.-X. yüzyıllarda) diğer taraftan araştırmalar, kuralları, yöntemleri ve kavramları olan bir niteliğe kavuşmuş ve İslam bilim tarihinin altın çağı yaşanmıştır. Bu dönem içindeki en parlak çalışmalar, matematik, tıp, fizik, kimya ve astronomi alanlarında gerçekleştirilmiş olup üretilen bilgiler, V. ila XI. yüzyıllar arasında skolastiğin koyu karanlığını yaşayan batı dünyası tarafından, ancak yüzyıllar sonra yani XI. yüzyıldan itibaren Arapçadan çeviriler yapılarak tanınabilmiştir. (shrink)

In this study a combination of computer tools for coupling and virtual screening is detailed, in 108 active molecules and 3620 decoys to find stabilizers for G quadruplex. To have more precise results, combinations of coupling programs with fifteen energy scoring functions were applied. The validation and evaluation of the metrics was done with the CompScore genetic algorithm. The results showed an increase in BEDROC and EF of 50% compared to other strategies, as well as reflecting early recognition of active (...) molecules. From these results it is possible to work with the molecules that showed a good early recognition and evaluate their effect as G4 stabilizers. This ensures more efficient and accurate results in the preclinical stage for the development of anticancer drugs. Keywords: Enrichment metrics; telomere; G quadruplex ; CompScore. References [1]M. Porru, P. Zizza, M. Franceschin, C. Leonetti and A. Biroccio. «EMICORON: A multi-targeting G4 ligand with a promising preclinical profile» 2017. Biochimica et Biophysica Acta - General Subjects, 1861, 1362–1370. [Online]. Available: https://doi.org/10.1007/s00294-018-0836-6. [2]K. Tomita. «How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasis». Current Genetics, 64, 1177–1181. 2018. [Online]. Available: https://doi.org/10.1016/j.bbagen. 2016.11.010. [3]M. Jafri, S. Ansari, M. Alqahtani and J. Shay. «Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies. Genome Medicine., 2016. [Online]. Available: https://doi.org/10.3390/ijms19020482. [4]J. Huppert and S. Balasubramanian. «G-quadruplexes in promoters throughout the human genome». 35, 406–413. 2007. [Online]. Available: https://doi.org/10.1016/j.bbapap.2017.06.012. [5]S. Joy, Vijayakumar, S. Choi and H. Sunhye. «Role of computer-aided drug design in modern drug discovery». Archives of Pharmacal Research. 2015. [Online]. Available: https://doi.org/10.1007/s12272-015-0640-5. [6]S. Asamitsu, S. Obata, Z. Yu, T. Bando and H. Sugiyama. «Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy». Molecules, 24, 429. 2019. [En línea]. Available: https://doi.org/10.3390/molecules24030429. [7]R. Monsen and J. Trent. «Biochimie G-quadruplex virtual drug screening : A review». Biochimie, 152, 134–148. 2018. [Online]. Available: https://doi.org/10.1039/c9cc06748e. [8]J. Beauvarlet, P. Bensadoun, E. Darbo, G. Labrunie, E. Richard, I. Draskovic and M. Djavaheri-mergny. «Modulation of the ATM / autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells». 1–18. 2019. [Online]. Available: https://doi.org/10.1093/nar/gkz095. [9].Z. Crees, J. Girard, Z. Rios, G. Botting, K. Harrington and C. Shearrow. « Oligonucleotides and G-quadruplex stabilizers: targeting telomeres and telomerase in cancer therapy».2014. [Online]. Available: https://doi.org/10.2174/1381612820666140630100702. [10].M. Meier, A. Moya-torres, N. Krahn, M. Mcdougall, L. Orriss, E. Mcrae and T. Patel. «Structure and hydrodynamics of a DNA Gquadruplex with a cytosine bulge»., 1–13. 2018. [Online]. Available: https://doi.org/10.1093/nar/gky307. (shrink)

Se presentan en este artículo los resultados que surgieron de incorporar lecciones de Autoconciencia por el Movimiento (ATM) -como estrategia pedagógica- para reconocer y actuar en pro de nuestro ambiente interno y externo, realizado con un grupo interprofesional de mujeres. El grupo se forma e investiga a sí mismo, bajo el enfoque de la Investigación Acción Participativa, y busca comprender mejor los procesos de formación ambiental en los campos de la salud y el ambiente.

This book focuses on informed consent in African Traditional Medicine (ATM). ATM forms a large portion of the healthcare systems in Africa. WHO statistics show that as much as 80% of the population in Africa uses traditional medicine for primary health care. With such a large constituency, it follows that ATM and its practices should receive more attention in bioethics. By comparing the ethics of care approach with the ATM approach to Relational Autonomy In Consent (RAIC), the authors argue that (...) the ATM focus on consent based on consensus constitutes a legitimate informed consent. This book is distinctive insofar as it employs the ethics of care as a hermeneutic to interpret ATM. The analysis examines the ethics of care movement in Western bioethics to explore its relational approach to informed consent. Additionally, this is the first known study that discusses healthcare ethics committees in ATM. (shrink)

I once stood staring at a map in a large US airport, looking for an ATM. Next to me a couple also stared at the map, trying to figure out where in the airport they were. “Sheesh!” said the male at last, pointing to the red dot and the words ‘You are here’ in the key beside the map: “We’re way over here, right off the map!” Jenann Ismael’s understanding of red dots lies very much at the other extreme, but (...) self-location – the task that couple were engaged in, however haplessly – is the unifying theme of The Situated Self. In Ismael’s hands, it is a thread that turns out to tie together a remarkable range of topics. Imagine being taken on a tour of your own home town, weaving in and out through various neighbourhoods, familiar and less so, and ducking between them via surprising paths and shortcuts. (“This next to that? Who knew!”) The Situated Self is that kind of book – an exhilarating and often demanding excursion, startling in its breadth and the ways it relates seemingly unconnected topics. Although the route of Ismael's tour is often highly original, the vehicle itself has a familiar shape, at least in outline. Ismael builds a chassis to specifications due especially to John Perry, fits it out to her own requirements, and then shows us where it can take us. Mostly, I found the excursion convincing, as well as fascinating. In what follows, I shall take up one case in which I was not convinced, and then raise an issue about another destination – somewhere in the same vicinity, apparently – and ask whether Ismael’s bus takes us there, too. First, though, to the fundamentals, as Ismael develops them. (shrink)

Resumen: Algo particular de los estudios de la ciencia, tecnología y sociedad son sus formas de relacionar objetos y prácticas. La relación difiere del papel que tiene en la sociología de la ciencia y en la construcción social de la tecnología. Suele afirmarse en CTS, contradiciendo conocimientos humanistas, que la naturaleza de los actores sociales no estaría definida por adelantado. Asumir lo semiótico como algo excepcional del sujeto humano, donde los objetos sólo acreditan sus agencias a través de procesos simbólicos, (...) sería perder de vista la riqueza empírica de las prácticas colectivas que articulan lo humano y lo no-humano. En cambio, sujetos y objetos suelen pensarse en CTS como efectos sociomateriales reconfigurables de relaciones in situ. La figura del actor-red, la lectura situada de actores material-semióticos, el estudio de objetos frontera y el uso de métodos de ensamblaje son algunas de los virajes en este giro de la teoría de la acción. Aquí voy a delinear un recorrido parcial a través de sus argumentos, introduciendo el debate sobre las divisiones entre naturaleza y cultura, para examinar la noción de agencia con los conceptos de traducción, configuración, multiplicidad y no-coherencia. A modo de ejemplo, termino con una lectura sobre la socialidad y espacialidad de los cajeros automáticos.: Studies of science, technology and society are characteristics in relating objects and practices. The relationship differs from the role it has in the sociology of science and in the social construction of technology. It is usually affirmed in STS, contradicting humanities, that the nature of the social actors would not be defined in advance. Considering that the semiotic is something exceptional of the human subject, where objects only accredit their agencies through symbolic processes, would be to lose sight of the empirical richness of collective practices that articulate the human and the non-human. Instead, subjects and objects are often thought of in STS as reconfigurable sociomaterial effects of in situ relationships. The figure of the actor-network, the situated reading of material-semiotic actors, the study of boundary objects and the use of assembly methods are some of the conceptual turns in this variation of action theory. Here I will delineate a partial route to travel through its arguments, introducing the debate on the divisions of nature and culture, to examine the notion of agency with the concepts of translation, configuration, multiplicity and non-coherence. As an example, I finish with a reading on the sociality and spatiality of ATMs. (shrink)

Dil, düşüncelerin ifade edilmesini, bilgi aktarımını ve sosyal etkileşimi sağlayan temel bir olgudur. Dil eğitimi ise kültürler arası iletişimi kolaylaştıran ve dünya genelinde etkili iletişim kurma becerisi kazandıran bir faaliyettir. Birden fazla dil bilmek, farklı kültürlere ve bakış açılarına açık olmayı sağlar. Yaşadığı dünya düzeni içerisinde çağın gerisinde kalmak istemeyen, uygar ve etkileşimli bir toplum olma niyetini taşıyan Fransa hükümet yetkilileri dil eğitimi konusunda ciddi adımlar atmıştır. 1795 yılında Doğu dilleri üzerine uzmanlaş Inalco’yu kurarak başta Osmanlı olmak üzere İslâm dünyasının (...) konuştuğu dili öğrenen uzmanlar yetiştirmeye başlamıştır. Kuruluşundan itibaren sistemli bir şekilde dil yelpazesini genişleten Inalco, Türkçe, Arapça, Çince, Farsça, Hintçe, Japonca, Korece, Rusça, İbranice ve daha birçok Doğu dilini bünyesine katmıştır. Bu dilleri öğrenen ve konuşan kişiler sayesinde Fransa, Doğuyla olan münasebetini güçlü tutmakta ve burada bulunan devletlerle uzaktan yahut yakından temas içerisinde kalmayı sürdürmektedir. Yaklaşık dört asırlık geçmişiyle Inalco, bir dil eğitimi merkezi olmanın yanında şarkiyat kurumları içerisinde önde gelen, sayısız oryantalist yetiştirip çeşitli sahalarda eserlerin yazılmasına imkân tanıyan bir kurumdur. Kuruluş, misyonuna uygun olarak uzun süre Doğu dilleri ve medeniyetleri üzerine uzmanlaşmış öncü isimleri yetiştirip çalışmalarıyla kültürel etkileşimi teşvik etmiş ve kültürler arası anlayışı geliştirmeye yardımcı olmuştur. Kurumsal tecrübesiyle ilgi alanını hep genişleten Inalco günümüzde neredeyse tüm dünya dilleri ve medeniyetleri üzerine çalışmalarını devam ettirmektedir. Artık dil ve kültür alanındaki uzmanlığı ve köklü geçmişiyle dünya genelinde saygın bir kurum olarak kabul edilmektedir. Inalco’da yetişen dil uzmanları Fransız hükümetinin diplomatik ve ticari ilişkilerinde aktif rol alarak bu konularda yetkililere tercümanlık hizmeti sunmuşlardır. Aynı zamanda uzman oldukları dillerin yeni nesillere öğretilmesinde öğretici pozisyonlarını korumuşlar ve ilişkide oldukları kültürlerin tanınmasında da önemli roller üstlenmişlerdir. Her ne kadar yaptıkları iş şarkiyat hizmeti olsa da Doğu kültürüne ait mirasın gün yüzüne çıkartılmasında, değerlendirilmesinde ve tasnifinde yer alarak bu kültürlere ait ögelerin korunmasında yardımcı unsur olmuşlardır. Silvestre de Sacy, Louis Bazin, Régis Blachère, Louis Massignon vb. birçok Doğu bilimci burada yetişerek hem kendi ülkelerine hem de Doğu kültürüne hizmet etmişlerdir. Ancak akademik ortamda Inalco ve benzeri kurumlar üzerine yeteri kadar çalışmanın olmadığı da bir gerçektir. Dolayısıyla bu çalışmada, Inalco’nun kuruluşu, işleyiş şekli ve faaliyet alanları tanıtıldıktan sonra bir şarkiyat kurumu olarak misyonu üzerinde durulacaktır. Saha araştırması, gözlem, yetkili mercilerden alınan bilgi ve belgelerle oluşturulan çalışmanın alandaki boşluğu dolduracağı düşünülmektedir. Yaklaşık dört asırlık geçmişiyle Inalco, bir dil eğitimi merkezi olmanın yanında şarkiyat kurumları içerisinde önde gelen, sayısız oryantalist yetiştirip çeşitli sahalarda eserlerin yazılmasına imkân tanıyan bir kurumdur. Fiilen 1795 yılında Fransa’da kurulan Inalco kuruluş misyonuna uygun olarak uzun süre Doğu dilleri ve medeniyetleri üzerine uzmanlaşmış öncü isimleri yetiştirmiştir. Uzun süre şarkiyat alanına odaklanan Inalco, Doğu dilleri ve medeniyetleri üzerindeki çalışmalarıyla kültürel etkileşimi teşvik etmiş ve kültürler arası anlayışı geliştirmeye yardımcı olmuştur. Kurumsal tecrübesiyle ilgi alanını hep genişleten Inalco günümüzde neredeyse tüm dünya dilleri ve medeniyetleri üzerine çalışmalarını devam ettirmektedir. Artık dil ve kültür alanındaki uzmanlığı ve köklü geçmişiyle dünya genelinde saygın bir kurum olarak kabul edilmektedir. Ancak akademik ortamda Inalco ve benzeri kurumlar üzerine yeteri kadar çalışmanın olmadığı da bir gerçektir. Dolayısıyla bu çalışmada, Inalco’nun kuruluşu, işleyiş şekli ve faaliyet alanları tanıtıldıktan sonra bir şarkiyat kurumu olarak misyonu üzerinde durulacaktır. Saha araştırması, gözlem, yetkili mercilerden alınan bilgi ve belgelerle oluşturulan çalışmanın alandaki boşluğu dolduracağı düşünülmektedir. (shrink)

Anlambilimsel bileşimsellik ilkesi, herhangi bir ifadenin anlamının o ifadenin parçalarının anlamlarının bir fonksiyonu olduğunu bildirmektedir. İlke Gottlob Frege’nin dilsel anlamı fonksiyon argüman uygulaması olarak ele alan çalışmalarına dayanmaktadır. Bileşimselliğin, Richard Montague ile birlikte biçimsel anlambilim içerisinde merkezi bir rol aldığı görülmektedir. Bileşimsellik ilkesi, dilsel yapı ve anlamsal yapı arasında homomorfik bir ilişki bulunduğunu bildirmektedir. İlkenin savunucuları bileşimselliğin dilin sistematik ve üretken yapısına önemli katkılar sağladığını iddia etmektedirler. Wlodek Zadrozny, bu görüşe karşı olarak, bileşimselliğin dilin sistematik yapısına herhangi bir katkı sağlamadığını (...) iddia etmektedir. Zadrozny, iddiasını temellendirmek için, herhangi bir anlambilimsel yapının bileşimsel olarak kodlanabileceğini gösteren bir ispat ortaya atmıştır. Zadrozny herhangi bir anlambilimsel yapı için böyle bir anlam fonksiyonunun var olduğunu ise Peter Aczel’in iyi-yapılanmamış kümeler kuramına dayandırmaktadır. Çözüm Lemması bize böyle bir anlam fonksiyonunun var olduğunu bildirmektedir. Zadrozny’nin iddiasına karşı önemli bir itiraz bulunmaktadır. Elde edilen anlamsal yapının asıl anlamsal yapıyı kodlamak için yeterli olmadığı iddia edilmektedir. Bu iddianın temelinde eş anlamlılık olgusu bulunmaktadır. Eş anlamlı ifadelerin yer değiştirme ilkesine uymadığı, bileşimsel olmayan anlambilimsel yapıların elde edilen bileşimsel yapılar tarafından temsil edilemeyeceği iddia edilmektedir. Bu çalışmada, Zadrozny’nin ispatı incelenerek, eş anlamlılık üzerinden yapılan itiraz cevaplandırılmaktadır. İtirazın konusu olan eş anlamlılığın, anlambilimsel olarak korunması gereken bir özellik olmadığı iddia edilmektedir. (shrink)

In response to DNA‐damage, cells have to decide between different cell fate programmes. Activation of the tumour suppressor HIPK2 specifies the DNA damage response (DDR) and tips the cell fate balance towards an apoptotic response. HIPK2 is activated by the checkpoint kinase ATM, and triggers apoptosis through regulatory phosphorylation of a set of cellular key molecules including the tumour suppressor p53 and the anti‐apoptotic corepressor CtBP. Recent work has identified HIPK2 as a regulator of the ultimate step in cytokinesis: the (...) abscission of the mother and daughter cells. Since proper cytokinesis is essential for genome stability and maintenance of correct ploidy, this finding sheds new light on the tumour suppressor function of HIPK2. Here we highlight the molecular mechanisms coordinating HIPK2 function and discuss its emerging role as a tumour suppressor. (shrink)

Imagine this scenario: a bank customer walks up to an ATM to withdraw cash from her account. While entering her PIN, she accidentally presses the '3' key at the same time as the 'Clear' key. Instantly $100 comes out of the cash dispenser! Curious, she checks the receipt and seeing that the money did not from her account, she tries the same operation. Again, $100 comes out of the cash dispenser. At this point she has two options, A: she can (...) continue to take advantage of this obvious flaw and tell her friends, or B: she can report this problem to the bank, telling no one else. While Kantian ethics might require the latter, the issue becomes much grayer when it comes to computer software vulnerabilities. Many variables exist to cloud the ethical judgment of a software flaw's discoverer. The question becomes: is it better to report any vulnerability that could cause catastrophic problems or to make the vulnerability information public in order to simultaneously compel the software vendor to address the problem while giving the vendor's customers a chance to prepare for potential exploitation? Software companies are facing this dilemma on a regular basis. There are dozens of websites, newsgroups, and e-mail lists dedicated to the task of sharing vulnerability information, whether condoned by the software company or not. The issue increases in severity as vulnerable software becomes ubiquitous across global networks. The public release of vulnerability information is often the first drop of the monsoon that is the malicious network worm. How this information is controlled and disseminated is critical to the stable operation of millions of computer systems and networks across the globe.Modern software with network capability is fundamentally complex and can span thousands of lines of source code for one small part of the package. Without proper testing and quality assurance, many bugs and errors slip through. Software development requires these iterations of coding and bug fixing to produce stable and polished final products. Larger and more complex software gives a greater chance for a bug to remain undiscovered. Yet, since major vulnerabilities have appeared in relatively smaller projects, proper code audit and testing are critical regardless of the size of a software package or the amount of source code required to produce it. If bugs or security vulnerabilities are not discovered and fixed by the software manufacturers, it is inevitable that they will be discovered by outside researchers.This breeds the ethical conundrum of what the researchers do with the information once it has been discovered. Foundational to disclosure, regardless of the ideology, is the notion of providing useful protective information to the most appropriate audience. Many suggest that disclosure is about doing the 'greatest good' for the greatest number of people, which is an obvious adherence to the ethical principle of Utilitarianism. There are numerous parties involved in the network security process such as software vendor, security researcher, system administrator, and even malicious attacker: all whose intentions reflect on the ethical principles behind their actions. (shrink)

DNA double‐strand breaks (DSBs) are one of the most deleterious forms of DNA damage and can result in cell inviability or chromosomal aberrations. The Mre11‐Rad50‐Nbs1 (MRN) ATPase‐nuclease complex is a central player in the cellular response to DSBs and is implicated in the sensing and nucleolytic processing of DSBs, as well as in DSB signaling by activating the cell cycle checkpoint kinase ATM. ATP binding to Rad50 switches MRN from an open state with exposed Mre11 nuclease sites to a closed (...) state with partially buried nuclease sites. The functional meaning of this switch remained unclear. A new study shows that ATP binding to Rad50 promotes DSB recognition, tethering, and ATM activation, while ATP hydrolysis opens the nuclease active sites to promote processing of DSBs. MRN thus emerges as functional switch that may coordinate the temporal transition from signaling to processing of DSBs. (shrink)

In das paper 1 ccmstder the rehabday condaton in Atm PlanungaS's proper functionabst account of eptstemtc warrant I begm by reviewing m some detail the features of the rehabdity condition as Planunga lias aruculated a From there, 1 consider what is needed to ground or secure the sort of rehability whzch Plantinga has m mind, and argue that what is needed is a significant causai condam which has generally been overlooked Then, after identifying eight verstons of the relevant sort of (...) reltabdity, I exam me each alternative as to whether as requirement, along with PlanungaSs other proposed conditions, would give us a sausfactory account of epis tenuc warrant I conclude that there is bale to no hope of formulatmg a rehabilay condaion that would yield a sattsfactory analysts of the sort Plantinga destres. (shrink)

Together, DNA repair and checkpoint responses ensure the integrity of the genome. Coordination of cell cycle checkpoints and DNA repair are especially important following genotoxic radiation or chemotherapy, during which unusually high loads of DNA damage are sustained. In mammalian cells, the checkpoint kinase, Cds1 (also known as Chk2) is activated by ATM in response to DNA damage. The role of Cds1 as a checkpoint kinase depends on its ability to phosphorylate cell cycle regulators such p53, Cdc25 and Brca1. A (...) role for Cds1 in repair is suggested by the finding that it interacts with the Holliday junction resolving activity Mus81. This review focuses on the many questions generated by recent progress in understanding the function and regulation of human Cds1. BioEssays 24:502–511, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

As recently as six years ago, three human diseases with similar phenotypes were mistakenly believed to be caused by a single genetic defect. The three diseases, Ataxia-telangiectasia, Nijmegen breakage syndrome, and an AT-like disorder are now known, however, to have defects in three separate genes: ATM, NBS1, and MRE11. Furthermore, new recent studies have shown now that all three gene products interact; the ATM kinase phosphorylates NBS1,1 which, in turn, associates with MRE11 to regulate DNA repair. Remarkably or expectedly, depending (...) on one's point of view, the similarity in disease phenotypes is evidently due to defects in a common DNA repair pathway. BioEssays 22:966–969, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

According to the widespread use of Web Services, composition of multiple services is becoming a main issue. BPEL was proposed as a Web Services workflow language in this context. Then, in many cases we need much interactions between a service requester and a BPEL process execution engine. However for the end user under the ubiquitous environment where the service is executed with a cellular phone or PDA, the interaction means simply a burden. The reason is: (1)it is hard to carry (...) out the operation manually, (2)a network connection is unstable, (3)a connection charge is relatively high. In this paper, we propose middle agents between ubiquitous users and Web Services. The agents analyze BPEL, extract the interaction which the ubiquitous users would need, then produce action operators. It makes a plan in order to achieve a service request from the user. Here the planning agent can reduce operations of the user by collecting the necessary information at the beginning which will be inputted during the IP execution. We show the architecture of the agents and an example regarding ATM service, then evaluate the number of inputs, the performance, and the quantity of data transmitted on network. Finally, we consider adaptability of this approach to generic BPEL flow. (shrink)

Driving licenses, identity cards, passports, boarding passes, credit cards, ATM cards – all of these are examples of credentials. Credentials are documents that play a fundamental role in all modern societies. However, philosophers and social ontologists have not yet addressed the analysis of their nature and function. This paper aims to fill this gap through a review of the essential characteristics of credentials, as documents whose primary purpose is to certify the identity and institutional status of the bearer, for example (...) as being the bearer of specific rights. However, credentials also allow their holders the concrete exercise of their rights, as when exercising a right concretely (e.g., crossing a border) requires the possession of a particular credential. The authors distinguish the different types of credentials and describe their functions and the various kinds of acts that are performable with their aid. (shrink)

Infinite machines (IMs) can do supertasks. A supertask is an infinite series of operations done in some finite time. Whether or not our universe contains any IMs, they are worthy of study as upper bounds on finite machines. We introduce IMs and describe some of their physical and psychological aspects. An accelerating Turing machine (an ATM) is a Turing machine that performs every next operation twice as fast. It can carry out infinitely many operations in finite time. Many ATMs can (...) be connected together to form networks of infinitely powerful agents. A network of ATMs can also be thought of as the control system for an infinitely complex robot. We describe a robot with a dense network of ATMs for its retinas, its brain, and its motor controllers. Such a robot can perform psychological supertasks - it can perceive infinitely detailed objects in all their detail; it can formulate infinite plans; it can make infinitely precise movements. An endless hierarchy of IMs might realize a deep notion of intelligent computing everywhere. (shrink)

Computer-facilitated self-service technologies have become ubiquitous in today’s consumer-focused world. Yet, few human–computer interactions elicit such dramatically polarizing emotional reactions from users as those involving SSTs. ATMs, pay-at-the-pump gas stations, and self-scanning retail registers tend to produce both passionate supporters and critics. While negative comments often center on unpleasant personal user experiences, the actual “abuse” related to such systems is really much deeper and more complex. SSTs carry with them a number of potentially insidious consequences, including the exploitation of consumers (...) as uncompensated temporary workers; the sacrifice of our inherent humanity to delegate both skills and cognition to electronic helpers; and the enabling of a new type of posthuman consumer identity, where each transaction is completed by a cyborg entity constructed of the human on one side and the electronic mechanism on the other. As a result, we may ultimately lose the boundary between the human and the machine. (shrink)

Computer-facilitated self-service technologies have become ubiquitous in today’s consumer-focused world. Yet, few human–computer interactions elicit such dramatically polarizing emotional reactions from users as those involving SSTs. ATMs, pay-at-the-pump gas stations, and self-scanning retail registers tend to produce both passionate supporters and critics. While negative comments often center on unpleasant personal user experiences, the actual “abuse” related to such systems is really much deeper and more complex. SSTs carry with them a number of potentially insidious consequences, including the exploitation of consumers (...) as uncompensated temporary workers; the sacrifice of our inherent humanity to delegate both skills and cognition to electronic helpers; and the enabling of a new type of posthuman consumer identity, where each transaction is completed by a cyborg entity constructed of the human on one side and the electronic mechanism on the other. As a result, we may ultimately lose the boundary between the human and the machine. (shrink)

Computer-facilitated self-service technologies have become ubiquitous in today’s consumer-focused world. Yet, few human–computer interactions elicit such dramatically polarizing emotional reactions from users as those involving SSTs. ATMs, pay-at-the-pump gas stations, and self-scanning retail registers tend to produce both passionate supporters and critics. While negative comments often center on unpleasant personal user experiences, the actual “abuse” related to such systems is really much deeper and more complex. SSTs carry with them a number of potentially insidious consequences, including the exploitation of consumers (...) as uncompensated temporary workers; the sacrifice of our inherent humanity to delegate both skills and cognition to electronic helpers; and the enabling of a new type of posthuman consumer identity, where each transaction is completed by a cyborg entity constructed of the human on one side and the electronic mechanism on the other. As a result, we may ultimately lose the boundary between the human and the machine. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 21.1 (2001) 109-111 [Access article in PDF] Seventh International Buddhist-Christian Conference David W.Chappell Soka University of America Pack your bags! The annual meeting of the Society for Buddhist-Christian Studies in Nashville decided that the next international conference will be held August 5-12, 2003, in Chiang Mai, Thailand.An invitation was extended to the society by Dr. John Butt, director of the Institute for the Study of Religion and (...) Culture (ISRC), and by the president of Payap University, Dr. Boonthong Poocharoen. As a Presbyterian faculty member of the McGilvary Faculty of Theology, John has extensive interreligious experience in Thailand and participated in the society's last international conference held in Tacoma, Washington, in August 2000.The institute's associate director, Professor Saeng Chandrangam, is a former Buddhist monk and is one of Thailand's most highly respected Buddhist laymen. He was Chair of the Department of Oriental Studies and the Department of Modern Languages and was Dean of Humanities of the government's Chiang Mai University, where he taught philosophy and theology. Currently he teaches at a Buddhist university in Chiang Mai as well as serving as the associate director ofISRC. Also, Donald Swearer, who has been active with the society since the first international conference in 1980, will be in residence in Chiang Mai in the springs of 2002 and 2003 and can help plan the conference.Payap University was founded in 1974 by the Church of Christ in Thailand, a consortium ofThai Christian congregations begun by Presbyterian, American Baptist, and Disciples missionaries. However, about 95 percent of Payap University's nine thousand students are Buddhist since Chiang Mai is centrally located in the Burmese-Thai axis with the heaviest concentration of Buddhists in the world. As a result, the conference will be set in a context of Protestant missions within a Theravadin Buddhist culture. This setting will increase the presence of conservative and evangelical Christians, as well as Theravadin Buddhists, to serve as an important balance to the already strong Mahayana and Catholic dialogue leaders in our international conferences. John wrote that "Holding the next conference here would demonstrate that there are other forms of Christian faith quite different from that represented by the evangelical missionaries" and that there are other ways of understanding and approaching other different religious communities. Accordingly, a possible theme [End Page 109] might be "Rethinking Mission Motivation and Practice (both Buddhist and Christian) for the Twenty-first Century."Chiang Mai is a city of a population of about three hundred thousand that preserves much of the charm of traditional Thai culture, while also having modern conveniences like Western fast foods and ATMs, but has not yet succumbed to the congestion of Bangkok. Its weather should be in the eighties or nineties and its hotels are inexpensive (about twenty-five dollars per day for two). The meetings at Payap University will be in air-conditioned rooms in a picturesque setting. Payap has three campuses and is affiliated with the McCormick Hospital. It offers twenty-four undergraduate degrees, as well as master's degrees in divinity, linguistics, business administration, international business, Teaching English as a Foreign Language, philosophy, and Christianity.Payap University can draw on considerable experience for hosting foreign programs. The vice president for external affairs, Martha Butt (wife of John), heads a committee that has planned, developed, and operated the in-country segments of all the Thai Elderhostel programs involving over three thousand participants. Also, they will be joined by faculty members from Mahidol, Chulalongkorn, and Thammasat Universities, including Dr. Parichart Suwanbubbha of Mahidol University, a Thai Buddhist (with a degree from Chicago comparing the concepts of karma and grace), who attended the Tacoma conference in 2000.ISRC is located on the Crystal Spring campus of Payap University and was founded in 1996 to serve as a research and study center for scholars and others interested in the comparative study of religion and culture. The institute's primary goal is to provide and nurture a broad ecumenical religious vision for the people ofThailand and Southeast Asia and for others visiting or working... (shrink)

Dysregulation of genes that control cell‐cycle progression and DNA repair is a hallmark of tumorigenesis. It is becoming increasingly apparent, however, that these defects also contribute to degeneration of post‐mitotic neurons under certain conditions. The gene for ataxia‐telangiectasia mutated (ATM) is a prototype for this dual mechanism of action, with loss‐of‐function mutations causing not only selective degeneration of cerebellar neurons but also increased susceptibility to breast cancer and hematologic malignancy. Increased dosage of amyloid precursor protein in Down syndrome (trisomy 21) (...) predisposes to dementia of Alzheimer type and may also contribute to acute leukemia and transient myeloproliferative disorder. The gene parkin, loss‐of‐function mutations in which account for about half of cases of early‐onset Parkinson disease, has been identified as a candidate tumor suppressor gene by several groups. Parkin is deleted or downregulated in several tumor types, and its re‐expression sensitizes derivative cell lines to inhibitors of cell‐cycle progression. The overlap of molecular pathways implicated in cancer and neurodegeneration challenges long‐held notions about differentiated cellular states and may open the door to novel therapeutic approaches to both groups of disorders. BioEssays 30:719–727, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Zakat is a monetary form of religious worship that establishes a bridge between a rich and a poor, helps those who are in need and contributes to peace and tranquillity within a society. When zakat is collected properly under a government control and transmitted to those who deserve, it helped to decrease the gap between the poor and the rich, supported activities of social solidarity and revived the economy as well. Malaysia after its independence in 1957 has developed an interest (...) in Islamic practices by drawing attention to a distinctive practice with the public zakat system. Even though a national- central system of zakat could not be established due to the federal structure of the country, the collection and distribution of zakat has been centralized on a state level. Parts of the practice are being criticized, reviewed and new regulations are introduced. Unlike Malaysia, the zakat practice in Turkey is out of state control, thus it hinders zakat from achieving its real purpose. There is a need to make use of the well-functioning zakat systems around the world and establish a public zakat system in our country so that we can make the most of the benefits that zakat has for individuals and societies. This article aims to be a step in that direction. -/- SUMMARY Zakat is one of the main forms of worship and is at the same time one of the main sources for the state budget in Islam. It aims at making sure that the rich –those with higher wealth and income– protects the poor and the powerless and through this it contributes to the peace in the society. In the Islamic creed wealth in reality belongs to Allah; therefore, those who live an affluent life should not attribute their wealth to themselves alone and help those who, for whatever reason, are unable to meet their needs. Because there is a social dimension to this form of worship, it is the duty of the head of state to collect the zakat and distribute it to the right people. Historically this duty has taken different forms and today, many Muslim countries sustain this collection and redistribution under state supervision. Malaysia is a country where zakat is collected and distributed officially at the state level. In each state, there is an Islamic council responsible for taking care of activities related to Islam and is semi-independent from the government that organizes the zakat process. Some of these do the collection and distribution together, some do it separately. In some states, the process has been totally privatized. Constitutionally, each state is dependent on its own sultan in religious affairs, thus each has its own mufti and partially different zakat practices and eac collect and distributes its zakat within that state. Because religious affairs have been codified as the privilege of the sultans of each state in the constitution during Malaysia’s foundation, there is no attempt at centralizing religious affairs and a centralization of zakat practices; the establishment of an institution to achieve this is not possible. Moreover, the secular character of the federation does not seem yet compatible with making zakat obligatory. However, due to the dominant Shafi‘i tradition and the convention in the country, people see it as imperative to hand over the charity and tithe to state institutions. Furthermore, there are local fatwas – which are considered as legal regulations in Malaysia – that require people with an income over a certain amount to pay zakat. Those who have the most are expected to give it voluntarily. In the 19th century, when wealth sources such as palm oil, cacao, rubber, tin were discovered, Malaysian officials were not able to extend the tithe to these; however, in the last twenty-five years, based on fatwas that income should be taxable under zakat has led to a boom in zakat. In all states, the largest portion of zakat is collected through income, usually automatically deducted from payroll. An influential factor in this outcome is that individually paid zakat can be deducted from income tax. From 2005 on, there have been other regulations to make it possible for legal personalities to deduct zakat from taxes. To increase zakat payment, especially publications have been produced to inform and encourage people, and modern opportunities to make payment easy have been developed. The most often used method is direct deduction from payroll. The second most common method is payment through zakat machines in different parts of the city by cash, check, Islamic credit card and, debit card. In addition to these, online, internet banking, telephone banking, ATM machines, post offices, kiosk machines, sms-zakat options are all available. The distribution of zakat differs from year to year and state to state. In general, there is an observable effort to pay all groups from zakat, but because there are no slaves in some states no payment is done under this category. There are both direct transfers and indirect transfers, such as through the construction of houses for poor people. There have been cases where poor people who had projects were supported with funds and those later returned in zakat. There is support for students in terms of scholarships through fuqarā’, fī sabīl allāh and ibn al-sabīl classes. For the muallafa al-qulūb class, there is a foundation to encourage local people to convert to Islam and help them for food, shelter, clothes and education. For Muslims who suffer as minorities in other countries help is provided through the riqāb, muallafa al-qulūb, fī sabīl allāh and ibn al-sabīl classes. In the ghārimīn class, especially victims of natural disasters such as flood and earthquake are supported. For those who have a right to receive zakat be able to receive it, the state has to side with the powerless and help zakat fulfill its social and individual functions. The way zakat is spent requires state policy and will. For this reason, zakat should be institutionalized and all activities should be organized by a single institution with state power behind it. Determining the recipients and the zakat-payers, and using the funds efficiently is easier with the coordination of state institutions. Extensive zakat councils that include state institutions should consider the ijtihāds in the area of zakat anew and make decisions to create a just and consistent zakat system. For these decisions to be applicable, the question of what kind of a system could be founded in our country should be on the agenda in these councils. Once an institution – official or autonomous but with state power behind it- is created, solutions can be found as they arise in the way. (shrink)

Türk ve İslam tarihinin kırılma noktalarından birisi 1040 yılında Selçuklular ile Gazneliler arasında cereyan eden Dandanakan Savaşı’dır. Savaşın ardından Selçuklular hızlı bir yükselişle özellikle Sünnî İslam coğrafyasında etkin ve belirleyici güç haline gelmiştir. Göçebe kültürden gelen ve bir oba hüviyetinde iken çok kısa bir sürede önlenemez bir şekilde hâkimiyet alanını Türkistan coğrafyasından Anadolu içlerine kadar genişleten Büyük Selçuklu Devleti, kurumsal olarak da olgunlaşmaya başlamıştır. Bu noktada hem merkezi yönetimde hem de vilayetlerde ortaya çıkan yetişmiş eleman ihtiyacını birçoğu daha önce Gazneli (...) devlet teşkilatında görev yapmış Fars asıllı devlet adamları karşılamıştır. Bu isimlerden birisi de ileride Nizâmülmülk adıyla şöhret bulacak ve namı isminin önüne geçecek olan Hasan b. Alî b. İshâk et-Tûsî’dir. Nizâmülmülk, devlet gücünün askeri alanda elde edilen zaferlere endekslendiği bir dönemde askerî, idarî, ilmî ve ekonomik alanda attığı adımlar ve aldığı tedbirlerle Büyük Selçuklu Devleti’nin kurumsallaşmasında son derece etkin bir isim olmuştur. Bu etkinlik neticesinde hem halk hem de devlet adamları nezdinde saygın bir yer edinmiştir. Bu çalışma çerçevesinde Nizâmülmülk’ün devlet bürokrasisi içerisindeki konumuna, hükümdar ve hanedan üyeleri ile olan ilişkilerine ve vezirlik sürecinde attığı adımların Selçuklu tarihine yansımalarına değinilecektir. Özet: Devlet kademesinde görev almaya Gazneliler Devleti’nin Horasan Valisi Ebü’l-Fazl Sûrî’nin yanında başlayan Nizâmülmülk, Horasan Bölgesi’nin Selçukluların kontrolüne geçmesiyle birlikte hizmetlerine Selçuklu Devleti’nde devam etmiştir. Çağrı Bey’in hizmetinde rüştünü ispat eden Nizâmülmülk, Çağrı Bey’in en güvendiği isimlerden biri haline gelmiştir. Öyle ki, Çağrı Bey ileride önce Horasan’ın sonrasında tüm Selçuklu yurdunun yönetimini üstlenecek olan oğlu Alparslan’ı Nizâmülmülk’e emanet etmiş, oğluna da Nizâmülmülk’ü bir baba olarak kabul etmesini, ona muhalefet etmemesini öğütlemiştir. Alparslan, babasının tavsiyeleri ve üvey kardeşi Süleyman ile giriştiği taht mücadelesinde gösterdiği yararlılık münasebetiyle devletin en önemli idari görevi olan vezirlik makamını Nizâmülmülk’e tevdi etmiştir. Bu dönemden itibaren vefatına kadar, yaklaşık 30 yıl kesintisiz bir süreyle Büyük Selçuklu Devleti’nin vezirliğini yapmış ve V./XI. yy.’ın ikinci yarısından itibaren Büyük Selçuklu siyasetinin en etkin figürü haline gelmiştir. Melikşah’ın tahta geçebilmesinin Nizâmülmülk ile ilişkilendirilmesi, onun döneminde elde edilen başarıların ve devlet sisteminin düzenlenmesi, şehirlerin imarı, ekonominin güçlenmesi gibi ülke içerisinde yaşanan olumlu gelişmelerin Nizâmülmülk’ün marifetiyle gerçekleştirildiğinin dillendirilmesi, Tanrı tarafından yeryüzünü yönetmek ve inşa etmek için seçildiği düşünülen bir sultan varken bir vezirin devlet için nimet olarak gösterilmesi sultanın vezirine bakışını etkilemiştir. Bu noktada üzerinde durulması gereken hususlardan birisi de Nizâmülmülk’ün kendisini nasıl gördüğü ve devlet içerisinde kendini nerede konumlandırdığıdır. Nizâmülmülk’ün Sultan Melikşah’a verdiği bir cevapta devletin geldiği noktayı ve sultanın mevcudiyetini kendi varlığıyla eşleştirmesi, tarihinin gördüğü en yetenekli vezirlerden biri olan Nizâmülmülk’ün özgüveninin son derece yüksek ve kendisini kudret sahibi olarak gördüğüne işaret etmektedir. Bu anlamlandırma halk nezdinde herhangi bir kutsiyeti bulunmayan vezirlik makamındaki bir kişinin, toplum nezdinde Allah tarafından seçildiğine inanılan kutlu kişiye meydan okutan gücü kendisinde hissetmesinin kaynağını sorgulatmaktadır. Aranan cevap Nizâmülmülk’ün vezirlik sürecinin çeşitli başlıklar altında ve bu başlıklara dair verilecek örneklerle incelenmesi neticesinde onun devletin iç işleyişine etkisinin tespitinde ve farklı kesimlerle kurduğu ilişkide saklıdır. Nizâmülmülk, Selçuklu tahtına karşı sıkı bir bağlılık göstermiştir. Bu bağlılığını lüzumu halinde savaş meydanında göğüs göğüse çarpışarak sergilemiş, gerekli olduğunda kıvrak zekâsı ile sorunları devlet için tehlikeli boyuta gelmeden çözmüş, siyasi öngörüsü ile aldığı tedbirler sayesinde devletin büyümesine katkı sağlamıştır. Onun bu sadakati ve samimiyeti, Selçuklu sultanları tarafından karşılık bırakılmamış, Alparslan vezirinin fikirlerine büyük önem verip tercihlerini bu doğrultuda şekillendirirken, aleyhine söylenen sözlerin hiçbirine kulak asmamıştır. Melikşah da, bir anlamda kendisine Selçuklu tahtını veren Nizâmülmülk’e gerekli hürmeti göstererek bütün devlet işlerinin yürütülmesini ona tevdi etmiş ve kendisini bir “baba” gibi gördüğünü ifade etmiştir. İlaveten Selçuklu tarihinde bir ilk olmak üzere Melikşah, Nizâmülmülk’e atabeg (el-emîrü’l-vâlid) unvanını vermiştir. Melikşah, Büyük Selçuklu tahtındaki ilk yıllarını, gençliğin etkisiyle, polo oynayıp, büyük av partileri düzenlemekle geçirmiş ve bundan dolayı devlet içerisinde bütün güç Nizâmülmülk’ün eline geçmiştir. Ortaya çıkan bu durum da “ülke resmen ve ismen sultanın olmakla birlikte gerçekte ‘Nizam’ına kavuştu.” ifadesiyle açıklanmıştır. Ayrıca Melikşah’ın saltanatı döneminde elde edilen askerî, siyasî ve ekonomik başarılar Nizâmülmülk’ün yeteneği ve devlet işlerinde attığı adımlara bağlanmıştır. Nizâmülmülk, hanedan ile kurduğu ilişkinin yanı sıra devlet kademesinde görev alan farklı zümrelerle de güven üzerine dayalı yakın bir ilişki biçimi geliştirmiştir. Örneğin, Nizâmülmülk’ün katıldığı askerî seferlerde bir nefer gibi askerlerin içerisinde savaşa katılması ordu içerisinde kendisine saygı duyulmasına yol açmıştır. Ayrıca, Melikşah ile Kirman Hâkimi Kavurd Bey arasındaki taht mücadelesinde Melikşah’ın safında yer almakla birlikte Kavurd Bey’i destekleyen bazı isimlerin yazdıkları destek mektuplarının ortaya çıkmasına engel olarak hem emirlerin korkularını yatıştırırmış hem de itibarını artırmıştır. Nizâmülmülk’ün yakın ilişki içerisinde olduğu bir diğer grup ilmiye sınıfı olmuştur. Bilge vezir, Tuğrul Bey döneminde Amidülmülk Kündürî tarafından takibata uğrayan ve baskılara maruz kalan ilim adamlarının yurtlarına dönebilmelerine imkân sağlamıştır. Bu ilim adamları da yurtlarına dönüşlerini sağlayan isme zihinlerinde ve gönüllerinde her zaman özel bir yer ayırmışlardır. Birçok âlimin çalışmalarını Nizâmülmülk’e ithaf etmesi, diğer saiklerle birlikte, bunun bir göstergesidir. Nizâmülmülk bir adım daha atarak, Sultan Alparslan ve Melikşah’ın müsaadeleriyle, bu ilim adamları için hâkim olunan coğrafyanın her tarafında ilimle iştigal edebilecekleri medreseler inşa etmiştir. Nizâmülmülk’ün adına nispetle Nizamiye Medreseleri olarak isimlendirilen bu medreselerde hem eğitim-öğretim kadrosuna hem de öğrenim süresi boyunca ve de mezun olduktan sonra öğrencilere sunulan imkânlar, insanların medreselere olan ilgisini arttırıyordu. Medreseler eliyle bir taraftan önceki dönemde yerlerinden edilen ve baskıya maruz kalan ilim adamlarına bir borç ödenip iade-i itibar sağlanırken diğer taraftan da Büyük Selçuklu Devleti’nin idari ve adli sisteminin ihtiyaç duyduğu yetişmiş insan gücü inşa edilmiştir. Nizâmülmülk, toplum lehine attığı adımlar ve sorunların çözümüne verdiği önem ile halkın desteğini sağlamıştır. Öyle ki insanların hayatları boyunca ona minnettar kaldığı vurgulanmıştır. Nizâmülmülk halkın sorunlarının çözümüne önem göstermiş ve onlarla yakından ilgilenmiştir. Nizâmülmülk’ün verdiği güven duygusu halkın hoşuna gitmiş ve toplum içerisinde kabul görmesine vesile olmuştur. Nizâmülmülk’ün bir diğer hasleti de fakirlere sofrasını açmasıdır. Böylece onlarla diyalog kurmuş ve gönüllerini kazanmıştır. Her yönüyle eksiksiz bir devlet adamı olan Nizâmülmülk, toplumun her türlü ihtiyacının çözümünü düşünmüş ve bu yönde adımlar atmıştır. Nizâmülmülk’ün toplumun her kesimi ile kurduğu samimi ve yakın ilişki o kadar büyük bir takdir ve beğeni toplamıştır ki bu durum Nizâmülmülk’ün toplum nezdinde sultan itibarı görmesine sebep olmuştur. İlaveten Selçuklu coğrafyasının her yerinden ve toplumun her kesiminden insanın kendisine yönelmesi hasebiyle Kâbe’ye benzetilmiştir. Nizâmülmülk, devlet kademesinde görev alan aile bireyleri, ilişki içerisinde olduğu âlimler, kendi ordusu ve emirleri ile bir güç odağı haline gelmiştir. Bunun sonucunda Nizâmülmülk, 11. yüzyılın son çeyreğinde rakipsiz bir şekilde Büyük Selçuklu siyasetinin en etkin figürü, Selçuklu yönetimini ve politikalarını belirleyen isim ve Selçuklu tarihinin en önemli olaylarında karar mercii olmuş ve sonuçta Selçuklu tarihine damga vurmuştur. İbnü’l-Esîr, Fatımî veziri Bedr el-Cemalî’nin kendisi için kullandığı sayısız lakabı kaydettikten sonra sadece Mısır’a hâkim olan bir devletin veziri bu kadar lakap kullanıyorsa Nizâmülmülk’ün “ilah”lık iddiasında bulunması gerekirdi diyerek hem Selçuklunun azametini hem de Selçuklu devletinde Nizâmülmülk’ün yerini göstermektedir. (shrink)

In the selection of job candidates who have the mental ability to become professional ATCOs, psychometric testing has been a ubiquitous activity in the ATM domain. To contribute to psychometric research in the ATM domain, we investigated the extent to which spatial orientation ability (SOA), as conceptualized in the spatial cognition and navigation literature, predicted air traffic conflict detection performance in a simulated free route airspace (FRA) environment. The implementation of free route airspace (FRA) over the past few years, notably (...) in Europe, have facilitated air traffic services by giving greater flexibility to aviation operators in planning and choosing preferred air routes that can lead to quicker arrivals. FRA offers enhanced system safety and efficiency, but these benefits can be outweighed by the introduction of air traffic conflicts that are geometrically more complex. Such conflicts can arise from increased number and distribution of conflict points, as well as from elevated uncertainty in aircraft maneuvering (for instance, during heading changes). Overall, these issues will make conflict detection more challenging for air traffic controllers (ATCOs). Consequently, there is a need to select ATCOs with suitably high levels of spatial orientation ability (SOA) to ensure flight safety under FRA implementation. In this study, we tested 20 participants who are eligible for ATCO job application, and found that response time-based performance on a newly developed, open access, computerized spatial orientation test (SOT) predicted time to loss of minimum separation (tLMS) performance on an air traffic conflict detection task (AT-CDT) we designed. We found this predictive relationship to be significant to a moderately large extent under scenarios with high air traffic density (raw regression coefficient = 0.58). Moreover, we demonstrated our AT-CDT as a valid test in terms of eliciting well-known mental workload and spatial learning effects. We explained these findings in light of similar or overlapping mental processes that were most likely activated optimally under task conditions featuring approximately equal numbers of outcome-relevant stimuli. We conclude by discussing the further application of the SOT to the selection of prospective ATCOs who can demonstrate high levels of conflict detection performance in FRA during training simulations. (shrink)

Bu çalı ş mada Nuh b. Mustafa el-Konevi’nin “fethu'l-celil alâ abdihi'z-zelîl fî beyâni mâ verede fi'l-istihlâf fi'l-cümü'ati mine'l-ekâvil ” adlı risalesinin tahkikli çalı ş ması yapıldı. Büyük bir alim ve fakih olan müellifimiz zamanın Konya müftüsüdür. Mısır’a tabli ğ ve ilmi faaliyetlerini gerçekleçtirmek için hicret ettikten sonra orada vefat etmi ş tir. İ lmi alanlarda bir çok gayreti vardır. Özellikle fıkıh ve fıkıh usulü sahasında önemli eserlere imza atmı ş tır. Söz konusu bu risale, süleymaniye kütüphanesine ba ğ lı veliyüddin (...) Efendi kütüphanesinden elde edilen iki el yazması esas alınarak tahkik edilmi ş tir. “Fethu'l-celil alâ abdihi'z-zelîl fî beyâni mâ verede fi'l-istihlâf fi'l-cümü'ati mine'l-ekâvil” adlı risalesi Cuma günü hutbe okumak için birinin imam tarafından tayin edilme konusunu ele alır. Nitekim son dönem hanefi fakihlerinden İ bn Kemal Pa ş a, Molla Hüsrev, Hasen e ş - Ş ürünbülâlî gibi di ğ er bir ço ğ u bu konuda eser kaleme almı ş tır. Bu sahada telif edenlerden birisi de müellifimiz Nuh b. Mustafa el-Konevi’dir. Bu çalı ş masında, konu gere ğ i alimlerin görü ş lerini zikreder, kendisi ile ihtilafa dü ş en görü ş ü ilmi bir üslupla tartı ş arak analiz ettikten sonra tercih etti ğ i görü ş ü ortaya koyar. Sonuç olarak, hutbe ve namaz için ister özür olsun ister olmasın imamın cemaatten birini tayin etmesi meselesine cevaz verir. (shrink)