Transmembrane receptor tyrosine kinases that bind to peptide factors transmit essential growth and differentiation signals. A growing list of orphan receptors, of which some are oncogenic, holds the promise that many unknown ligands may be discovered by tracking the corresponding surface molecules. The neu gene (also called erbB‐2 and HER‐2) encodes such a receptor tyrosine kinase whose oncogenic potential is released in the developing rodent nervous system through a point mutation. Amplification and overexpression of neu are thought to contribute to (...) malignancy of certain human adenocarcinomas. The search for soluble factors that interact with the Neu receptor led to the discovery of a 44 kDa glyco‐protein that induces phenotypic differentiation of cultured mammary tumor cells to growth‐arrested and milk‐producing cells. The Neu differentiation factor (NDF or heregulin), however, also acts as a mitogen for epithelial, Schwann and glial cells. Multiple forms of the factor are produced by alternative splicing and their expression is confined predominantly to the central and to the peripheral nervous systems. One identified neuronal function of this family of polypeptides is to control the formation of neuromuscular junctions, but their physiological role in secretory epithelia is still unknown. Other open questions relate to the transmembrane topology of various precursors, the identity of a putative co‐receptor, the possible existence of additional ligands of Neu and the functional significance of the interaction between Neu and at least three highly related receptor tyrosine kinases. (shrink)

Considerable attention in bioethics has been devoted to moral expertise and its implications for handling applied moral problems. The existence and nature of moral expertise has been a contested topic, and particularly, whether philosophers are moral experts. In this study, we put the question of philosophers’ moral expertise in a wider context, utilizing a novel and global study among 4,087 philosophers from 96 countries. We find that despite the skepticism in recent literature, the vast majority of philosophers do believe in (...) moral expertise and in the contribution of philosophical training and experience to its acquisition. Yet, they still differ on what philosophers’ moral expertise consists of. While they widely accept that philosophers possess superior analytic abilities regarding moral matters, they diverge on whether they also possess improved ability to judge moral problems. Nonetheless, most philosophers in our sample believe that philosophers possess an improved ability to both analyze and judge moral problems and that they commonly see these two capacities as going hand in hand. We also point at significant associations between personal and professional attributes and philosophers’ beliefs, such as age, working in the field of moral philosophy, public involvement, and association with the analytic tradition. We discuss the implications of these findings for the debate about moral expertise. -/- . (shrink)

ʻEdut be-Hosef -- Derekh ʻets ha-ḥayim -- Refuʼat ha-nefesh -- ha-Tapuaḥ.

In this paper I shall offer new definitions for what seem to be the most dominant terms in Epicurus’ theory of pleasures - “kinetic” and “katastematic”. While most of the scholarly literature treats these terms as entirely concerned with states of motion and states of stability, I shall argue that the distinction concerns whether pain is or is not removed by this or that pleasure. As the removal of pain is a necessary condition for the Epicurean goal of ataraxia and (...) aponia, “katastematic” pleasure, having to do with the removal of pain, is the necessary pleasure pertaining both to the process of removing pain and to its result, namely the absence of pain, while “kinetic” pleasure is an unnecessary pleasure having nothing to do with the removal of pain, e.g. it starts after pain has been removed. If my analysis and interpretation prove correct, the two conventional classifications - “kinetic-katastematic” and “necessary-unnecessary” - turn out to be referring to the same phenomenon and are aspects of one classification. Moreover, this new interpretation resolves some of the main problems arising from our testimonia concerning “kinetic” and “katastematic” pleasures. (shrink)

Over recent years, the stakes and complexity of online content moderation have been steadily raised, swelling from concerns about personal conflict in smaller communities to worries about effects on public life and democracy. Because of the massive growth in online expressions, automated tools based on machine learning are increasingly used to moderate speech. While ‘design-based governance’ through complex algorithmic techniques has come under intense scrutiny, critical research covering algorithmic content moderation is still rare. To add to our understanding of concrete (...) instances of machine moderation, this article examines Perspective API, a system for the automated detection of ‘toxicity’ developed and run by the Google unit Jigsaw that can be used by websites to help moderate their forums and comment sections. The article proceeds in four steps. First, we present our methodological strategy and the empirical materials we were able to draw on, including interviews, documentation, and GitHub repositories. We then summarize our findings along five axes to identify the various threads Perspective API brings together to deliver a working product. The third section discusses two conflicting organizational logics within the project, paying attention to both critique and what can be learned from the specific case at hand. We conclude by arguing that the opposition between ‘human’ and ‘machine’ in speech moderation obscures the many ways these two come together in concrete systems, and suggest that the way forward requires proactive engagement with the design of technologies as well as the institutions they are embedded in. (shrink)

Are philosophers moral experts, and if so, what does this imply for their proper role in moral decision-making? The dominant view on this subject argues that philosophers have superior moral understanding, but they are not better judges of what is morally right. Consequently, philosophers cannot and should not have an authoritative role in moral decision-making. In this article, I challenge this view and argue that an examination of the intimate connection between two capacities – to understand and to judge – (...) reveals that it is both inconsistent and simplistic. It is inconsistent because, all things being equal, if philosophers better understand moral problems, they are also better judges of them. It is simplistic because it adopts an all-or-nothing approach to moral expertise, while expertise is in fact conditional. Inspired by the psychological literature on expertise, I claim that we should not ask whether philosophers are moral experts but rather under which conditions they successfully execute their expertise. The conclusion of the dominant view needs to be reconsidered to reflect the conditional nature of philosophers' expertise. Although more empirical research is required, I offer several hypotheses for future endeavours that demonstrate what a conditional view of philosophers' moral expertise could look like. -/- . (shrink)

kerekh 1. Ba-halakhah uve-agadah -- kerekh 2. [without special title].

A new view of the functional role of the left anterior cortex in language use is proposed. The experimental record indicates that most human linguistic abilities are not localized in this region. In particular, most of syntax (long thought to be there) is not located in Broca's area and its vicinity (operculum, insula, and subjacent white matter). This cerebral region, implicated in Broca's aphasia, does have a role in syntactic processing, but a highly specific one: It is the neural home (...) to receptive mechanisms involved in the computation of the relation between transformationally moved phrasal constituents and their extraction sites (in line with the Trace-Deletion Hypothesis). It is also involved in the construction of higher parts of the syntactic tree in speech production. By contrast, basic combinatorial capacities necessary for language processing – for example, structure-building operations, lexical insertion – are not supported by the neural tissue of this cerebral region, nor is lexical or combinatorial semantics. The dense body of empirical evidence supporting this restrictive view comes mainly from several angles on lesion studies of syntax in agrammatic Broca's aphasia. Five empirical arguments are presented: experiments in sentence comprehension, cross-linguistic considerations (where aphasia findings from several language types are pooled and scrutinized comparatively), grammaticality and plausibility judgments, real-time processing of complex sentences, and rehabilitation. Also discussed are recent results from functional neuroimaging and from structured observations on speech production of Broca's aphasics. Syntactic abilities are nonetheless distinct from other cognitive skills and are represented entirely and exclusively in the left cerebral hemisphere. Although more widespread in the left hemisphere than previously thought, they are clearly distinct from other human combinatorial and intellectual abilities. The neurological record (based on functional imaging, split-brain and right-hemisphere-damaged patients, as well as patients suffering from a breakdown of mathematical skills) indicates that language is a distinct, modularly organized neurological entity. Combinatorial aspects of the language faculty reside in the human left cerebral hemisphere, but only the transformational component (or algorithms that implement it in use) is located in and around Broca's area. Key Words: agrammatism; aphasia; Broca's area; cerebral localization; dyscalculia; functional neuroanatomy; grammatical transformation; modularity; neuroimaging; syntax; trace deletion. (shrink)

In recent decades, the discipline of bioethics has grown rapidly, as has the practice of ethical consultation. Interestingly, this new recognition of the relevance of moral philosophy to our daily life has been accompanied by skepticism among philosophers regarding the existence of moral expertise or the benefits of philosophical training. In his recent article in Bioethics, William R. Smith suggested that this skepticism is rooted in philosophers' belief that moral expertise is inconsistent with liberal–democratic values, when in fact they are (...) compatible. In this paper, we provide a unique opportunity to empirically examine Smith's observation by utilizing and extending global data on philosophers' beliefs about moral expertise, involving 4087 philosophers from 96 countries. Our findings support Smith's theoretical observation and show that societal levels of support for liberal–democratic values are associated with greater skepticism about moral expertise. We suggest that these findings might be explained by the cognitive process of motivated reasoning and an invalid inference of “is” from “ought.” Consequently, the potential tension between moral expertise and liberal–democratic values is invalidly used for rejecting the existence of moral expertise, while its main and valid implication is for how moral expertise should be applied in liberal–democratic settings. (shrink)

Translation based on: Y. Katz, Noam Chomsky on Where Artificial Intelligence Went Wrong, The Atlantic, November 1, 2012.

Beyond Scandal will give you the resources to talk to your kinds about: Sex, Gossip, Lying, Politics, Scandal, Friendship, Values, Leadership, Dirty Jokes.

I begin with a characterization of neurolinguistic theories, trying to pinpoint some general properties that an account of brain/language relations should have. I then address specific criticisms made in the commentaries regarding the syntactic theory assumed in the target article, properties of the Trace Deletion Hypothesis (TDH) and the Tree-Pruning Hyothesis (TPH), other experimental results from aphasia, and findings from functional neuroimaging. Despite the criticism, the picture of the limited role of Broca's area remains unchanged.

This short paper is to provide answer to the question what is there outside the Universe? If the Universe is expending, what does it expend into? An answer was provided, the universe is expanding into its complementary universe. If that is so, then what the complementary universe is? A new perception is provided that matter exist as a logical state. What is the logical state creating matter? This question is being answered by the relationship between the universe and its complementary (...) universe satisfying the equilibrium equation that total matter of both universes, the inner universe and the complementary universe, collapse into zero, i.e. no matter. Furthermore, the existence of matter out of void is a logical state resulted from the void existence. (shrink)

The Upper Palaeolithic Revolution, sometimes called ‘the Creative Explosion’, is seen as the period when the forefathers of modern forager societies emerged. Similarly to the Industrial and Neolithic Revolutions, it represents a short time span when numerous inventions appeared and cultural changes occurred. The inventions were in the domain of technology, that is, shaping of new stone tool forms, longdistance exchange of raw materials, the use of bone, antler and ivory as well as rare minerals for the production of domestic (...) and ritual objects. Spatial analysis of ‘living floors’ indicates the presence of a kitchen area, sleeping grounds, storage facilities (in certain regions) and a discard zone. We can also detect a certain increase in social hierarchy and the presence of shamans. Body decorations indicate the appearance of personal individuality. Several hypotheses were offered as an explanation for the initiation of all these cultural changes often grouped under the term ‘modern behaviour’. It stands to reason that attributing the new successful technologies observed in the Eurasian Upper Palaeolithic to intrinsic social processes and economic innovations by local Middle Palaeolithic populations would need a better archaeological demonstration than that available today. For the time being, the emergence of Modern humans in sub-Saharan Africa, their socio-economic dynamism that caused their expansion through the Nile Valley into the Near East, and their migration along the ‘southern route’ of Asia as far as Australia, is the most plausible scenario though it still leaves much to be desired from future archaeological research. (shrink)

Determining Risk Factors and Demographic Patterns of Suicide in Tehran Suicide refers to the death of a person that is primarily achieved by self-harm. Today, it is considered one of the major public health issues. One of the important risk factors associated with attempted suicide is social relations. This study is a descriptive and analytical study that aims to identify the suicide rate, the risk factors in suicide, and the methods of suicide. The findings show that there is a significant (...) relationship between suicide and demographic variables that include age, sex, educational level, adherence to religion, and occupation. This research also shows the psychological factors that lead to suicide include depression, addiction, lack of social activities, and mental disorders caused by chronic disease. (shrink)

The conclusion that language is not really innate or modular is based on several fallacies. I show that the target article confuses communicative skills with linguistic abilities, and that its discussion of brain/language relations is replete with factual errors. I also criticize its attempt to contrast biological and linguistic principles. Finally, I argue that no case is made for the “alternative” approach proposed here.

Judaism is a religion and a way of life that combines beliefs as well as practical commandments and traditions, encompassing all spheres of life. Some of the numerous precepts emerge directly from the Torah (the Law of Moses). Others are commanded by Oral Law, rulings of illustrious Jewish legal scholars throughout the generations, and rabbinic responsa composed over hundreds of years and still being written today. Like other religions, Judaism has also developed unique symbols that have become virtually exclusive to (...) it, such as the Star of David and the seven-branched menorah. This book argues that Judaism impacts human geography in significant ways: it shapes the environment and space of its believers, thus creating a unique "Jewish geography.". (shrink)

1. Śiḥot, ʻetsot, sipurim, ṿe-hadrakhot maʻaśiyot li-veniyat ha-ḳesher ben bene ha-zug ... -- 2. Be-parashat ha-shavuʻa.

Deals with the whole complex of relations between the land of Israel, the Jewish Torah and the people of Israel from the Pre-Zionist period until the establishment of the State of Israel. The book examines the dynamics of those relations through the modernization of Jewish society, and the problem of Jewish identity vis-a-vis modernity. The discussion follows historical events in both philosophy and everyday life. It explores the anti-Zionist sphere and also discusses the attitudes towards the conflict of religion and (...) nationalism in the world of religious Zionism. The dispute between advocates of a religious concept of the community and proponents of a secular nation revolved primarily around perceptions of the ideal relationship between the religious and national entities. One group sought to make religion a tool of the nation; the other sought to make the nation a tool of religion." --Publisher provided. (shrink)

1. Halakhah. Maḥshavah. Divre rishonim -- 2. Mishnat ha-Rambam. Yehude Teman -- 3. Meḳorot. Zuṭot.

Contributed articles presented at the Colombo Conference on "Building Spirituality and Culture of Peace Beyond Globalization" held on Aug. 13-16, 2003; with reference to Asia and Africa.

Sefer Ḳol min ḥayim -- Sefer Ḳol rinah ṿi-yeshuʻah -- Sefer Orḥot ḥayim ʻim perush Netiv ḥayim -- Sefer Zikhron ʻolam -- Maʼamar Zikhron Yerushalayim.