While the concept of Bildung has acquired international currency in educational and philosophical studies, its moral implications have been obscured by existing educational accounts. I present the moral implications inherent in the term through specific reference to the early works of Wilhelm von Humboldt. In contrast to previous scholarships, where Humboldt’s theory of Bildung has been deployed for drawing on the account of the true end of the human being and the inner process of interaction between the self and the (...) world, I draw on Bildung as a moral conception of promoting a good life for others. To illustrate this conception, I (a) demonstrate the basic structure of Humboldt’s theory of Bildung by examining its four core components, (b) reconstruct Humboldt’s notion of virtue balanced state of various faculties as a moral ideal (c) consider Humboldt’s philosophical historiography to illustrate how Bildung can be mediated at individual and collective levels, and (d) present the concrete forms of the obligation to promote the good lives of others in his anthropological writings. (shrink)

This paper has three tasks. First, I offer an interpretation of Jeremy Bentham’s theory of language which I hope can conciliate or integrate the three rival interpretations of its epistemological implication: reductionist realist, pragmatist, and fictionalist. It is accompanied by an interpretation of Bentham’s strategy for improving the state of language, which characterizes it as a “two-level” strategy. Second, by focusing on the linguistic thoughts of three philosophers, Locke, Condillac, and Tooke, I inquire into the sources of Bentham’s theory of (...) language, and then try to evaluate the originality of Bentham’s theory in the context of the empiricist tradition of linguistic thought of the age of the Enlightenment. The inquiry also enables us to understand how Bentham’s theory came to have such a complex structure as is revealed in the first part of this paper. Third, I ask the question as to why Bentham, after about a thirty-year hiatus, suddenly resumed writing on the problems of language and logic around 1811. Through exhibiting the outline of my answer to this question, I argue that his discovery of “delusion” led him to fight the “war of words” in various fields of society, and his awareness of the strong force of delusion for aggravating the state of language made him realize the urgent necessity to develop at length “an entirely new system of Logic, in which shall be comprehended a theory of language, considered in the most general point of view.”. (shrink)

Sister chromatid separation in anaphase is an important event in the cell's transmission of genetic information to a descendent. It has been investigated from different aspects: cell cycle regulation, spindle and chromosome dynamics within the three‐dimensional cell architecture, transmission fidelity control and cellular signaling. Integrated studies directed toward unified understanding are possible using multidisciplinary methods with model organisms. Ubiquitin‐dependent proteolysis, protein dephosphorylation, an unknown function by the TPR repeat proteins, chromosome transport by microtubule‐based motors and DNA topological change by DNA (...) topoisomerase II are all necessary for progression from metaphase to anaphase. Chromosome condensation, mitotic kinetochore function and spindle formation require a large number of proteins, which are prerequisites for successful sister chromatid separation. Factors that help to retain sister chromatid connection after replication and prevent premature separation remain to be determined. Although sister chromatid separation occurs in anaphase, gene functions in other cell cycle stages also ensure the progression of correct chromatid separation. (shrink)

The telomere is a functional domain of the chromosome, located at the extreme ends, and is essential for normal chromosome stability. Chromosomes lacking telomeres are inherited improperly, and mutations in the telomeric repeat sequences are thought to lead to senescence and possibly to cancer. The molecular mechanisms maintaining chromosomes by telomeres, however, have been unclear. Results recently reported by Kirk et al.(1) offer an insight into new telomerase function. They have identified a novel telomerase mutation that blocks sister chromatid separation (...) in mitosis. (shrink)