A major trend that characterized the naturalization of the Aristotelian habitus concept in the medieval Islamic world was its application to religious discourses. This trend was not limited to the works of Muslim thinkers. The present communication focuses on the ways in which Maimonides used the concept, naturalizing it in the religious Jewish system.

Habitus is a logical and ethical Aristotelian concept that was first introduced to the Islamic world through the translation of Greek philosophical works into Arabic in the ninth century. Following its introduction and until the nineteenth century, thinkers and scholars of the Islamic world naturalized it creatively in various intellectual systems. In ethical usage, habitus is a disposition that, once acquired and well established through a process of accustoming, allows humans to perceive and act in certain ways without deliberation or (...) reflection. This concept explained how humans transcended their inborn natures, and as such it was amenable to employment in manifold fields and contexts. The present article studies significant applications from the ninth to the nineteenth century by thinkers of the Islamic world, who fleshed out the Aristotelian concept and used it for their own purposes. Among other things, it shows that the two main trends of naturalization involved application of the concept to religious Islamic discourses and to the study of humans and their society, anticipating modern Western sociological usage. (shrink)

This article examines how Arabic handled societal taboos in the medieval Islamic world and the ways by which language users applied censorship that led to the creation of euphemisms. Special attention is given to sources from the eastern part of the Islamic world dating to the fourth/tenth and the fifth/eleventh centuries, and to the taboo topics and types of euphemisms they disclose. The complex relationship between the concept of euphemism and kināya, the polysemous Arabic term that renders it, is examined. (...) As a whole, the evidence demonstrates an overwhelming Arabic preference for figurative speech over change of form as the essential generation mechanism of euphemisms. Finally, light is shed on the ways in which discerning medieval literary critics anticipated significant modern sociolinguistic observations: the relations between euphemism, orthophemism, and dysphemism, in addition to the incessant process of euphemism degradation. (shrink)

Literature and the Islamic Court: Cultural Life under al-Ṣāḥib Ibn ʿAbbād. By Erez Naaman. Culture and Civilization in the Middle East, vol. 52. London: Routledge, 2016. Pp. xv + 315. $155, £115.

This book offers a new way of approaching the place of the will in Descartes' mature epistemology and ethics. Departing from the widely accepted view, Noa Naaman-Zauderer suggests that Descartes regards the will, rather than the intellect, as the most significant mark of human rationality, both intellectual and practical. Through a close reading of Cartesian texts from the Meditations onward, she brings to light a deontological and non-consequentialist dimension of Descartes' later thinking, which credits the proper use of free (...) will with a constitutive, evaluative role. She shows that the right use of free will, to which Descartes assigns obligatory force, constitutes for him an end in its own right rather than merely a means for attaining any other end, however valuable. Her important study has significant implications for the unity of Descartes' thinking, and for the issue of responsibility, inviting scholars to reassess Descartes' philosophical legacy. (shrink)

Critics of investment citizenship often appeal to the idea that citizenship should not be commodified. This chapter clarifies how the different arguments in support of this Commodification Objection are best understood as versions of wider claims in the literature on the moral limits of markets (MLM). Through an analysis of the three main objections – The Wrong Distribution Argument, The Value Degradation Argument, and the Motivational Corruption Argument – it claims that these objections rely on flawed and partial interpretations of (...) the broader debates. As such, they do not in fact support the conclusions critics of investment citizenship wish to draw from them. The paper concludes that the commodification objection to investment citizenship should therefore be abandoned, and that normative resistance to the practice should be made on other grounds. (shrink)

The convergence of morphogenesis into viable organisms under variable conditions suggests closed‐loop dynamics involving multiscale functional feedback. We develop the idea that morphogenesis is based on synergy between mechanical and bio‐signaling processes, spanning all levels of organization: molecular, cellular, tissue, up to the whole organism. This synergy provides feedback within and between all levels of organization, to close the loop between the dynamics of the morphogenesis process and its robust functional outcome. Hydra offer a powerful platform to explore this direction, (...) thanks to their simple body plan, extraordinary regeneration capabilities, and the accessibility and flexibility of their tissues. Our recent experiments show that structural inheritance of the actomyosin organization directs body‐axis formation during Hydra regeneration. Morphogenesis is then stabilized through dynamic cytoskeletal reorganization induced by the inherited structure. The observed cytoskeletal stability and reorganization capabilities suggest that mechanical feedback integrates with biochemical processes to establish viable patterns and ensure canalization. (shrink)

This article contributes to an emerging literature on the “neo” or “entrepreneurial” developmental state that emphasizes the role of innovation policy in promoting the structural transformation of industry. It finds further evidence that supports this approach and advances it by making two unique contributions. First, it highlights an essential yet underappreciated feature of contemporary innovation policy: the state’s capacity to condition public assistance and discipline private firms that do not adhere to government guidelines. These capacities are necessary to guarantee that (...) the benefits of public investment in innovation—the social and economic spillovers—are not appropriated by private actors but shared more broadly within society. Second, it highlights that politics—reflected in the relations between innovation agencies and key social actors—represents an important causal factor in both the formation and subsequent transformation of these institutional capacities. These points are illustrated through a historical analysis of a crucial case: the state-led development of Israel’s thriving high-tech sector. (shrink)

As a way of comparing qualitative and quantitative approaches to critical discourse analysis, two analysts independently examined similar datasets of newspaper articles in order to address the research question ‘How are different types of men represented in the British press?’. One analyst used a 41.5 million word corpus of articles, while the other focused on a down-sampled set of 51 articles from the same corpus. The two ensuing research reports were then critically compared in order to elicit shared and unique (...) findings and to highlight strengths and weaknesses between the two approaches. This article concludes that an effective form of CDA would be one where different forms of researcher expertise are carried out as separate components of a larger project, then combined as a way of triangulation. (shrink)

According to the so-called Hempel’s Dilemma, the thesis of physicalism is either false or empty. Our intention in this paper is not to propose a solution to the Dilemma, but rather to argue as follows: to the extent that Hempel’s Dilemma applies to physicalism it equally applies to any theory that gives a deep-structure and changeable account of our experience or of high-level theories. In particular, we will show that it also applies to mind-body dualistic theories. The scope of Hempel’s (...) Dilemma turns out to be very wide: it is a special case of a general sceptical argument against changeable deep-structure theories in and outside science. (shrink)

This article reconstructs the political motivation argument against cosmopolitanism, according to which the extension of social justice beyond bounded communities would be motivationally unstable, and thus unjustified. It does so through an analysis of the stability problem, and a reconstruction of the three most prominent anti-cosmopolitan arguments—Rawlsian statism, liberal nationalism, and civic republicanism—as solutions to this problem. It then examines, and rejects, three prominent objections, each denying a different level of the argument. The article concludes that the civic republican version (...) of the argument is the most plausible, and implications for cosmopolitanism are considered. (shrink)

Should facts about motivation play a role in the justification of political ideals? Many theorists argue that political ideals should be tailored to the limitations of human nature—‘taking people as they are’—while others maintain that facts about motivation should be excluded. This article offers a critical intervention in this debate: the important question is not so much whether people can motivate themselves, or whether they are capable of being motivated, but what social mechanisms would be required to motivate them, and (...) whether these mechanisms are legitimate. Reframing the question of motivation as a political question of legitimacy, I argue that if people could only be motivated to act through illegitimate use of power, the ideal in question cannot be fully justified. (shrink)

The expressivist account of knowledge attributions, while claiming that these attributions are nonfactual, also typically holds that they retain a factual component. This factual component involves the attribution of a belief. The aim of this work is to show that considerations analogous to those motivating an expressivist account of knowledge attributions can be applied to belief attributions. As a consequence, we claim that expressivists should not treat the so-called factual component as such. The phenomenon we focus on to claim that (...) belief attributions are non-factual is that of normative doxastic disagreement. We show through several examples that this kind of disagreement is analogous to that of the epistemic kind. The result will be a doxastic expressivism. Finally, we answer some objections that our doxastic expressivism could seem to face. (shrink)

In recent years, state-of-the-art artificial intelligence systems have started to show signs of what might be seen as human level intelligence. More specifically, large language models such as OpenAI’s GPT-3, and more recently Google’s PaLM and DeepMind’s GATO, are performing amazing feats involving the generation of texts. However, it is acknowledged by many researchers that contemporary language models, and more generally, learning systems, still lack important capabilities, such as understanding, reasoning and the ability to employ knowledge of the world and (...) common sense in order to reach or at least advance toward general intelligence. Some believe that scaling will eventually bring about these capabilities; others think that a different architecture is needed. In this paper, we focus on the latter, with the purpose of integrating a theoretical–philosophical conception of understanding as knowledge of dependence relations, with the high-level requirements and engineering design of a robust AI system, which integrates machine learning and symbolic components. (shrink)

Triggered Inversion (TI) in Hebrew has been previously analyzed as canonical A'-movement to the specificer position of a functional projection in the CP-layer (Doron & Shlonsky 1990, Shlonsky 1997). This article examines the semantic properties of TI constructions in Hebrew, specifically the cross-linguistic similarities between TI in Hebrew and pseudoclefts (PC) in English, as discussed in Heycock & Kroch (1999). A structure is proposed for Hebrew TI that parallels the structure given for equatives in Hebrew by Rothstein (1995), in which (...) the trigger is base-generated in the operator layer and the inverted surface word order is an artifact of subject movement to a position below that of the verb. Finally, TI is considered in the crosslinguistic typology of focus constructions outlined in Kiss (1998). (shrink)

While many argue investment-based criteria for immigration are wrong or at least problematic, skill-based criteria remain relatively uncontroversial. This is normatively inconsistent. This article assesses three prominent normative objections to investment-based selection criteria for immigrants: that they wrongfully discriminate between prospective immigrants that they are unfair, and that they undermine political equality among citizens. It argues that either skill-based criteria are equally susceptible to these objections, or that investment-based criteria are equally shielded from them. Indeed, in some ways investment-based criteria (...) are less normatively problematic than skill-based criteria. Given this analysis, the resistance to investment-based migration criteria, but not to skill-based criteria, is inconsistent. (shrink)

In the research field of machine ethics, we commonly categorize artificial moral agents into four types, with the most advanced referred to as a full ethical agent, or sometimes a full-blown Artificial Moral Agent (AMA). This type has three main characteristics: autonomy, moral understanding and a certain level of consciousness, including intentional mental states, moral emotions such as compassion, the ability to praise and condemn, and a conscience. This paper aims to discuss various aspects of full-blown AMAs and presents the (...) following argument: the creation of full-blown artificial moral agents, endowed with intentional mental states and moral emotions, and trained to align with human values, does not, by itself, guarantee that these systems will have _human_ morality. Therefore, it is questionable whether they will be inclined to honor and follow what they perceive as incorrect moral values. we do not intend to claim that there is such a thing as a universally shared human morality, only that as there are different human communities holding different sets of moral values, the moral systems or values of the discussed artificial agents would be different from those held by human communities, for reasons we discuss in the paper. (shrink)

Artificial general intelligence is not a new notion, but it has certainly been gaining traction in recent years, and academic as well as industry resources are redirected to research in AGI. The main reason for this is that current AI techniques are limited as they are designed to operate in specific problem-domains, following meticulous preparation. These systems cannot operate in an unknown environment or under conditions of uncertainty, reuse knowledge gained in another problem domain, or autonomously learn and understand the (...) problem-domain. We shall call AI systems capable of such feats artificial general intelligent systems. The three tasks of this paper are to provide a working definition of the term AGI, examine the “missing G”, i.e., the set of abilities that current AI systems lack and whose implementation will result in a basic AGI system, and consider different approaches, including a hybrid one, to a comprehensive solution for an AGI. (shrink)

South Africa has been undergoing a process of transformation since the end of White minority rule in 1994. During this period, various employment and lifestyle opportunities have given rise to a growing Black middle class. Against this backdrop, the article draws upon an intersectional approach to corpus-assisted discourse studies in order to examine the construction of the BMC in a 1.4 million-word corpus composed of 20 mainstream Anglophone South African newspaper titles published between 2008 and 2014. With the help of (...) the corpus tool AntConc, the article investigates the collocates of ‘black middle class’, ‘black diamonds’, ‘clever blacks’ and ‘coconuts’, classifying results according to semantic categories in order to provide an idea of the multiple but nuanced representations of the BMC in contemporary SA. The analysis finds several lexically rich moralizing and paternalistic discourses that, in accordance with an intersectional perspective, enact a complex pattern of strategies that are simultaneously exclusionary and inclusionary. (shrink)

When discussing AI alignment, we usually refer to the problem of teaching or training advanced autonomous AI systems to make decisions that are aligned with human values or preferences. Proponents of this approach believe it can be employed as means to stay in control over sophisticated intelligent systems, thus avoiding certain existential risks. We identify three general obstacles on the path to implementation of value alignment: a technological/technical obstacle, a normative obstacle, and a calibration problem. Presupposing, for the purposes of (...) this discussion, that the technical and normative problems are solved, we focus on the problem of how to calibrate a system, for a specific value, to be on a specific location within a spectrum stretching between righteous and normal or average human behavior. Calibration, or more specifically mis-calibration, also raises the issue of trustworthiness. If we cannot trust AI systems to perform tasks the way we intended, we would not use them on our roads and at our homes. In an era where we strive to construct autonomous machines endowed with common sense, reasoning abilities and a connection to the world, so they would be able to act in alignment with human values, such mis-calibrations can make the difference between trustworthy and untrustworthy systems. (shrink)

As even those who endorse it concede, cosmopolitanism has a motivational problem. There is a need for strategies to generate support of global norms conducive to cosmopolitanism, but which do not rely primarily on the motivating force of the moral argument. This article makes the case for civic vigilance as an answer to this problem. It argues that support for cosmopolitan norms could be advanced by encouraging a recognition of the ‘boomerang effect’: the ways in which global injustice undermines the (...) freedom of one’s own political community. The article offers evaluative criteria for different motivational strategies, assesses prominent alternatives to moral motivation, and finally defends the appeal to civic vigilance. (shrink)

The article presents the argument that administrative decision-making should be understood as devoted to balancing between conflicting interests of individuals or groups, usually when none of the affected parties has predefined legal rights that are relevant to the substantial content of the administrative decision. Administrative decisions often have a direct effect not only on human and civil rights issues, but also on matters bearing on the quality of life, living conditions, prices of regulated products, and the allocation of government funds. (...) Since the decision as to which interest should prevail in the conflict is a distributive one and has many possible answers, the role of administrative law is primarily to ensure that these decisions are made fairly, with due weight given to the conflicting interests of the various groups and individuals involved. With this as background, the article shows how the doctrines of positive administrative law are designed to meet the challenge of coping with conflicting interests in the administrative decision-making process, using such examples as the prohibitions against decision-makers’ conflicts of interest and the rules regarding interest representation and judicial review. In the second part, the article applies the interest perspective to the administrative decision-making process in order to analyze the highly extensive regulation of land resources in Israel. The analysis concentrates on the Israeli Supreme Court decision in one of the most controversial petitions brought before it: against administrative decisions on the development of formerly agricultural lands. (shrink)

This article takes a close look at a rhetoric strategy, often used in an attempt to preserve an appearance of neutrality in conflicts over rights. This strategy rests on the concept of symmetry, and in particular concerns symmetry between so-called 'positive rights' (described as the right to obtain or have an object, to engage in an activity, or to enjoy a desired state of affairs) and 'negative rights' (the right not to have this object, not to engage in this activity, (...) or to prevent this state of affairs). When a positive and a negative right protect contradictory options, this strategy conveys that they are of equal standing. The article cautions against the risks entailed by this inference. The deceptive nature of symmetry is first examined in the context of procreation rights and subsequently in other contexts, including conflicts concerning freedom of expression, active euthanasia, and abortion. Our conclusion is that the explicit or implicit recourse to the argument from symmetry is a recurrent feature of rights discourse, deserving attention and cautious handling. (shrink)

Imprisonment calls into question the institutionalized violence of the state and its organs. It touches on the very core of the meaning of state sovereignty and concerns one of the most disempowered groups of society: indicted criminals. Therefore, privatization of prisons signals the willingness to apply privatization policies almost with no limitations. Private prisons have become a known phenomenon in many countries. After the debate on this issue seemed to lose its pragmatic value—in contrast to its importance on the theoretical (...) level—privatization of prisons reemerged as an issue of legal debate due to the Israeli Supreme Court decision that declared a law authorizing the establishment of a private prison unconstitutional. The following analysis evaluates this decision using it as a microcosm for studying the role of law in regulating privatization policies. The Article starts by studying the full range of privatization policies, in order to offer an analysis that would be relevant also to other cases along the privatization spectrum. It then challenges the traditional premise of public law that the move to privatization is merely a matter of policy and not of law. More concretely, the Article offers an analysis based upon distinguishing among three distinct spheres of discussion: the boundaries of privatization, the privatization process, and the regulation of privatized actions. This model of analysis is then applied to the case-study of prison privatization as decided by the Israeli Supreme Court. (shrink)

Ostracism is known to cause psychological distress. Thus, defining the factors that can lead to recovery or diminish these negative effects is crucial. Three experiments examined whether suggesting the possible causes of ostracism to victims could decrease or eliminate their ostracism distress. They also examined whether death-anxiety mediated the association between the suggested possible cause for being ostracized and recovery. Participants were randomly assigned to six experimental and control groups and were either ostracized or included in a game of Cyberball. (...) Two control conditions were used: participants who were ostracized but received no explanation and participants who were included. Immediately after the ostracism experience, participants in the experimental groups were presented with one of four causes for being ostracized, using locus of control and stability, the two causal dimensions of Weiner’s attribution theory. After a short delay they were administered a mood or needs-satisfaction questionnaire. The results highlight the interaction between locus of control and stability, and underscore the relative importance of different attributions in alleviating self-reported ostracism distress. Specifically, both external and unstable attributions decreased distress, and an unstable attribution led to complete recovery in some participants. Thus, recovery from ostracism may be accelerated when the victim receives an explanation for ostracism that attributes the incident to unstable, external causes soon after the incident. Death-anxiety fully mediated the association between locus of control attribution and mood, but for on needs-satisfaction or the stability of the attribution. (shrink)

What happens when men and women feel powerful in intimate relationships? When does power corrupt and when does it lead to positive consequences, such as increased sensitivity to others' needs, personal growth, and social responsibility? This book offers anyone interested in such questions a clear and accessible depiction of the effects of social power, based on cutting-edge theory and research. The book starts with a general discussion on the ways power influences individuals. The role of one's personality, goals, and culture (...) seem to play a decisive role in whether power leads to benevolent or malevolent consequences. Some effects of power are more intuitively understood (e.g., taking from or contributing to a common resource, or aggressive responses in parents who feel powerless), while other effects regard much more surprising phenomena (e.g., self-fulfilling prophecies, stopping an annoying fan, or forgiveness for a transgression). Following the description of this social-psychological mechanism, The Power to Care discusses the cultural and developmental circumstances in which power is experienced. Culturally acquired gender-roles, experiencing racism, egoistic vs. altruistic motivations, and defensive tendencies - all influence what men and women want in intimate relationships, and the way power can motivate them to attain their goals. These circumstances may explain the gender differences found in the results of three experiments, described in Chapter 4. In these experiments, men and women in long-term, intimate relationships reacted differently to a temporary sense of power, in terms of their tendency to self-focus, take the perspective of others, and objectify their relationship partners.In the last section, The Power to Care discusses the seemingly contradictory beliefs of professionals and laymen alike, that power corrupts, but that the empowerment processes yields positive results. In this section, the role of power and empowerment processes is discussed, mainly in macro-level interventions, in intimate partner violence (for both victims and perpetrators), overcoming addiction, and in policy practice (e.g., in court verdicts regarding cases of post-divorce relocation of custodial parents). (shrink)

A model of Peano Arithmetic is short recursively saturated if it realizes all its bounded finitely realized recursive types. Short recursively saturated models of $\PA$ are exactly the elementary initial segments of recursively saturated models of $\PA$. In this paper, we survey and prove results on short recursively saturated models of $\PA$ and their automorphisms. In particular, we investigate a certain subgroup of the automorphism group of such models. This subgroup, denoted $G|_{M(a)}$, contains all the automorphisms of a countable short (...) recursively saturated model of which can be extended to an automorphism of the countable recursively saturated elementary end extension of the model. (shrink)

David Axelsen has recently introduced a novel critique of the motivational argument against cosmopolitanism : even if it were the case that lack of motivation could serve as a normative constraint, people’s anti-cosmopolitan motivations cannot be seen as constraints on cosmopolitan duties as they are generated and reinforced by the state. This article argues that Axelsen 's argument misrepresents the nationalist motivational argument against cosmopolitanism : the nationalist motivational argument is best interpreted as an argument about normative feasibility rather than (...) as an argument about the technical feasibility. Nationalists ' objection to cosmopolitanism arises not from the impossibility of cosmopolitan motivation, but from the moral costs of achieving and sustaining it. Given this interpretation, this article argues that Axelsen fails to demonstrate that nationalists would have to accept cosmopolitan conclusions from their own premises. (shrink)

One of the distinctive features of the primate genome is the Alu element, a repetitive short interspersed element, over a million highly similar copies of which account for >10% of the genome. A direct consequence of this feature is that primates' transcriptome is highly enriched in long stable dsRNA structures, the preferred target of adenosine deaminases acting on RNAs (ADARs), which are the enzymes catalyzing A‐to‐I RNA editing. Indeed, A‐to‐I editing by ADARs is extremely abundant in primates: over a hundred (...) million editing sites exist in their genomes. However, there are few essential editing sites conserved across mammals that have maintained their editing level despite the radical change in ADAR target landscape. Here, we review and discuss the cost of having an unusual amount of dsRNA and editing in the transcriptome, as well as the opportunities it presents, which might have contributed to the accelerated evolution of the primates. (shrink)

info:eu-repo/semantics/publishedVersion.

In this paper we investigate the properties of automorphism groups of countable short recursively saturated models of arithmetic. In particular, we show that Kaye's Theorem concerning the closed normal subgroups of automorphism groups of countable recursively saturated models of arithmetic applies to automorphism groups of countable short recursively saturated models as well. That is, the closed normal subgroups of the automorphism group of a countable short recursively saturated model of PA are exactly the stabilizers of the invariant cuts of the (...) model which are closed under exponentiation. This Galois correspondence is used to show that there are countable short recursively saturated models of arithmetic whose automorphism groups are not isomorphic as topological groups. Moreover, we show that the automorphism groups of countable short arithmetically saturated models of PA are not topologically isomorphic to the automorphism groups of countable short recursively saturated models of PA which are not short arithmetically saturated. (shrink)

This article presents a new understanding of the problem of cosmopolitan motivation in war, comparing it to the motivational critique of social justice cosmopolitanism. The problem of cosmopolitanism’s “motivational gap” is best interpreted as a political one, not a meta-ethical or ethical one. That is, the salient issue is not whether an individual soldier is able to be motivated by cosmopolitan concerns, nor is it whether being motivated by cosmopolitanism would be too demanding. Rather, given considerations of legitimacy in the (...) use of political power, a democratic army has to be able to motivate its soldiers to take on the necessary risks without relying on coercion alone. Patriotic identification offers a way to achieve this in wars of national defense, but less so in armed humanitarian interventions (AHIs). Two potential implications are that either AHIs should be privatized or that national armies should be transformed to become more cosmopolitan. (shrink)

This article provides a new interpretation of Richard Rorty’s notion of the private-public distinction. The first section of the article provides a short theoretical overview of the origins of the public-private distinction in Rorty’s political thought and clarifies the Rortian terminology. The main portion of the article is dedicated to the critique of Rorty’s private-public distinction, divided into two thematic sections: (i) the private-public distinction as undesirable and (ii) the private-public distinction as unattainable. I argue that Rorty’s formulation provides plausible (...) answers to the first kind of criticism, but not to the second. Finally, a reformulation of the private-public distinction will be suggested, which both mitigates the second line of criticism and better coheres with Rorty’s general theory. (shrink)

BackgroundThe Patient-Centered Outcomes Research Institute is obligated to peer review and to post publicly “Final Research Reports” of all funded projects. PCORI peer review emphasizes adherence to PCORI’s Methodology Standards and principles of ethical scientific communication. During the peer review process, reviewers and editors seek to ensure that results are presented objectively and interpreted appropriately, e.g., free of spin.MethodsTwo independent raters assessed PCORI peer review feedback sent to authors. We calculated the proportion of reports in which spin was identified during (...) peer review, and the types of spin identified. We included reports submitted by April 2018 with at least one associated journal article. The same raters then assessed whether authors addressed reviewers’ comments about spin. The raters also assessed whether spin identified during PCORI peer review was present in related journal articles.ResultsWe included 64 PCORI-funded projects. Peer reviewers or editors identified spin in 55/64 submitted research reports. Types of spin included reporting bias, inappropriate interpretation, inappropriate extrapolation of results, and inappropriate attribution of causality. Authors addressed comments about spin related to 47/55 of the reports.Of 110 associated journal articles, PCORI comments about spin were potentially applicable to 44/110 articles, of which 27/44 contained the same spin that was identified in the PCORI research report. The proportion of articles with spin was similar for articles accepted before and after PCORI peer review.DiscussionJust as spin is common in journal articles and press releases, we found that most reports submitted to PCORI included spin. While most spin was mitigated during the funder’s peer review process, we found no evidence that review of PCORI reports influenced spin in journal articles. Funders could explore interventions aimed at reducing spin in published articles of studies they support. (shrink)

The identification of molecules controlling embryonic patterning and their functional analysis has revolutionized the fields of Developmental and Cell Biology. The use of new sequence information and modern bioinformatics tools has enriched the list of proteins that could potentially play a role in regulating cell behavior and function during early development. The recent application of efficient methods for gene knockout in zebrafish has accelerated the functional analysis of many proteins, some of which have been overlooked due to their small size. (...) Two recent publications report on the identification of one such protein and its role in zebrafish embryogenesis. The protein, currently designated Apela, was shown to act as a secreted protein whose absence adversely affected various early developmental processes. Additional signaling proteins that have been identified in one of the studies are likely to open the way to unraveling hitherto unknown developmental pathways and have the potential to provide a more comprehensive understanding of known developmental processes. (shrink)