Usage of the Greek verb ‘to be’ is generally divided into three broad categories — the predicative use, the existential and the veridical—and these usages often inform the way we understand Being in ancient philosophy. This article challenges this approach by arguing that Being is not the product of linguistic reflection in Parmenides, Plato and Aristotle; rather, these thinkers treat Being as the ontological and epistemological primary. Though this may overlap with the linguistic senses, it is not the same thing. (...) The article is divided into three sections: the first one raises several basic issues with the predicative interpretation of Being, the second argues that Being is unified and singular in a significant sense and the third brings out the special pre-immanence of Being. (shrink)

The U.S. National Institute of Allergies and Infectious Diseases and the National Institute of Mental Health have a new research priority: inclusion of terminally ill persons living with HIV in HIV cure-related research. For example, the Last Gift is a clinical research study at the University of California San Diego for PLWHIV who have a terminal illness, with a prognosis of less than 6 months. As end-of-life HIV cure research is relatively new, the scientific community has a timely opportunity to (...) examine the related ethical challenges. Following an extensive review of the EOL and HIV cure research ethics literature, combined with deliberation from various stakeholders and our experience with the Last Gift study to date, we outline considerations to ensure that such research with terminally ill PLWHIV remains ethical, focusing on five topics: 1) protecting autonomy through informed consent, 2) avoiding exploitation and fostering altruism, 3) maintaining a favorable benefits/risks balance, 4) safeguarding against vulnerability through patient-participant centeredness, and 5) ensuring the acceptance of next-of-kin/loved ones and community stakeholders. EOL HIV cure-related research can be performed ethically and effectively by anticipating key issues that may arise. While not unique to the fields of EOL or HIV cure-related research, the considerations highlighted can help us support a new research approach. We must honor the lives of PLWHIV whose involvement in research can provide the knowledge needed to achieve the dream of making HIV infection curable. (shrink)

Six recently discussed problems in discrete probabilistic sample space, which have been found puzzling and even paradoxical, are reexamined. The importance is stressed of a sharp distinction between the formalization of mathematical problems and their formal solution that, applied to probability theory, must lead through the explicit partitioning of a sample space. If this approach is consistently followed, such problems reveal themselves to be either inherently ambiguous, and therefore without solution, or quite straightforward. In both cases nothing remains of any (...) sense of paradox. (shrink)

Jaynes contends that in many statistical problems a seemingly indeterminate probability distribution is made unique by the transformation group of necessarily implied invariance properties, thereby justifying the principle of indifference. To illustrate and substantiate his claims he considers Bertrand's Paradox. These assertions are here refuted and the traditional attitude is vindicated.

The form of the Good in Plato’s Phaedo and Republic seems, by our standards, to do too much: it is presented as the metaphysical princi­ple, the epistemological principle and the principle of ethics. Yet this seemingly chimerical object makes good sense in the broader context of Plato’s philosophical project. He sought certain knowledge of neces­sary truths (in sharp contrast to the contingent truth of modern science). Thus, to be knowable the cosmos must be informed by timeless princi­ples; and this leads (...) to teleology and the Good. The form of the Good, it is argued, is what makes the world knowable insofar as it is knowable. This interpretation plugs a significant gap in the scholarship on the Good and draws attention to a deep connection between Plato’s episte­mology and his teleological understanding of the cosmos. (shrink)

Objective To assess parental permission for a neonate's research participation using the MacArthur competence assessment tool for clinical research (MacCAT-CR), specifically testing the components of understanding, appreciation, reasoning and choice. Study Design Quantitative interviews using study-specific MacCAT-CR tools. Hypothesis Parents of critically ill newborns would produce comparable MacCAT-CR scores to healthy adult controls despite the emotional stress of an infant with critical heart disease or the urgency of surgery. Parents of infants diagnosed prenatally would have higher MacCAT-CR scores than parents (...) of infants diagnosed postnatally. There would be no difference in MacCAT-CR scores between parents with respect to gender or whether they did or did not permit research participation. Participants Parents of neonates undergoing cardiac surgery who had made decisions about research participation before their neonate's surgery. Methods The MacCAT-CR. Results 35 parents (18 mothers; 17 fathers) of 24 neonates completed 55 interviews for one or more of three studies. Total scores: magnetic resonance imaging (mean 36.6, SD 7.71), genetics (mean 38.8, SD 3.44), heart rate variability (mean 37.7, SD 3.30). Parents generally scored higher than published subject populations and were comparable to published control populations with some exceptions. Conclusions The MacCAT-CR can be used to assess parental permission for neonatal research participation. Despite the stress of a critically ill neonate requiring surgery, parents were able to understand study-specific information and make informed decisions to permit their neonate's participation. (shrink)

Common probabilistic fallacies and putative paradoxes are surveyed, including those arising from distribution repartitioning, from the reordering of expectation series, and from misconceptions regarding expected and almost certain gains in games of chance. Conditions are given for such games to be well-posed. By way of example, Bernoulli's "Petersburg Paradox" and Hacking's "Strange Expectations" are discussed and the latter are resolved. Feller's generalized "fair price, in the classical sense" is critically reviewed.

‘Probability dynamics’ (PD) is a second-order probabilistic theory in which probability distribution d X = (P(X 1), . . . , P(X m )) on partition U m X of sample space Ω is weighted by ‘credence’ (c) ranging from −∞ to +∞. c is the relative degree of certainty of d X in ‘α-evidence’ α X =[c; d X ] on U m X . It is shown that higher-order probabilities cannot provide a theory of PD. PD applies to (...) both subjectivist and frequentist theories. ‘Straight PD’ (SPD) produces associative and commutative mergers of evidence, in which evidences of positive credence are mutually reinforcing. ‘Offsetting PD’ (OPD) sets off conflicting evidences against each other. Subjectivist PD is a quantified second-order logic of action. Frequentist PD relates to descriptions of physical states of affairs. Acceptance of evidence α 1 X = [c 1; d 1 X ] at t 1 updates α 0 X = [c 0; d 0 X ] at t 0 into SPD-merger or OPD-merger . Given ‘co-evidence’ at t 0 < t 1, ‘indirect’ PD accepts evidence at t 1 and produces support for update α 10 X = [c10;d 10 X α 0 X such that in SPD and in OPD. For binary X and Y, with α 0 X = [c 0; P 0(X)] at t 0 (short-hand for ) and the accepted evidence, the support is ; ; where ρ0(X, Y) is the correlation coefficient of X and Y, and update α 10 X of α 0 X is with ‘accord’ λ = 1 in SPD and in OPD. As , tends toward update P 1(Y) of P 0(Y), but P 10(X) does not converge toward ‘ ’ of ‘probability kinematics’. Therefore PD is not compatible with probability kinematics. A process of ‘normalization’ interprets ‘β-evidence’ [[c 1; q 1]& . . . &[c m ; q m ]; U m X ]] with [c j ; q j ] on and m ≥ 3, as an α-evidence on {X 1, . . . , X m }. It is shown that SPD- and OPD-updates can be derived from updated cumulative functions. Time-biased updates are discussed. A PD-based theory of confirmation (PDCT) is presented. (shrink)

This article seeks to present a detailed textual analysis of Protagoras’ Great Speech in Plato's Protagoras. I will argue that the concept of ἀρετή as it appears in the Great Speech is whittled down to a vague notion of civic duty. In this respect, Protagoras is bringing himself in line with the democracy, but in doing so the ἀρετή he claims to teach loses much of its initial appeal, particularly in the eyes of his aristocratic clientele. Nevertheless, if thecontentof Protagoras’ (...) Great Speech overlooks the abilities required to rise to political prominence, theformmost assuredly does not. As one would expect from Plato's Protagoras, his speech is replete with just that oratorical prowess his students might expect to acquire from him. This, in turn, has a number of interesting and important implications in the broader context of theProtagoras, in particular regarding the contrast or conflict between long speeches and short-answer dialectic. Moreover, although it has long been noticed that Protagoras neglects rhetoric and personal pre-eminence in his account, as far as I know there has not been any serious attempt to analyse the stylistic aspects of this masterful speech. Accordingly, both this and my attempt to interpret it within the economy of the dialogue are original. (shrink)