At first glance the three eukaryotic protein translocation machineries – the ER‐associated degradation (ERAD) transport apparatus of the endoplasmic reticulum, the peroxisomal importomer and SELMA, the pre‐protein translocator of complex plastids – appear quite different. However, mechanistic comparisons and phylogenetic analyses presented here suggest that all three translocation machineries share a common ancestral origin, which highlights the recycling of pre‐existing components as an effective evolutionary driving force.Editor's suggested further reading in BioEssays ERAD ubiquitin ligases Abstract.

Abstract The debate on corporate social responsibility (CSR) has been going on for decades, without leading to a clearer understanding of the term. Furthermore, the current literature on the topic remains relatively silent on the actual impact of CSR, especially the impact on issues of international development, for example poverty reduction in the Global South. By developing a conceptual assessment framework with a bipolar differentiated definition of CSR and a Sen-based notion of poverty, the article analyses the effects and impact (...) of two different types of CSR-strategies on the reduction of poverty. For this, two case studies have been conducted in Phnom Penh, Cambodia. The results imply that CSR measures which are built into the core business of a company (both transnational companies and small/medium sized companies) have larger effects on poverty than CSR measures which are located outside of the core business activities. Content Type Journal Article Pages 1-33 DOI 10.1007/s13520-012-0016-6 Authors Maike J. Schölmerich, Institute for Development and Peace, University of Duisburg-Essen, Duisburg, Germany Journal Asian Journal of Business Ethics Online ISSN 2210-6731 Print ISSN 2210-6723. (shrink)

In _Form, Matter, Substance_, Kathrin Koslicki defends a hylomorphic analysis of concrete particular objects (e.g., living organisms). The Aristotelian doctrine of hylomorphism holds that those entities that fall under it are compounds of matter (hulē) and form (morphē or eidos). Koslicki argues that a hylomorphic analysis of concrete particular objects is well-equipped to compete with alternative approaches when measured against a wide range of criteria of success. A successful application of the doctrine of hylomorphism to the special case of (...) concrete particular objects, however, hinges on how hylomorphists conceive of the matter composing a concrete particular object, its form, and the hylomorphic relations which hold between a matter-form compound, its matter and its form. Through the detailed answers to these questions Koslicki develops in this book, matter-form compounds, despite their metaphysical complexity, emerge as occupying the privileged ontological status traditionally associated with substances, due in particular to their high degree of unity. (shrink)

The objects we encounter in ordinary life and scientific practice - cars, trees, people, houses, molecules, galaxies, and the like - have long been a fruitful source of perplexity for metaphysicians. The Structure of Objects gives an original analysis of those material objects to which we take ourselves to be committed in our ordinary, scientifically informed discourse. Koslicki focuses on material objects in particular, or, as metaphysicians like to call them "concrete particulars", i.e., objects which occupy a single region of (...) space-time at each time at which they exist and which have a certain range of properties that go along with space-occupancy, such as weight, shape, color, texture, and temperature. The Structure of Objects focuses in particular on the question of how the parts of such objects, assuming that they have parts, are related to the wholes which they compose. (shrink)

As meaning's claim to normativity has grown increasingly suspect the normativity thesis has shifted to mental content. In this paper, we distinguish two versions of content normativism: 'CE normativism', according to which it is essential to content that certain 'oughts' can be derived from it, and 'CD normativism', according to which content is determined by norms in the first place. We argue that neither type of normativism withstands scrutiny. CE normativism appeals to the fact that there is an essential connection (...) between content and correctness conditions. But, we argue, this fact is by itself normatively innocent, and attempts to add a normative dimension via the normativity of belief ultimately fail. CD normativism, in turn, falls prey to the 'dilemma of regress and idleness': the appeal to rules either leads to some form of regress of rules, or the notion of rule-following is reduced to an idle label. We conclude by suggesting that our arguments do not support naturalism: it is a mistake to assume that normativism and naturalism are our only options. (shrink)

Normativism in the theory of meaning and content is the view that linguistic meaning and/or intentional content are essentially normative. As both normativity and its essentiality to meaning/content can be interpreted in a number of different ways, there is now a whole family of views laying claim to the slogan “meaning/content is normative”. In this essay, we discuss a number of central normativist theses, and we begin by identifying different versions of meaning normativism, presenting the arguments that have been put (...) forth for and against them. (shrink)

After many years of enduring the drought and famine of Quinean ontology and Carnapian meta-ontology, the notion of ground, with its distinctively philosophical flavor, finally promises to give metaphysicians something they can believe in again and around which they can rally: their very own metaphysical explanatory connection which apparently cannot be reduced to, or analyzed in terms of, other familiar idioms such as identity, modality, parthood, supervenience, realization, causation or counterfactual dependence. Often, phenomena such as the following are cited as (...) putative examples of grounding connections: systematic connections between entire realms of facts (mental/physical; moral/natural; etc.); truthmaking (e.g., the relation between the truth of the proposition that snow is white and snow’s being white); logical cases (e.g., the connection between conjunctive facts or disjunctive facts and their constituent facts); the determinate/determinable relation (e.g., the relation between something’s being maroon and its being red). I argue in this paper that classifying all of these phenomena as exhibiting grounding connections does not achieve much in the way of illumination. In fact, by treating a collection of phenomena which is in fact heterogeneous as though it were homogeneous, we have, if anything, taken a dialectical step backward. (shrink)

This chapter reviews several varieties of grounding skepticism as well as responses that have been proposed by grounding enthusiasts to considerations raised by grounding skeptics. Grounding skeptics, as I conceive of them here, are theorists who belong to one of the following two schools of thought. “Old-school” grounding skeptics doubt the theoretical utility of the grounding idiom by denying one of its presuppositions, viz., that this notion is at least intelligible or coherent. “Second-generation” grounding skeptics call into question the theoretical (...) utility of the grounding idiom for other reasons; their skeptical doubts tend to focus on one of the following three purported theoretical virtues grounding enthusiasts ascribe to their idiom: (i) its alleged power to unify an apparently heterogeneous collection of phenomena; (ii) its alleged power to capture and/or elucidate the distinction between the fundamental and the non-fundamental; or (iii) the alleged metaphysical (as opposed to mind-dependent, epistemic, or psychological) utility of grounding claims. Grounding enthusiasts have already formulated responses to many of the objections described in this chapter. At this point, however, it is fair to say that the state of the literature is still evolving, and no conclusive judgment can therefore be reached as of yet as to whether grounding enthusiasts or grounding skeptics have gained the upper hand in these debates. In the meantime, though, grounding skeptics continue to maintain that the classification of factual and/or nonfactual connections under the rubric of grounding does not really help us illuminate the nature of the connections at issue; instead, from the view of the grounding skeptic, we are better off studying these various connections separately and in their own right. (shrink)

It is common to think of essence along modal lines: the essential truths, on this approach, are a subset of the necessary truths. But Aristotle conceives of the necessary truths as being distinct and derivative from the essential truths. Such a non-modal conception of essence also constitutes a central component of the neo-Aristotelian approach to metaphysics defended over the last several decades by Kit Fine. Both Aristotle and Fine rely on a distinction between what belongs to the essence proper of (...) an object and what merely follows from the essence proper of an object. In order for this type of approach to essence and modality to be successful, we must be able to identify an appropriate consequence relation which in fact generates the result that the necessary truths about objects follow from the essential truths. I discuss some proposals put forward by Fine and then turn to Aristotle’s account: Aristotle’s central idea, to trace the explanatory power of definitions to the causal power of essences has the potential to open the door to a philosophically satisfying response to the question of why certain things are relevant, while others are irrelevant, to the nature or essence of entities. If at all possible, it would be desirable for example to have something further to say by way of explanation to such questions as ‘Why is the number 2 completely irrelevant to the nature of camels?’. (shrink)

A significant reorientation is currently under way in analytic metaphysics, away from an almost exclusive focus on questions of existence and towards a greater concentration on questions concerning the dependence of one type of phenomenon on another. Surprisingly, despite the central role dependence has played in philosophy since its inception, interest in a systematic study of this concept has only recently surged among contemporary metaphysicians. In this paper, I focus on a promising account of ontological dependence in terms of a (...) non-modal and sufficiently constrained conception of essence developed by Kit Fine. I argue that even this essentialist account is, as it stands, not fine-grained enough to recognize different varieties of dependence which ought to be distinguished even within the realm of ontology. In some cases, an entity may be ontologically dependent on its essential constituents out of which it is constructed; but in other cases, an entity may be ontologically dependent on another for a different reason. A framework which glosses over these differences does not offer a proper diagnosis of why one entity ontologically depends on another. (shrink)

Today, many philosophers think that perceptual experiences are conscious mental states with representational content and phenomenal character. Subscribers to this view often go on to construe experience more precisely as a propositional attitude sui generis ascribing sensible properties to ordinary material objects. I argue that experience is better construed as a kind of belief ascribing 'phenomenal' properties to such objects. A belief theory of this kind deals as well with the traditional arguments against doxastic accounts as the sui generis view. (...) Moreover, in contrast to sui generis views, it can quite easily account for the rational or reason providing role of experience. (shrink)

This article investigates the constructions of Hebrew, classical, and “Northern” antiquities put forward by an eighteenth-century network of Anglo-German scholars. It asks to what extent these constructions propose a cultural equality between these competing “antiquities”, how such equality relates to the contemporaneous conception of universal history, and to what extent this development is driven by emancipatory tendencies within Enlightenment thinking. By discussing the changing approaches to Homer, Old Testament texts, and “early” European literature, the article relates the emergence of primitivism (...) and orientalism to Enlightenment historicism and an interest in the sublime, which produces a growing focus on the importance of authentic culture and the role of the bard-poet. By discussing the connections between the work of Joseph Trapp, Thomas Blackwell, Robert Lowth, and Thomas Percy on the one hand, and Johann David Michaelis, Christian Gottlob Heyne, Johann Jakob Bodmer, and Johann Gottfried Herder on the other, the article illustrates the significance in this context of newly emerging Anglo-German scholarly networks and illuminates lesser-known aspects of Anglo-German relations in the second half of the eighteenth century. (shrink)

The continuous revaluation of rewards lies at the core of Ainslie's account of willpower. Yet, he does not explicate the underlying experiential mechanisms. We draw upon theoretical, neuroscientific, and computational evidence to demonstrate that boredom evokes revaluation. By biasing behavior toward exploration, boredom necessitates effortful willpower to balance it against exploitation, thereby rendering suppression a highly adaptive function of willpower.

This essay provides an opinionated survey of some recent developments in the literature on ontological dependence. Some of the most popular definitions of ontological dependence are formulated in modal terms; others in non-modal terms (e.g., in terms of the explanatory connective, ‘because’, or in terms of a non-modal conception of essence); some (viz., the existential construals of ontological dependence) emphasise requirements that must be met in order for an entity to exist; others (viz., the essentialist construals) focus on conditions that (...) must be satisfied in order for an entity to be the very entity it is at each time at which it exists; some are rigid, in the sense that they concern a relation between particular entities; others are generic, in the sense that they involve only a relation between an entity and some entities or other, which bear certain characteristics. I identify three potential measures of success with respect to which these different definitions of ontological dependence can be evaluated and consider the question of how well they in fact meet these desiderata. I end by noting that certain challenges face even the most promising essentialist construals of ontological dependence. (shrink)

Does the notion of ground, as it has recently been employed by metaphysicians, point to a single unified phenomenon? Jonathan Schaffer holds that the phenomenon of grounding exhibits the unity characteristic of a single genus. In defense of this hypothesis, Schaffer proposes to take seriously the analogy between causation and grounding. More specifically, Schaffer argues that both grounding and causation are best approached through a single formalism, viz., that utilized by structural equation models of causation. In this paper, I present (...) several concerns which suggest that the structural equation model does not transfer as smoothly from the case of causation to the case of grounding as Schaffer would have us believe. If it can in fact be shown that significant differences surface in how the formalism in question applies to the two types of phenomena in question, Schaffer’s attempt at establishing an analogy between grounding and causation has thereby been weakened and, as a result, the application of the Unity Hypothesis to the case of grounding once again stands in need of justification. (shrink)

Sum rules are derived for the quantum wave functions of the Hadamard billiard in arbitrary dimensions. This billiard is a strongly chaotic (Anosov) system which consists of a point particle moving freely on a D-dimensional compact manifold (orbifold) of constant negative curvature. The sum rules express a general (two-point)correlation function of the quantum mechanical wave functions in terms of a sum over the orbits of the corresponding classical system. By taking the trace of the orbit sum rule or pre-trace formula, (...) one obtains the Selberg trace formula. The sum rules are applied in two dimensions to a compact Riemann surface of genus two, and in three dimensions to the only non-arithmetic tetrahedron existing in hyperbolic 3-space. It is shown that the quantum wave functions can be computed from classical orbits. Conversely, we demonstrate that the structure of classical orbits can be extracted from the quantum mechanical energy levels and wave functions (inverse quantum chaology). (shrink)

This inaugural lecture, delivered on 17 November 2021 at the University of Neuchâtel, addresses the question: Are material objects analyzable into more basic constituents and, if so, what are they? It might appear that this question is more appropriately settled by empirical means as utilized in the natural sciences. For example, we learn from physics and chemistry that water is composed of H2O-molecules and that hydrogen and oxygen atoms themselves are composed of smaller parts, such as protons, which are in (...) turn composed of yet smaller parts, such as quarks, and so on. While the question at the center of this lecture might thus appear to fall more appropriately into the empirical domain of natural science, I argue that metaphysics in fact has an important role to play in determining how best to answer the question before us. More concretely, I propose that the Aristotelian doctrine of hylomorphism, when appropriately interpreted, provides the best metaphysical answer to the question of whether and how material objects are analyzable into more basic constituents. Hylomorphism holds that those entities to which this doctrine applies are, in some sense, compounds of matter (“hylē”) and form (“morphē” or “eidos”). Thus, the title of this lecture, “Form, Matter, Substance”, refers to the claim that lies at the center of the doctrine of hylomorphism, as applied to the domain of material objects, namely that sensible substances are the result of combining matter and form in the right sort of way; or, for short, “form + matter = substance”. I begin in Section II by providing some historical background which brings out Aristotle’s motivations for proposing the doctrine of hylomorphism in the context of his analysis of change. Section III turns to some of the main features of the contemporary hylomorphic theory I have defended especially in Koslicki (2008) and Koslicki (2018). Section IV discusses some challenging questions concerning artifacts which arise for both hylomorphic and other approaches to the metaphysics of concrete particular objects. Section V concludes by summarizing why, as contemporary metaphysicians, we should prefer a hylomorphic theory over its competitors as an analysis of concrete particular objects that is compatible with our current scientific understanding of the world. (shrink)

We have argued against the thesis that content is essentially normative (Glüer & Wikforss 2009). In the course of doing so, we also presented some considerations against the thesis that belief is essentially normative. In this paper we clarify and develop these considerations, thereby paving the road for a fully non-normative account of the nature of belief.

The compound eyes of insects exhibit stunning variation in size, structure, and function, which has allowed these animals to use their vision to adapt to a huge range of different environments and lifestyles, and evolve complex behaviors. Much of our knowledge of eye development has been learned from Drosophila, while visual adaptations and behaviors are often more striking and better understood from studies of other insects. However, recent studies in Drosophila and other insects, including bees, beetles, and butterflies, have begun (...) to address this gap by revealing the genetic and developmental bases of differences in eye morphology and key new aspects of compound eye structure and function. Furthermore, technical advances have facilitated the generation of high‐resolution connectomic data from different insect species that enhances our understanding of visual information processing, and the impact of changes in these processes on the evolution of vision and behavior. Here, we review these recent breakthroughs and propose that future integrated research from the development to function of visual systems within and among insect species represents a great opportunity to understand the remarkable diversification of insect eyes and vision. (shrink)

There are cases such as climate change where the cumulative effects of the actions of several agents lead to grave harm but where no individual agent can make a perceptible difference for the better or worse. According to Derek Parfit, dealing with such imperceptible difference cases requires substantial changes to the way we think about morality. In On What Matters, Parfit builds on Kantian Ethics to address the problem of imperceptible differences, but the transformation that Kant's theory undergoes in his (...) hands is radical. I argue that Parfit's changes to Kant's theory are not only unnecessary but also detrimental to making sense of the ethical dimensions of action in collective contexts. Building on the notion of imperfect duties, I offer an alternative solution to the problem of imperceptible difference cases that remains closer to Kant's original theory and avoids the difficulties of Parfit's approach. (shrink)

This paper evaluates six contenders which might be invoked by essentialists in order to meet Quine’s challenge, viz., to provide necessary and sufficient conditions for the crossworld identity of individuals: (i) an object’s qualitative character; (ii) matter; (iii) origins; (iv) haecceities or primitive non-qualitative thisness properties; (v) “world-indexed properties”; and (iv) individual forms. The first three candidates, I argue, fail to provide conditions that are both necessary and sufficient for the crossworld identity of individuals; the fourth and fifth criteria are (...) open to the charge that they do not succeed in meeting Quine’s demand in an explanatorily adequate fashion. On balance, then, individual forms, or so I propose, deserve to be taken very seriously as a possible response to Quine’s challenge, especially by neo-Aristotelians who are already committed to a hylomorphic conception of composite concrete particular objects for other reasons. Theorists who also accept a non-modal conception of essence, i.e., a conception according to which essence is not reducible to modality, in addition face the further difficult task, over and above what is required to meet Quine’s challenge, of having to explain how an object’s de re modal profile in some way follows from facts about its essence. Haecceities and world-indexed properties, as I indicate, are unlikely to be of much help with respect to this second challenge, while the forms of hylomorphic compounds are in fact well-suited for this purpose. (shrink)

Essentialists hold that at least a certain range of entities can be meaningfully said to have natures, essences, or essential features independently of how these entities are described, conceptualized or otherwise placed with respect to our specifically human interests, purposes or activities. Modalists about essence, on the one hand, take the position that the essential truths are a subset of the necessary truths and the essential properties of entities are included among their necessary properties. Non-modalists about essence, on the other (...) hand, oppose the reduction of essence to modality and hold, rather, that essence is more basic than, and explanatory of, modality. This chapter begins with a brief summary of Kit Fine’s well-known challenges to the modal account of essence and considers a recent attempt by “sparse modalists” like Sam Cowling and Nathan Wildman to respond to Fine’s counterexamples by adding a sparseness constraint to the “bare” modal account of essence. A further question arises, however, as to whether and how Fine’s definitional approach can avoid his own counterexamples against the modal approach to essence. The chapter concludes with some final thoughts concerning the theoretical roles ascribed to essence by modalists and non-modalists. (shrink)

It is widely acknowledged that moral principles are not sufficient to guide moral thought and action: they need to be supplemented by a capacity for judgement. However, why can we not rely on this capacity for moral judgement alone? Why do moral principles need to be supplemented, but are not supplanted, by judgement? So-called moral particularists argue that we can, and should, make moral decisions on a case-by-case basis without any principles. According to particularists, the person of moral judgement is (...) a person of empathy, sensibility and virtue, rather than a person of principle. In this paper I argue that this is a false dichotomy. The person of good moral judgement is a person of principle. I propose that we think of moral principles as internalised long-term commitments that form our moral character and sensitivity, and, as such, are constitutive of moral judgement. (shrink)

In this book, Kathrin Gl¨uer carefully outlines Donald Davidson's principal claims and arguments, and discusses them in some detail, providing a concise, systematic introduction to all the main elements of Davidson's philosophy.

In public debate GMPs are oftenreferred to as being unnatural or a violationof nature. Some people have serious moralconcerns about departures from what is natural.Others are concerned about potential risks tothe environment arising from the combination ofhereditary material moving across naturalboundaries and the limits of scientificforesight of long-term consequences. To addresssome of these concerns we propose that anadditional element in risk assessment based onthe concept of familiarity should beintroduced. The objective is to facilitatetransparency about uncertainties inherent inthe risk assessment of (...) the GMP. Familiarityconventionally involves data and experiencerelating to the plant species and the ecosystemin question. We would like to extend thisconcept to the molecular level of plantbreeding and suggest that GMP characteristicsshould be compared to a reference baselinedetermined by conventional breeding techniques.Three GMPs are ranked according to familiarityat the plant and ecosystem level and themolecular level. The approach may help tointegrate discussion of the scientificarguments and moral questions raised in thedebate about GMOs by providing an operationalscheme within which moral concerns are broughtwithin the framework of science-based riskassessment. (shrink)

Recent evidence indicates that transcriptional bursts are intrinsically amplified by messenger RNA cytoplasmic processing to generate large stochastic fluctuations in protein levels. These fluctuations can be exploited by cells to enable probabilistic bet‐hedging decisions. But large fluctuations in gene expression can also destabilize cell‐fate commitment. Thus, it is unclear if cells temporally switch from high to low noise, and what mechanisms enable this switch. Here, the discovery of a post‐transcriptional mechanism that attenuates noise in HIV is reviewed. Early in its (...) life cycle, HIV amplifies transcriptional fluctuations to probabilistically select alternate fates, whereas at late times, HIV utilizes a post‐transcriptional feedback mechanism to commit to a specific fate. Reanalyzing various reported post‐transcriptional negative feedback architectures reveals that they attenuate noise more efficiently than classic transcriptional autorepression, leading to the derivation of an assay to detect post‐transcriptional motifs. It is hypothesized that coupling transcriptional and post‐transcriptional autoregulation enables efficient temporal noise control to benefit developmental bet‐hedging decisions. (shrink)

Some theories of linguistic meaning, such as those of Paul Grice and David Lewis, make appeal to higher–order thoughts: thoughts about thoughts. Because of this, such theories run the risk of being empirically refuted by the existence of speakers who lack, completely or to a high degree, the capacity of thinking about thoughts. Research on autism during the past 15 years provides strong evidence for the existence of such speakers. Some persons with autism have linguistic abilities that qualify them as (...) speakers, but manifest a severely impaired capacity to understand what it is to have beliefs. (shrink)

The purpose of this article is to outline the missionary self-perception that is mediated in meaningful stories about activities and experiences of Protestants while serving as missionaries abroad. Research is based on a model of narrative identity that aids for understanding the dilemmatic aspects of identity: continuity/change, sameness/difference, agency/non-agency. Findings of a cultural psychological analysis of missionaries’ autobiographical narratives are presented in form of these three types of identity dilemmas and discussed with respect to their implications for cultural psychology of (...) religion. In utilizing qualitative research, the present study enlarges the understanding of the diversity of cross-cultural experiences in mission. (shrink)

Emotion Review, Volume 14, Issue 1, Page 84-95, January 2022. Emotional stimuli such as images, words, or video clips are often used in studies researching emotion. New sets are continuously being published, creating an immense number of available sets and complicating the task for researchers who are looking for suitable stimuli. This paper presents the KAPODI-database of emotional stimuli sets that are freely available or available upon request. Over 45 aspects including over 25 key set characteristics have been extracted and (...) listed for each set. The database facilitates finding of and comparison between individual sets. It currently contains sets published between 1963 and 2020. A searchable online version allows users to select specific set characteristics and to find matching sets accordingly, as well as to add new published sets. (shrink)

This paper seeks to unveil the agency of widows in late antiquity beyond prevailing limits of asceticism and euergetism. Based on a Bourdieu’ian field-analysis this approach seeks to illustrate that some widows used their recently achieved liberty not for withdrawing from society, i.e. living an ascetic life among their peers, praying all night and day. They used their liberty to actively engage within this society, within the elite in particular, instead. In so doing, these (wealthy) widows constructed, contested, and negotiated (...) power relations by appropriating and nuancing communication strategies of allegedly male domains of practice, i. e. the daily business of the household. These widows, strictly speaking, set up new power relations with which they started negotiating and maintaining, indeed creating new field positions, through which new interactions occurred that rendered her agency. An exemplary context in this respect is that of inheritance hunting in the widows’ households. (shrink)

ZusammenfassungAuf dem Wiesbadener Internistenkongress von 1949 forderten Alexander Mitscherlich und Viktor von Weizsäcker eine Erweiterung des naturwissenschaftlichen Kausalitätsbegriffs um die Suche nach dem Sinn von Krankheit in der Lebensgeschichte. Hiermit wurde ein traditionelles psychiatrisches Paradigma infrage gestellt: die vermutete somatische Ursache psychischer Erkrankungen. Damit standen auch psychiatrische Evidenzpraktiken auf dem Prüfstand. Im ersten Teil dieses Beitrags werden im Sinne eines Querschnitts drei psychiatrische Positionen rekonstruiert, die auf dem Kongress zur Darstellung kamen. Im zweiten Teil wird die Entwicklung eines der beteiligten (...) Psychiater, Jürg Zutt, im Längsschnitt untersucht, wobei der Fokus auf der Frage nach möglichen Auswirkungen der Wiesbadener Debatte auf seine wissenschaftliche Neuausrichtung sowie den Konsequenzen für seine Auffassung von psychiatrischer Evidenz liegt. (shrink)

In his excellent book, Four-Dimensionalism: An Ontology of Persistence and Time (Sider, 2001), Theodore Sider defends a version of four-dimensionalism which he calls the ‘stage-theory’. This paper focuses on Sider's argument from vagueness and argues that, due to the problematic nature of the argument from vagueness, Sider’s case in favor of four-dimensionalism is in the end not successful.

Natural kind terms have exercised philosophical fancy ever since Kripke, in Naming and Necessity, claimed them to be rigid designators. He there drew attention to the peculiar, name-like behavior of a family of prima facie loosely related general terms of ordinary English: terms such as ‘water’, ‘tiger’, ‘heat’, and ‘red’. Just as for ordinary proper names, Kripke argued that such terms cannot be synonymous with any of the definite descriptions ordinary speakers associate with them. Rather, the name-like behavior of these (...) so-called natural kind terms is to be explained, just as in in the case of proper names, by the doctrine of rigid designation. And as a consequence of thus extending the notion of rigid designation to general terms, he famously endorsed the claim that so-called ‘theoretical identifications’, i.e. statements like (1) Water is H2O, are necessary, if true. (shrink)

Concrete particular objects (e.g., living organisms) figure saliently in our everyday experience as well as our in our scientific theorizing about the world. A hylomorphic analysis of concrete particular objects holds that these entities are, in some sense, compounds of matter (hūlē) and form (morphē or eidos). The Grounding Problem asks why an object and its matter (e.g., a statue and the clay that constitutes it) can apparently differ with respect to certain of their properties (e.g., the clay’s ability to (...) survive being squashed, as compared to the statue’s inability to do so), even though they are otherwise so much alike. In this paper, I argue that a hylomorphic analysis of concrete particular objects, in conjunction with a non-modal conception of essence of the type encountered for example in the works of Aristotle and Kit Fine, has the resources to yield a solution to the Grounding Problem. (shrink)

Despite its age, quantum theory still suffers from serious conceptual difficulties. To create clarity, mathematical physicists have been attempting to formulate quantum theory geometrically and to find a rigorous method of quantization, but this has not resolved the problem. In this article we argue that a quantum theory recursing to quantization algorithms is necessarily incomplete. To provide an alternative approach, we show that the Schrödinger equation is a consequence of three partial differential equations governing the time evolution of a given (...) probability density. These equations, discovered by Madelung, naturally ground the Schrödinger theory in Newtonian mechanics and Kolmogorovian probability theory. A variety of far-reaching consequences for the projection postulate, the correspondence principle, the measurement problem, the uncertainty principle, and the modeling of particle creation and annihilation are immediate. We also give a speculative interpretation of the equations following Bohm, Vigier and Tsekov, by claiming that quantum mechanical behavior is possibly caused by gravitational background noise. (shrink)

Whenever an object constitutes, makes up or composes another object, the objects in question share a striking number of properties. This paper is addressed to the question of what might account for the intimate relation and striking similarity between constitutionally related objects. According to my account, the similarities between constitutionally related objects are captured at least in part by means of a principle akin to that of strong supervenience. My paper addresses two main issues. First, I propose independently plausible principles (...) by means of which to delineate, in a non-ad-hoc, non-stipulative and non-circular fashion, those properties which can be expected to be shared among constitutionally related objects in virtue of their being so related from those which in general cannot be expected to be shared, or which are shared for other reasons. Secondly,I spell out in detail the nature of the supervenience-principle at work in this context. My account thus aims at isolating, in a methodologically responsible fashion, the particular sort of restricted indiscernibility principle which is a component of the constitution-relation. (shrink)

In this chapter, we critically examine the most important extant ways of understanding and motivating the idea that reasons for belief are normative. First, we examine the proposal that the distinction between explanatory and so-called normative reasons that is commonly drawn in moral philosophy can be rather straightforwardly applied to reasons for belief, and that reasons for belief are essentially normative precisely when they are normative reasons. In the course of this investigation, we explore the very nature of the reasons-for-belief (...) relation, as well as the ontology of such reasons. Second, we examine the idea that the normativity derives from the internal connection between reasons for belief and epistemic justification, distinguishing between two distinct normativist accounts of justification, a weaker and a stronger one. We argue that neither line of argument is compelling. Pending further arguments, we conclude that normativism about reasons for belief is not supported. (shrink)

Beta‐oxidation of fatty acids and detoxification of reactive oxygen species are generally accepted as being fundamental functions of peroxisomes. Additionally, these pathways might have been the driving force favoring the selection of this compartment during eukaryotic evolution. Here we performed phylogenetic analyses of enzymes involved in beta‐oxidation of fatty acids in Bacteria, Eukaryota, and Archaea. These imply an alpha‐proteobacterial origin for three out of four enzymes. By integrating the enzymes' history into the contrasting models on the origin of eukaryotic cells, (...) we conclude that peroxisomes most likely evolved non‐symbiotically and subsequent to the acquisition of mitochondria in an archaeal host cell. (shrink)