We define a complete theory SHF e of separably closed fields of finite invariant e (= degree of imperfection) which carry an infinite stack of Hasse-derivations. We show that SHF e has quantifier elimination and eliminates imaginaries.

Alm, Margit Review of: Countdown: Our last, best hope for a future on earth?, by Alan Weisman, First Published in the US by Little, Brown and Company, Hachette Book Group ISBN 978-1-4087-0267-3.

This article addresses the sacredness of Ayahuasca from the perspective of the global shamanic vocation. If encounters with Ayahuasca are said to revitalize forms of sacredness in contemporary societies, this is perhaps clearest in cases where individuals understand themselves to be called to lead ceremonies. Recognizing the global scale of Ayahuasca shamanism, we compare facilitators of ceremonies in two societies to discern differences and similarities in how Ayahuasca vocations exist in differently modernized societies: Peru, a predominantly Catholic society with a (...) substantial Indigenous Amazonian population and an active Ayahuasca shamanism tourism sector, and Denmark, a secular society in Northern Europe, where Ayahuasca is illegal. Building on recent reappraisals of Weber’s reflection on vocation and Durkheim’s theory of the sacred, we argue that being called by Ayahuasca to follow shamanic vocations in contemporary societies leads to tensions around the need to both justify and resist the rationalization of Ayahuasca. (shrink)

Alm, Margit Review of: Growing for broke: How the government has sold out to private interests, by Peter North, Published in 2016 by Tomorrow Press, PO Box 238, Berwick, Vic. 3806 ISBN 978-168418977-9.

As artificial intelligence systems are becoming increasingly autonomous and will soon be able to make decisions on their own about what to do, AI researchers have started to talk about the need to align AI with human values. The AI ‘value alignment problem’ faces two kinds of challenges—a technical and a normative one—which are interrelated. The technical challenge deals with the question of how to encode human values in artificial intelligence. The normative challenge is associated with two questions: “Which values (...) or whose values should artificial intelligence align with?” My concern is that AI developers underestimate the difficulty of answering the normative question. They hope that we can easily identify the purposes we really desire and that they can focus on the design of those objectives. But how are we to decide which objectives or values to induce in AI, given that there is a plurality of values and moral principles and that our everyday life is full of moral disagreements? In my paper I will show that although it is not realistic to reach an agreement on what we, humans, really want as people value different things and seek different ends, it may be possible to agree on what we do not want to happen, considering the possibility that intelligence, equal to our own, or even exceeding it, can be created. I will argue for pluralism which is compatible with objectivism. In spite of the fact that there is no uniquely best solution to every moral problem, it is still possible to identify which answers are wrong. And this is where we should begin the value alignment of AI. (shrink)

This article focuses on healthcare ethics discussions in Estonia. We begin with an overview of the reform policies that the healthcare institutions have undergone since the region regained independence from the Soviet Union in 1991. The principles of distributing healthcare services and questions regarding just what ethical healthcare should look like have received abundant coverage in the national media. An example of this is the exceptionally public case of V—a woman with leukemia whose expensive drugs the national health insurance fund (...) refused to compensate. In our subsequent discussion, we focus on a grand-scale local healthcare and research project—the Estonian Genome Project—that attempts to include 1 million DNA samples into one database. (shrink)

Photographs and text document disappearing cultural landscapes and lifestyles in rural China, capturing poignant scenes far from Beijing or Shanghai. Just a few kilometers from the glittering skylines of Shanghai and Beijing, we encounter a vast countryside, an often forgotten and seemingly limitless landscape stretching far beyond the outskirts of the cities. Following traces of old trade routes, once-flourishing marketplaces, abandoned country estates, decrepit model villages, and the sites of mystic rituals, the authors of this book spent seven years exploring, (...) photographing, and observing the vast interior of China, where the majority of Chinese people live in ways virtually unchanged for centuries. China's Vanishing Worlds is an impressive documentation in images and text of modernization's effect on traditional ways of life, and a sympathetic portrait of lives burdened by hardship but blessed by simplicity and tranquility. The scars of China's recent history and the decay of centuries-old traditions are made visible in this volume, but so is the lure and promise of technology and another life for young people. In the next twenty years, an estimated 280 million Chinese villagers will become city dwellers, leaving their ancestral homes in search of urban jobs and opportunities. In striking and evocative color photographs, we see picturesque villages set against a background of rolling hills, planned centuries ago according to the principles of feng shui; a restaurant with bright pink resin chairs and a wide-screen television; traditional buildings preserved by the accident of poverty and isolation; ramshackle rooms decorated with portraits of Chairman Mao; backpack-wearing children walking to school; festivals with elaborately costumed performers; old men playing cards; buyers and sellers at open-air markets. China's Vanishing Worlds offers readers a rare opportunity to glimpse China as it once was, and as it will soon no longer be. (shrink)

Physiologically accurate mouse models of cancer are critical in the pre‐clinical development of novel cancer therapies. However, current standardized animal‐housing temperatures elicit chronic cold‐associated stress in mice, which is further increased in the presence of tumor. This cold‐stress significantly impacts experimental outcomes. Data from our lab and others suggest standard housing fundamentally alters murine physiology, and this can produce altered immune baselines in tumor and other disease models. Researchers may thus underestimate the efficacy of therapies that are benefitted by immune (...) responses. A potential mediator, norepinephrine, also underlies stress pathways common in mice and humans. Therefore, research into mechanisms connecting cold‐stress and norepinephrine signaling with immune depression in mice could highlight new combination therapies for humans to simultaneously target stress while stimulating anti‐tumor immunity. (shrink)

Whereas in the 1970s early bioethicists believed that bioethics is an arena for the application of philosophical theories of utilitarianism, deontology, and natural law thinking, contemporary policy-oriented bioethicists seem rather to be keen on framing ethical issues through political ideologies. Bioethicists today are often labeled “liberal” or “communitarian,” referring to their different understandings of the relationship between the individual and society. Liberal individualism, with its conceptual base of autonomy, dignity, and privacy, enjoyed a long period of dominance in bioethics, but (...) it has increasingly come under attack from ideologies promoting a more salient role for concepts of solidarity, community, and public interest. (shrink)

This article challenges hierarchical and binary thinking in constitutional theory, and offers an alternative basis that draws on multidimensionality. The recognition that constitutionalism is a collection of ingrained tensions between competing forces and conceptual bases is applied in a study of the executive branch, a field that is especially lacking in general theory. The existing research of the executive is almost entirely concerned with specific legal systems and is typically normative; descriptively, references to puzzles and ambiguity offer an inadequate, a-theoretical (...) basis for the understanding of the nature of the executive. Rejecting three alternative models, two of them hierarchical, the third, binary, I reach the internal tension model, which acknowledges the internal irresolvable tension between the executive’s subservience to law and its dominance beyond law, which underlies executive action. The article addresses the ways law can, and does, maintain this internal tension, and ends with some comments on future research directions. (shrink)

Apoptosis is a physiological mechanism for the removal of unwanted or damaged cells. Apoptotic cells are rarely seen in living tissues, however, because of their rapid and efficient removal by phagocytosis. Phagocytotic cells such as macrophages or dendritic cells recognize apoptotic cells by specific changes of cell surface markers, which usually are not present on normal cells. One such event is the exposure of phosphatidylserine, which moves from the plasma membrane inner leaflet to the outer leaflet in preapoptotic cells. An (...) unresolved problem, however, was the nature of the phosphatidylserine receptor on the phagocytotic cells. In a recent issue of Nature, Fadok et al.(1) have reported the cloning of a phosphatidylserine receptor using an antibody raised against activated macrophages. Antibody treatment of these macrophages blocks this capacity to engulf. BioEssays 22:878–881, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

Auf die Frage nach der Rationalität des Glaubens hat William P. Alston, einer der prominentesten Vertreter der Analytischen Religionsphilosophie, eine zeitgemäße, aber auch spannungsreiche Antwort vorgelegt. Alstons Ansatz wird in diesem Buch systematisch aufgearbeitet und damit einer breiteren Rezeption im deutschsprachigen Raum zugänglich gemacht. Die Analyse der Autorin Margit Wasmaier macht deutlich, dass Alston angesichts der Frage, ob man religiöse Überzeugungen heute überhaupt noch begründet vertreten kann, einen pragmatischen Weg einschlägt, ohne aber den Standpunkt eines metaphysischen Realismus zu verlassen.

This article examines non-statutory executive powers, which are commonly employed in the modern state but rarely studied as a distinct concept. The article assesses three treatments of these powers available in current English public law—prerogative, common law powers which rely on analogies between the state and legal persons, and judicial review—and argues that they fail to provide a proper balance between legality and need. Royal prerogative connotes a shrinking reservoir of ancient powers, while non-statutory powers respond to unexpected futures and (...) statute’s intrinsic eventual failings. Analogies to legal persons fail to address the particularities of executive powers. Judicial review provides only a partial solution, since absence of parliamentary approval is not, in itself, ground for special treatment of executive action. The author joins calls for theoretization of public law and advances a model of executive powers that draws on a composite theory of the executive branch and its functions.This article examines non-statutory executive powers, which are commonly employed in the modern state but rarely studied as a distinct concept. The article assesses three treatments of these powers available in current English public law—prerogative, common law powers which rely on analogies between the state and legal persons, and judicial review—and argues that they fail to provide a proper balance between legality and need. Royal prerogative connotes a shrinking reservoir of ancient powers, while non-statutory powers respond to unexpected futures and statute’s intrinsic eventual failings. Analogies to legal persons fail to address the particularities of executive powers. Judicial review provides only a partial solution, since absence of parliamentary approval is not, in itself, ground for special treatment of executive action. The author joins calls for theoretization of public law and advances a model of executive powers that draws on a composite theory of the executive branch and its functions. (shrink)

Die Beiträge des Bandes untersuchen die Genese der Rechtsphilosophie Kants und zeigen auf, dass deren grundlegende Thesen lange vor der „Metaphysik der Sitten“ existierten. Das erfordert die Analyse der kantischen Vorlesungen zum Naturrecht in den handschriftlichen Quellen, die die Interpretation der veröffentlichten Werke entscheidend ergänzen können: Kant hielt in Königsberg von 1767 bis 1788 Vorlesungen zum Naturrecht, von denen nur eine einzige handschriftliche Abschrift aus dem Sommersemester 1784 erhalten ist – „Naturrecht Feyerabend“. Mit der philosophischen Analyse der Vorlesungsnachschrift, die bislang (...) von Forschern unter rechts-, moral- und kulturphilosophischen Aspekten nur in Ansätzen untersucht wurde, soll durch die Bestimmung des Verhältnisses von Recht und Moral eine grundlegende theoretische Vorarbeit für einen internationalen Dialog über die normativen Grundlagen des modernen Rechtsstaates geleistet werden. Nach der Wiederentdeckung der normativen Ethik Kants sowie seines politischen Denkens in der internationalen Kantforschung und den „Humanities“ vervollständigt die Neubewertung der Rechtslehre die Renaissance der praktischen Philosophie Kants – sicherlich eines der wichtigsten Phänomene der moralischen und der Rechts-Kultur unserer Zeit. (shrink)

This article provides a short survey of Joachim Kopper’s understanding of Kant’s theory of cognition in CPR. Kant’s critical thought is developed via a dogmatic method but marks a transition to transcendental thought delivered from dogmatic assertions. The assertion that cognition emerges from the relation between mind and objects is made at the beginning of CPR. Kopper holds that transcendental reflection starts not on the basis of this distinction but on the impossibility of logical assertion about existence as it is (...) reached in antinomic. The fact of experience must thus be explained otherwise than by dogmatic assertions of relations between objects or between objects and thought. Reflection on necessity, affirmed by the law of causality, enables transcendental inspection to understand experience and human life in one unrelational meaning. (shrink)

Open source software production is a successful new innovation model which disproves that only private ownership of intellectual property rights fosters innovations. It is analyzed here under which conditions the open source model may be successful in general. We show that a complex interplay of situational, motivational, and institutional factors have to be taken into account to understand how to manage the ‘tragedy of the commons’ as well as the ‘tragedy of the anticommons’. It is argued that the success of (...) this new innovation model is greatly facilitated by a well balanced portfolio of intrinsic and extrinsic motivation, low costs for contributors and governance mechanisms that do not crowd out intrinsic motivation. (shrink)

Burial in the forest is a recent, non-confessional alternative to the established cemeteries owned and run by the Evangelical Lutheran Church in Denmark. Danish forest burials fulfil common criteria for non-religion and they are an example of institutionalized non-religion. Their non-confessional character is emphasized in the information material directed towards potential buyers of forest burial plots. Forest burials appeal to both non-members and members of the Evangelical Lutheran Church; in fact, nearly two-thirds of those who had a forest burial by (...) the end of 2021 were members of the church. I have participated in seven tours conducted at different forest burial sites, and I have interviewed nearly fifty participants about their motives for considering buying a forest burial plot. In my analyses, I structure the interviews along the three dimensions, knowing, doing, and being. I found that the motives for people to choose a forest burial reflected both non-religious and religious/spiritual considerations. Forest burials exemplify a religious complexity where nature, non-religion, religion, and spirituality intersect. In this complexity, I see the institution of forest burial as a non-religious vessel, which the buyers fill with their individual thoughts and acts. (shrink)

Muscle synergies reflect the presence of a common neural input to multiple muscles. Steering small sets of synergies is commonly believed to simplify the control of complex motor tasks like walking and running. When these locomotor patterns emerge, it is likely that synergies emerge as well. We hence hypothesized that in children learning to run the number of accompanying synergies increases and that some of the synergies’ activities display a temporal shift related to a reduced stance phase as observed in (...) adults. We investigated the development of locomotion in 23 children aged 2–9 years of age and compared them with seven young adults. Muscle activity of 15 bilateral leg, trunk, and arm muscles, ground reaction forces, and kinematics were recorded during comfortable treadmill walking and running, followed by a muscle synergy analysis. We found that toddlers and preschoolers utilize a “walk-run strategy” when learning to run: they managed the fastest speeds on the treadmill by combining double support and flight phases. In particular the activity duration of the medial gastrocnemius muscle was weakly correlated with age. The number of synergies across groups and conditions needed to cover sufficient data variation ranged between four and eight. The number of synergies tended to be smaller in toddlers than it did in preschoolers and school-age children but the adults had the lowest number for both conditions. Against our expectations, the age groups did not differ significantly in the timing or duration of synergies. We believe that the increase in the number of muscle synergies in older children relates to motor learning and exploration. The ability to run with a FP is clearly associated with an increase in the number of muscle synergies. (shrink)

A decade has passed since the mapping of the human genome—an event that paved the way for many new developments in biomedicine and related fields. In ethics, this milestone was accompanied by calls for changes in ruling ethical frameworks.

This paper is concerned with analyzing transformations in the development, marketing, prescription, and access issues of pharmaceuticals, paying special attention to a variety of ethical and social aspects. A major focus of the article is on pharmacogenetics – a rapidly developing discipline which in the near future might well have a major effect on both drug development and clinical medicine.

Performance evaluation in research is more and more based on numbers of publications, citations, and impact factors. In the wake of New Public Management output control has been introduced into research governance without taking into account the conditions necessary for this kind of control to work efficiently. It is argued that to evaluate research by output control is counterproductive. It induces to substitute the ‘taste for science’ by a ‘taste for publication’. Instead, input control by careful selection and socialization serves (...) as an alternative. (shrink)