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  1. Reconceptualising risk–benefit analyses: the case of HIV cure research.Robert Steel - 2020 - Journal of Medical Ethics 46 (3):212-219.
    Modern antiretroviral therapies are capable of suppressing HIV in the bloodstream to undetectable levels. Nonetheless, people living with HIV must maintain lifelong adherence to ART to avoid the re-emergence of the infection. So despite the existence and efficacy of ART, there is still substantial interest in development of a cure. But HIV cure trials can be risky, their success is as of yet unlikely, and the medical gain of being cured is limited against a baseline of ART access. The medical (...)
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  • Lessons learned from the Last Gift study: ethical and practical challenges faced while conducting HIV cure-related research at the end of life.John Kanazawa, Stephen A. Rawlings, Steven Hendrickx, Sara Gianella, Susanna Concha-Garcia, Jeff Taylor, Andy Kaytes, Hursch Patel, Samuel Ndukwe, Susan J. Little, Davey Smith & Karine Dubé - forthcoming - Journal of Medical Ethics.
    The Last Gift is an observational HIV cure-related research study conducted with people with HIV at the end of life at the University of California San Diego. Participants agree to voluntarily donate blood and other biospecimens while living and their bodies for a rapid research autopsy postmortem to better understand HIV reservoir dynamics throughout the entire body. The Last Gift study was initiated in 2017. Since then, 30 volunteers were enrolled who are either terminally ill with a concomitant condition and (...)
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  • Ethical and practical considerations for HIV cure-related research at the end-of-life: a qualitative interview and focus group study in the United States.Karine Dubé, Davey Smith, Brandon Brown, Susan Little, Steven Hendrickx, Stephen A. Rawlings, Samuel Ndukwe, Hursch Patel, Christopher Christensen, Andy Kaytes, Jeff Taylor, Susanna Concha-Garcia, Sara Gianella & John Kanazawa - 2022 - BMC Medical Ethics 23 (1):1-17.
    BackgroundOne of the next frontiers in HIV research is focused on finding a cure. A new priority includes people with HIV with non-AIDS terminal illnesses who are willing to donate their bodies at the end-of-life to advance the search towards an HIV cure. We endeavored to understand perceptions of this research and to identify ethical and practical considerations relevant to implementing it.MethodsWe conducted 20 in-depth interviews and 3 virtual focus groups among four types of key stakeholders in the United States (...)
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