The modifier effect is the reduction in perceived likelihood of a generic property sentence, when the head noun is modified. We investigated the prediction that the modifier effect would be stronger for mutable than for central properties, without finding evidence for this predicted interaction over the course of five experiments. However Experiment 6, which provided a brief context for the modified concepts to lend them greater credibility, did reveal the predicted interaction. It is argued that the (...) modifier effect arises primarily from a general lack of confidence in generic statements about the typical properties of unfamiliar concepts. Neither prototype nor classical models of concept combination receive support from the phenomenon. 2010 Elsevier Inc. All rights reserved. (shrink)

Within-category induction is the projection of a generic property from a class to a subtype of that class. The modifier effect refers to the discovery reported by Connolly et al., that the subtype statement tends to be judged less likely to be true than the original unmodified sentence. The effect was replicated and shown to be moderated by the typicality of the modifier. Likelihood judgements were also found to correlate between modified and unmodified versions of sentences. (...) Experiment 2 elicited justifications, which suggested three types of reason for the effect-pragmatics, knowledge-based reasoning, and uncertainty about attribute inheritance. It is argued that the results provide clear evidence for the default inheritance of prototypical attributes in modified concepts, although a full account of the effect remains to be given. (shrink)

The modifier effect refers to the fact that the perceived likelihood of a property in a noun category is diminished if the noun is modified. For example, “Pigs live on farms” is rated as more likely than “Dirty pigs live on farms.” The modifier effect has been demonstrated in many studies, but the underlying cognitive mechanisms are still unclear. This paper reports two series of experiments that jointly point to the conclusion that the modifier (...) class='Hi'>effect is the result of a superposition of three cognitive mechanisms: (a) probabilistically softened default inheritance, (b) pragmatic implicatures due to Gricean relevance assumptions, and (c) inference based on world knowledge. We present evidence that the pragmatic effects operate largely on an unconscious level and that their influence can be reduced by changing the presentation format of the cognitive task. (shrink)

The advantages and risks of a number of new genome modifying procedures seeking to create healthy or enhanced individuals, such as Maternal Spindle Transfer, Pronuclear Transfer, Cytoplasmic Transfer and Genome Editing, are currently being assessed from an ethical perspective, by national and international policy organizations. One important aspect being examined concerns the effects of these procedures on different kinds of identity. In other words, whether or not a procedure only modifies the qualities or properties of an existing human being, meaning (...) that merely the qualitative identity of this single individual is affected, or whether a procedure results in the creation of a new individual, meaning that a numerically distinct human being would have come into existence. In this article, the different identity arguments proposed, so far, are presented with respect to these novel reproductive procedures. An alternative view is then developed using the Origin Essentialism argument to indicate that any cha... (shrink)

A number of concerns have been raised about the possible future use of pharmaceuticals designed to enhance cognitive, affective, and motivational processes, particularly where the aim is to produce morally better decisions or behavior. In this article, we draw attention to what is arguably a more worrying possibility: that pharmaceuticals currently in widespread therapeutic use are already having unintended effects on these processes, and thus on moral decision making and morally significant behavior. We review current evidence on the moral effects (...) of three widely used drugs or drug types: propranolol, selective serotonin reuptake inhibitors, and drugs that effect oxytocin physiology. This evidence suggests that the alterations to moral decision making and behavior caused by these agents may have important and difficult-to-evaluate consequences, at least at the population level. We argue that the moral effects of these and other widely used pharmaceuticals warrant further empirical research and ethical analysis. (shrink)

Cognitive reappraisal is one of the core treatment components of cognitive behavioral therapy and is the gold standard treatment for major depressive disorders. Accumulating evidence indicates that cognitive reappraisal could function as a protective factor of cognitive vulnerability to depression. However, the neural mechanism by which CR training reduces cognitive vulnerability to depression is unclear. There is ample evidence that the prefrontal–amygdala circuit is involved in CR. This study proposes a novel cognitive bias model of CR training which hypothesizes that (...) CR training may improve the generation ability of CR with altered prefrontal–amygdala functional activation/connectivity, thus reducing negative cognitive bias and alleviating depressive symptoms. This study aims to explore whether there is abnormal CR strategy generation ability in individuals who are cognitively vulnerable to depression; test the hypothesis that CR training alleviates depressive symptoms through the mediators of cognitive bias ; explore the neural mechanism by which CR training may enhance the ability of CR strategy generation; and examine the short- and long-term effects of CR training on the reduction in depressive symptoms in individuals who are cognitively vulnerable to depression following intervention and 6 months later. The study is promising, providing theoretical and practical evidence for the early intervention of depression-vulnerable individuals. (shrink)

Background: Frailty is a natural consequence of the aging process. With the increasing aging population in Mainland China, the quality of life and end-of-life care for frail older people need to be taken into consideration. Advance Care Planning has also been used worldwide in long-term facilities, hospitals and communities to improve the quality of end-of-life care, increase patient and family satisfaction, and reduce healthcare costs and hospital admissions in Western countries. However, it has not been practiced in China. Research objective: (...) This study aimed to evaluate the effectiveness of a modified Advance Care Planning intervention in certainty of end-of-life care, preferences for end-of-life care, quality of life concerns, and healthcare utilization among frail older people. Research design: This study used a quasi-experimental design, with a single-blind, control group, pretest and repeated posttest approach. Participants and research context: A convenience sample of 74 participates met the eligibility criteria in each nursing home. A total of 148 frail older people were recruited in two nursing homes in Zhejiang Province, China. Ethical considerations: The study received ethical approval from the Clinical Research Ethics Committee, the Faculty of Medicine, and The Chinese University of Hong Kong, CREC Ref. No: 2016.059. Findings: The results indicated the Advance Care Planning programme was effective at increasing autonomy in decision making on end-of-life care issues, decreasing decision-making conflicts over end-of-life care issues, and increasing their expression about end-of-life care. Discussion: This study promoted the participants’ autonomy and broke through the inherent custom of avoiding talking about death in China. Conclusion: The modified Advance Care Planning intervention is effective and recommended to support the frail older people in their end-of-life care decision in Chinese society. (shrink)

Cross-education is the phenomenon in which repeated practice of a unilateral motor task does not only result in performance improvement of the trained limb, but also in the untrained contralateral limb. The aim of this study was to test whether cross-education or positive transfer of learning is also achieved for tasks in which both limbs contribute in different ways by using modified equipment that switches the limbs’ role. To this end, a reverse field hockey stick was used that requires a (...) mirroring of arm and hand use and dominance. Two groups of young skilled female field hockey players participated in a crossover-design, in which participants received four training sessions with a reverse hockey stick followed by four training sessions with a regular hockey stick, or vice versa. In a pre-test, intermediate test, a post-test and a retention test, participants’ performance on a field hockey skill test with a regular hockey stick was measured. The results revealed that training with the reversed hockey stick led to significantly increased improvements compared to training with a regular hockey stick. We conclude that modified equipment can be used to exploit positive transfer of learning by switching the limbs’ roles. The findings are discussed by referring to the symmetry preservation principle in dynamic systems theory and have clear practical relevance for field hockey trainers and players seeking to further improve field hockey skills. (shrink)

Modified numerals, such as at least three and more than five, are known to sometimes give rise to ignorance inferences. However, there is disagreement in the literature regarding the nature of these inferences, their context dependence, and differences between at least and more than. We present a series of experiments which sheds new light on these issues. Our results show that the ignorance inferences of at least are more robust than those of more than, the presence and strength of the (...) ignorance inferences triggered by both at least and more than depends on the question under discussion, and whether ignorance inferences are detected in a given experimental setting depends partly on the task that participants are asked to perform. We offer an Optimality Theoretic account of these findings. In particular, the task effect is captured by assuming that in performing an acceptability task, participants take the speaker’s perspective in order to determine whether an expression is optimal given a certain epistemic state, while in performing an inference task they take the addressee’s perspective in order to determine what the most likely epistemic state of the speaker is given a certain expression. To execute the latter task in a fully rational manner, participants have to perform higher-order reasoning about alternative expressions the speaker could have used. Under the assumption that participants do not always perform such higher-order reasoning but also often resort to so-called unidirectional optimization, the task effect finds a natural explanation. This also allows us to relate our finding to asymmetries between comprehension and production that have been found in language acquisition. (shrink)

It is a fact that human subjects rate sentences about typical properties such as “Ravens are black” as very likely to be true. In comparison, modified sentences such as “Feathered ravens are black” receive lower ratings, especially if the modifier is atypical for the noun, as in “Jungle ravens are black”. This is called the modifier effect. However, the likelihood of the unmodified statement influences the perceived likelihood of the modified statement: the higher the rated likelihood of (...) the unmodified sentence, the higher the rated likelihood of the modified one. That means the modifier effect does not fully block default inheritance of typical properties from nouns to modified nouns. This paper discusses this inheritance effect. In particular, I ask whether it is the direct result of composing concepts from nouns, that is, a bias toward “black” when processing “raven”. I report a series of experiments in which I find no evidence for a direct inheritance from composition. This supports the view that default inheritance is rather an inference than a bias. (shrink)

BackgroundStress is a major risk factor for the impairment of psychological well-being. The present study aimed to evaluate the empirical evidence of the Transactional Stress Model proposed by Lazarus and Folkman in patients with psychosomatic health conditions.MethodsA structural equation model was applied in two separate subsamples of inpatients from the Department of Psychosomatic Medicine for consecutive model building and confirmatory analyses using self-reported health status information about perceived stress, personal resources, coping mechanisms, stress response, and psychological well-being.ResultsThe initial model was (...) created to reflect the theoretical assumptions by Lazarus and Folkman about their transactional stress concept. This model was modified until a sufficient model fit was reached. The modified model was confirmed in a second sample. Perceived external stressors and personal resources explained 91% of the variance of the stress response, which was closely related to symptoms of depression. The attenuating effect of resources on stress response was higher than the impact of perceived stressors on stress response.ConclusionThe empirical data largely confirmed the theoretical assumption of the Transactional Stress Model, which was first presented by Lazarus and Folkman, in patients with a wide range of psychosomatic conditions. However, data analyses were solely based on self-reported health status. Thus, proposed inner psychological mechanisms such as the appraisal process could not be included in this empirical validation. The operationalization and understanding of coping processes should be further improved. (shrink)

Food products with genetically modified ingredients are common, yet many consumers are unaware of this. When polled, consumers say that they want to know whether their food contains GM ingredients, just as many want to know whether their food is natural or organic. Informing consumers is a major motivation for labeling. But labeling need not be mandatory. Consumers who want GM-free products will pay a premium to support voluntary labeling. Why do consumers want to know about GM ingredients? GM foods (...) are tested to ensure safety and have been on the market for more than a decade. Still, many consumers, including some with food allergies, want to be cautious. Also, GM crops may affect neighboring plants through pollen drift. Despite tests for environmental impact, some consumers may worry that GM crops will adversely effect the environment. The study of risk and its management raises questions not settled by the life sciences alone. This book surveys various labeling policies and the cases for them. It is the first comprehensive, interdisciplinary treatment of the debate about labeling genetically modified food. The contributors include philosophers, bioethicists, food and agricultural scientists, attorneys/legal scholars, and economists. (shrink)

We compute the effect of collapse models on neutrino oscillations. The effect of the collapse is to modify the evolution of the spatial part of the wave function and we will show that this indirectly amounts to a change on the flavor components. For the analysis we use the mass proportional CSL model, and perform the calculation to second order perturbation theory. As we will show, the CSL effect is very small—mainly due to the very small mass (...) of neutrinos—and practically undetectable. (shrink)

It has been shown that when participants are asked to make sensibility judgments on sentences that describe a transfer of an object toward or away from their body, they are faster to respond when the response requires a movement in the same direction as the transfer described in the sentence. This phenomenon is known as the action compatibility effect. This study investigates whether the ACE exists for volunteers with Alzheimer's disease, whether the ACE can facilitate language comprehension, and also (...) whether the ACE can still be produced if the order of the two events is inverted, that is, whether overt movement can prime comprehension of transfer sentences. In Study 1, participants with AD, younger, and older adults were tested on an adaptation of the ACE Paradigm. In Study 2, the same paradigm was modified to include an arm movement that participants had to perform prior to sentence exposure on screen. In Study 1, young, older adults, and individuals with AD were faster to respond when the direction of the response movement matched the directionality implied by the sentence. In Study 2, no traditional ACE was found; participants were faster when the direction of the movement immediately preceding the sentence matched the directionality of the sentence. It was found that compatibility effects generated a relative advantage, that transfer schemata are easier to process, and that an ACE-like effect can be the result of mutual priming between language and movement. Results suggested preservation in AD of the neural systems for action engaged during language comprehension, and conditions under which comprehension in AD can be facilitated in real life may be identified. (shrink)

Methods of punishing corporations have changed from self-regulation to economic sanctions by government as corporations have evolved from small groups of entrepreneurs to multinational entities. It is proposed that the next stage in the evolution of punishment methods is modified vendettas, or organized attempts by non-government groups to influence corporations through the application of economic and non-economic sanctions.This paper develops the concept of modified vendettas as a complement to government-initiated economic sanctions. The effectiveness of modified vendettas is analyzed through two (...) case examples. As with any punishment method, however, the usefulness of a modified vendetta depends not only on its effectiveness but also on how well it meets society's needs to monitor and check corporate activity while preserving corporations' rights to operate. To resolve this issue, modified vendettas are assessed using a philosophical framework incorporating both retributive and utilitarian principles. It is found that modified vendettas extend society's ability to control corporate behavior while corporations have legal and public relations means to protect themselves from frivolous use of the technique. Did you ever expect a corporation to have a conscience, when it has no soul to be damned, and no body to be kicked? (Baron Thurlow). (shrink)

According to Grice's “Modified Occam's Razor”, in case of uncertainty between the implicature account and the polysemy account of word uses it is parsimonious to opt for the former. However, it is widely agreed that uses can be partially conventionalised by repetition. This fact, I argue, raises a serious problem for MOR as a methodological principle, but also for the substantial notion of implicature in lexical pragmatics. In order to overcome these problems, I propose to reinterpret implicatures in terms of (...) implicature-like effects delivered by non-inferential processes. (shrink)

Many industrial processes are operated in multiple modes due to different manufacturing strategies. Multimodality of process data is often accompanied with nonlinear and non-Gaussian characteristics, which makes data-driven monitoring more complicated. In this paper, statistics pattern analysis is introduced to extract low- and high-order statistics from raw process data. Support vector data description, which can deal with nonlinear and non-Gaussian problems, is applied to monitor multimode process in this paper. To improve detection performance of SVDD for training multimode data with (...) outliers, modified local reachability density ratio is proposed as a weight factor to be embedded in the weighted-SVDD model, in which the local neighbors in terms of both space and time are considered. Finally, the effectiveness and superiority of our proposed method are demonstrated by the Tennessee-Eastman process and wastewater treatment process. (shrink)

The existence of current–time universe’s acceleration is usually modeled by means of two main strategies. The first makes use of a dark energy barotropic fluid entering by hand the energy–momentum tensor of Einstein’s theory. The second lies on extending the Hilbert–Einstein action giving rise to the class of extended theories of gravity. In this work, we propose a third approach, derived as an intrinsic geometrical effect of space–time, which provides repulsive regions under certain circumstances. We demonstrate that the effects (...) of repulsive gravity naturally emerge in the field of a homogeneous and isotropic universe. To this end, we use an invariant definition of repulsive gravity based upon the behavior of the curvature eigenvalues. Moreover, we show that repulsive gravity counterbalances the standard gravitational attraction influencing both late and early times of the universe evolution. This phenomenon leads to the present speed up and to the fast expansion due to the inflationary epoch. In so doing, we are able to unify both dark energy and inflation in a single scheme, showing that the universe changes its dynamics when \, at the repulsion onset time where this condition is satisfied. Further, we argue that the spatial scalar curvature can be taken as vanishing because it does not affect at all the emergence of repulsive gravity. We check the goodness of our approach through two cosmological fits involving the most recent union 2.1 supernova compilation. (shrink)

An unlinked seroprevalence study of HIV and other viruses was conducted on pregnant women on the Caribbean island of Grenada in 1994. Investigators were from both the developed world and the Grenadian Ministry of Health . There was then no board on Grenada to protect research subjects or review ethical aspects of studies. Nurses from the MOH were asked to verbally inform their patients about the study, and request that patients become subjects of the study and give blood for screening. (...) If consent was given nurses took blood and administered a survey about each subjects' knowledge of HIV transmission routes. Nurses shared a spoken dialect and cultural heritage with prospective subjects and were probably more effective than foreign researchers at informing subjects. Informed consent was obtained with a simplified consent form supplemented by conversation with each prospective research subject. Facilitating discussion between people with common cultural backgrounds helps apply the Western approach to informed consent to communities in the developing world. Researchers must disclose all information to nurses or other mediators, and ensure that nurses disclose as much information as possible to prospective subjects. So modified, informed consent maintains respect for persons and becomes applicable and relevant to various cultures. (shrink)

Utterances can convey more information than they explicitly encode, and speakers exploit communicative conventions in order to say more with less. However, the burden this places on perceivers is not well understood. This chapter examines the effect of speaker-specific information on pragmatic inferences using data from an experiment which investigated the time course of the use of pragmatic information in language comprehension. Previous evidence suggests that comprehenders who encounter a referential form, including a modifier that commonly indicates contrastiveness, (...) assume that the referential form is being used contrastively. Thus, they consequently look to the relevant object in the scene very early when processing the referential expression. In this case, people appear to be implicitly following H. P. Grice’s maxim of quantity. This chapter demonstrates that comprehenders stop using contrastive information early in resolving reference when speakers consistently do not use contrastive elements appropriately, consistent with a pragmatic explanation of referential contrast effects. (shrink)

An unlinked seroprevalence study of HIV and other viruses was conducted on pregnant women on the Caribbean island of Grenada in 1994. Investigators were from both the developed world and the Grenadian Ministry of Health . There was then no board on Grenada to protect research subjects or review ethical aspects of studies. Nurses from the MOH were asked to verbally inform their patients about the study, and request that patients become subjects of the study and give blood for screening. (...) If consent was given nurses took blood and administered a survey about each subjects' knowledge of HIV transmission routes. Nurses shared a spoken dialect and cultural heritage with prospective subjects and were probably more effective than foreign researchers at informing subjects. Informed consent was obtained with a simplified consent form supplemented by conversation with each prospective research subject. Facilitating discussion between people with common cultural backgrounds helps apply the Western approach to informed consent to communities in the developing world. Researchers must disclose all information to nurses or other mediators, and ensure that nurses disclose as much information as possible to prospective subjects. So modified, informed consent maintains respect for persons and becomes applicable and relevant to various cultures. (shrink)

ObjectiveTo explore the effect of modified constraint-induced movement therapy on upper limbs residual dysfunction for infancy with the sequelas of unilateral brachial plexus injury.MethodsSingle blind randomized controlled trial of mCIMT vs. standard care. An enrolling 31 infants with a uBPI exhibiting residual dysfunction of the affected upper limb for over 6 months was conducted. And functional outcomes pertaining to the affected upper limb were assessed via AMS, GRES, RHS, and MSS at 0, 3, and 6 months after treatment.ResultsNo differences (...) were found in baseline AMS, MSS, GRES, or RHS between the control and mCIMT groups [F = 0.062, P = 0.086; F = 0.483, P = 0.499; F = 0.272, P = 0.610; Z = −0.336, P = 7.373]. At the 3- and 6-month follow-up time points, AMS, MSS, and GRES scores were significantly improved over baseline in both groups [mCIMT: F = 183.750, 128.614, 110.085, P < 0.05; Control: F = 204.007, 75.246, 51.070, P < 0.05]. No significant differences were found between two treatment groups at the 3-month follow-up time point [F = 0.565, P = 0.465; F = 0.228, P = 0.641; F = 0.713, P = 0.413; Z = −0.666, P = 0.505]. However, at the 6-month follow-up time point, AMS and MSS scores were significantly improved in the mCIMT group relative to the control group [F = 8.077, P = 0.013; F = 18.692, P = 0.001].ConclusionmCIMT may benefit the rehabilitation of residual upper limb dysfunction associated with a uBPI in infants.Clinical Trial Registration[www.chictr.org.cn], identifier [ChiCTR1900022119]. (shrink)

This book is comprised of a number of articles written by women on the impact of feminism on academic disciplines. Fundamental to feminism is the premise that women have been 'left out' of codified knowledge, so that the world has been explained in terms of men but not women. The contributors explore not only how this happened but why. They document, discipline by discipline, the gain that feminism has made in establishing alternative processes and alternative knowledge and the effect (...) these are having in modifying the academic curriculum. (shrink)

This paper addresses the job shop scheduling problem including time lag constraints. This is an extension of the job shop scheduling problem with many applications in real production environments, where extra delays can be introduced between successive operations of the same job. It belongs to a category of problems known as NP-hard problem due to large solution space. Biogeography-based optimization is an evolutionary algorithm which is inspired by the migration of species between habitats, recently proposed by Simon in 2008 to (...) optimize hard combinatorial optimization problems. We propose a hybrid biogeography-based optimization algorithm for solving the job shop scheduling problem with additional time lag constraints with minimization of total completion time. In the proposed HBBO, the effective greedy constructive heuristic is adapted to generate the initial population of habitat. Moreover, a local search metaheuristic is investigated in the mutation step in order to ameliorate the solution quality and enhance the diversity of the population. To assess the performance of HBBO, a series of experiments on well-known benchmark instances for job shop scheduling problem with time lag constraints is performed. (shrink)

Purpose: Empirical studies suggest that corporate social responsibility impacts young job seekers’ choices of an employer. Values seem to affect CSR preferences, influencing the felt fit between the person and the organization and hereby the valence of working for that company. This article aims to research in more detail the preference structure of young graduate job seekers. In particular, it seeks to understand whether CSR is important when there is a trade-off between CSR and non-CSR attributes and whether basic value (...) orientations of job seekers have a moderating effect on their employer preferences. Design/methodology/approach: This article used a quantitative approach with a survey sample of 577 German students who were in their last year of study. To gain information on the relative impact of CSR- and non-CSR-related employer characteristics on employer attractiveness, an adaptive conjoint analysis was applied. Correlation analysis and a two-step hierarchical regression were conducted to detect the effects of individual value orientations. Findings: Only a few CSR attributes are relevant for young job seekers compared with other traditional employer attributes. Specific value orientations can be identified as having a moderating effect on CSR preferences. This is particularly the case for value orientations indicating a concern for the welfare of others and the environment positively affect the importance of most CSR attributes while more selfish value orientations have a negative effect. Originality/value: This study sheds light on the relative importance of CSR attributes when compared with non-CSR attributes. Moreover, it relates employee-related preferences to individual value orientations and shows that selected values have a modifying effect on the importance of CSR for job choice. (shrink)

The Iowa Gambling Task (IGT) simulates uncertain gains and losses in real life situations and thus is a good measure of uncertain decision making. The role of working memory (WM) in IGT performance still remains unclear. The present study aimed to examine the effect of WM on IGT performance. Three groups of participants matched on gender ratio were randomly assigned to no WM load, low WM load, and high WM load conditions. Initially the three groups did not show significant (...) difference in WM capacity. They finished a modified version of IGT and then their implicit learning effect and explicit cognition on IGT were assessed. Results indicated a linear increasing trend of IGT performance among high WM load, low WM load and no WM load groups; participants in the no WM load and low WM load groups revealed implicit learning effect, while participants in the high WM load group did not; all participants showed explicit cognition on IGT to the same level. These results suggested that participants in the high WM load group showed good explicit cognition to IGT but showed poor performance. This pattern is similar to frontal patients. Further studies should be conducted to explore this issue. (shrink)

The Doctrine of Double Effect (DDE) is an influential non-consequentialist principle positing a role for intention in affecting the moral permissibility of some actions. In particular, the DDE focuses on the intend/foresee distinction, the core claim being that it is sometimes permissible to bring about as a foreseen but unintended side-effect of one’s action some harm it would have been impermissible to aim at as a means or as an end, all else being equal. This article explores the (...) meaning and application of the DDE along with current debates over the nature of the intend/foresee distinction and its moral significance. How is the line between intended effects and merely foreseen but unintended side-effects to be drawn, and how are problem cases best handled? What is an appropriate methodology for debating the tenability of the DDE? How might the DDE interact with other non-consequentialist principles, and how might it be modified to capture other related factors (resulting perhaps in a Doctrine of Triple Effect) or to avoid certain problem cases? Does the DDE make permissibility turn on the actual intentions of particular agents, as critics such as Thomson and Scanlon assume, or is the role of intention more abstract? (shrink)

The origin and development of consciousness is poorly understood. Although it is clearly a naturalistic phenomenon evolved through Darwinian evolution, explaining it in terms of physicochemical, neural, or symbolic mechanisms remains elusive. Here I propose that two steps had to be taken in its evolution. First, living systems evolved an intrinsic goal-directedness by internalizing Darwinian fitness as a self-estimated fitness. The self-estimated fitness participates in a feedback loop that effectively produces intrinsic meaning in the organism. Second, animals with advanced nervous (...) systems evolved a special form of communication that modifies the way each partner estimates fitness. The resulting change in intrinsic meaning is experienced subjectively as a primary form of consciousness. This primary form is subsequently used to generate, partly through internalized dialogue, more complex forms of consciousness, such as consciousness of the natural and social worlds, consciousness of the self, and language-dependent forms of consciousness. An updated version of the theory in this paper can be found as Chapter 12 ('Consciousness') in my book 'The estimator theory of life and mind: how agency and consciousness can emerge', see VANTET-8 at philpapers . (shrink)

Variegated phenotypes often result from chromosomal rearrangements that place euchromatic genes next to heterochromatin. In such rearrangements, the condensed structure of heterochromatin can spread into euchromatic regions, which then assume the morphology of heterochromatin and become transcriptionally inactive. In position‐effect variegation (PEV) therefore, gene inactivation results from a change in chromatin structure. PEV has been intensively investigated in the fruitfly Drosophila, where the phenomenon allows a genetic dissection of chromatin components. Consequently, many genes have been identified which, when mutated, (...) act as dominant modifiers (suppressors or enhancers) of PEV. Data available already demonstrate that genetic, molecular and developmental analysis of these genes provides an avenue to the identification of regulatory and structural chromatin components, and hence to fundamental aspects of chromosome structure and function. (shrink)

It has generally been recognized that while Bruno Latour’s and Martin Heidegger’s respective philosophies of technology converge on key points there is also a significant difference of attitudes towards the themes discussed. To better appreciate the similarities and differences, I suggest that we seek to understand both Latour and Heidegger as philosophers of the event, who seek to rescue the novel emergence of beings from the sedimentation of reductive, explanatory frameworks. I take up this line of thought and compare Latour’s (...) and Heidegger’s theories of things and the types of experiences they presume. Latour’s metaphysics of the actant ensures that no actant’s activity is ever reduced to being the passive effect of another. Yet while the actant can be ‘applied’ to any entity, from a Heideggerian standpoint this strength is precisely its weakness. Latour’s metaphysics provides a horizon of thought that blocks an original experience of things that Heidegger’s thought points towards. By stepping back from the horizonal experience Latour’s metaphysical blueprint for entities imposes, one can enter into an original opening that stems neither from humans nor nonhumans, but an ineradicable mystery at the origin of being. This mystery is nothing more than the inability to give ultimate reasons for the presence of beings. While Latour’s actant as _Ding_ is simply an actant with innumerable relations, Heidegger’s _das Ding_ is the concrete experience of the dissolution of metaphysical reasons, first and last causes. Precisely because Heidegger’s _das Ding_ emerges from a prior mystery that suspends any overarching causal or purposive schema, things can more freely presence from themselves. (shrink)

This article analyzes the relative effectiveness and limitations of companies’ voluntarily produced transparency reports in promoting change in firm and government behavior. Such reports are published by telecommunications companies and disclose how often and on what grounds government agencies compel customer data from these companies. These reports expose corporate behaviors while lifting the veil of governmental secrecy surrounding these kinds of compulsions. Fung, Graham, and Weil’s “targeted transparency” model is used to evaluate the extent to which these reports affect behavior. (...) From the analysis, it is evident that telecommunications companies’ transparency reports are only partially effective; while firms may modify their reports to present more information, these reports do not necessarily induce government to more broadly reveal its own activities. The article ultimately suggests that voluntarily produced transparency reports may become more comparable with one another as a result of either corporate reports evolving in consultation with external stakeholders or following a crisis that prompts government or industry to adopt a given standard. Such standards may positively influence the effectiveness of reports while concealing as much about firm behaviors as they purport to reveal. (shrink)

Pragmatist responses to skepticism about empirical justification have mostly been underwhelming, either presupposing implausible theses like relativism or anti-realism, or else showing our basic empirical beliefs to be merely psychologically inevitable rather than rationally warranted. In this paper I defend a better one: a modified version of an argument by Wilfrid Sellars that we are pragmatically warranted in accepting that our perceptual beliefs are likely to be true, since their likely truth is necessary for the satisfaction of our goal of (...) effective agency. On the version of the argument I defend, the great good for human life of control over our empirical circumstances renders our goal of effective agency reasonable. But only if our perceptual beliefs are likely to be true—and only if we accept that this is so, assuming it as a premise for inference and a guide for action—will the success of our actions be due to our effective agency, not mere luck. Since we’re warranted in taking the necessary means to our reasonable ends, we’re warranted in accepting that our perceptual beliefs are generally justified, and so that skepticism about empirical justification is false. (shrink)

A review of the arguments that make up the current controversy on genetically modified foods (GMFs) is briefly given as well as an assessment of their cogency. The two main arguments for GMFs are utilitarian (we can feed a greater number of people with them than without) and environmental (we can increase the food supply without diminishing the wilderness areas by displacing them with farm land). The arguments against evolve around the idea of unforeseen consequences which could have irreversible effects (...) on the food supply and consumers. A major philosophical issue centers on the claim that genetic engineering is equivalent to conventional breeding (the advocates claim this) and the opponents who deny the equivalence. Because of the uncertainties involved in GMFs, it is suggested that their labeling, in addition to non-GMFs’ labeling, should be enforced so that the public can make their own decision as to what they should eat. The inference drawn from this debate is that we should proceed on a case by case basis, because of the rapidly changing biotechnologies. (shrink)

In its original expression as a medical value confidentiality may have been absolute; this concept has become eroded by patient consent, legal actions and change in the climate of public opinion. In particular requirements arising out of legal statutes and common law judgements have greatly modified the confidentiality of the doctor-patient relationship in societies deriving their law from English origins. Despite this, confidentiality remains a value which the physician must strive to preserve. He cannot however do this without considering its (...) effect upon possible innocent third parties. (shrink)

In the Trolley Case (Figure 1), as devised by Philippa Foot and modified by Judith Jarvis Thomson, a runaway trolley (i.e. tram) is headed down a main track and will hit and kill five unless you divert it onto a side track, where it will hit and kill one.