Abstract Non-reductive physicalism is currently the most widely held metaphysic of mind. My aim in this essay is to show that supervenience physicalism?perhaps the most common form of non-reductive physicalism?is not a defensible position. I argue that, in order for any supervenience thesis to ground a legitimate form of physicalism, it must yield the right sort of determination relation between physical and non-physical properties. Then I argue that non-reductionism leaves one without any explanation for the laws that are implied by (...) supervenience theses that deliver this determination relation. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Discipline Over Punishment is an exploration of the transformative potential of restorative discipline practices in schools, ranging from the micro-level of one-on-one interactions with students to the macro-level of re-routing the school-to-prison pipeline and improving life outcomes for young people. Gardner, who continues to teach high school in Oakland, CA, has spent nearly 20 years innovating, struggling, and succeeding to implement various restorative justice practices in classrooms and schools around the Bay Area. Using classrooms and schools where he has taught (...) and students, families and educators with whom he has worked, Gardner examines how restorative justice, as a set of beliefs and practices can be a force for justice and equity in our classrooms, schools, and beyond. (shrink)

Marjorie Perloff’s Wittgenstein’s Ladder investigates the relationship between Wittgenstein’s manner of writing—a “process of interrogation... tentative, self-canceling, and self-correcting” —and what she terms the “‘ordinary language’ poetics so central to our own time”. “Philosophy ought really to be written only as a form of poetry,” Wittgenstein proposed, in Perloff’s translation of a remark in Culture and Value. What form of poetry, Perloff asks, do we find in Wittgenstein’s work? We find a “poetry” which, “travel[ing] over a wide field of thought (...) criss-cross in every direction,” attempts to “command a clear view of the use of our words” through a sort of “understanding which consists in ‘seeing connexions’”. In particular, we find a poetry which brings out the beauty and complexity and strangeness in everyday communication by “arranging what we have always known” into texts in which we might think language through, from within. In the words of the conceptual artist Joseph Kosuth: “One of the lessons for art which we can derive from the Philosophical Investigations is that I believe the later Wittgenstein attempted with his parables and language-games to construct theoretical object-texts which could make recognizable aspects of language that, philosophically, he could not assert explicitly”. Just as Wittgenstein-as-philosopher constructs texts which make language visible rather than employing language to make assertions, so Wittgenstein-as-poet, Perloff suggests, dramatizes our life in language rather than using language for self-expression. (shrink)