Do-not-resuscitate (DNR) orders are typically signed by physicians in conjunction with patients or their surrogate decision makers in order to instruct healthcare providers not to perform cardiopulmonary resuscitation (CPR). Both the medical literature and CPR guidelines fail to address when it is appropriate for physicians to sign DNR orders without any knowledge of a patient’s wishes. We explore the ethical issues surrounding instituting a twophysician DNR for a dying patient with multiple comorbidities and no medical record on file, no advance (...) directives, and no surrogate decision maker. Through this case we also highlight the issues of poor prognostication and the reversal of a DNR in such circumstances. (shrink)

Individuals with agrammatic Broca's aphasia experience difficulty when processing reversible non-canonical sentences. Different accounts have been proposed to explain this phenomenon. The Trace Deletion account attributes this deficit to an impairment in syntactic representations, whereas others propose that the underlying structural representations are unimpaired, but sentence comprehension is affected by processing deficits, such as slow lexical activation, reduction in memory resources, slowed processing and/or intermittent deficiency, among others. We test the claims of two processing accounts, slowed processing and intermittent deficiency, (...) and two versions of the Trace Deletion Hypothesis, in a computational framework for sentence processing implemented in ACT-R. The assumption of slowed processing is operationalized as slow procedural memory, so that each processing action is performed slower than normal, and intermittent deficiency as extra noise in the procedural memory, so that the parsing steps are more noisy than normal. We operationalize the TDH as an absence of trace information in the parse tree. To test the predictions of the models implementing these theories, we use the data from a German sentence—picture matching study reported in Hanne, Sekerina, Vasishth, Burchert, and De Bleser. The data consist of offline and online measures. From among the models considered, the model assuming that both slowed processing and intermittent deficiency are present emerges as the best model of sentence processing difficulty in aphasia. The modeling of individual differences suggests that, if we assume that patients have both slowed processing and intermittent deficiency, they have them in differing degrees. (shrink)

According to Character Shifting Theory, the rules determining indexical reference vary according to the communication technology used. These rules are established by conventions arising as solutions to coordination problems. I present two objections against Character Shifting Theory. First, I show that individuating context-types according to technologies makes incorrect truth-value predictions. Secondly, such individuation is not possible, as there are no coordination problems that occur when speakers communicate over these technologies. I then consider four ways by which one can respond against (...) my objections and show that none of them succeed. The failure of Character Shifting Theory has implications on the larger debate about whether a fixed-rule intention-insensitive account of indexical reference can be successful. (shrink)

Umesh Bagade’s historic critique of the caste blindness of the Subaltern Studies project retraces its emergence as a criticism of the Nationalist and Marxist schools of Indian history. He shows how the subaltern historians borrowed Antonio Gramsci’s concept of “subaltern” in order to retain a broadly Marxist framework without “class” but discarded the crucial Gramscian emphasis on oppression and economic exploitation. They grievously misread, confused, or omitted caste as a “system” when they constructed their model of the subaltern as (...) subordinate but autonomous. The caste system functioned as a graded inequality with close links to patriarchy in which the lower castes were oppressed, exploited, and subordinated rather than autonomous. A homogenized “subaltern” status thus lumped the oppressed lower-caste peasants and the tribal peasantry with upper-caste peasantry. It was not acknowledged that the “solidarity” that expanded the base of subaltern revolt was achieved through coercion of the lower castes and women. The subaltern cultural “consciousness” of caste Panchayats, which was central to the project’s epistemology, was governed by Brahmanical religion and culture. The kinship relations that comprised peasant solidarities were built on endogamous caste practices. Predictably, the Subaltern Studies project found a close affinity with postmodernism and eschewed the question of emancipatory politics. The project therefore excluded anticaste mobilizations from the purview of “subaltern revolts” and simultaneously rejected the need for a comprehensive historical interpretation in which the caste system and patriarchy could be analyzed and opposed. In exposing the biases and lacunae of subaltern historiography, Bagade provides a clinical observation of history with an eye on history’s ability to influence reality. He shows the path that was not taken, which anticaste scholarship is now forging. (shrink)

What is ethics in the contemporary world? What is the need of defining ethics and, secondly, defining it in contemporary context? The meaning of ethics is so ambiguous to nonphilosophical academicians, corporate world, and others who look to the meaning in the branch of Philosophy called Ethics. At the end of endless debates, if the purpose of getting a definition is done, it is clarity in thinking in defining ethics which would happen. This may lead to clarity in the study (...) of ethics. And why should one study ethics at all? Ethics is interwoven at various levels in our life. The same individual is often in an obligation to face ethics at different levels like home, office, society, etc., or different ethical obligations. With a number of normative theories, the individual mind would be indefinite as to which one to follow. Is it just one theory alone which can be resorted to in an ethical dilemma or a combination of them? Are these theories practical also? Or are they just theories per se? To clear this ambiguity and in order to define ethics, the discussion of the meaning of ethics is important. This paper answers the above questions and throws light on the enquiry. This study hence is an exploratory one. Since the word ethics is interwoven with morality, it is worthwhile to define the word moral. (shrink)

Festschrift volume in honour of Mohd. Sabir Hussain, b. 1935.

In this work, we explore modeling of wormholes in framework of f(R, T) gravity with the functional form f(R,T)=R+αR2+λT\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$f(R, T)= R+\alpha R^2 +\lambda T$$\end{document}, where R and T are the Ricci scalar and trace of energy-momentum tensor respectively, α\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\alpha$$\end{document} and λ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\lambda$$\end{document} are arbitrary constants. Using the equation of state (EoS) pr=ωρ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} (...) \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$p_r=\omega \rho$$\end{document} and shape function b(r)=r0arar0,(0shrink)

Ancient Indian philosophies consider self-realization as a fundamental concept and aim of human life, which appears theoretically similar to the self-actualization concept of the West. This article compares and contrasts the self-actualization concept with the views of ancient Indian wisdom to create a model. Both ideas strive for a more elevated Self, unleashing our potential or the realization/actualization of the true Self. From the Indian Vedanta philosophy emerged the Panchakosha theory of personality, which provides a structural framework for human states (...) of consciousness leading to higher development and transcendental identity. According to the scriptures, any form of stress is due to an underdeveloped state of consciousness at these levels or due to disconnection from the true Self; once an individual comes in contact with the ‘true Self’, the problems of life are eliminated. Yoga is a systematic process and way of human development, and applying the principles of Yoga philosophy in life will help in transcending one from the lower Self to the higher Self, awakening human potential, and becoming self-actualized. Yogis, who practice Yoga, could be responsible for a positive shift towards sustainable communities or transformative environments through enhanced mindfulness, self-actualization, and social capital demonstrated by enhanced moral values, trust, engagement, and acceptance. This theoretical model from classical Indian thought has the potential to provide the needed guidelines to create more self-actualized people. The dimension of well-being and prescriptions on how to reach this state of highest well-being is the essence of Indian philosophy. (shrink)

Structural biology has experienced several transformative technological advances in recent years. These include: development of extremely bright X-ray sources and the use of electrons to extend protein crystallography to ever decreasing crystal sizes; and an increase in the resolution attainable by cryo-electron microscopy. Here we discuss the use of these techniques in general terms and highlight their application for biological filament systems, an area that is severely underrepresented in atomic resolution structures. We assemble a model of a capped tropomyosin-actin minifilament (...) to demonstrate the utility of combining structures determined by different techniques. Finally, we survey the methods that attempt to transform high resolution structural biology into more physiological environments, such as the cell. Together these techniques promise a compelling decade for structural biology and, more importantly, they will provide exciting discoveries in understanding the designs and purposes of biological machines. Structural biology is undergoing technological advancements that now reveal the structures of previously inaccessible biological machines. Microfocus synchrotron beamlines, X-ray free electron lasers, and MicroED cope with vanishingly small crystals, while cryo-electron microscopy targets single molecules at near atomic resolution. These advances promise an exciting decade for structural biology. (shrink)