Fanconi anaemia (FA) comprises a group of autosomal recessive disorders resulting from mutations in one of eight genes (FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF and FANCG). Although caused by relatively simple mutations, the disease shows a complex phenotype, with a variety of features including developmental abnormalities and ultimately severe anaemia and/or leukemia leading to death in the mid teens. Since 1992 all but two of the genes have been identified, and molecular analysis of their products has revealed a complex (...) mode of action. Many of the proteins form a nuclear multisubunit complex that appears to be involved in the repair of double‐strand DNA breaks. Additionally, at least one of the proteins, FANCC, influences apoptotic pathways in response to oxidative damage. Further analysis of the FANC proteins will provide vital information on normal cell responses to damage and allow therapeutic strategies to be developed that will hopefully supplant bone marrow transplantation. BioEssays 24:439–448, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

The aim of this paper is to examine the relationship between education and technological rationality from the perspective of the philosophy of education, and to show that while education is deeply related to technique, skills, or technology, it can never be reduced to technical knowledge, and that there are things in education that overflow technical knowledge. I will here ask why there is something in education that overflows technical knowledge — I will define it as knowledge of pathos — and (...) why it is necessary to redefine the meaning of education in terms of knowledge of pathos. In order to address this issue, I will first examine the relationship between technology and transcendence in the world of education in Kei Hachiya’s Education and Transcendence. Second, I will show that recent outstanding theoretical achievements of Japanese philosophers of education — Satoji Yano’s Education from the Perspectives of Gift and Exchange, Yasuo Imai’s Medial Perspective on Education, and Tsunemi Tanaka’s Clinical Theory of Human Becoming — are all located within the problematic area of ‘technology-pathos-education’. Finally, I would like to propose a ‘philosophy of education built on fragile parts’, with a view to redefining education through the knowledge of pathos, paying attention to the experience of pathei mathos and the opportunity of weakness in the philosophy of education. (shrink)

This is a brief historical view, based on my personal experience, of the phenomenological study of the assembly of actin in Japan. The morphogenesis and dynamics of protein filaments and cytoskeleton now represent one of the central problems in cell biology. The approach to this problem at the molecular level was first undertaken on actin from muscle.

地球環境問題など、文明社会がもたらしたさまざまな負の作用がクローズアップされているいま、必要なのは量の時代から質の時代への移行である。「人間」「科学」「技術」がどのように相互作用してきたかをふりかえり 、人間、自然、地球が豊かになるための道をさぐる。.

In lieu of an abstract, here is a brief excerpt of the content:Conference of the Japan Society for Buddhist-Christian StudiesEiko Hanaoka and Jonathan A. SeitzFour lectures were given, with the theme “The Philosophy of Religion in Hajime Tanabe”:1. “Philosophy as Metanoetics” by Professor Masakazu Fujita2. “Hajime Tanabe’s Philosophy and Christian Dialectic” by Professor Emeritus Isao Onodera3. “‘Christianity’ and ‘Philosophy of Religion’ in Tanabe’s Philosophy” by Professor Emerita Eiko Hanaoka4. “The Original Subjectivity in Pure-Land Buddhism” by Professor Emeritus Akira Kawanami.Professor (...) Emeritus Ausluv Lande from Lund University in Sweden also participated in this conference. [End Page 193]Eiko HanaokaOsaka Prefecture UniversityPalace Side Hotel, Kyoto September 2–4, 2013Copyright © 2014 University of Hawai‘i Press... (shrink)

In the contemporary world all kinds of culture, thought modes, philosophies and religions are complicatedly active. Social conditions of our contemporary world wear a nihilistic look which Nietzsche prophesied as a fact, 200 years after his time. In this nihilistic ambience, the whole world seems to be overrun by various crimes neglecting morality and ethics. In such a world we are urged to consider how morals and ethics can be realized. In this meaning the „bounds of ethics‟ are considered in (...) regard to the paradigms of different historical epochs as the framework and basis of life, culture and thinking. One of these paradigms, common to East and West, is the one based on being and nothingness: relative being, relative nothingness, absolute being, nihil, and absolute nothingness, which last-mentioned paradigm subsumes the other four. In essence, this paper will discuss how morality and ethics in the paradigm of absolute nothingness can finally act in oneness with religion and overcome nihilism in the contemporary world, even if it acts very slowly. (shrink)

In this paper I discuss the new possibility of social transformation by religion in order to save the global nihilistic situation in the contemporary world because of the modern technology which neglected human dignity in all over the world since the Industrial Revolution started from England in the latter half of the 18th Century. Such possibility by religion can be realized, in my view, by “the way of walking” on the ground of “self-awareness”, where each person realizes the great death (...) of egoistic ego and is aware of the true self, which is common to each of all nature, which awareness then results in the faith in God as action, God who is non-substantial and has no peculiar nature of its own. Such religion could be found in the religion and the philosophy of religion advocated by A. N. Whitehead and K. Nishida. (shrink)

One of the profound changes in cellular morphology during mitosis is a massive alteration in the organization of microfilament cytoskeleton. It has been recently discovered that nonmuscle caldesmon, an actin and calmodulin binding microfilament‐associated protein of relative molecular mass Mr = 83000, is dissociated from microfilaments during mitosis, apparently as a consequence of mitosis‐specific phosphorylation. cdc2 kinase, which is a catalytic subunit of MPF (maturation or mitosis promoting factor), is found to be responsible for the mitosis‐specific phosphorylation of caldesmon. Because (...) caldesmon is implicated in the regulation of actin myosin interactions and/or microfilament organization, these results suggest that cdc2 kinase directly affects microfilament re‐organization during mitosis. (shrink)

How can we effectively promote the public’s prevention of coronavirus disease 2019 infection? Jordan et al. found with United States samples that emphasizing either self-interest or collective-interest of prevention behaviors could promote the public’s prevention intention. Moreover, prosocially framed messaging was more effective in motivating prevention intention than self-interested messaging. A dual consideration of both cultural psychology and the literature on personalized matching suggests the findings of Jordan et al. are counterintuitive, because persuasion is most effective when the frame of (...) the message delivered and the recipient of the message are culturally congruent. In order to better understand the potential influence of culture, the current research aimed to replicate and extend Jordan et al. findings in the Japanese context. Specifically, we examined the question whether the relative effectiveness of the prosocial appeal is culturally universal and robust, which types of ‘others’ especially promote prevention intention, and which psychological mechanisms can explain the impact of messaging on prevention intention. In Study 1, we confirmed that self-interested framed, prosocially framed, and the combination of both types of messaging were equally effective in motivating prevention intention. In Study 2, we found that family-framed messaging also had a promoting effect similar to that from self-interested and prosocial appeals. However, the relative advantage of prosocial appeals was not observed. Further, a psychological propensity relevant to sensitivity to social rejection did not moderate the impact of messaging on prevention intention in both studies. These results suggest that since engaging in the infection control itself was regarded as critical by citizens after public awareness of COVID-19 prevention has been sufficiently heightened, for whom we should act might not have mattered. Further, concerns for social rejection might have had less impact on the prevention intentions under these circumstances. These results suggest that the relative advantage of a prosocial appeal might not be either culturally universal or prominent in a collectivistic culture. Instead, they suggest that the advantages of such an appeal depends on the more dynamic influence of COVID-19 infection. (shrink)

誕生から今日まで、文芸・演劇が芸術に占める位置ばどう変わっているのか?古今東西の具体的な動きに即しつつ、類型論的・理論的パースペクティブを示す。.

While changes in response to the different stages of the pandemic remain unknown, this study investigated the longitudinal impact of the COVID-19 pandemic on depressive symptoms in Japanese university students and identified factors associated with new onset of depression and suicidal ideation. Two surveys were conducted at one university in Akita, Japan, during the first COVID-19 outbreak period and 1 year later. Moderate depressive symptoms were defined as a Patient Health Questionnaire-9 score ≥ 10 and suicide-related ideation score ≥ 1 (...) on question 9 of the questionnaire. Among 985 students who completed surveys in T1 and T2, participants with moderate depressive symptoms and suicide-related ideation increased from 11 to 17% and from 5.8 to 11.8%, respectively. Among 872 students at risk after excluding those with moderate depressive symptoms at T1, 103 students developed moderate depressive symptoms at T2. Among the 928 students at risk, after excluding those who had suicidal ideation at T1, 79 developed suicidal ideation. Multivariate logistic modeling revealed financial insecurity and academic performance as risk factors, while having someone to consult about worries was a coping factor for depressive symptoms and suicidal ideation. Our findings demonstrated that socioenvironmental factors may determine depressive symptoms of university students. (shrink)