The idea that intuition plays a basic role in moral knowledge and moral philosophy probably began in the eighteenth century. British philosophers such as Anthony Shaftsbury, Francis Hutcheson, Thomas Reid, and later David Hume talk about a “moral sense” that they place in John Locke’s theory of knowledge in terms of Lockean reflexive perceptions, while Richard Price seeks a faculty by which we obtain our ideas of right and wrong. In the twentieth century intuitionism in moral philosophy was revived by (...) the works of G. E. Moore, H. A. Prichard, and W. D. Ross. These philosophers reject Kantian deontological ethics and utilitarianism insisting that intuition is the only source of moral knowledge. Recently, there is a renewed interest in intuition by philosophers doing meta-philosophy by reflecting on what philosophers do, and why they disagree. In this essay we plan to take some of this recent literature on intuition and apply it to moral philosophy. We will proceed by defining a conception of intuition, answering some skeptical challenges, delimiting its target, and arguing that intuition is often a source of moral knowledge. (shrink)

Gap junction intercellular communication channels permit the exchange of small regulatory molecules and ions between neighbouring cells and coordinate cellular activity in diverse tissue and organ systems. These channels have short half‐lives and complex assembly and degradation pathways. Much of the recent work elucidating gap junction biogenesis has featured the use of connexins (Cx), the constituent proteins of gap junctions, tagged with reporter proteins such as Green Fluorescent Protein (GFP) and has illuminated the dynamics of channel assembly in live cells (...) by high‐resolution time‐lapse microscopy. With some studies, however, there are potential short‐comings associated with the GFP chimeric protein technologies. A recent report by Gaietta et al., has highlighted the use of recombinant proteins with tetracysteine tags attached to the carboxyl terminus of Cx43, which differentially labels ‘old’ and ‘new’ connexins thus opening up new avenues for studying temporal and spatial localisation of proteins and in situ trafficking events.1 BioEssays 24:876–880, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

The Alternative Model of Personality Disorders integrates several theoretical models of personality functioning, including interpersonal theory. The interpersonal circumplex dimensions of warmth and dominance can be conceptualized as traits similar to those in AMPD Criterion B, but interpersonal theory also offers dynamic hypotheses about how these variables that change from moment to moment, which help to operationalize some of the processes alluded to in AMPD Criterion A. In the psychotherapy literature, dynamic interpersonal behaviors are thought to be critical for identifying (...) therapeutic alliance ruptures, yet few studies have examined moment-to-moment interpersonal behaviors that are associated with alliance ruptures at an idiographic level. The current study examined the concurrent and cross-lagged relationships between interpersonal behaviors and alliance ruptures within each session in the famous Gloria films. Interpersonal behaviors as well as alliance ruptures were calculated at half minute intervals for each dyad. We identified distinct interpersonal patterns associated with alliance ruptures for each session: Gloria ’s warmth was positively related with withdrawal ruptures concurrently in the session with Carl Rogers; Gloria’s dominance and coldness were related with increased confrontation ruptures in the session with Fritz Perls concurrently, while her coldness was also predicted by confrontation ruptures at previous moments; lastly, both Gloria’s dominance and Albert Ellis’s submissiveness were positively related with withdrawal ruptures. These interpersonal patterns demonstrated the promise of using AMPD dimensions to conceptualize momentary interpersonal processes related to therapy ruptures, as well as the clinical importance of attuning to repetitive, dyad-specific interpersonal cues of ruptures within each session. (shrink)

It is the prevailing paradigm in contemporary physics to model the dynamical evolution of physical systems in terms of a real parameter conventionally denoted as 't' ('little tee'). We typically call such dynamical models laws of nature' and t we call 'physical time'. It is common in the philosophy of time to regard t as time itself, and to take the global structure of general relativity as the ultimate guide to physical time, and so consequently the true nature of time. (...) In this paper we defend the idea that physical time, t, is rather better defined as an operational modelling parameter: we measure relations between changing physical quantities using bespoke physical systems---i.e. clocks---that coordinate local coincidences. We argue that the sorts of physical systems that make good clocks---what we call precision clocks---are those that exhibit self-sustained oscillations known as limit cycles, which are ubiquitous in open, driven, stable, dissipative systems. We develop the physical and philosophical ramifications of this conception of physical time, particularly the notion that physical time does not track something 'out there' in the world. As a result, we speculate that physical time is perhaps not as different from manifest time as many philosophers of time (and apparently general relativity) seem to suggest. (shrink)

Commentaries on the target article offer diverse perspectives on integrative experiment design. Our responses engage three themes: (1) Disputes of our characterization of the problem, (2) skepticism toward our proposed solution, and (3) endorsement of the solution, with accompanying discussions of its implementation in existing work and its potential for other domains. Collectively, the commentaries enhance our confidence in the promise and viability of integrative experiment design, while highlighting important considerations about how it is used.

The dominant paradigm of experiments in the social and behavioral sciences views an experiment as a test of a theory, where the theory is assumed to generalize beyond the experiment's specific conditions. According to this view, which Alan Newell once characterized as “playing twenty questions with nature,” theory is advanced one experiment at a time, and the integration of disparate findings is assumed to happen via the scientific publishing process. In this article, we argue that the process of integration is (...) at best inefficient, and at worst it does not, in fact, occur. We further show that the challenge of integration cannot be adequately addressed by recently proposed reforms that focus on the reliability and replicability of individual findings, nor simply by conducting more or larger experiments. Rather, the problem arises from the imprecise nature of social and behavioral theories and, consequently, a lack of commensurability across experiments conducted under different conditions. Therefore, researchers must fundamentally rethink how they design experiments and how the experiments relate to theory. We specifically describe an alternative framework, integrative experiment design, which intrinsically promotes commensurability and continuous integration of knowledge. In this paradigm, researchers explicitly map the design space of possible experiments associated with a given research question, embracing many potentially relevant theories rather than focusing on just one. Researchers then iteratively generate theories and test them with experiments explicitly sampled from the design space, allowing results to be integrated across experiments. Given recent methodological and technological developments, we conclude that this approach is feasible and would generate more-reliable, more-cumulative empirical and theoretical knowledge than the current paradigm – and with far greater efficiency. (shrink)

The different interpretations of quark mixing involved in weak interaction processes in the Standard Model and the Generation Model are discussed with a view to obtaining a physical understanding of the Cabibbo angle and related quantities. It is proposed that hadrons are composed of mixed-quark states, with the quark mixing parameters being determined by the Cabibbo-Kobayashi-Maskawa matrix elements. In this model, protons and neutrons contain a contribution of about 5% and 10%, respectively, of strange valency quarks.

Using covariant derivatives and the operator definitions of quantum mechanics, gauge invariant Proca and Lehnert equations are derived and the Lorenz condition is eliminated in U(1) invariant electrodynamics. It is shown that the structure of the gauge invariant Lehnert equation is the same in an O(3) invariant theory of electrodynamics.

The existence of the longitudinal field B (3) in the vacuum implies that the gauge group of electrodynamics is O(3),and not U(1) [or O(2)].This results directly in the charge quantization condition e=h(ϰ/A (0)).This condition is derived independently in this paper from the relativistic motion of one electron in the field and is shown to he that in which the electron travels infinitesimally close to the speed of light.

Stanovich & West distinguish between evolutionary rationality and normative rationality, and System 1 and System 2 mental processes. They hold that the main function of System 2 has to do with normative and not evolutionary rationality. We ask how System 2 could then be an adaptation, especially given S&W's own work on individual differences.

We show that there is a limit lemma for enumeration reducibility to 0 e ', analogous to the Shoenfield Limit Lemma in the Turing degrees, which relativises for total enumeration degrees. Using this and `good approximations' we prove a jump inversion result: for any set W with a good approximation and any set X< e W such that W≤ e X' there is a set A such that X≤ e A< e W and A'=W'. (All jumps are enumeration degree jumps.) (...) The degrees of sets with good approximations include the Σ0 2 degrees and the n-CEA degrees. (shrink)

The paper defends Gareth Evan's argument against vague identity "de re" from a criticism that quantum mechanics provides actual counter-examples to its validity. A more general version of Evans's argument is stated in which identity involving properties are not essential and it is claimed that the scientific facts as so far known are consistent with the Evansian thesis that indeterminacy in truth-value must always be due to semantic indecision.

Derrida and Phenomenology is a collection of essays by various authors, entirely devoted to Jacques Derrida's writing on Edmund Husserl's phenomenology. It gives a wide range of reactions to those writings, both critical and supportive, and contains many in-depth studies. Audience: Communicates new evaluations of Derrida's critique of Husserl to those familiar with the issues: specialists in phenomenology, deconstruction, the philosophies of Derrida and Husserl. Also contains a bibliography of recent relevant literature.