Mack and Rock show evidence that no consciousperception occurs without a prior attentiveact. Subjects already executing attention taskstend to neglect visible elements extraneous tothe attentional task, apparently lacking evenbetter-than-chance ``implicit perception,''except in certain cases where the unattendedstimulus is a meaningful word or has uniquepre-tuned salience similar to that ofmeaningful words. This is highly consistentwith ``enactive'' notions that consciousnessrequires selective attention via emotional subcortical and limbic motivationalactivation as it influences anterior attentionmechanisms. Occipital activation withoutconsciousness suggests that motivated search,enacted through the (...) organism's subcorticalmotivational functions, is needed beforevisual stimulation engenders consciousness.This enactive view – that searching for,rather than receiving or processing input isthe basis of consciousness – was slow ingaining acceptance lacking empirical evidenceof this kind, combined with thestimulus-response assumption that brain eventssubserving perceptual consciousness must resultfrom transformation of perceptual input ratherthan from the organism's self-regulatedactivity as manifested through subcorticalactivity. Implicit perception occurring withword priming is ``paradoxical'' according to Mackand Rock, suggesting late selection forattention after extensive unconsciousprocessing, while most trials involvingnonverbal rather than verbal images mightsuggest earlier selection, sinceunattended objects are unseen, apparently evenimplicitly. This paper argues that anteriorand subcortical motivational mechanisms play animportant role in early selection; posteriormechanisms then unconsciously enhance signals;if data survive early gating andcorticothalamic enhancement, then still further anterior-limbic loops motivatedlyactivate ``image schemas'' resonating withposterior nonconscious processing; at thatpoint, consciousness occurs. (shrink)

The intention of the article is to offer stakeholders affected by mergers a criterion from which moral arguments may be generated for the organization of each individual case. The criterion: "Any operation causing legitimate interests to suffer vital infringement should be avoided in a merger process." A vital infringement of these interests is assumed when the merger undermines unique positive opportunities or considerable impairment in the future, impossible to overcome for the person affected without an unacceptable level of difficulty. Therefore, (...) we mainly concentrate on implicit contracts – which should be based on the principle pacta sunt servanda as well. These contracts are mandatory to run an economy that produces increasingly more knowledge-based goods. (shrink)

Owing to technological advances, genomic medicine is moving from specific to broader genetic analyses and from specialised to mainstream services. Sahan et al 1 point to complex ethical cases encountered by clinical laboratory scientists in the context of genomic medicine’s expansion. The authors discuss debates on interpreting and reporting genetic results, offering extended genetic testing and differences in the perceived responsibility of clinical laboratory scientists in different settings. As demonstrated by the case examples in the article, while genomic medicine holds (...) the promise of providing clinical answers, its mainstreaming can introduce a new type of ‘odyssey’ for patients and/or relatives, such as when there are uncertain findings. The integration of genomics in healthcare at large can also impact communication decisions and perceptions of responsibility for clinical laboratory scientists. Clinical laboratory scientists might report less to non-specialists than to genetic/genomic specialists, as they feel responsible for minimising the potential of non-specialists misunderstanding, misinterpreting or miscommunicating the genetic findings to patients.1 In this way, the perceived responsibility affects patients and the type and amount of genetic information they receive. We agree with the authors that current limitations in knowledge and capabilities among non-specialist clinicians necessitate identifying effective ways to communicate outcomes and …. (shrink)