The chromosomes of eukaryotic cells possess many potential DNA replication origins, of which a subset is selected in response to the cellular environment, such as the developmental stage, to act as active replication start sites. The mechanism of origin selection is not yet fully understood. In this review, we summarize recent observations regarding replication origins and initiator proteins in various organisms. These studies suggest that the DNA‐binding specificities of the initiator proteins that bind to the replication origins and promote DNA (...) replication are primarily responsible for origin selection. We particularly focus on the importance of transcription factors in the origin selection process. We propose that transcription factors are general regulators of the formation of functional complexes on the chromosome, including the replication initiation complex. We discuss the possible mechanisms by which transcription factors influence the selection of particular origins. BioEssays 27:1107–1106, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

Product recommendation system is realized by applying business rules acquired by data maining techniques. Business rules such as demographical patterns of purchase, are able to cover the groups of users that have a tendency to purchase products, but it is difficult to recommend products adaptive to various personal preferences only by utilizing them. In addition to that, it is very costly to gather the large volume of high quality survey data, which is necessary for good recommendation based on personal preference (...) model. A method collecting kansei information automatically without questionnaire survey is required. The constructing personal preference model from less favor data is also necessary, since it is costly for the user to input favor data. In this paper, we propose product recommendation system based on kansei information extracted by text mining and user's preference model constructed by Category-guided Adaptive Modeling, CAM for short. CAM is a feature construction method that can generate new features constructing the space where same labeled examples are close and different labeled examples are far away from some labeled examples. It is possible to construct personal preference model by CAM despite less information of likes and dislikes categories. In the system, retrieval agent gathers the products' specification and user agent manages preference model, user's likes and dislikes. Kansei information of the products is gained by applying text mining technique to the reputation documents about the products on the web site. We carry out some experimental studies to make sure that prefrence model obtained by our method performs effectively. (shrink)

Futabatei Shimei (1864-1909) was an early modern Japanese novelist, translator, and critic. He wrote what is now generally conceived of as the first Japanese ‘modern’ novel, Drifting Clouds (1887-89). He translated works by Turgenev, Leo Tolstoy, Garshin, Gorky, and others. He also published a number of critical essays, treatises on literary theory, political papers, and so forth. His early translation of Turgenev’s short stories: Aibiki (Rendevous, 1888) and Meguriai (Three Trysts, 1889) were extremely influential on the contemporary literati, who were (...) amazed at the fresh, poetic prose used in stark contrast to the traditional Japanese fiction in the pre-Reformation period. These translations, seen in the light of the present-day readers, were unique in what we might term today ‘foreignizing translation’. Lawrence Venuti in Invisibility of the Translator argues that the ideal of (English) translation has been to conceal itself as a translation, i.e. to present itself as an original text (chap I and passim). In that sense, Futabatei’s translations, scandalously presenting itself as a translation, that is to say, as an alien text, is extremely ‘foreignizing’. (shrink)

Spontaneous actions are preceded by brain signals that may sometimes be detected hundreds of milliseconds in advance of a subject's conscious intention to act. These signals have been claimed to reflect prior unconscious decisions, raising doubts about the causal role of conscious will. Murakami et al. (2014. Nat Neurosci 17: 1574–1582) have recently argued for a different interpretation. During a task in which rats spontaneously decided when to abort waiting, the authors recorded neurons in the secondary motor cortex. The (...) neural activity and relationship to action timing was parsimoniously explained using an integration-to-bound model, similar to those widely used to account for evidence-based decisions. In this model, the brain accumulates spontaneously occurring inputs voting for or against an action, but only commits to act once a certain threshold is crossed. The model explains how spontaneous decisions can be forecast (partially predicted) by neurons that reflect either the input or output of the integrator. It therefore presents an explicit hypothesis capable of rejecting the claim that such predictive signals imply unconscious decisions. We suggest that these results can inform the current debate on free will but must be considered with caution. (shrink)

Do people tend to disagree over political issues because of conflicting values? Or do they disagree about which policies will most effectively promote shared values? In a previous article, I argued that the issues most people think are most important tend to fall into the latter category. On the issues of greatest importance to the mass public, most citizens agree about the ends that are desirable, but disagree about which policy means would best effectuate those ends. Consequently, disputes about facts—disputes (...) about the actual effects of proposed public policies—lie at the heart of the most important divisions in contemporary American public opinion. However, people do not necessarily interpret their political disagreements this way. If they fail to recognize that facts that they see as self-evident are disputed by their opponents, they may see their opponents as having different values, since there could be few other explanations for their opponents' disagreement with them. However, evidence that disagreements about facts are really driving public opinion can be found by using conditional surveys, which ask respondents if they would support a given policy if they believed that it would cause specific negative consequences. (shrink)

Parties are back, and many are cheering. Party polarization has voters seeing stark differences between Democrats and Republicans and demonstrating more ideological constraint than previous generations. But these signs of a more “responsible” electorate are an illusion, because the public is no more knowledgeable than ever about the type of “information” it needs if it is to exercise effective control over the public‐policy outcomes it cares the most about. Indeed, polarization has produced a political environment where both voters and policy (...) makers may be less likely to learn about the potential consequences of their governing choices. The result is that holding elected politicians to account for policies treated as divisive ends in themselves has become easier—but that holding them accountable for policies intended as means to the achievement of consensual ends has become harder. (shrink)

頽廃に至っても、いまだ発現する偶然への希望はある。しかし、頽廃、すなわち消尽に至るならば、無と慨嘆の現実しかありえない。希望の存立自体、五分の可能性に生きる偶然なのである。.

Do people tend to disagree over political issues because of conflicting values? Or do they disagree about which policies will most effectively promote shared values? In a previous article, I argued that the issues most people think are most important tend to fall into the latter category. On the issues of greatest importance to the mass public, most citizens agree about the ends that are desirable, but disagree about which policy means would best effectuate those ends. Consequently, disputes about facts—disputes (...) about the actual effects of proposed public policies—lie at the heart of the most important divisions in contemporary American public opinion. However, people do not necessarily interpret their political disagreements this way. If they fail to recognize that facts that they see as self-evident are disputed by their opponents, they may see their opponents as having different values, since there could be few other explanations for their opponents' disagreement with them. However, evidence that disagreements about facts are really driving public opinion can be found by using conditional surveys, which ask respondents if they would support a given policy if they believed that it would cause specific negative consequences. (shrink)

This paper examines how British war veterans fold together war time and post war experiences in practices of remembering and reconciliation. We examine these practices as networks of association between British ex-servicemen (veterans) and the people, places and circumstances associated with their experiences as prisoners in Japan during WW2. We focus on the experience of World War 2 British ex-servicemen (veterans) who were prisoners of war in Far East. During their period of captivity they worked to build Thai-Burma Railway before (...) transfer to a copper mine in Japan. Some 50 years later they participated in a "reconciliation trip" to Japan. We discuss two related issues. First, how and in what ways are the post war lives and war time experiences of these veterans gathered up in the emergent collectivity of such practices? In other words in what ways do these practices emerge and sustain themselves as a process of collection and dispersion of circulating reference in networks of association between people places and things. Second, we examine how accounts of redemption (claims to the consequences of experience as being other than you would expect them to be) create the basis for emergent forms of agency and settlement in expanding networks of remembering and reconciliation. (shrink)

Future practitioners of sustainable agriculture and agroecology must have the capacity to address the wicked problems in the food system to make progress toward sustainability. Undergraduate sustainable agriculture students from a variety of backgrounds may struggle with the question, is the challenging and complex work of addressing wicked problems of agroecology for me? Our case study investigated sociocultural tensions associated with identity encountered when wicked problems teaching units were integrated into the Advanced Practices of Sustainable Agriculture course at a large, (...) Midwestern Land Grant University. The research and course employed a four-part framework that focused on attending to individual needs and identities, facilitating practice-based and community-based learning, engaging in problems situated in regional contexts, and supporting awareness of local and global political and ecological issues. Researchers used a community of practice theoretical lens, and focused on the sociocultural tensions that may have impacted individual and community identity formation. Two wicked problems teaching units are described by drawing upon documentation and audio recordings from planning meetings, course sessions, student and instructor interviews, and course artifacts. Vignettes were constructed to situate four interrelated types of sociocultural tensions encountered by instructors and students. These tensions reflected forces at the individual, community, local, and global levels which interact to influence learners’ capacity to become full participants in sustainable agriculture. The study fills a gap related to affective dimensions of learning like identity in agroecology education. Dilemmas and implications related to identity, pedagogy, and epistemology are discussed. (shrink)

This paper generalizes the simple regret model by Bell in Operations Research 30(5), 961-981 and Loomes and Sugden in The Economic Journal 92(368), 805-824 to cope with the situation in which decision outcomes are multi-attributed. We propose a model that combines the simple regret model for ex ante preferences and the additive difference representation for ex post preferences. We first present a necessary and sufficient axiomatization of our model in Savage’s framework. The proposed model is composed of three types of (...) functions. One is a value function for each attribute. The others are attribute-dependent and holistic regret-rejoicing functions that capture trade-offs among value-differences of chosen and forgone outcomes for each attribute and among all attributes, respectively. We then provide constructive procedures for those functions and methods for consistency checks of the procedures. We, finally, conduct an experiment to estimate those functions in the two attributes case by means of the constructive procedure and give an application of the model and our findings. (shrink)

The present article is based on a interview with a Japanese experienced caregiver who specializes in patients with amyotrophic lateral sclerosis, which generally leads to the locked-in syndrome. Professional caregivers for ALS patients with ventilator experience two particular temporalities in their practice. First, they must monitor the patient continuously during a seven-hour stay. Because a single problem in the ventilator can have fatal consequences, the care of an ALS patient with a ventilator requires long periods of sustained concentration. Second, trying (...) to understand the signs of a patient with a ventilator sometimes requires three hours to go through ten alphabets. In addition to the huge effort that such communication requires, caregivers must complete the meaning of the signs with their imagination: the ten alphabets are not sufficient to understand what the patient really wants to say. This imaginative capacity, however, is based on a long relationship, which started when the patient was still able to speak and move. That is why, as this article will show, even when a patient has entered total LIS, the caregiver can continue to realize his or her wishes. (shrink)

La disociación, surgida a raíz del acontecimiento traumático, pone de manifiesto algunos caracteres fenomenológicos propios del cuerpo. En primer lugar, la destrucción de la esquematización propia del cuerpo es lo que genera el estado hipnótico. En segundo lugar, sólo si entendemos la facultad de esquematización como relacionada con la auto-conciencia podemos comprender el extraño fenómeno del sí-mismo despegado que se da en el estado de disociación. En tercer lugar, este desmoronamiento de la capacidad esquematizante tiene su origen en la destrucción (...) de un tipo muy especial y fundamental de intersubjetividad (se trata, por así decirlo, de la �phantasia �perceptiva� intersubjetiva�). (shrink)

A bounded ultrasheaf is a nonstandard universe constructed from a superstructure in a Boolean valued model of set theory. We consider the bounded elementary embeddings between bounded ultrasheaves. Then the standardization principle is true if and only if the ultrafilters are comparable by the Rudin-Frolik order. The base concept is that the bounded elementary embeddings correspond to the complete Boolean homomorphisms. We represent this by the Rudin-Keisler order of ultrafilters of Boolean algebras.

Le silence et le sommeil constituent la base sur laquelle la cure psychothérapeutique et la créativité humaine se produisent. Or c’est avec le concept de sens latéral que Merleau-Ponty a esquissé la structure phénomé­nologique de la créativité humaine. Du point de vue du sens latéral qui surgit au creux de l’articulation intentionnelle du monde, le corps vivant apparaît comme style qui canalise la production du sens. Chaque surgissement du sens latéral est précédé par un silence qui suspend momentanément l’intention­nalité thématisante (...) et articulante. Le corps comme style n’est pas le corps réel mais le corps imaginaire qui se situe au centre du monde imaginaire en le fabriquant et en le déformant. Le corps imaginaire engendre la « déforma­tion » par rapport à l’articulation objective du monde et cette déformation constitue l’essence de la créativité. La création artistique, la cure dans la psychothérapie et le rêve sont les exemples éminents de cette créativité. Par contre, dans le silence et le sommeil qui précèdent la création et le rêve, non seulement l’articulation intentionnelle mais aussi celle du corps imaginaire sont suspendues. Le silence et le sommeil désignent le degré zéro du corps imaginaire en deçà du sens latéral. (shrink)

神を認めると個人の自由の場がなくなる。では個人は神なしで自分を救済することができるのか?人間にはそれだけの力量はない。田辺元は、この深淵のなかで苦悩する。.

Este artigo, realizado por meio de estudo bibliográfico, pretende abordar a respeito dos desafios do uso de tecnologias na sala de aula para a educação no século XXI. A cultura analógica na escola com práticas tradicionais seculares é conflitante com a cultura digital provocando dissonâncias entre o mundo dos estudantes e o mundo da escola. A pandemia provocou catalisação no uso das tecnologias devido ao ensino remoto. Os avanços e a propagação do uso das tecnologias digitais de informação e comunicação (...) na educação têm ampliado as possibilidades de melhorar a aprendizagem de forma atraente, significativa e personalizada. A escola tem a responsabilidade de formar cidadãos críticos e criativos para solucionar os problemas antigos e novos da sociedade. Porém, os desafios são grandes e provocados por desigualdades de acesso e pela necessidade de revisão na formação inicial e continuada de educadores. (shrink)

SOCREAL 2007: International Workshop on Philosophy and Ethics of Social Reality. Sapporo, Japan, 2007-03-09/10. Session 3: Obligation and Rationality.

A real but typical case of identity fraud is used to open up the complex web of identification systems in Brazil. It is argued that identification has two poles related to the nature of citizenship—repression and inclusion—and that reactions from citizens to new identification schemes can be attributed to how they view the purpose of the cards in these terms. In Brazil, a sense of inclusion and citizenship based on a fear of anonymity and exclusion predominates leading to widespread support (...) amongst even critics of state activities. However, this may be undermined by the lack of state preparation for an information society, particularly the absence of meaningful data protection laws. (shrink)