The literature on autonomous language learning reveals both, scholars’ great enthusiasm for the revolutionary potential of learner autonomy as well as pessimism for its continual depoliticization within higher education. Similar to how ‘learner autonomy’ is still today an unfinished construct that raises considerable confusion among scholars, the critical theory of learner autonomy in the field of language learning remains largely unexplored; and thus, yet to be fully articulated. Building on the relevant literature, this article attempts to provide a coherent and (...) nuanced theoretical framework for the critical practice of learner autonomy in higher education. Results show how the field of language learning is dominated by uncritical and apolitical approaches that render learner autonomy a politically impotent practice. Critical autonomous language learning must be both critically aware—so it can raise students’ awareness of the structural and discursive constraints on their autonomy—and politically active—so it may lead to education reform and social change—, while also aiming at reaching the highest levels of institutional material support and student control possible. (shrink)

El presente estudio se inscribe en la línea de las investigaciones acerca del pensamiento de Evagrio Póntico, el monje filósofo del siglo IV d.C, que se vienen realizando en los últimos años. En este marco, nos interesa profundizar en la significación que tiene en la obra evagriana un concepto filosófica y teológicamente relevante como es el de sophía y cuál es la relación que la realidad que éste designa tiene con la vida moral. Evagrio establece una relación de connaturalidad entre (...) las virtudes y la sabiduría, de tal modo que el ejercicio ético propio de la primera etapa de desarrollo espiritual es planteado como un requisito para alcanzar la sabiduría. En este contexto se plantea el concepto de apátheia como el estado del alma capaz de alcanzar la sabiduría. No obstante, la ciencia que otorga la sabiduría es siempre en el Póntico un don divino. Por esta razón esta división en etapas no puede ni debe ser planteada de modo taxativo como si las mismas fueran compartimentos estancos. (shrink)

The nineteenth century was a time of great economic, social, and political change. The population of a modernizing Europe began demanding more freedom, which in turn propelled the ongoing discussion on the philosophy of nature. This spurred on Central European sheep breeders to debate the deepest secrets of nature: the transmission of traits from one generation to another. Scholarly questions of heredity were profoundly entwined with philosophy and politics when particular awareness of “the genetic laws of nature” claimed natural equality. (...) The realization that the same rules of inheritance may apply to all living beings frightened both the absolutist political power and the divided society of the day. Many were not prepared to separate religious questions from novel natural phenomena. Open-minded breeders put their knowledge into practice right away to create sheep with better wool traits through inbreeding and artificial selection. This was viewed, however, as the artificial modification of nature operating against the cultural and religious norms of the day. Liberal attempts caught the attention of the secret police and, consequently, the aspirations of scholars were suppressed by political will during approximately 1820–1850. (shrink)

In the valley of the Trujala, Hornos and Guadalimar rivers in the Sierra de Segura, northeast of the province of Jaén, is an articulated system of preserved Andalusi structures that configure a landscape. To orient in a landscape, one needs a map that accurately represents the elements involved in its formation. The objective of this work is to reveal these points and to draw a chart that serves to understand and read into the palimpsest of the landscape. To achieve this, (...) an intensive prospecting of the territory is carried out to document the existing remains and an evaluation model based on Geographic Information Systems is elaborated. This process allowed for quantifying variables, obtaining statistically relevant data and classifying the information obtained in places where there is some Andalusi preexistence. The results supply useful parameters in the analytical reading of the landscape, provide quantitative knowledge about factors that connect the sites, and allow for the determination of settlement patterns. The results also reveal the mode of occupation in a territory -the ancientʿamal Šaqūra- as a reflection of the Andalusi organization in the rural world and the anthropic role that these settlements, which are associated with structures built of rammed-earth during the 12th century, have had in the landscape’s configuration. (shrink)

1. La definición de "derecho" y de "norma jurídica".--2. Los conceptos básicos del derecho.--3. El concepto de sistema jurídico y la validez moral.--4. La ciencia del derecho y la interpretación jurídica.

Many writers interested in Kelsen's concept of validity state that it is primarily related to such issues as the identity of a legal system, the membership of particular norms in a legal system, its internal consistency, and so on. The result is that for many, Kelsen's concept of validity bears no affinity to the idea of validity prevailing in traditional legal philosophy. This chapter argues that this reading of Kelsen's concept of validity is mistaken. Proponents of this reading have been (...) led to disregard important aspects of Kelsen's theory, formulating unwarranted and tortuous interpretations of it in order to show how it deals with issues that are erroneously supposed to be primarily connected to its concept of validity. It is shown that Kelsen's theory, like traditional philosophical accounts of law, equates the validity of law with its binding force and its existence, and that it conceives of the ascription of validity as a normative judgement. (shrink)

Considera a produção científica brasileira da Ciência da Informação (CI), de pesquisadores institucionalmente reconhecidos da área, para realçar movimentos de transformação e influências intelectuais sobre o quadro teórico por eles construído. Questiona os conceitos de pós-modernidade e pós-modernismo no contexto destas produções, analisando criticamente a produção científica periódica, indexada na Base de Dados Referenciais de Artigos de Periódicos em Ciência da Informação (Brapci), dos Bolsistas de Produtividade em Pesquisa (PQ), do Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), desde o (...) ano de 1990 até 2022, para descrever o fenômeno do pós-modernismo e da pós-modernidade, tanto como processo de transformação e estímulo à produção sobre as contradições encontradas nessa cultura, quanto para o reconhecimento de teorias, conceitos, posicionamentos políticos e ideológicos. Adota a distinção apresentada por Terry Eagleton, entre pós-modernismo e pós-modernidade, para reconhecer os significados dos termos enfocados e seus correlatos, e em quais contextos são analisados no corpus da pesquisa. Seleciona os textos com potencial de contribuição para uma síntese histórico-evolutiva. Conclui, destacando duas posições mais evidentes. A predominante associa à condição da CI como ciência pós-moderna, à arquivística pós-moderna, ao paradigma pós-custodial, à sociedade pós-moderna e a considerações genéricas sobre o saber e a informação como mercadorias básicas da pós-modernidade. A posição mais crítica fundamenta-se em autores como Terry Eagleton, ao denunciar as ilusões do pós-modernismo e David Harvey, cujos principais argumentos relacionam a ascensão de formas culturais pós-modernas e a emergência de modos flexíveis de acumulação ao ciclo de compressão do tempo-espaço na organização do capitalismo. (shrink)

El término Teodicea fue acuñado por Leibniz a comienzos de la Ilustración y recoge desde entonces los intentos teístas de justificar su idea de un Dios interesado en el mundo, omnipotente y bueno con la realidad tozuda e innegable del mal. Esa justificación se nos revela hoy como necesariamente etiológica, aunque no por ello menos fructífera o relevante para nuestro propio predicamento. El presente trabajo pretende mostrar muy someramente las condiciones socioculturales que se revelan en las etiologías más destacadas posteriores (...) a Leibniz y sus paralelismos con nuestra situación presente. A partir de esos paralelismos se apuntarán los posibles rasgos de una Teodicea actual desde los supuestos de la filosofía analítica y la teología filosófica, centrada en los diferentes tipos de mal y una comprensión de las características del mundo y de la mente que apunten a posibles soluciones. (shrink)

Este artículo se enfoca en la concepción kantiana de un derecho de guerra, en particular en la controversial figura del enemigo injusto del apartado “Derecho de gentes” de la Rechtslehre, que ha dado pie a que se considere a Kant un teórico de la guerra justa (e. g. Carl Schmitt y B. Orend). Rechazo dicha interpretación y defiendo que al filósofo alemán no se le puede colocar esta etiqueta sin desvirtuar su visión crítica de la guerra, lo que supone comprender, (...) por una parte, la función de esta en el progreso de la humanidad, y, por otra, aceptar el veto de la razón práctica que la prohíbe. Con ese propósito retomo la defensa que hace Howard Williams frente a B. Orend e intento imprimir mayor fuerza a su argumento incorporando la noción de “ley permisiva” al derecho de guerra que se emprende contra el enemigo injusto. (shrink)

Un requisito para demostrar la vigencia de un programa de posgrado es la evaluación de su pertinencia social. El presente trabajo tiene como objetivo describir los resultados de la evaluación de la pertinencia social del programa de maestría Humanidades Médicas. Se muestran sus características esenciales derivadas de los procesos realizados en el Centro para el Desarrollo de las Ciencias Sociales y Humanísticas en Salud; se define la pertinencia social y sus indicadores como conceptos esenciales para la evaluación de los procesos (...) del posgrado; por último, se presenta la metodología y su aplicación en el proceso de evaluación. Se realizó triangulación metodológica de fuentes de datos provenientes de encuestas y entrevistas a profesores, maestrantes de la edición actual y de egresados; además, datos de los informes de autoevaluación y de la comisión técnica en el proceso de evaluación externa para la acreditación acaecida en marzo de 2016. A requisite for demonstrating the validity of a postgraduate program is the assessment of its social relevance. This work aims to describe evaluative results related to the social relevance of the Masters of Science in Medical Humanities degree. The evaluation process was carried out in the Health Humanities and Social Sciences Development Centre of Camaguey. Social relevance and related indicators were defined and considered for this specific master's degree level evaluation. The methodology and its application in the evaluation process are presented. Data triangulation between surveys collected and interviews granted from faculty, current students of the Medical Humanities program, and graduates of the department was utilized. Additionally, data from self-evaluation reports and from the external evaluation technical commission for accreditation in March 2016 were considered in the data triangulation. (shrink)

In this study a combination of computer tools for coupling and virtual screening is detailed, in 108 active molecules and 3620 decoys to find stabilizers for G quadruplex. To have more precise results, combinations of coupling programs with fifteen energy scoring functions were applied. The validation and evaluation of the metrics was done with the CompScore genetic algorithm. The results showed an increase in BEDROC and EF of 50% compared to other strategies, as well as reflecting early recognition of active (...) molecules. From these results it is possible to work with the molecules that showed a good early recognition and evaluate their effect as G4 stabilizers. This ensures more efficient and accurate results in the preclinical stage for the development of anticancer drugs. Keywords: Enrichment metrics; telomere; G quadruplex ; CompScore. References [1]M. Porru, P. Zizza, M. Franceschin, C. Leonetti and A. Biroccio. «EMICORON: A multi-targeting G4 ligand with a promising preclinical profile» 2017. Biochimica et Biophysica Acta - General Subjects, 1861, 1362–1370. [Online]. Available: https://doi.org/10.1007/s00294-018-0836-6. [2]K. Tomita. «How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasis». Current Genetics, 64, 1177–1181. 2018. [Online]. Available: https://doi.org/10.1016/j.bbagen. 2016.11.010. [3]M. Jafri, S. Ansari, M. Alqahtani and J. Shay. «Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies. Genome Medicine., 2016. [Online]. Available: https://doi.org/10.3390/ijms19020482. [4]J. Huppert and S. Balasubramanian. «G-quadruplexes in promoters throughout the human genome». 35, 406–413. 2007. [Online]. Available: https://doi.org/10.1016/j.bbapap.2017.06.012. [5]S. Joy, Vijayakumar, S. Choi and H. Sunhye. «Role of computer-aided drug design in modern drug discovery». Archives of Pharmacal Research. 2015. [Online]. Available: https://doi.org/10.1007/s12272-015-0640-5. [6]S. Asamitsu, S. Obata, Z. Yu, T. Bando and H. Sugiyama. «Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy». Molecules, 24, 429. 2019. [En línea]. Available: https://doi.org/10.3390/molecules24030429. [7]R. Monsen and J. Trent. «Biochimie G-quadruplex virtual drug screening : A review». Biochimie, 152, 134–148. 2018. [Online]. Available: https://doi.org/10.1039/c9cc06748e. [8]J. Beauvarlet, P. Bensadoun, E. Darbo, G. Labrunie, E. Richard, I. Draskovic and M. Djavaheri-mergny. «Modulation of the ATM / autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells». 1–18. 2019. [Online]. Available: https://doi.org/10.1093/nar/gkz095. [9].Z. Crees, J. Girard, Z. Rios, G. Botting, K. Harrington and C. Shearrow. « Oligonucleotides and G-quadruplex stabilizers: targeting telomeres and telomerase in cancer therapy».2014. [Online]. Available: https://doi.org/10.2174/1381612820666140630100702. [10].M. Meier, A. Moya-torres, N. Krahn, M. Mcdougall, L. Orriss, E. Mcrae and T. Patel. «Structure and hydrodynamics of a DNA Gquadruplex with a cytosine bulge»., 1–13. 2018. [Online]. Available: https://doi.org/10.1093/nar/gky307. (shrink)

Sob o tema da filosofia do Espírito em Mestre Eckhart, o presente artigo revitaliza alguns escritos anteriores do autor sobre aquele filósofo, agora atendendo sobretudo ao Sermão do Homem Nobre e no contexto epocal de um intelectualismo ético enquanto pretexto de discussão de conflitos epistémicos. Alguns textos inseríveis nessa corrente são apresentados e confrontados, de seguida, com a expressão tomista com que dialogaram, mas da qual se distinguiram. Sob a dominante matricial da "vida segundo o espírito", de Pseudo-Dionísio a Eckhart, (...) convidar-se-á à superação de uma metafísica do espírito por uma filosofia da liberdade. Em termos disciplinares tradicionais, embora na esteira pensante de Eckhart, isto equivale, contra Feuerbach, justamente, a dizer que o verdadeiro sentido da antropologia é a teologia. /// 'Living in accordance with the spirit' is the theoretical underlying motive of this paper. It resumes previous articles of the author on Eckhart, now stressing the theme of the Noble Man focused on the following historical horizon: the ethical intellectualism of Siger, Boethius and Peter of Auvergne is confronted with the anthropology of beatitude of Thomas Aquinas and mainly with the anthropology of the Portuguese Jesuits of the 16th Century, being the reason for this Duns Scotus' criticism of the former while the latter tried to respond to that criticism. The above-mentioned historical and hermeneutical horizon invites to surpass a permanent metaphysics of the spirit by a philosophy of freedom, thus allowing one to defend that the true meaning of anthropology lies in theology. (shrink)

El propósito de este artículo es el de justificar una interpretación genuinamente hegeliana de la dimensión religiosa en el pensamiento de Hegel, particularmente a partir de la Fenomenología del espíritu. Tanto la izquierda como la derecha hegeliana desarrollaron un carácter unívoco, o bien reduciendo el concepto hegeliano de lo divino a la razón natural o histórica, o bien pasando por alto que la concepción hegeliana de una divinidad inmanente resultaba incompatible con el cristianismo ortodoxo. Analizaremos en detalle los capítulos de (...) la Fenomenología del espíritu que se centran en la Ilustración, en los cuales el autor se desmarca de forma más clara de lo que podría ser una religiosidad puramente deísta. Finalmente, la propuesta de Hegel consistirá en un modelo orgánico de estado, dentro del cual la religión sería aceptada como parte de la misma substancia ética que fundamenta las leyes de cada comunidad. (shrink)

The Spanish Federal Council of the European Movement (SFCEM), founded as a Spanish organization to favour the integration of Spain in Europe, was composed of representatives of various political organizations of the Republican government in exile. Correspondence between the President, Salvador de Madariaga, and the members of the Basque and Catalonian delegations discloses one of the most critical issues of the time: how to organize the Spanish regions after the fall of Franco’s regime. This article explores how the ideas of (...) a Spanish federation – defended by Madariaga – and the interest of the nationalist groups collided during the decades of 1950s and 1960s. The result was a harsh debate on separatism between the Basques and Catalans, who saw Franco’s Spain as the representation of centralism and repression of their identities, and other Spanish exiles. (shrink)