Chemotherapy is an important therapeutic approach for cancer treatment. However, drug resistance is an obstacle that often impairs the successful use of chemotherapies. Therefore, overcoming drug resistance would lead to better therapeutic outcomes for cancer patients. Recently, studies by our own and other groups have demonstrated that there is an intimate correlation between the loss of the F‐box and WD repeat domain‐containing 7 (FBW7) tumor suppressor and the incurring drug resistance. While loss of FBW7 sensitizes cancer cells to certain drugs, (...) FBW7‐/‐ cells are more resistant to other types of chemotherapies. FBW7 exerts its tumor suppressor function by promoting the degradation of various oncoproteins that regulate many cellular processes, including cell cycle progression, cellular metabolism, differentiation, and apoptosis. Since loss of the FBW7 tumor suppressor is linked to drug resistance, FBW7 may represent a novel therapeutic target to increase drug sensitivity of cancer cells to conventional chemotherapeutics. This paper thus focuses on the new functional aspects of FBW7 in drug resistance. (shrink)

Integrating norms of reciprocity, affect theory of social exchange, and ambivalence literature, we investigated how leader-member exchange (LMX) ambivalence influences employees’ interpersonal behaviors toward supervisors. Study 1, with a time-lagged field method, revealed that LMX ambivalence was positively related to _both_ employee-rated supervisor-directed helping and deviant behaviors and that such relationships were mediated by emotional ambivalence toward supervisors. We also confirmed the amplification effects of workplace gossip about supervisors (WGS). Specifically, while receiving more positive WGS (PWGS) or less negative WGS (...) (NWGS) could strengthen the positive relationship between emotional ambivalence and supervisor-directed helping behaviors, receiving less PWGS or more NWGS would accentuate the positive effect of emotional ambivalence on supervisor-directed deviant behaviors. Study 2 replicated our results with a scenario-based method and offered evidence for the mediating effect of emotional ambivalence toward supervisors. Study 3 included supervisor-rated helping and deviant behavior and a subjective measure of emotional ambivalence and again confirmed the mediating role of emotional ambivalence. Our findings extend knowledge of the interpersonal consequences of LMX ambivalence. (shrink)

According to social information processing theory and conservation of resource theory, we examine whether and how authoritarian-benevolent leadership influences employees’ proactive work behaviors (PWBs) and unethical pro-organizational behaviors (UPBs). Study 1, a survey of 351 participants, revealed that authoritarian-benevolent leadership was positively related to LMX ambivalence, and that LMX ambivalence was negatively related to employees’ PWBs as well as UPBs. Further, the results showed that LMX ambivalence mediated the relationship between authoritarian-benevolent leadership and employees’ PWBs as well as UPBs. We (...) also found that dialectical thinking negatively moderated the effect of authoritarian-benevolent leadership on employee LMX ambivalence. Study 2, using manipulations in the form of scenarios, examined the mediating effect of LMX ambivalence linking authoritarian-benevolent leadership with employees’ PWBs and UPBs. We discussed the theoretical and practical implications of our findings. (shrink)

It is difficult for the conventional image compression method to achieve good compression effect in the underwater acoustic image, because the UWAI has large amount of noise and low correlation between pixel points. In this paper, fractal coding is introduced into UWAI compression, and a fractal coding algorithm based on interest region is proposed according to the importance of different regions in the image. The application problems of traditional quadtree segmentation in UWAIs was solved by the range block segmentation method (...) in the coding process which segmented the interest region into small size and the noninterest region into large size and balanced the compression ratio and the decoded image quality. This paper applies the classification, reduction codebook, and correlation coefficient matching strategy to narrow the search range of the range block in order to solve the problem of the long encoding time and the calculation amount of encoding process is greatly reduced. The experimental results show that the proposed algorithm improves the compression ratio and encoding speed while ensuring the image quality of important regions in the UWAI. (shrink)

Purpose: Short track speed skating is a racing sport with racing tactics are equally crucial to speed and technical skating skills. Therefore, to investigate the relationship between starting and finishing positions for elite skaters and subsequently, explore pacing patterns for champions are necessary.Methods: To investigate a pattern of effective tactical positioning strategy, Kendall’s tau-b correlations between starting and finishing position were calculated, with 500 m races having the most positive correlation.Results: Furthermore, starting position distributions of winners in each round, as (...) well as the fluctuations in champion starting positions across rounds were analyzed. Our findings showed that skaters on the first track were inclined to win the rounds in 500, 1,000, and 1,500 m, and the differences between starting and finishing positions for champions were minimized in semi-finals. Meanwhile, the pacing patterns were gaining more fluctuations by the increase of race distances for champions, as the average standard deviation of lap rankings equaled 0.90, 1.15, and 2.21 for 500, 1,000, and 1,500 m races, respectively.Conclusion: In conclusion, elite skaters should adopt flexible tactics at the lowest cost of energy consumption. The overall variability of lap ranking in long-distance races were distinctly higher than it in short distance. (shrink)

该书内容涵盖马克思历史观的思想背景、时代愿望的时代自我阐明、人的感性活动与历史来历、人的现实生存与叙述历史等六部分。.

Ben shu ji zhong fan ying le dang dai ri ben zhe xue jia dui ma ke si zhu yi zhe xue de li jie.Shu zhong shou lu le ti ming xiu zi ran li shi guo cheng de si xiang,Ping tian qing ming xun huan= ji lei li lun yu li shi ren shi,Yan yuan qing yi ri ben de1844 nian jing ji xue zhe xue shou gao yan jiu deng wen zhang.

Ontology: An Ontological Interpretation to Baudrillard’s Consumption Society TheoryJean Baudrillard used “Consumption society” to describe a novel transformation of the contemporary life, “consumption society” has become to the symbol of contemporary ideology. From this we can say that reading Jean Baudrillard is very necessary. Compared with what Jean Baudrillard said, what we comprehended is more important, so it is very necessary to analyze Jean Baudrillard’s consumption society theory on the ontological viewpoint. To this, Iattach great important to the follow key (...) issues: what kind of existent character Jean Baudrillard revealed? Hegel’s modern western philosophy participated in the foundation of the Capitalist civilization; Jean Baudrillard was unavoidably involved in, so what is the advancement in theory system? How to define the demarcation to Jean Baudrillard? He animadverted on Marx and appropriated his valuable thoughts. (shrink)

Resumen: En las dinastías Tang y Song, los clanes zongzu oficiales comunes dominaron gradualmente la comunidad de clanes, lo que interrumpió el riguroso sistema de sacrificios orientado a los estratos. Por lo tanto, como una forma emergente de sacrificio ancestral privado, la sala de imágenes yingtang apareció en las mansiones de los funcionarios comunes o en las casas de la gente común. Cuando la estatua anterior dio paso a una imagen, este nuevo signo cultural llevó a cada ejecutor del sacrificio (...) a lograr una identificación psicológica y emocional con la comunidad. A través de imágenes o retratos colgados en los salones, los albaceas pudieron comprobar si se podía crear visualmente un reino espiritual para comunicarse con sus antepasados o contarles sus oraciones. (shrink)

本书对历史主体及其选择活动的本质,历史选择中的自由与必然,历史选择与历史规律的关系等理论问题进行富有新意探讨和论述。.

Ethics in the modern context is under the dual pressure of scientific-technological rationality and market commercialization, which has led to breakthroughs in the original boundaries of knowledge and academic methodology. The gradual separation of the domain of public life and that of private life in modern society and the former's increasing pressure on the latter, in addition to the above dual pressure on ethics, is causing a dramatic transformation of the structure of ethical knowledge itself. All of these raise new (...) theoretical problems for ethics and ethicists in the modern context. Answering and solving these problems makes sense for the future development of ethics as one of the classic humanities, and tests modern ethicists' ability to realize their moral and theoretical duties. /// 现代语境中的伦理学面临着科技理性主义和市场商业化的双重挤压，致使伦 理学原有的知识边界和学理方法均被突破。现代社会之公共生活领域与私人生活领 域的日趋分化以及前者对后者日益增强的压迫，又使得伦理学在不得不承受双重挤 压的同时，还经历着自身知识结构的急剧转型。凡此种种都给现代社会的伦理学和 伦理学家提出了诸多新的理论课题，如何应对和处理这些课题，将不仅关系到作为 一门经典人文科学的伦理学之未来发展，而且也将考验当代伦理学家承诺自身学术 道义和理论责任的能力。. (shrink)

In spite of numerous studies of program outcomes finding little or no positive effect on violent behavior, the Duluth model remains the most common program type of interventions with perpetrators of domestic violence. In addition, Duluth model programs often ignore serious mental health and substance abuse issues present in perpetrators. These and other issues of possible threat to mental health professional ethics are reviewed in light of the court-mandated, compulsory nature of most Duluth model programs and client and victim expectations (...) for program efficacy. (shrink)

It is commonly held that implicit learning is based largely on familiarity. It is also commonly held that familiarity is not affected by intentions. It follows that people should not be able to use familiarity to distinguish strings from two different implicitly learned grammars. In two experiments, subjects were trained on two grammars and then asked to endorse strings from only one of the grammars. Subjects also rated how familiar each string felt and reported whether or not they used familiarity (...) to make their grammaticality judgment. We found subjects could endorse the strings of just one grammar and ignore the strings from the other. Importantly, when subjects said they were using familiarity, the rated familiarity for test strings consistent with their chosen grammar was greater than that for strings from the other grammar. Familiarity, subjectively defined, is sensitive to intentions and can play a key role in strategic control. (shrink)

This study examines the influences of individual behaviour and organizational commitment towards the enhancement of Islamic Work Ethics at the Royal Malaysian Air Force. It involved 312 respondents of different backgrounds and the data were analysed using descriptive analysis and structural equation modelling analysis. The results show that both individual behaviour and organizational commitment have significantly correlated with the enhancement of IWE. The findings could help managers especially of multinational corporations operating in Muslim countries to enhance the company performances by (...) instituting elements of IWE in their organizations. This can be done by promoting the understanding of IWE and providing a conducive environment to practice it. (shrink)

王船山，名夫之，字而农，号姜斋，中岁自称“一瓠道人”。生于明朝万历四十七（1619）年，卒在清康熙三十一（1692）年。湖南衡阳人。王船山先生是中国历史上广博的学者和伟大的思想家。本书作者在详细查阅充 足的史料、充分躬身研究多年和多次船山遗迹考察的基础上，详述了船山的传奇一生及其心路历程。书中虽然主要是以船山的实际人生经历为表达目标，但同时也涉及了船山一些很精深的思想。通过对于船山及其思想的理解，我 们也可以进而了解人类的精神之伟大与崇高，了解古今中外的贤哲们，为了延续和发展人类的精神慧命所作的坚忍不拔的努力和贡献的意义。阅读此书，可以激发读者对于湖湘文化和传统文化的兴趣。.

This paper investigates the leaderless and leader-follower time-varying formation design and analysis problems for a group of networked agents subject to discontinuous communications. Firstly, a leaderless time-varying formation control protocol is proposed via the intermittent control strategy, where the control input of each agent is constructed by the distributed local state information and formation instructions in the communication time unit, but it is zero in the noncommunication time unit. Then, an explicit formulation of the formation center function is determined to (...) describe the formation movement trajectory of the whole networked agents. Leaderless time-varying formation design and analysis with discontinuous communications are given in the form of linear matrix inequalities. Moreover, the main results of the leaderless cases are extended to the leader-follower cases. Finally, two numerical examples are provided to illustrate the theoretical results of leaderless and leader-follower cases, respectively. (shrink)

Grapheme-colour synaesthetes experience unusual colour percepts when they encounter letters and/or digits. Studies of English-speaking grapheme-colour synaesthetes have shown that synaesthetic colours are sometimes triggered by rule-based linguistic mechanisms . In contrast, little is known about synaesthesia in logographic languages such as Chinese. The current study shows the mechanisms by which synaesthetic speakers of Chinese colour their language. One hypothesis is that Chinese characters might be coloured by their constituent morphological units, known as radicals, and we tested this by eliciting (...) synaesthetic colours for characters while manipulating features of the radicals within them. We found that both the function and position of radicals influence the nature of the synaesthetic colour generated. Our data show that in Chinese, as in English, synaesthetic colours are influenced by systematic rules, rather than by random associations, and that these rules are based on existing psycholinguistic mechanisms of language processing. (shrink)

001. 인간의 본질 002. 한민족과 전통사상 003. 민주주의 004. 현대사회와 직업윤리 005. 산업사회와 환경윤리 006. 북한체제의 신 정치이념 007. 민족통이론.

This study was conducted to investigate the relationship between posttraumatic growth, resilience, positive coping style, and self-efficacy among the primary caregivers of children with developmental disorders in Chongqing, China. A total of 198 primary caregivers aged from 22 to 66 years old, including 155 females and 43 males, were enrolled. The Posttraumatic Growth Inventory, Connor-Davidson Resilience Scale-10, Simplified Coping Style Questionnaire, and General Self-Efficacy Scale were used for data collection. The results found that PTG could be positively predicted by resilience. (...) Positive coping style and self-efficacy mediated the relationship between resilience and PTG. The different levels of PTG were determined by the resident location, monthly income and education of the primary caregivers. The results suggest that it is critical to improve the mental health of the primary caregivers of children with developmental disabilities. Our results also provide a scientific basis for future research. (shrink)

The current study presents an integrative model examining the double-edged sword effect of unethical pro-organizational behavior (UPB) from the perspective of the actors. Drawing on the moral self-regulation perspective and psychological entitlement literature, we propose that employees who engage in UPB may experience an increase in moral deficits and psychological entitlement, resulting in increased organizational citizenship behavior (OCB) and decreased work effort, respectively. We further propose that moral attentiveness strengthens the positive relationship between UPB and moral deficits but weakens the (...) positive relationship between UPB and psychological entitlement. Moreover, the strength of the indirect effects of employee UPB on OCB and work effort is also contingent upon employees’ moral attentiveness. The hypothesized moderated mediation model is supported by a multisource and time-lagged research design based on a sample of 256 supervisor–subordinate dyads. Key theoretical and practical implications and future research directions are discussed. (shrink)

Neurofeedback is a complex learning scenario, as the task consists of trying out mental strategies while processing a feedback signal that signifies activation in the brain area to be self-regulated and acts as a potential reward signal. In an attempt to dissect these subcomponents, we obtained whole-brain networks associated with efficient self-regulation in two paradigms: parallel, where the task was performed concurrently, combining feedback with strategy execution; and serial, where the task was performed consecutively, separating feedback processing from strategy execution. (...) Twenty participants attempted to control their anterior midcingulate cortex using functional magnetic resonance imaging NF in 18 sessions over 2 weeks, using cognitive and emotional mental strategies. We analyzed whole-brain fMRI activations in the NF training runs with the largest aMCC activation for the serial and parallel paradigms. The equal length of the strategy execution and the feedback processing periods in the serial paradigm allows a description of the two task subcomponents with equal power. The resulting activation maps were spatially correlated with functionally annotated intrinsic connectivity brain maps. Brain activation in the parallel condition correlates with the basal ganglia network, the cingulo-opercular network, and the frontoparietal control network ; brain activation in the serial strategy execution condition with the default mode network, the FPCN, and the visual processing network; while brain activation in the serial feedback processing condition predominantly with the CON, the DMN, and the FPCN. Additional comparisons indicate that BG activation is characteristic to the parallel paradigm, while supramarginal gyrus and superior temporal gyrus activations are characteristic to the serial paradigm. The multifaceted view of the subcomponents allows describing the cognitive processes associated with strategy execution and feedback processing independently in the serial feedback task and as combined processes in the multitasking scenario of the conventional parallel feedback task. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:59. HUME ON IDENTITY It is well-known that Hume has a quite unusual theory of personal identity. For him, personal identity is but the identity of mind. But to him mind is just a bundle of perceptions which keeps changing its constituent members; hence a mind is not something constant. In other places he also argues that mind is not a substance which unites all the perceptions which a (...) person may have. His conclusion is that cases of personal identity for ordinary people are not genuine cases of identity for him at all. This probably is a direct consequence of his unusual notion of identity. My concern then is to see what Hume takes identity to be as an idea and as a relation. The idea of identity, according to Hume, is an idea betwixt unity and number. (T 201 J1 So I want to see first how the ideas of number and unity originate. Hume says that; a single object, plac'd before us, and survey 'd for any time without our discovering in it any interruption or variation, is able to give us a notion of identity. For when we consider any two points of this time, we may place them in different lights: We may either survey them at the very same instant; in which case they give us the idea of number, both by themselves and by the object; which must be multiply 'd, in order to he conceiv'd at once, as existent in these two different points of time. (T 201)2 What is surveyed is a single object, i.e., an object which is neither interrupted nor varied. According to Price, "At this stage of [Hume's] inquiry, he ought only to be talking of sense-impressions ( 'perceptions ')," so, here instead of talking about a single object, I shall talk about a single perception, i.e., an uninterrupted, unchanged perception which persists through a certain period of time. Roughly speaking, a perception is interrupted if it is not temporally 60. continuous; it is varied, if it changes either its sensible qualities, or its spatial characteristics, viz., shape, size, pattern. But what is a single perception which is uninterrupted and unchanged? This question as stated is misleading, for it suggests that there may be a single though interrupted or varied perception. The question I am now asking is the question of individuating perceptions. It is clear that for Hume the principle of individuation of perceptions is their invariableness and uninterruptedness through a supposed variation of time. (T 201) Hence there would be no such thing as a single but interrupted or varied perception. Since Hume gives us no example of an uninterrupted and unchanged perception, let us choose an example for ourselves. Suppose we have nothing but twelve eggs in front of us, and suppose that the eggs and their immediate environment do not change during a certain period of time. Then the perception we have of these twelve eggs during this period of time would be an uninterrupted and unchanged perception. Let P be 4 this perception. What Hume wants to do is to consider two points of time t ^ and t2 in this period. Let P1 and P2 i,s the perceptions we have of the twelve eggs at t, and t2, respectively. P ^ and P2 are then two stages of the perception P. Since P is uninterrupted and unchanged, its 'content' at each point of time during this period should remain the same. As Hume puts it, we suppose the change to lie only in... time (T 203); and the change in time, when applied to an unchangeable object, 'tis only by a fiction of the imagination, by which the unchangeable object is suppos'd to participate of the changes of the coexistent objects, and in particular of that of our perceptions. (T 200-201) We now are told to survey P. and P. at once. But this can only be done at a time t- which is 61. later than both t ^ and t 2·How can we survey them after t ^ and t2? Presumably by memory we may recall P1 and P 2 at t3. Now Hume tells... (shrink)

Recent work by Wan and McLean has shown that all quantum measurements may be reduced to local position measurements. Using an array of particle detectors as the measuring apparatus we show how a model employing superselection rules and unitary evolution leads to a single detector triggering in each act of measurement. We also present an explicit model of particle detection as a unitary ionization process producing a single ion in the detector, subsequent amplification of which to the visible can be (...) described adequately in classical terms. (shrink)

> The Japanese have a word which summarizes all the best in Japanese life, yet it has no explanation and cannot be translated. It is the word shibui, and the best approximation to its meaning is 'acerbic good taste'.—James A. Michener in Iberia The austere beauty of lacquerware, the wizened lines and thickened trunk of a 100-year-old bonsai, the veiled beauty of murky jade—what do all these have in common? These are the qualities of shibumi, a Japanese aesthetic defined by (...) the seven characteristics described by Dr Yanagi Soetsu1 in The Unknown Craftsman: simplicity, implicity, modesty, naturalness, everydayness, imperfection, silence. Derived from the root word shibui, literally meaning ‘bitter’, the antonym of amai, for sweet—the etymology of shibusa encapsulates the jolting acerbity of one inadvertently sinking her teeth into an unripe persimmon; paradoxically described as a moment of inward transcendence. Quite distinct from wabi-sabi—while pottery and stoneware may be embraced for organic lines reflecting naturalness and imperfections as an aesthetic; within the distillation of shibumi, beyond the asymmetrical and flawed, lies an appreciation of ‘beauty with inner implications’ that ‘allows depth of feeling to be visible through spare surface design thereby manifesting the invisible core that …. (shrink)

Volume 20, Issue 7, July 2020, Page W12-W14.

The orthodox presentation of quantum theory often includes statements on state preparation and measurements without mentioning how these processes can be achieved. The often quoted projection postulate is regarded by many as problematical. This paper presents a systematic framework for state preparation and measurement. Within the existing Hilbert space formulation of quantum mechanics for spinless particles we show that it is possible (1)to prepare an arbitrary state and (2)to reduce all quantum measurements to local position measurements in an asymptotic way (...) by unitary evolution processes without recourse to the projection postulate. A generalization to spin-1/2particles is also given. The theory presented provides a general mathematical and theoretical foundation for many practical schemes for state preparation and measurement. (shrink)

Synaesthesia is a neurological condition in which a sensory or cognitive stimulus consistently co-activates another sensory/cognitive quality in addition to its usual qualities. For example, synaesthetes might see colours when they read words. Coloured language is one of the most common and most studied types of synaesthesia. The processes that govern the associations of colours and language have been linked to the mechanisms underlying the processing of language more generally. This chapter reviews evidence from current psycholinguistic synaesthesia research in Chinese, (...) focusing in particular on how synaesthetic colouring works in Chinese characters, the basic writing units in Chinese. I consider this in relation to the psycholinguistic processes of character recognition. This chapter reviews evidence for the following facts: that synaesthetic colouring of Chinese characters is a genuine phenomenon in the Chinese population and may affect as many as 1 in 100 in the Chinese population, with a non-significant difference across the sexes that the colouring of characters is rule-based and influenced by a number of linguistic factors; and that synaesthetic colouring can transfer across Chinese and English in bilinguals. These findings are discussed in relation to native versus non-native Chinese synaesthetes, and to the Chinese versus English systems. (shrink)

001. 인간의 본질 002. 한민족과 전통사상 003. 민주주의 004. 현대사회와 직업윤리 005. 산업사회와 환경윤리 006. 북한체제의 신 정치이념 007. 민족통이론.

The Oscar Wilde trials (1895) have usually been interpreted either as a historical document which gives insight into the regulation of sexuality in the late nineteenth century, or as literary biography explicating the playwright's life and works. Taking its cue from recent scholarship in ‘law and literature’, and also from Wilde's own conception of the relationship between art and life, this article proposes a reading of the trials which blurs the distinction between legal history and literary criticism by considering them (...) as a form of literature. It argues that the trial transcripts enact and reflect Wilde's vision of what literature is and how it should be read, and as such should be given a place amongst his literary works, alongside such aesthetic manifestos as ‘The Decay of Lying’ and ‘The Critic as Artist’. (shrink)