The definition of life has been one of the greatest philosophical questions of mankind. In recent years, this debate had intensified due to the discovery of naturally occurring biological entities, such as viruses and prions, which lie at the boundary of what we consider as living. “Are viruses alive?” has turned out to be the largest vote swinging debate in an introductory course to microbiology [1], with 79% of the students changing their opinions before and after the debate compared to (...) genetic engineering (56% opinion swing) and childhood immunization (25% opinion swing). Using boundary cases as classification criteria, also known as the decision boundary or decision surface, had been well established [2]. (shrink)

Reason: The article, Kgatle, M.S., 2017, ‘The unusual practices within some Neo-Pentecostal churches in South Africa: Reflections and recommendations’, HTS Teologiese Studies/Theological Studies 73, a4656. https://doi.org/10.4102/hts.v73i3.4656, published on 29 September 2017 in HTS Teologiese Studies/Theological Studies has been retracted by the journal’s Editor-in-Chief, Prof. Andries van Aarde, because of sections of plagiarised text. Verbatim work was cited but presented to the readers as paraphrased from the original, providing the impression that the lifted passages were the author’s own words. The verbatim (...) text directly affects the findings of the paper and could not be removed. The article is hereby retracted to correct the publication record.We apologise for any inconvenience to the authors and readers of HTS Teologiese Studies/Theological Studies. (shrink)

One of the most beautiful and enigmatic texts in the corpus of the Apocryphal Acts of the Apostles is beyond doubt the so-called Hymn of the Pearl, whose meaning, however, is far from getting an academic consensus in the current bibliography. As A.F.J. Klijn in his «The So-Called Hymn of the Pearl », Vigiliae Christianae, vol. 14, n. 3 156, stated a coherent analysis of the poem should bring an answer to two main questions: «What is meant with the pearl? (...) and Who is the principal person in this hymn?». The following pages will try to propose a tenable meaning to this passage by allocating it in its due conceptual context and will offer a consequent hypothesis to those questions that remain still opened. (shrink)

Despite widespread support for the claim that death can harm the one who dies, debate continues over how to rescue this harm thesis (HT) from Epicurus’s challenge. Disagreements focus on two of the three issues that any defense of HT must resolve: the subject of death’s harm and the timing of its injury. About the nature of death’s harm, however, a consensus has emerged around the view that death harms a subject (when it does) by depriving her of the goods (...) life would’ve afforded had she continued living. This deprivation view of death’s harm (DV) derives some of its credibility from the general deprivation theory of which it is an instance: mortal harm is subject to the same kind of analysis plausibly given of other non-mortal harms. Furthermore, note that the weak formulation of HT—asserting only that death can inflict harm, not that it always or necessarily does—accommodates the intuition that instances of rational suicide and justifiable euthanasia present cases in which death fails to harm. DV is equipped to explain how in these cases the harms involved in continued existence outweigh the goods of which death deprives the subject. I agree that suicide can be rational and that euthanasia can be justifiable. Likewise I accept both HT and DV as far as they go. But they do not go far enough. Specifically, I argue here that death harms even those who die as a result of rational suicide or justifiable euthanasia; that death’s harm is neither undifferentiated nor wholly contingent, but multifaceted and partly necessary; that the necessary part of death’s harm is distinctive, inflicting a peculiar restriction on the autonomy of one who dies; and, regarding the timing and subject issues, that this restriction harm is inflicted on the antemortem subject prior to her death. (shrink)

Industrial drug design methodology has undergone remarkable changes in the recent history. Up to the 1970s, the screening of large numbers of randomly selected substances in biological test system was often a crucial step in the development of novel drugs. From the early 1980s, such ‘blind’ screening was increasingly rejected by many pharmaceutical researchers and gave way to ‘rational drug design’, a method that grounds the design of new drugs on a detailed mechanistic understanding of the drug action. Surprisingly, however, (...) the chance-based method of random screening returned to center stage of industrial drug development in the 1990s in the form of ‘high-throughput screening’ (HTS). I will argue in this paper that this to-and-fro in the prominence of random screening comes with fundamental changes in the epistemic significance of chance experiments in pharmaceutical development. While up to the 1970s, random screening used to be chosen as an empirical search strategy primarily because suffi- cient knowledge of the mechanistic basis of drug action was lacking, it has turned with high-throughput screening into an experimental method that employs chance variation and testing to illuminate this mechanistic basis. As a consequence, research into the underlying mechanisms of drug action and the development of new drugs have become closely integrated. The rise of HTS therefore not only shows how chance experiments have assumed a new epistemic role in drug development. It also allows for a detailed study of the much debated emergence of a new relationship between scientific understanding and the development of technological artifacts. (shrink)

This article contributes empirical findings and sociological theoretical perspectives to discussions of the role of community lay health workers, including in improving the health of individuals and communities. We focus on the role of the Health Trainer (HT), at its inception described as one of the most innovative developments in UK Public Health policy. As lay health workers, HTs are tasked with reducing health inequalities in disadvantaged communities by supporting clients to engage in healthier lifestyles. HTs are currently sociologically under-researched, (...) particularly in relation to occupational identity work, and the boundary work undertaken inter-occupationally with other health workers. To address this research lacuna, a qualitative study was undertaken with 25 HTs based in the Midlands region of the UK. In theorising our findings, we employ a novel combination of symbolic interactionist conceptualisation of 1) identity work, and of 2) boundary work. The article advances knowledge in the field of health and exercise by investigating and theorising how HTs construct, work at, manage, and communicate about professional/occupational boundaries, in order to provide personalised support to their clients in achieving and sustaining healthy behaviour change within the constraints of clients’ lifeworlds. (shrink)