In the mammalian central nervous system (CNS), each neuron receives signals from other neurons through numerous synapses located on its cell body and dendrites. Molecules involved in the postsynaptic signaling pathways need to be targeted to the appropriate subcellular domains at the right time during both synaptogenesis and the maintenance of synaptic functions. The presence of messenger RNAs (mRNAs) in dendrites offers a mechanism for synthesizing the appropriate molecules at the right place in response to local extracellular stimuli. Several dendritic (...) mRNAs have been identified, and the mechanisms controlling their localization are beginning to be understood. In many cell types, controls on mRNA stability play an important role in the regulation of gene expression, but it is unclear to what extent this type of control operates in dendrites. The regulation of protein synthesis and the control of mRNA stability in dendrites could have important implications for neuronal function. BioEssays 20:70–78, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

With the popularization of mobile Internet and smart terminals, mobile reading with diversity and mobility has become a hot issue in the industry and academia. This article comes up with a hypothetical model of mobile reading user acceptance behavior based on the technology acceptance model and unified theory of acceptance and use of technology and conducts an analysis of the reliability and validity of questionnaire data. Based on this, the model fitness is analyzed as well as the path hypotheses testing. (...) We find that user-perceived ease of use greatly influences perceived usefulness, and user attitude and behavioral intention are significantly impacted by perceived usefulness. The impact of social influence on user attitude toward using mobile reading is significant, but the influence of perceived payment is not obvious. The moderating effect of living habit is not obvious because the absolute value of the critical ratio is under 2.58 with a significance level of 0.01. (shrink)

本书以科技理性与伦理价值的互动关系为逻辑起点,运用历史主义的方法、系统整体论的分析方法、唯物辩证的方法,从社会发展观层面、科技活动层面、人的全面发展层面,论述了对科技理性的伦理价值关怀。.

Since the late 1990s, the dynamics of welfare reform in Taiwan have gradually shifted to tackling new social risks emerging from economic globalization and labor market changes. This article analyzes these structural changes and the relevant institutional features of the labor market. The rise of atypical work has generated wide concern regarding its low wage income and insufficient social protection, triggering debates about which policy measures can effectively tackle the problem of the working poor. Drawing on the quantitative data from (...) a social quality survey conducted by the Social Policy Research Center in National Taiwan University (NTUSPRC) in 2009, our analysis explores the social exclusion differences between regular and atypical workers for their objective and subjective experiences. The objective experiences include current financial situations, negative events, living conditions and political activities of the workers, whereas the subjective experiences refer to their feelings in family position, welfare assessment, discrimination, and autonomy. Our analysis helps explain the effects of work status on the degrees of social exclusion, both in the private and public spheres. The social exclusion experiences of working conditions shed light on social quality in Asia. (shrink)

This paper investigates the applicability of reliabilism to scientific knowledge, and especially focuses on two doubts about the applicability: one about its difficulty in accounting for the epistemological role of scientific instruments, and the other about scientific theories. To respond to the two doubts, we extend virtue reliabilism, a reliabilist-based virtue epistemology, with a distinction of two types of epistemic virtues and the extended mind thesis from Clark and Chalmers (Analysis 58:7–19, 1998 ). We also present a case study on (...) the quantitative research methodology of social sciences to show that the methodology is actually an extended virtue reliabilism on how social science instruments and theories contribute to the formation of social scientific knowledge. (shrink)

Our aim was to describe Chinese nurses' experiences of workplace distress and ethical dilemmas on a neurological ward. Qualitative interviews were performed with 20 nurses. On using latent content analysis, themes emerged in four content areas: ethical dilemmas, workplace distress, quality of nursing and managing distress. The ethical dilemmas were: (1) conflicting views on optimal treatment and nursing; (2) treatment choice meeting with financial constraints; and (3) misalignment of nursing responsibilities, competence and available resources. The patients' relatives lacked respect for (...) the nurses' skills. Other dilemmas could be traced to the transition from a planned to a market economy, resulting in an excessive workload and treatment withdrawal for financial reasons. Lack of resources was perceived as an obstacle to proper patient care in addition to hospital organization, decreasing the quality of nursing, and increasing moral and workplace distress. The nurses managed mainly by striving for competence, which gave them hope for the future. (shrink)

The lateral mobility of membrane lipids and proteins is presumed to play an important functional role in biomembranes. Photobleaching studies have shown that many proteins in the plasma membrane have diffusion coefficients at least an order of magnitude lower than those obtained when the same proteins are reconstituted in artificial bilayer membranes. Depending on the protein, it has been shown that either the cytoplasmic domain or the ectodomain is the key determinant of its lateral mobility. Single particle tracking microscopy, which (...) allows the motions of single or small groups of membrane molecules to be followed, promises not only to reveal new features of membrane dynamics, but also to help explain longstanding puzzles presented by the photobleaching studies, particularly the so‐called immobile fraction. The combination of the two complementary technologies should measurably enhance our understanding of membrane microstructure. (shrink)

The developmental trajectory of speechreading skills is poorly understood, and existing research has revealed rather inconsistent results. In this study, 209 Chinese students with hearing impairment between 7 and 20 years old were asked to complete the Chinese Speechreading Test targeting three linguistics levels. Both response time and accuracy data were collected and analyzed. Results revealed no developmental change in speechreading accuracy between ages 7 and 14 after which the accuracy rate either stagnates or drops; no significant developmental pattern in (...) speed of speechreading across all ages. Results also showed that across all age groups, speechreading accuracy was higher for phrases than words and sentences, and overall levels of speechreading speed fell for phrases, words, and sentences. These findings suggest that the development of speechreading in Chinese is not a continuous, linear process. (shrink)

The present study intends to provide empirical evidence on the effect of Philosophy for Children integrated with English picture storybook instruction on adolescent learners of English as a foreign language. Previous studies have documented the instructional benefits of P4C in various fields; very little evidence, however, can be found in ESL or EFL contexts. The present study was therefore carried out to explore the beneficial effects of P4C applied in EFL instruction with picture storybooks as instructional materials. A total of (...) 62 students participated in the study, divided into one P4C group and one non-P4C group. Participants in the P4C group underwent 10 weeks of English storybook instruction with P4C in a school club, and the effects of instruction were measured by questionnaires and reading comprehension tests. Results of the study showed that students in the P4C group experienced a slightly higher level of English learning anxiety, retained higher English learning motivation after the instruction, and improved their English reading comprehension. Finally, pedagogical implications are presented. (shrink)

Comparative syllogism is a type of scientific reasoning widely used, explicitly or implicitly, for inferences from observations to conclusions about effectiveness, but its philosophical significance has not been fully elaborated or appreciated. In its simplest form, the comparative syllogism derives a conclusion about the effectiveness of a factor (e.g. a treatment or an exposure) on a certain property via an experiment design using a test (experimental) group and a comparison (control) group. Our objective is to show that the comparative syllogism (...) can be understood as encoding a simulation view of counterfactuals, in that counterfactual situations are conceptual constructs that can be correctly simulated by homogeneous comparison groups. In this simulation view, the empirical data from the comparison groups play an evidential role in the evaluation of counterfactuals and in obtaining counterfactual knowledge. We further indicate how successful experimental designs can help us to obtain correct simulations, and thus to bring us to scientifically-empirically based counterfactual knowledge. (shrink)

A two-part survey was conducted, where respondents reported ethically challenging incidents encountered in the previous two years and actions taken to address them. 132 certified counseling psychologists participated and reported 136 ethical dilemmas. The top categories of dilemmas pertained to breaking confidentiality between respondents and clients, including mandatory reporting, collaborating with education associates, and interjecting by the authority. 82% of the respondents took actions to address the dilemmas. These actions ranged from steering a middle course, upholding professional ethical standards, seeking (...) consultation to taking no actions. Potential environmental contributors to the dilemmas and actions taken to address them were explored. (shrink)

The aim of this study was to compare the learning effectiveness of peer tutored problem-based learning and conventional teaching of nursing ethics in Taiwan. The study adopted an experimental design. The peer tutored problem-based learning method was applied to an experimental group and the conventional teaching method to a control group. The study sample consisted of 142 senior nursing students who were randomly assigned to the two groups. All the students were tested for their nursing ethical discrimination ability both before (...) and after the educational intervention. A learning satisfaction survey was also administered to both groups at the end of each course. After the intervention, both groups showed a significant increase in ethical discrimination ability. There was a statistically significant difference between the ethical discrimination scores of the two groups (P < 0.05), with the experimental group on average scoring higher than the control group. There were significant differences in satisfaction with self-motivated learning and critical thinking between the groups. Peer tutored problem-based learning and lecture-type conventional teaching were both effective for nursing ethics education, but problem-based learning was shown to be more effective. Peer tutored problem-based learning has the potential to enhance the efficacy of teaching nursing ethics in situations in which there are personnel and resource constraints. (shrink)

The article focuses on the analysis of curriculum documents from Taiwan to investigate how benchmarks for learning nature of science are positioned in different versions of the science curricula. Following a review of different approaches to the conceptualization of NOS and the role of NOS in promoting scientific literacy, an empirical study is reported to illustrate how the science curriculum documents represent different aspects of NOS. The article uses the family resemblance approach as the account of NOS and adapts it (...) for analysis of the curriculum documents. The FRA defines NOS as cognitive-epistemic and social-institutional systems that serve as constructs of knowledge categories with a high level of interconnectedness. The FRA was used as an analytical tool for investigating two sets of Taiwanese curriculum guidelines published 10 years apart, providing an opportunity to discuss how NOS is addressed in the curriculum reforms. The findings show a shift away from the excessive centralization of the cognitive-epistemic system to a consideration of the social-institutional system. Modifications to the benchmarks are proposed in order to achieve a more holistic and progressive approach to NOS. The article contributes to studies on NOS in science education by illustrating how the FRA can act as a tool for exploring interconnectedness of NOS ideas in the curriculum. (shrink)

This article discusses friendship and filial piety in Ming Neo-Confucianism, particularly the Yangming learning. I argue that the Yangming jianghui provided important social settings for elevating the value of friendship. True friendship was considered as a means for moral improvement, and to prevent the risk of moral subjectivism in the Yangming philosophy.I also revisit the question of whether Ming Neo-Confucians did challenge the order of the five cardinal relationships by elevating friendship as the most important one. Through the investigation of (...) filial piety in imperial culture and the Yangming learning, I emphasize that filial piety was not only the basis of socio-political order, but also the essence of the true self. The importance of friendship lies in its capacity to aid moral cultivation and to become a better self. It could never surpass that of filial piety. It remained a supplement to familial ethics. (shrink)

Cet article porte sur l'amitié et la piété filiale dans le néo-confucianisme de l’époque Ming, notamment dans l’enseignement de Wang Yangming. J’avance que les jianghui cultivant la pensée de Yangming offrirent un environnement social idéal pour ennoblir l’amitié. On considérait la véritable amitié comme un vecteur de perfectionnement moral et le moyen de réduire le risque de subjectivisme dans la philosophie inspirée de Yangming. Je reconsidère également la question de savoir si les néo-confucianistes de l’époque Ming ont contesté l’ordre des (...) cinq relations cardinales en faisant de l’amitié la plus importante d’entre elles. À travers l’examen approfondi de la piété filiale dans la culture impériale et l’enseignement de Yangming, je souligne que la piété filiale ne constituait pas seulement la base de l’ordre socio-politique, mais aussi l’essence du vrai moi. L’amitié tire son importance de sa capacité à nous aider sur la voie du perfectionnement moral et de l’amélioration de soi. Néanmoins, elle n’a jamais pu surpasser l’importance que revêt la piété filiale et elle ne vint que compléter l’éthique familiale. (shrink)

Cet article porte sur l'amitié et la piété filiale dans le néo-confucianisme de l’époque Ming, notamment dans l’enseignement de Wang Yangming. J’avance que les jianghui cultivant la pensée de Yangming offrirent un environnement social idéal pour ennoblir l’amitié. On considérait la véritable amitié comme un vecteur de perfectionnement moral et le moyen de réduire le risque de subjectivisme dans la philosophie inspirée de Yangming. Je reconsidère également la question de savoir si les néo-confucianistes de l’époque Ming ont contesté l’ordre des (...) cinq relations cardinales en faisant de l’amitié la plus importante d’entre elles. À travers l’examen approfondi de la piété filiale dans la culture impériale et l’enseignement de Yangming, je souligne que la piété filiale ne constituait pas seulement la base de l’ordre socio-politique, mais aussi l’essence du vrai moi. L’amitié tire son importance de sa capacité à nous aider sur la voie du perfectionnement moral et de l’amélioration de soi. Néanmoins, elle n’a jamais pu surpasser l’importance que revêt la piété filiale et elle ne vint que compléter l’éthique familiale. (shrink)

This chapter discusses the reception of The Classic of Filial Piety (Xiaojing孝經) from medieval to late imperial China. Based on the records found in Scripta Sinica database, we see the way in which female biographies indicate the increasing importance of The Classic of Filial Piety in female education during late imperial China. Male biographies, however, demonstrate the opposite trend. I suggest this phenomenon does not reflect the decline in its male readership, but rather a change in the status of the (...) book. I then discuss how the text played a significant role in political culture before medieval period and became mainly a primer after Southern Song. The marginalization of the text in political and elite circles caused it to figure less prominently in male biographies. In addition, this chapter also discusses certain aspects related to The Classic of Filial Piety and female education, as well as the revival of the study of the Canon during the late Ming and how the book regained its political importance by the support of the Qing state. (shrink)

In this paper, I discuss how, as part of the Logic-Based Therapy (LBT) Primary Certificate Program offered in Taiwan, I applied LBT to the case of Zhou, a fourth-year graduate school student in the Department of Guidance & Counseling.