DNA double‐strand breaks (DSBs) are one of the most deleterious forms of DNA damage and can result in cell inviability or chromosomal aberrations. The Mre11‐Rad50‐Nbs1 (MRN) ATPase‐nuclease complex is a central player in the cellular response to DSBs and is implicated in the sensing and nucleolytic processing of DSBs, as well as in DSB signaling by activating the cell cycle checkpoint kinase ATM. ATP binding to Rad50 switches MRN from an open state with exposed Mre11 nuclease sites to a closed (...) state with partially buried nuclease sites. The functional meaning of this switch remained unclear. A new study shows that ATP binding to Rad50 promotes DSB recognition, tethering, and ATM activation, while ATP hydrolysis opens the nuclease active sites to promote processing of DSBs. MRN thus emerges as functional switch that may coordinate the temporal transition from signaling to processing of DSBs. (shrink)

A theorem on the extendability of certain subsets of a Boolean algebra to ultrafilters which preserve countably many infinite meets (generalizing Rasiowa-Sikorski) is used to pinpoint the mechanism of the Barwise proof in a way which bypasses the set theoretical elaborations.

The present note is a reworking and streamlining of Daigneault and Monk's Representation Theory for Polyadic Algebras. MSC: 03G15.

INTRODUCTORY* Teleology, ok Moeal Causation. 1. Man aim 8 Before studying the laws which gov- at Fruition — ie, ern human actions, it is useful, ...