Difficulty engaging in reciprocal social interactions is a core characteristic of autism spectrum disorder. The mechanisms supporting effective dynamic real-time social exchanges are not yet well understood. This proof-of-concept hyperscanning electroencephalography study examined neural synchrony as the mechanism supporting interpersonal social interaction in 34 adolescents with autism spectrum disorder, age 10–16 years, paired with neurotypical confederates of similar age. The degree of brain-to-brain neural synchrony was quantified at temporo-parietal scalp locations as the circular correlation of oscillatory amplitudes in theta, alpha, (...) and beta frequency bands while the participants engaged in a friendly conversation. In line with the hypotheses, interpersonal neural synchrony was significantly greater during the social interaction compared to the baseline. Lower levels of synchrony were associated with increased behavioral symptoms of social difficulties. With regard to sex differences, we found evidence for stronger interpersonal neural synchrony during conversation than baseline in females with autism, but not in male participants, for whom such condition differences did not reach statistical significance. This study established the feasibility of hyperscanning during real-time social interactions as an informative approach to examine social competence in autism, demonstrated that neural coordination of activity between the interacting brains may contribute to social behavior, and offered new insights into sex-related variability in social functioning in individuals with autism spectrum disorders. (shrink)

As a global public health concern, elder abuse negatively affects health, psychosocial wellbeing, and mortality among elders. Research and practice efforts made to explore effective prevention and intervention strategies are growing. Despite the growing number of intervention studies on elder abuse, research synthesis on the empirical literature seems lacking. This study aims to identify the pooled effect size of prevention and interventions targeted ultimate and intermediate outcomes for elder abuse that occurred in community settings. Following the Cochrane guideline, our team (...) searched across eight electronic databases and manually searched reference lists of eligible studies and existing systematic reviews for all potentially eligible studies. A random-effects model of 51 effect size estimates reported an overall positive and statistically significant treatment effect of psychosocial interventions for elder abuse, d = 0.63, p < 0.05. The overall treatment effect was approaching statistical significance at 0.1 level for ultimate outcomes, d = 0.32, p = 0.09, and intermediate outcomes, d = 0.75, p = 0.1. An overall significant effect size was found among family-based interventions, d = 0.59, p < 0.05, and interventions targeting older adults and their caregivers, d = 0.45, p < 0.05. Existing evidence supports an overall significant effect for psychosocial interventions for elder abuse. Interventions that used a family-based model, combined education and supportive services, and targeted both caregivers and elders, showed significant effect size, suggesting such features being considered in elder abuse intervention design. Future intervention research is needed to shed light on the link between intervention activities and ultimate change in elder abuse behaviors. (shrink)

Using the Lascar inequalities, we show that any finite rank δ-closed subset of a quasiprojective variety is definably isomorphic to an affine δ-closed set. Moreover, we show that if X is a finite rank subset of the projective space P n and a is a generic point of P n , then the projection from a is injective on X. Finally we prove that if RM = RC in DCF 0 , then RM = RU.

Background:Doctors should disclose the diagnosis to patients according to the principle of autonomy. However, not disclosing the diagnosis and prognosis to cancer patients remains common in mainland China.Objective:The study explored the experiences and attitudes of patients with cancer, family members, and the medical staff in truth-telling.Research design:A quantitative survey with three closed-ended questionnaires was conducted.Participants:In all, 137 patients with cancer, 134 family members caring for cancer cases, and 54 medical staff were surveyed. Descriptive statistics were used to summarize all characteristics, (...) and the chi-square test was performed to analyze group differences in attitudes toward cancer disclosure.Ethical considerations:This study was approved by the Committee on Ethics of Biomedicine Research, at the Second Military Medical University (HJEC-2018-YF-001). Informed consent was obtained from all participants prior to study commencement.Findings:A total of 59.8% of patients were informed about their diagnosis within 1 week, and 19.7% inferred theirs. The medical staff preferred to prioritize family members in informing about patient diagnosis while 77.4% of patients preferred to be told the whole truth at the time of initial diagnosis. More patients than family members and medical staff wanted the patients to be informed about the diagnosis ( p < 0.001). A significant difference was found between the patients and family members regarding who should tell the patients.Discussion:The willingness of patients in knowing the truth was underestimated by their family members as well as the medical staff. Guessing the truth indirectly may exert negative effects on the patients, and not telling the truth is inappropriate in patients who want to be informed.Conclusion:Disclosure of a cancer diagnosis is a complex process involving medical practice, as well as a range of cultural, ethical, and legal factors. The medical staff should first assess each patient’s willingness in truth-telling and inform about disease diagnosis with respect. Emotional support and comfort from family members are encouraged. Anyone in the patient’s care team, especially nurses, could be integrated in the process of truth-telling. (shrink)

Organizational sustainability in the form of environmental management and sustainable production is becoming more important for small and medium-sized enterprises throughout the world. This research evaluates the factors affecting the understanding of the CEO's and managers' intention to adopt practices of green supply chain management and clean innovation technology in the manufacturing SMEs of Pakistan. This empirical research identifies key determinants influencing the adoption of GSCM practices. Using structural equation modeling, we selected a sample size of 350 different manufacturing firms (...) in Pakistan. The results of the study revealed that six factors, namely, environmental, government, organization, suppliers, market, and operational factors, significantly influence the intention to adopt GSCM and positively impact sustainable production. The study's findings reveal that market and operational factors are highly significant for adopting GSCM practices at a p-value of 0.05. Environmental and organizational factors are equally significant to adopt GSCM practices at a p-value of 0.10. This research also analyzed CIT as a moderator between environmental, government, organization, customer, supplier, economic, market, and operational factors in the context of Pakistan. Hypotheses H9a, H9b, H9f, and H9g were validated and support the use of CIT to boost enterprise production and consumption. The research findings would help policymakers understand how to implement GSCM practices and guide enterprises to implement GSCM and CIT practices for enhancing enterprise performance and environmental sustainability. (shrink)

Status in an organization is considered a significant antecedent to an employee's work-related behaviors. However, the relationship between knowledge workers' informal status and "taking charge" has been ignored in previous human resource management (HRM) research. Based on the self-consistency theory, this study examines the mechanisms underlying the influence of knowledge workers’ informal status on taking charge. Data were collected from 337 dyads of employees and their immediate supervisors in 24 enterprises and companies. Based on moderated mediation analysis, results indicated that (...) knowledge workers’ informal status is positively related to taking charge and organization-based self-esteem (OBSE). OBSE fully mediated the relationship between knowledge workers’ informal status and taking charge, while person-job fit (P-J fit) and person-supervisor fit (P-S fit) each moderated the relationship between knowledge workers’ informal status and OBSE, in addition to the indirect effect of knowledge workers’ informal status on taking charge. Specifically, the indirect effect was strongest when P-J fit or P-S fit was high. The theoretical and managerial implications of the findings, limitations of the study, and future research directions are discussed. (shrink)

Remanufacturing widely exists in production activities. Two different game models are involved while considering reverse channels: In Model P, the manufacturer provides new and remanufactured products to two retailers. New products are sold through an online platform, while remanufactured products are sold in offline physical stores in a decentralized scenario. In Model C, the manufacturer provides new and remanufactured units to only one retailer that operates both online and offline channels in a centralized scenario. This research showed that a manufacturer’s (...) profitability and industry profits in Model P were higher than those in Model C from the perspective of economic performance; the sum of the profits of both retailers in Model P was worse than the profits of the retailer in Model C. Moreover, Model P was found to be greener than Model C from the perspective of environmental sustainability. From a social viewpoint, Model P had a higher consumer surplus than Model C; the higher the cost of distributing a remanufactured unit, the more disadvantageous the model to the consumers. (shrink)

Pt. 1. Book of nirvāṇa -- pt. 2. Book of nirvāṇa.

P. M. S. Hacker's tetralogy on human nature (2007–2021) is a recent contribution to philosophical anthropology. In this work, the expression ‘form of representation’ appears at crucial points of discussion. This paper begins with an exposition and analysis of this notion, followed by a look at how it is utilised in the discussion of knowledge, the mind, and other emotive and moral concepts. It then turns to a comparison of ‘forms of representation’ with two important concepts, namely, analogy and metaphor. (...) To offer an evaluation of ‘forms of representation’ as a critical tool, this paper examines the increasingly common tendency for humans to identify with their brains. (shrink)

Using the Epicurean position on death as a starting point, this article re-examines the basic assumptions of philosophers regarding their views on whether death should be seen as a bad. It questions the positions of philosophers such as Thomas Nagel and Derek Parfit by applying Wittgenstein’s notion of grammar as developed by G. P. Baker and P. M. S. Hacker. While philosophers may characterize questions such as ‘What is the nature of death?’ and ‘Is death a bad?’ as metaphysical, I (...) propose that such questions can be better characterized as grammatical. The failure to understand the grammatical character of such questions creates the illusion that questions concerning the nature of death can be adequately tackled with reference to empirical or metaphysical ‘facts’. If the arguments in this article are substantiated, some philosophical puzzles about death can be dissolved. (shrink)

Computer multistage adaptive test combines the advantages of paper and pencil-based test and computer-adaptive test. As CAT, MST is adaptive based on modules; as P&P, MST can meet the need of test developers to manage test forms and keep test forms parallel. Cognitive diagnosis can accurately measure students’ knowledge states and provide diagnostic information, which is conducive to student’s self-learning and teacher’s targeted teaching. Although MST and CD have a lot of advantages, many factors prevent MST from applying to CD. (...) In this study, we first attempt to employ automated test assembly to achieve the objectives of MST in the application of CD via heuristic algorithms. The mean correct response probability of all KSs for each item is used to describe the item difficulty of CD. The attribute reliability in CD is defined as the test quantitative target. A simulation study with the G-DINA model was carried out to investigate the proposed CD-MST, and the results showed that the assembled panels of CD-MST satisfied the statistical and the non-statistical constraints. (shrink)

ObjectiveThis study aims to investigate anxiety and its influencing factors in patients with drug-induced liver injury (DILI).Materials and MethodsNinety-four patients with DILI were enrolled and evaluated with a self-rating anxiety scale (SAS). According to the anxiety score, they were divided into four groups: the non-anxiety, mild anxiety, moderate anxiety, or severe anxiety groups, and the scores were analyzed based on demographic and biochemical indicators.ResultsOf the 94 patients with DILI, 63 did not have anxiety and 31 had anxiety (32.9%), of which (...) 27 had mild, 3 had moderate, and 1 had severe anxiety. There were no statistically significant differences in gender, age, occupation, and level of education between the groups (F= 1.42,H= 2.361,H= 6.751,H= 1.796, andP> 0.05); anxiety score and degree of anxiety between the types of drugs that led to the liver injury (H= 0.812,H= 1.712, andP> 0.05); anxiety score between the different degrees of liver injury (H= 2.836,H= 4.957,P> 0.05); or length of hospital stay or prognosis between the degrees of anxiety (F= 1.487,H= 0.761,P> 0.05). However, there were statistically significant differences in the degree of anxiety between different degree and types of liver injury (H= 7.981,H= 8.208,P< 0.05).ConclusionPatients with DILI may have anxiety, especially mild anxiety. The occurrence of anxiety in patients with DILI is not related to gender, age, occupation, or level of education but may be related to the degree and type of liver injury. Anxiety has no impact on the length of stay in hospital or the prognosis of the DILI. These findings may contribute to the development of management strategies for patients with DILI. (shrink)

BackgroundThe effects of psychological interventions on symptoms and psychology of functional dyspepsia remain unclear. We aimed to comprehensively evaluate the effects of psychological interventions on symptoms and psychology of FD.MethodsWe searched the PubMed, Cochrane Library, and Embase electronic databases for randomized controlled trials evaluating the role of psychological interventions in FD patients published before July 2021. Standardized mean differences, risk ratios and 95% confidence intervals were calculated by a random effects model. Subgroup analyses and sensitivity analyses were also performed.ResultsFourteen RCTs (...) with a total of 1,434 FD patients were included. Compared with the control group, psychological interventions were significantly more likely to symptom improvement [RR = 1.74, 95% CI, p = 0.01], relieve gastrointestinal symptoms scores at follow up [SMD = −1.06, 95% CI, p < 0.0001], relieve gastrointestinal symptoms scores at end of treatment [SMD = −0.98, 95% CI, p < 0.001], decrease anxiety [SMD = −0.8, 95% CI, p = 0.006] and depression levels [SMD = −1.11, 95% CI, p < 0.001]. The results of the subgroup analysis showed that psychotherapy was more likely to symptom improvement, relieve gastrointestinal symptoms scores and decreased depression levels compared to the control.ConclusionsPsychological interventions may be effective in alleviating the symptoms and psychology of FD, but the effect appears to be limited to psychotherapy with fewer trials for other psychological interventions. More data from high-quality RCTs are needed to confirm their use in the treatment of FD. (shrink)

Mental health issues are becoming increasingly prevalent amongst university students. However, research on the psychological profile of the general university population is relatively limited. Thus, this study analyses the current state of university students’ psychological conditions; the demographic differences in depression, anxiety, and stress and the influencing factors. The objectives are to provide additional appropriate guidance in mental health for university students with different demographic characteristics. A cross-sectional study of 6,032 university students nationwide was conducted from October 2020 to January (...) 2021. A randomized whole-group sampling method was used to select the study participants, and the 21-item Depression, Anxiety, and Stress Scale was used. P < 0.05 in the final model were considered statistically significant. The number of university students with no complain of depression, anxiety, or stress was 3,751. The odds of developing complain of depression were higher amongst anxious respondents and senior year than their counterparts. Students with “myopia” were 1.263 times more likely to be anxious. In terms of “impaired” or not, impaired is defined as any injury, such as sprain, strain, and fracture, “impaired” university students were 1.321 times more likely to be anxious. Furthermore, history of impairment and myopia increased the odds of stress by 1.305 and 1.305, respectively. Myopia, physical-activity-related injury and irrational eating habits are risk factors for complain of anxiety and stress. Males, upper grades, low parental education, and irrational eating habits are risk factors for complain of depression. Low physical activity levels are also an influential factor for complain of depression. DASS consists of interchangeable risk factors and multiple complains of DASS may coexist. (shrink)

The authors of the numerous medieval and early modern Sanskrit-medium commentaries on the various recensions and sub-recensions of the Vālmīkirāmāyaṇa frequently found themselves in a somewhat awkward hermeneutical position. The epic itself, like many Indic texts, is highly revered both as a religious text, one of the earliest and most influential Vaiṣṇava texts, and as a literary work that is not only a great poem but indeed the very first poem and the fons et origo of all subsequent poetry. Moreover, (...) like Vyāsa, the author of the Rāmāyaṇa’s sister epic, the Mahābhārata, Vālmīki was regarded not merely as an inspired poet and sage, but as a ṛṣi, that is to say an inerrant seer whose speech, in his case inspired directly by the creator divinity Brahmā and the god’s gift of a divine vision, must therefore be accepted as absolutely true and authoritative. The problem facing the work’s commentators is that Vālmīki’s text portrays its hero, Rāma, as not only a god in the form of a man, but as one who, ignorant of his own divinity, suffers all of the mental, emotional, and physical pain to which ordinary mortals are prey. In this Rāma differs sharply from the subsequent Vaiṣṇava avatāra and central figure of the Mahābhārata, Kṛṣṇa, who, fully aware of his godhood, rarely suffers in any way mentally or physically. But the Rāmāyaṇa’s commentators are living and writing in a world in which the development of the medieval bhakti movements has led poets and theologians to conceive of and write about Rāma as an omnipotent and omniscient figure very much like Kṛṣṇa. The present essay discusses the lexical, grammatical, and hermaneutical strategies the commentors adopted to negotiate the tension between Vālmīki’s apparent depiction of the suffering of his hero and a proposed deeper meaning in which the avatāra conforms more fully to what became the medieval and modern theology of god on earth. (shrink)

Kapitalizm, bireysel özgürlüğün son durağı mı? Liberal kuramcılar diyor ki: "Serbest piyasa ekonomisi, belki eşitlik, kardeşlik ve adalet sağlayamıyor ama hiç olmazsa özgürlüğü garanti altına alıyor." Özgürlüğün, tüketicilerin marka seçme özgürlüğüne ya da soyut vatandaşların eşit yasal haklarına indirgenemeyeceğini düşünüyorsak, liberalizmin ilk eleştirmenlerinden Rousseau ve Marx'ın alternatif özgürlük anlayışlarından hâlâ öğreneceğimiz çok şey var. Çoğumuz, ya özgürlüğü kuralsızlık olarak tanımlayıp, mutlak özgürlüğün hiçbir toplumda var olamayacağını düşünüyoruz, ya da özgürlüğü "özel alan" içindeki serbestliğe indirgeyip, kendimizi özgür hissetmenin özgür olmak için (...) yeterli olduğuna inanıyoruz. Peki, ya Rousseau'nun iddia ettiği gibi ayağımızdaki zincirleri halhal zannedip çiçeklerle süslüyorsak? Özgürleşmenin ilk adımı, şu anda neden özgür olmadığımızı kavramaktan geçiyor. Modern toplumda içine düştüğümüz "özgürlük yanılsaması"nı açıklayan Rousseau ve Marx, özgürlüğün ihtiyaçlarla ilişkisine dair iki farklı tez öne sürüyor. Rousseau'ya göre, uygarlık, arzuları ve bağımlılıkları artırdıkça toplumlar yozlaşır ve insanlar farkına varmadan özgürlüklerini kaybeder. Özgürlüğün koşulu "yapay arzular"dan kurtularak yetenekler ve ihtiyaçlar arasında denge kurulmasıdır. Oysa Marx'a göre özgürleşme ancak ihtiyaçların artması ve insancıllaşmasıyla mümkündür. Bütün ihtiyaçlarımızı para ihtiyacına indirgeyen "meta fetişizmi"nden kurtulma mücadelesi, yabancılaşmanın aşılmasının da önünü açar. Bu kitap, "Biz kimiz? Nereden geldik? Nereye gidiyoruz? Nasıl özgürleşebiliriz?" sorularının peşine düşen herkesi düşünsel bir yolculuğa davet ediyor. (shrink)

The Rāmāyaṇa of Vālmīki: An Epic of Ancient India. Vol. 6: Yuddhakāṇḍa. Translation and annota tion by Robert P. Goldman, Sally J. Sutherland Goldman, and Barend A. van Nooten. Introduction by Robert P. Goldman and Sally J. Sutherland Goldman. Princeton Library of Asian Translations. Princeton. Princeton University Press, 2009. Pp. 1655 + xviii. $210, $75. The Rāmāyaṇa of Vālmīki: An Epic of Ancient India. Vol. 7: Uttarakāṇḍa. Introduction, translation, and annotation by Robert P. Goldman and Sally J. Sutherland Goldman. Princeton (...) Library of Asian Translations. Princeton: Princeton University Press, 2017. Pp. 1522 + xxii. $175. (shrink)