What is free will? Can it exist in a determined universe? How can we determine who, if anyone, possesses it? Philosophers have been debating these questions for millennia. In recent decades neuroscientists have joined the fray with questions of their own. Which neural mechanisms could enable conscious control of action? What are intentional actions? Do contemporary developments in neuroscience rule out free will or, instead, illuminate how it works? Over the past few years, neuroscientists and philosophers have increasingly (...) come to understand that both fields can make substantive contributions to the free-will debate, so working together is the best path forward to understanding whether, when, and how our choices might be free. We therefore asked leading philosophers and neuroscientists which questions related to free will they would most like the other field to answer. Those experts then voted on the 15 most important questions for each field to answer. This book is a collection of the answers to those questions along with follow-up questions from world experts in the neuroscience and philosophy of free will. These varied perspectives will fascinate, illuminate, and stimulate students from both fields along with anyone who wants to be brought up to date on these profound issues. (shrink)

The approach the majority of neuroscientists take to the question of how consciousness is generated, it is probably fair to say, is to ignore it. Although there are active research programs looking at correlates of consciousness, and explorations of informational properties of what might be relevant neural ensembles, the tacitly implied mechanism of consciousness in these approaches is that it somehow just happens. This reliance on a “magical emergence” of consciousness does not address the “objectively unreasonable” proposition that elements (...) that have no attributes or properties that can be said to relate to consciousness somehow aggregate to produce it. Neuroscience has furnished evidence that neurons are fundamental to consciousness; at the fine and gross scale, aspects of our conscious experience depend on specific patterns of neural activity – in some way, the connectivity of neurons computes the features of our experience. So how do we get from knowing that some specific configurations of cells produce consciousness to understanding why this would be the case? Behind the voltages and currents electrophysiologists measure is a staggeringly complex system of electromagnetic fields – these are the fundamental physics of neurons and glia in the brain. The brain is entirely made of electromagnetism phenomena from the level of the atoms up. The EM field literally manifests the computations, or signaling, or information processing/activities performed by connected cellular ensembles that generate a 1st-person perspective. An investigation into the EM field at the cellular scale provides the possibility of identifying the outward signs of a mechanism in fundamental terms, as opposed to merely describing the correlates of our mental abstractions of it. (shrink)

The target articles by Dixon (2012), Scarantino (2012), and Mulligan and Scherer (2012) explore the nature of emotion from philosophical and psychological perspectives. I discuss how neuroscience can also contribute to debates about the nature of emotion. I focus on the aspects of emotion that usually fall within the topic of basic emotions, but conclude that we may need to revise how we conceive and study these kinds of emotional states in relation to the brain.

This commentary suggests that the physical substrate of integrated information is dependent on the reference frame used to observe it. Furthermore, it uses a thought experiment – can a neuroscientist, locked in a closed room and connected through Zoom with his grandmother to demonstrate that the consciousness of his grannie is NOT in the PC? – to underline the problems that neglecting reference frames may cause to consciousness research.

Evolutionary theory and methods are central to understanding the design of organisms, including their brains. This book does much to demonstrate the value of evolutionary neuroscience. Further work is needed to clarify the ways that neural systems evolved in general (specifically, the interaction between mosaic and coordinated evolution of brain components), and phylogenetic methods should be given a more prominent role in the analysis of comparative data.

Abstract:This essay explores new technologies of communication, mischievously suggesting that an ordinary memoir, on some fundamental level, is no different from what occurred with a young woman in a persistent vegetative state who “willfully modulated [her] brain activity.” If, as Elaine Scarry famously suggested, readers produce mental imagery “under the instruction of a writer,” then thinking about the role of alternative and augmentative communication (AAC) in providing such instruction might help us to think through the relationship between cognition and generic (...) innovation while, importantly, making room for neurodivergent writers. When George Perec wrote The Void without using the letter “e,” he imposed a restriction that could be said to work a bit like a “tennis-yes, navigation-no” protocol. In Eavesdropping: A Memoir of Blindness and Listening, the blind writer Stephen Kuusisto reinvents travel writing by having hearing and touch take the lead. Narrative itself ends up being transformed. This essay explores how disability puts pressure on the procedures of conventional narrative. (shrink)

Addiction is increasingly described as a “chronic and relapsing brain disease”. The potential impact of the brain disease model on the treatment of addiction or addicted individuals’ treatment behaviour remains uncertain. We conducted a qualitative study to examine: (i) the extent to which leading Australian addiction neuroscientists and clinicians accept the brain disease view of addiction; and (ii) their views on the likely impacts of this view on addicted individuals’ beliefs and behaviour. Thirty-one Australian addiction neuroscientists and clinicians (...) (10 females and 21 males; 16 with clinical experience and 15 with no clinical experience) took part in 1 h semi-structured interviews. Most addiction neuroscientists and clinicians did not uncritically support the use of brain disease model of addiction. Most were cautious about the potential for adverse impacts on individuals’ recovery and motivation to enter treatment. While some recognised the possibility that the brain disease model of addiction may provide a rationale for addicted persons to seek treatment and motivate behaviour change, Australian addiction neuroscientist and clinicians do not assume that messages about “diseased brains” will always lead to increased treatment-seeking and reduced drug use. Research is needed on how neuroscience research could be used in ways that optimise positive outcomes for addicted persons. (shrink)

In a remarkable exchange between neuroscientist Jean-Pierre Changeux and philosopher Paul Ricoeur, this book explores the vexed territory between these...

This paper presents findings from an empirical study that explored the meaning of ethics in the everyday work of neuroscientists. Observation and interviews were carried out in one neuroscience research group that was involved in bench-to-bedside translational research. We focus here specifically on the scientists’ perceptions of bioethics. Interviewees were often unfamiliar with bioethics as a discipline, particularly the more junior members of the group. Those who were aware of its existence largely viewed it as something distant from them, (...) and as either too abstract, not relevant or an alien imposition on their work. Some interviewees themselves pointed to the need for better ‘bridge building’ between ethical principles and real-world examples drawn from scientific practice, and we argue that this space is where a more empirically grounded ethics may be useful in terms of actually engaging scientists at both the bench and the bedside. (shrink)

Will understanding our brains help us to know our minds? Or is there an unbridgeable distance between the work of neuroscience and the workings of human consciousness? In a remarkable exchange between neuroscientist Jean-Pierre Changeux and philosopher Paul Ricoeur, this book explores the vexed territory between these divergent approaches--and comes to a deeper, more complex perspective on human nature.Ranging across diverse traditions, from phrenology to PET scans and from Spinoza to Charles Taylor, What Makes Us Think? revolves around a central (...) issue: the relation between the facts of science and the prescriptions of ethics. Changeux and Ricoeur ask: Will neuroscientific knowledge influence our moral conduct? Is a naturally based ethics possible? Pursuing these questions, they attack key topics at the intersection of philosophy and neuroscience: What are the relations between brain states and psychological experience? Between language and truth? Memory and culture? Behavior and action? What is a mental representation? How does a sign relate to what it signifies? How might subjective experience be constructed rather than discovered? And can biological or cultural evolution be considered progressive? Throughout, Changeux and Ricoeur provide unprecedented insight into what neuroscience can--and cannot--tell us about the nature of human experience.Changeux and Ricoeur bring an unusual depth of engagement and breadth of knowledge to each other's subject. In doing so, they make two often hostile disciplines speak to one another in surprising and instructive ways--and speak with all the subtlety and passion of conversation at its very best. (shrink)

Network neuroscience represents the brain as a collection of regions and inter-regional connections. Given its ability to formalize systems-level models, network neuroscience has generated unique explanations of neural function and behavior. The mechanistic status of these explanations and how they can contribute to and fit within the field of neuroscience as a whole has received careful treatment from philosophers. However, these philosophical contributions have not yet reached many neuroscientists. Here we complement formal philosophical efforts by providing an applied perspective (...) from and for neuroscientists. We discuss the mechanistic status of the explanations offered by network neuroscience and how they contribute to, enhance, and interdigitate with other types of explanations in neuroscience. In doing so, we rely on philosophical work concerning the role of causality, scale, and mechanisms in scientific explanations. In particular, we make the distinction between an explanation and the evidence supporting that explanation, and we argue for a scale-free nature of mechanistic explanations. In the course of these discussions, we hope to provide a useful applied framework in which network neuroscience explanations can be exercised across scales and combined with other fields of neuroscience to gain deeper insights into the brain and behavior. (shrink)

Two radically different families of theory currently compete for acceptance among theorists of human consciousness. The majority of theorists believe that the human brain somehow causes consciousness, but a significant minority holds that how the brain would cause this property is not only currently incomprehensible, but unlikely to become comprehensible despite continuing advances in brain science. Some of these latter theorists hold an alternate view that consciousness may well be one of the fundamentals in nature, and that the extremely complex (...) functional systems of the human brain inform this basic property, giving rise to our specifically human variety thereof. If these contesting families of theory are to be useful to neuroscientists, testable notions flowing from these theories need to be developed. (shrink)

Impaired control over drug use is a defining characteristic of addiction in the major diagnostic systems. However there is significant debate about the extent of this impairment. This qualitative study examines the extent to which leading Australian addiction neuroscientists and clinicians believe that addicted individuals have control over their drug use and are responsible for their behaviour. One hour semi-structured interviews were conducted during 2009 and 2010 with 31 Australian addiction neuroscientists and clinicians (10 females and 21 males; (...) 16 with clinical experience and 15 with no clinical experience). Although many addiction neuroscientists and clinicians described uncontrolled or compulsive drug use as characteristic of addiction, most were ambivalent about whether or not addicted people could be said to have no control of their drug use. Most believed that addicted individuals have fluctuating levels of impaired control over their drug use but they nonetheless believed that addicted persons were responsible for their behaviour, including criminal behaviour engaged in to fund their drug use. Addiction was not seen as exculpating criminal behaviour but as a mitigating factor. (shrink)

Centered on the question of normativity and ethics, neuroscientist Jean-Pierre Changeux and philosopher Paul Ricoeur engage in a lively and informative dialogue. They share a common insight concerning ethics, but let us first look at some of their differences.

Feminist science studies scholars have documented the historical and cultural contingency of scientific knowledge production. It follows that political and social activism has impacted the practice of science today; however, little has been done to examine the current cultures of science in light of feminist critiques and activism. In this article, I argue that, although critiques have changed the cultures of science both directly and indirectly, fundamental epistemological questions have largely been ignored and neutralized through these policy reforms. I provide (...) an auto-ethnography of my doctoral work in a neuroscience program to a) demonstrate how the culture of science has incorporated critiques into its practices and b) identify how we might use these changes in scientific practices to advance feminist science agendas. I critically analyze three areas in current scientific practice in which I see obstacles and opportunities: 1) research ethics, 2) diversity of research subjects and scientists, and 3) identification of a project's significance for funding. I argue that an understanding of the complicated and changing cultures of science is necessary for future feminist interventions into the sciences that directly challenge science's claim to epistemic authority. (shrink)

Stereological techniques allow biologists to create quantitative, three-dimensional descriptions of biological structures from two- dimensional images of tissue viewed under the microscope. For example, they can accurately estimate the size of a particular organelle, the total length of a mass of capillaries, or the number of neurons or synapses in a particular region of the brain. This book provides a practical guide to designing and critically evaluating stereological studies of the nervous system and other tissues. It explains the basic concepts (...) behind design-based stereology and how to get started. Also included are detailed descriptions of how to prepare tissue appropriately, perform pilot studies and decide on the appropriate sampling strategy, and account for phenomena such as tissue shrinkage. Numerous examples of applications of stereological methods that are applicable to studies of the central system and a wide variety of other tissues are explained. The book is therefore essential reading for neurobiologists and cell biologists interested in generating accurate representations of cell and tissue architecture. (shrink)

“[I]t has become next to impossible for a single mind fully to command more than a small specialized portion of it. I can see no other escape from this dilemma […] than that some of us should venture to..

Dramatic modern advances in emergency and resuscitation medicine, starting perhaps with the development of effective mechanical ventilators in the mid-20th century, have created a large class of persons who in earlier times would almost certainly have died, but who can now go on existing, suspended at least temporarily in a state somewhere between death and the conscious life they formerly pursued. A very wide range of brain injuries lead first to coma, in which the patient shows no sign of conscious (...) awareness, or even of wakefulness, in which eye openings and closings indicate the presence of a sleep/wake cycle unconsciously mediated by structures in the brain stem. Following emergence from coma, which may take days to months or more if it happens at all, patients typically show signs of wakefulness without conscious awareness – they are then in a so-called vegetative state (VS). For many this state becomes permanent, but some go on to a more recently described condition called the minimally conscious state (MCS), in which signs of conscious awareness can be detected by careful neurological examination (see Laureys & Tononi, 2009, chapter 14). A very few such persons ultimately progress to more or less full recovery, but another and particularly horrifying possible outcome is the “locked-in” state, in which a patient is fully conscious but has extremely little or no capacity for voluntary motor action. A famous modern example is that of Jean-Dominique Bauby, author of The Diving Bell and the Butterfly, who suffered a stroke to his upper brainstem and awakened 20 days later to find himself fully conscious but capable only of blinking his left eye. A tiny fraction of surgical patients find themselves in similarly terrifying conditions caused by the combination of muscle relaxants with insufficient levels of anesthetic agents (Kelly et al., 2007, p. 387 n. 18). (shrink)

The latest trend in ethics, sometimes dismissed as a fad, is the effort to connect ethics to empirical science. Two different versions of this “latest thing” can be found in the work of Jonathan Haidt and Joshua Greene. Their projects are, at least partly, unwitting recoveries of eighteenth-century Christian moral sense theory. Such similarities need not worry Christian ethicists but should instead inspire a careful retrieval of sentimentalism. It provides much of what today’s empirical ethicists hope to deliver without the (...) pitfalls. (shrink)

The Brain as a Tool considers two distinct views about the functions of the brain and how it interacts with the world. The book relates neural events to our sense of self and consciousness, summarizing important evidence which links neuroscience with cognitive psychology and philosophy.

The target article developed a dynamic systems framework that viewed the causal basis of emotion as a self-organizing process giving rise to cognitive appraisal concurrently. Commentators on the article evaluated this framework and the principles and mechanisms it incorporated. They also suggested additional principles, mechanisms, modeling strategies, and phenomena related to emotion and appraisal, in place of or extending from those already proposed. There was general agreement that nonlinear causal processes are fundamental to the psychology and neurobiology of emotion.

Too little has been written about the biology of joy. Most of the articles in the medical literature about brains and emotions are devoted to explaining how we feel fear, anger, anxiety and despair. This is understandable, because we don't go to doctors when we are feeling optimistic, happy and joyful. Most of what we know about the chemistry of our emotions has been learned from the disorders and the treatments of people who are sad and depressed. -/- But we (...) can't just accept this and say, ‘Why bother?’, because too many of us are seeking to find joy by taking chemicals. We need to ask, ‘What happens inside our brains when we experience happiness? Is there a way to stimulate pleasure in our brains, and what really happens when we do that?’. (shrink)

Neuroscientists continue to search for 'the' neural correlate of consciousness (NCC). In this article, I argue that a framework in which there are at least two distinct NCCs is increasingly making more sense of empirical results than one in which there is a single NCC. I outline the distinction between phenomenal NCC and access NCC, and show how they can be distinguished by experimental approaches, in particular signal- detection theory approaches. Recent findings in cognitive neuroscience provide an empirical case (...) for two different NCCs. (shrink)

This book proposes a new, unified view of the mind which integrates the insights of philosophers, psychologists, and neuroscientists. Through a detailed discussion of major theories from all these, and related disciplines, the author gradually reveals fundamental links between these previously unconnected approaches to human thought and experience. The author has studied medicine, philosophy, mathematics and history, and is currently a practising psychiatrist and a teacher at the Harvard Medical School. He discusses diverse fields of thought with depth and (...) clarity, and his unique perspective should stimulate a re-evaluation of our traditional approaches to the mind. (shrink)

Computational neuroscientists not only employ computer models and simulations in studying brain functions. They also view the modeled nervous system itself as computing. What does it mean to say that the brain computes? And what is the utility of the ‘brain-as-computer’ assumption in studying brain functions? In previous work, I have argued that a structural conception of computation is not adequate to address these questions. Here I outline an alternative conception of computation, which I call the analog-model. The term (...) ‘analog-model’ does not mean continuous, non-discrete or non-digital. It means that the functional performance of the system simulates mathematical relations in some other system, between what is being represented. The brain-as-computer view is invoked to demonstrate that the internal cellular activity is appropriate for the pertinent information-processing task.Keywords: Computation; Computational neuroscience; Analog computers; Representation; Simulation. (shrink)

Cognitive neuroscientists are turning to an increasingly rich array of neurodynamical systems to explain mental phenomena. In these explanations, cognitive capacities are decomposed into a set of functions, each of which is described mathematically, and then these descriptions are mapped on to corresponding mathematical descriptions of the dynamics of neural systems. In this paper, I outline a novel explanatory schema based on these explanations. I then argue that these explanations present a novel type of dynamicism for the philosophy of (...) mind and neuroscience, componential dynamicism, that focuses on the parts of cognitive systems that fill certain functional roles in producing cognitive phenomena. (shrink)

While neuroscientists often characterize brain activity as representational, many philosophers have construed these accounts as just theorists’ glosses on the mechanism. Moreover, philosophical discussions commonly focus on finished accounts of explanation, not research in progress. I adopt a different perspective, considering how characterizations of neural activity as representational contributes to the development of mechanistic accounts, guiding the investigations neuroscientists pursue as they work from an initial proposal to a more detailed understanding of a mechanism. I develop one illustrative (...) example involving research on the information-processing mechanisms mammals employ in navigating their environments. This research was galvanized by the discovery in the 1970s of place cells in the hippocampus. This discovery prompted research in what the activity of these cells represents and how place representations figure in navigation. It also led to the discovery of a host of other types of neurons—grid cells, head-direction cells, boundary cells—that carry other types of spatial information and interact with place cells in the mechanism underlying spatial navigation. As I will try to make clear, the research is explicitly devoted to identifying representations and determining how they are constructed and used in an information processing mechanism. Construals of neural activity as representations are not mere glosses but are characterizations to which neuroscientists are committed in the development of their explanatory accounts. (shrink)

Neuroscientists are searching for the engram within the conceptual framework established by John Locke's theory of mind. This framework was elaborated before the development of information theory, before the development of information processing machines and the science of computation, before the discovery that molecules carry hereditary information, before the discovery of the codon code and the molecular machinery for editing the messages written in this code and translating it into transcription factors that mark abstract features of organic structure such (...) as anterior and distal. The search for the engram needs to abandon Locke's conceptual framework and work within a framework informed by these developments. The engram is the medium by which information extracted from past experience is transmitted to the computations that inform future behavior. The information-conveying symbols in the engram are rapidly generated in the course of computations, which implies that they are molecules. (shrink)

The authors comments on several articles on addiction. Research suggests that addicted individuals have substantial impairments in cognitive control of behavior. The authors maintain that a proper study of addiction must include a neurobiological model of addiction to draw the attention of bioethicists and addiction neurobiologists. They also state that more addiction neuroscientists like S. E. Hyman are needed as they understand the limits of their research. Accession Number: 24077921; Authors: Carter, Adrian 1; Email Address: [email protected] Hall, Wayne 1; (...) Affiliations: 1: The University of Queensland, Brisbane, Australia; Subject: EDITORIALS; Subject: ADDICTIONS; Subject: BEHAVIOR; Subject: HYMAN, S. E.; Subject: NEUROBIOLOGISTS; Subject: NEUROSCIENTISTS; Number of Pages: 3p. (shrink)

Cognitive neuroscientists have anticipated the union of neural and behavioral science with ethics (Gazzaniga 2005). The identification of an ethical rule—the dictum that we should treat others in the manner in which we would like to be treated—apparently widespread among human societies suggests a dependence on fundamental human brain mechanisms. Now, studies of neural and molecular mechanisms that underlie the feeling of fear suggest how this form of ethical behavior is produced. Counterintuitively, a new theory presented here states that (...) it is actually a loss of social information that leads to sharing others' fears with our own, thus allowing us to treat others as we would like to be treated. Adding to that hypothetical mechanism is the well-studied predilection toward affiliative behaviors. Thus, even as Chomsky hypothesizes that humans are predisposed to utter grammatical sentences, we propose that humans are 'wired for reciprocity'. However, these two neural forces supporting ethical behavior do not explain individual or collective violence. At any given moment, the ability to produce behavior that obeys this ethical rule is proposed to depend on a balance between mechanisms for prosocial and antisocial behaviors. That balance results not only from genetic influences on temperament but also from environmental effects particularly during critical neonatal and pubertal periods. (shrink)