Package downsizing is a practice where the package content is reduced without changing the package or the price of the product. In a market that is defined by ‘hyper-competition,’ package downsizing is often practiced by marketers to effect an invisible price increase for their products. Although marketers may maintain that providing, the legally required, quantity indication on the package is adequate for customers to make logical and informed choices, research indicates that consumers often do not consult quantity indications on packages (...) but use alternative methods (e.g., visual impressions of the package size, total package price, or previous purchase experience) to judge product quantity and to calculate product value. As a subtle means, package downsizing therefore has the potential to mislead customers in the buying process due to an unfavorable balance of information within the dyad. This could give rise to serious moral and ethical consideration. In this paper, we examined various issues related to package downsizing, such as why sellers resort to this type of practice, consumer vulnerability to package downsizing, as well as the extent of protection offered to consumers by the existing laws and regulations with respect to product packaging. Finally, we examined the ethics of package downsizing using the existing legal, moral, and professional ethical standards as well as the principle of equivalence. Our analysis indicates that package downsizing, as it is practiced by the marketers and sellers today, is unethical as far as the consumers are concerned. (shrink)

Substantive scientific letter writing is a cost-effective mode of complementing observational and experimental research. The value of such philosophically uncommitted and unsponsored well-balanced scientific activity has been relegated. Critical letter writing entails the abilities to: maintain rational scepticism; refuse to conform in order to explain data; persist in keeping common sense centre-stage; exercise logic to evaluate the biological significance of mathematical figures, including statistics, and the ability to sustain the will to share insights regarding disease mechanisms on an ostensibly lower (...) research platform. During peer review, innovative letter writing may share the occasionally unfortunate fate of innovative research. Rejected scientific letters do not automatically lose copyright. Periodicals with high letter loads will see some valuable contributions wasted, but that is the price for maintaining autonomy in scientific publication. The scientific community is an integrated whole that must respect the rights of authors at all levels. Unauthorised forwarding of rejected letters sets the dangerous precedent of justifying unjust means. (shrink)

The development of improved methods for genome‐wide association studies (GWAS) for genetics of quantitative traits has been an active area of research during the last 25 years. This activity initially started with the use of mixed linear model (MLM), which was variously modified. During the last decade, however, with the availability of high throughput next generation sequencing (NGS) technology, development and use of pangenomes and novel markers including structural variations (SVs) and k‐mers for GWAS has taken over as a new (...) thrust area of research. Pangenomes and SVs are now available in humans, livestock, and a number of plant species, so that these resources along with k‐mers are being used in GWAS for exploring additional genetic variation that was hitherto not available for analysis. These developments have resulted in significant improvement in GWAS methodology for detection of marker‐trait associations (MTAs) that are relevant to human healthcare and crop improvement. (shrink)

Regulation of microtubule (MT) dynamics is essential for many cellular processes, but the machinery that controls MT dynamics remains poorly understood. MT plus‐end tracking proteins (+TIPs) are a set of MT‐associated proteins that dynamically track growing MT ends and are uniquely positioned to govern MT dynamics. +TIPs associate with each other in a complex array of inter‐ and intra‐molecular interactions known as the “+TIP network.” Why do so many +TIPs bind to other +TIPs? Typical answers include the ideas that these (...) interactions localize proteins where they are needed, deliver proteins to the cortex, and/or create regulatory pathways. We propose an additional and more mechanistic hypothesis: that +TIPs bind each other to create a superstructure that promotes MT assembly by constraining the structural fluctuations of the MT tip, thus acting as a polymerization chaperone. (shrink)

A natural realist approach to the philosophy of arithmetic is defended by way of considering and arguing against contemporary attempts to solve Paul Benacerraf's dilemma . The first horn of the dilemma concerns the existence of abstract mathematical objects, which seems necessitated by a desire for a unified semantics. Benacerraf adopts an extensional semantics whereby the reference of terms for natural numbers must be abstract objects. The second horn concerns a desirable causal constraint on knowledge, according to which "for X (...) to know that S is true requires some causal relation to obtain between X and the referents of the names, predicates, and quantifiers of S". Within the philosophical tradition, Benacerraf's dilemma crystallizes the tension between realists and empiricists . It is shown that natural realism and naturalism meet. ;Both horns of the dilemma are amended.objects are conceived along conceptualist lines such that their existence is not mind-independent. The causal constraint is refined by drawing upon the work of Mark Steiner . Natural realism is the notion that the truth-values of arithmetical statements are recognition-transcendent. Natural realism explains why one and only one arithmetic is applicable. It is in some sense discovered, which is captured by the idea that arithmetical statements have truth-values even if one is not able to adduce what they are. ;It is argued that with proper emendation, like that of Philip Kitcher , empiricism as envisioned by J. S. Mill is defensible. Furthermore, the epistemology of arithmetical knowledge is divided into two tiers. The first principles of arithmetic are acquired by causal interaction with physical objects. As Kitcher has shown, empiricism functions at the first-tier. The a priori is revised such that arithmetical knowledge generated from the first-tier is considered non-empirical. ;It is argued that pragmatists' indispensability argument, once qualified, allows that arithmetic's applicability is one reason to consider natural realism for that domain . Furthermore, this thesis provides a case where aspects of Hilary Putnam's early and later views are rendered consistent. By way of utilizing both Putnam's writing in favour of realism , and those that break with them , it is suggested that he should not have abandoned his earlier view. In a nutshell, the realization of knowledge can depend upon agents' values, methods, and so on, without forcing the abandonment of realism . Putnam's early view sets the criteria for when one can be a realist about a given domain. (shrink)

The presence of vegetation on railway tracks threatens track safety and longevity. However, vegetation inspections in Sweden are currently being carried out manually. Manually inspecting vegetation is very slow and time consuming. Maintaining an even quality standard is also very difficult. A machine vision-based approach is therefore proposed to emulate the visual abilities of the human inspector. Work aimed at detecting vegetation on railway tracks has been split into two main phases. The first phase is aimed at detecting vegetation on (...) the tracks using appropriate image analysis techniques. The second phase is aimed at detecting the rails in the image to determine the cover of vegetation that is present between the rails as opposed to vegetation present outside the rails. Results achieved in the current work indicate that the machine vision approach has performed reasonably well in detecting the presence/absence of vegetation on railway tracks when compared with a human operator. (shrink)

This article is concerned with examining Kant's derivation of the various formulae of his Categorical Imperative. It is in agreement with Paton in maintaining that Kant actually mentions five formulae. But it is not in agreement with him, and some others, in maintaining that they are ultimately reducible to three. Nor is it in agreement with those who maintain that they are ultimately reducible to just one. According to the present article, they are ultimately reducible to two: that about a (...) moral law being a universal law; and that about a moral law involving treating human beings as ends in themselves. (shrink)

Scholars have often criticized Hinduism for being an ecologically unfriendly religion, due to being too “other worldly” and “indifferent” toward the natural world. According to Hindus, they argue that the natural world is simply māyā—“ephemeral,” “illusory,” and “unreal.” The Bhāgavata Purāṇa, for example, features over 60 passages that reduce the material world to nothing more than a passing dream. ). Meanwhile, other scholars have tried to correct this image by pointing to passages in Indian sacred literature that highlight the divinity (...) of nature, as well as Hindu rituals that involve worshiping the earth, plants, animals, trees, water, sun, and sky. This paper will argue, however, that both the scholarly criticisms and responses are problematic for two reasons. First, these discussions often assume that a religious practitioner’s beliefs concerning the world and environment directly correspond to her attitude toward, and treatment of, the environment. Second, the scholarly criticisms and responses are based on a narrow interpretation and understanding of the concept of māyā. The word “māyā” has held a variety of meanings in Indian sacred literature. This paper focuses on conceptions of māyā found within the Bhāgavata Purāṇa and explores resources in the Bhāgavata that may be useful for developing a Vaiṣṇava ecotheology. (shrink)