Spatiotemporal regulation of the biochemical information is often linked to supramolecular organizations proteins and nucleic acids, the driving forces of which have yet to be elucidated. Although the critical role of multivalency in phase transition has been recognized, the organization principles of higher-order structures need to be understood. Here, we present a fuzzy mathematical framework to handle the heterogeneity of interactions patterns and the resultant multiplicity of conformational states in protein assemblies. In this model, redundant binding motifs can establish simultaneous (...) and partial interactions with multiple targets. We demonstrate that these multivalent, weak contacts facilitate polymer formation, while recapitulating the observed valency-dependence. In addition, the impact of linker dynamics and motif binding affinity, as well as the interplay between the two effects was studied. Our results support that fuzziness is a critical factor in driving higher-order protein organizations, and this could be used as a general framework to simulate different kinds of supramolecular assemblies. (shrink)

Provability, Computability and Reflection.

We introduce the notion of an alphabetic trace of a cut-free intuitionistic prepositional proof and show that it serves to characterize the equality of arrows in cartesian closed categories. We also show that alphabetic traces improve on the notion of the generality of proofs proposed in the literature. The main theorem of the paper yields a new and considerably simpler solution of the coherence problem for cartesian closed categories than those in [11, 14].

The Elements of Philosophy: Readings from Past and Present offers an extensive collection of classic and contemporary readings, organized topically into five main sections: Religion and Belief, Moral and Political Philosophy, Metaphysics and Epistemology, Philosophy of Mind and Language, and Life and Death. Within these broad areas, readings are arranged in clusters that address both traditional issues--such as the existence of God, justice and the state, knowledge and skepticism, and free will--and contemporary topics--including God and science, just war theory, vegetarianism, (...) and time travel. Carefully chosen selections from a wide range of pre-20th-century philosophers are paired with writings from more than fifty leading contemporary philosophers and thinkers. The traditional philosophers represented range from Plato and Aristotle to Immanuel Kant and A.J. Ayer; the contemporary philosophers include Saul Kripke, David Lewis, Thomas Nagel, Derek Parfit, Hilary Putnam, Robert Nozick, Judith Jarvis Thomson, John Rawls, Bernard Williams, and Susan Wolf. Also included are selections from linguist Noam Chomsky, physicist Albert Einstein, and psychologist William James. Edited by a team of scholars who are also highly esteemed instructors, The Elements of Philosophy is uniquely student-friendly. A team of undergraduate philosophy majors played a central role in helping to select topics, choose readings, and identify terms likely to require clarification. In response to their suggestions, the volume includes detailed introductions to each section, explanatory footnotes that define unfamiliar terms and concepts, an extensive glossary, and a guide to further resources. A companion Instructor's Manual, available on CD, offers article summaries, suggested essay questions, reading guides, model handouts, and sample syllabi. One of the most extensive and expansive anthologies available, The Elements of Philosophy is an ideal choice for both general and targeted introductory philosophy courses. (shrink)

SummaryWe present a systematic discussion of the structural and conceptual simplifications of proofs of standard theorems afforded by nonstandard methods and examine to what extent the resulting nonstandard proofs satisfy the informal criterion of “plausibility”. We introduce the concept of a “standard detour” and show that all nonstandard proofs considered avoid such detours. Among the proofs examined are proofs of the Intermediate Value Theorem, the Riemann Integration Theorem, the Spectral Theorem for compact Hermitian operators, and the Arzela‐Ascoli Theorem.RésuméNous discutons systématiquement (...) les simplifications structurelles et conceptuelles apportées par des méthodes non standard aux démonstrations de théorèmes standard et examinons jusQuà quel point de telles démonstrations non standard satisfont à un critère informel de plausibilityé. Nous introduisons la notion de détour standard et montrons que toutes les démonstrations non standard considérées évitent de tels détours. Parmi les démonstrations examinées: celles du théoréme de la valeur intermédiate, du théorème ?on;intégration de Riemann, du théorème spectral pour les opérateurs hermitiques compacts et du théorème ?on;Arzelà‐Arcoli.ZusammenfassungWir stellen eine systematische Betrachtung der durch die Nichtstandard‐Methoden gegebe‐nen strukturellen und begrifflichen Vereinfachungen von Beweisen von Standardsätzen an, und untersuchen, wie weit die entstandenen Nichtstandard‐Beweise das informelle Kriterium der Plausibilität erfüllen. Wir führen den Begriff eines Standard‐Umweges ein, und zeigen, dass alle betrachteten Nichtstandard‐Beweise solche Umwege vermeiden. Unter den betrachteten Beweisen befinden sich Beweise des Zwischenwertsatzes, des Riemannschen lntegralsatzes, des Spektralsatzes für kompakte, hermitische Operatoren, und des Theorems von Arzelà‐Ascoli. (shrink)

Is the societal-level of analysis sufficient today to understand the values of those in the global workforce? Or are individual-level analyses more appropriate for assessing the influence of values on ethical behaviors across country workforces? Using multi-level analyses for a 48-society sample, we test the utility of both the societal-level and individual-level dimensions of collectivism and individualism values for predicting ethical behaviors of business professionals. Our values-based behavioral analysis indicates that values at the individual-level make a more significant contribution to (...) explaining variance in ethical behaviors than do values at the societal-level. Implicitly, our findings question the soundness of using societal-level values measures. Implications for international business research are discussed. (shrink)

Introduction: Physical distancing under the coronavirus disease 2019 pandemic had a significant impact on lifestyles, including exercise routines. In this study, we examined the relationship between mental health and addictive behaviors, such as excessive exercise and the use of image and performance enhancing drugs across 12 sport disciplines.Materials and methods: A large cross-sectional sample of the adult population was surveyed. The mean age was 33.09. The number of male participants was 668. The use of IPEDs was assessed in conjunction with (...) psychometric measures such as the Exercise Addiction Inventory and the Appearance Anxiety Inventory. The participants were grouped into activity group and non-activity group according to the presence or absence of their exercise habits. The results were compared between these groups, as well as across sport disciplines, while taking into account the relationship between different psychological measures and IPEDs consumption.Results: The frequency of IPEDs use was higher among AG than NAG, although AG participants reported less history of addictions than NAG. The logistic regression analysis revealed that scores equal to or above cutoff points, in both the EAI and AAI, predicted the IPEDs use. Regarding the differences across the various sport disciplines, those who were involved in practicing Weight Lifting and Cross Fit were found to be more at risk of excessive exercising and more inclined to use a wide range of IPEDs.Conclusions: Although exercise could help to increase well-being and prevent addictions during the COVID-19 pandemic, our results show that those in the AG are particularly vulnerable to excessive IPEDs use. Sport disciplines associated with higher EAI and AAI scores have also shown a higher tendency to excessive IPEDs use. Furthermore, the factor of having above the cutoff scores in EAI or AAI in each sport could indicate larger IPEDs consumption regardless of the discipline. In light of the current findings, it is necessary to better define the “non-excessive” levels of exercise in various sport disciplines and an adequate intake of IPEDs to ensure the safety and well-being of people during a pandemic. (shrink)

In this paper, we approach the problem of the relationship between Greek mathematics and Eleatic philosophy from a new perspective, which leads us to a reappraisal of Szabó’s hypothesis about the origin of mathematics out of Eleatic philosophy. We claim that Parmenidean philosophy, particularly its semantic core, has possibly been shaped by reflexion on the Pythagoreans’ mathematical practice, particularly in arithmetic. Furthermore, Pythagorean arithmetic originates not from another domain outside mathematics but from counting, i.e., it has its roots in man’s (...) practical activity. This interpretation restores the historically inverse relationship between mathematics and philosophy, refuting the attribution of mathematics’ origin to a field outside mathematics, for which Szabó’s hypothesis has been criticised. Moreover, Parmenidean theory of truth is viewed not as a defective predecessor of Aristotle’s classical theory of truth that needs to be remedied but as a semantic conception coordinated with the mathematics of Parmenides’ times. (shrink)

This chapter contains sections titled: Going Deep The Porns of Our Lives Dial M for Missionary For Your Thighs Only A Clear and Present Stranger Enema of the State Good Will Humping Notes.

(ed. Tamar Szabo Gendler, Susanna Siegel and Steven M. Cahn) Oxford, 2007.

Words form a fundamental basis for our understanding of linguistic practice. However, the precise ontology of words has eluded many philosophers and linguists. A persistent difficulty for most accounts of words is the type-token distinction [Bromberger, S. 1989. “Types and Tokens in Linguistics.” In Reflections on Chomsky, edited by A. George, 58–90. Basil Blackwell; Kaplan, D. 1990. “Words.” Aristotelian Society Supplementary Volume LXIV: 93–119]. In this paper, I present a novel account of words which differs from the atomistic and platonistic (...) conceptions of previous accounts which I argue fall prey to this problem. Specifically, I proffer a structuralist account of linguistic items, along the lines of structuralism in the philosophy of mathematics [Shapiro, S. 1997. Philosophy of Mathematics: Structure and Ontology. Oxford University Press], in which words are defined in part as positions in larger linguistic structures. I then follow Szabò [1999. “Expressions and Their Representations.” The Philosophical Quarterly 49 (195): 145–163] and Parsons [1990. “The Structuralist View of Mathematical Objects.” Synthese 84: 303–346] in further defining words as quasi-concrete objects according to a representation relation. This view aims for general correspondence with contemporary generative linguistic approaches to the study of language. (shrink)

A collection of articles in English, German and French by fourteen Hungarian authors. Of particular interest and value is "Über die erkenntnistheoretischen Ansichten des jungen Marx" by György Markus. Although the footnotes are full of criticisms of the "revisionists", the early Marx is taken seriously as a philosophical thinker in his own right, and an effort is made to lay out what might be a theory of knowledge for this early Marx. Other articles of interest are by Edit Rózsahegyi, "The (...) Place and Role of Purpose in the Process of Cognition" and a criticism of Heisenberg by A. Szabó. On the whole, the articles are genuinely philosophical and deserve attention, although long, boring and dogmatic pieces such as "Objective Contradiction" by G. Tamás, and "Communism and Conditions for the Development of Personality" by A. Wirth are also present.--K. A. M. (shrink)

The Elements of Philosophy: Readings from Past and Present is a comprehensive collection of historical and contemporary readings across the major fields of philosophy. With depth and quality, this introductory anthology offers a selection of readings that is both extensive and expansive; the readings span twenty-five centuries. They are organized topically into five parts: Religion and Belief, Moral and Political Philosophy, Metaphysics and Epistemology, Philosophy of Mind and Language, and Life and Death. The product of the collaboration of three highly (...) respected scholars in their fields - Tamar Szabó Gendler, Susanna Siegel, and Steven M. Cahn - The Elements of Philosophy also includes introductions from the editors, explanatory footnotes, and a glossary. (shrink)

…entities? 2. How to be a nominalist 2.1. “Speak with the vulgar …” 2.2. “…think with the learned” 3. Arguments for nominalism 3.1. Intelligibility, physicalism, and economy 3.2. Causal..

…entities? 2. How to be a nominalist 2.1. “Speak with the vulgar …” 2.2. “…think with the learned” 3. Arguments for nominalism 3.1. Intelligibility, physicalism, and economy 3.2. Causal..

I will sketch a possible way of empirical/operational definition of space and time tags of physical events, without logical or operational circularities and with a minimal number of conventional elements. As it turns out, the task is not trivial; and the analysis of the problem leads to a few surprising conclusions.