I want to join Dummett in saying that the reality of the past (and, by analogy, the reality of the future) is an issue of realism versus anti-realism: (Dummett 1969) If you affirm the reality of the past, you are a realist about the past. If you deny the reality of the past, you are an anti-realist about the past. (And likewise, in each case, for the future). It makes sense to think of these issues by analogy with realism about (...) the external world, unobservable objects, mathematical objects, universals, and so on. These are all properly described as ontological issues. (shrink)

In _"Masterpiece" Studies_ Kermit Champa offers new ways to interpret modernism that have previously been closed off by the application of the reigning art-historical methodologies to the study of the modernist achievement. He focuses on four separate phenomena—Manet's last Salon painting, _Bar at the Folies-Bergèr_e;_ L'Oeuvre_, Zola's novel about the realist/impressionist movement; Van Gogh's problematic versions of a single painting, _La Berceuse_; and the immanent "series" phenomenon of Monet's work of the period. Champa reveals the importance of music, in (...) particular Wagner's music, as a paradigm for later nineteenth-century French painting. He also shows the crucial significance of the concept of the masterpiece as thematized by Zola in his novel for our understanding of certain aspects of the art of Manet, Monet, and Van Gogh. Employing postformalist methodology, the book explores the conversation between works of art produced in close succession and elaborates an aesthetic context for that conversation. Champa also shows how paintings and fictional representations of paintings can announce their points in common, and it is out of this exploration that he radically redefines what constitutes "context.". (shrink)

If the former is the case, let us say that anti-reductionism about relational facts is true; if the latter, that reductionism about relational facts is true. Let us say that a fact is relational if it makes true some relational proposition (a proposition that asserts that a relation holds between some objects1), that it is irreducibly relational if, in addition, it does not make true any nonrelational propositions, and that it is monadic if it is not irreducibly relational (if it (...) makes true some proposition that does not assert that a relation holds between some objects). (shrink)

O‐glycosylation is the post‐translational process whereby carbohydrate is added to hydroxylated amino acids of proteins. The major O‐glycosylation pathway in animal cells is involved in the synthesis of oligosaccharides linked by N‐acetylgalactosamine to serine or threonine residues in ‘mucin‐type’ proteins or their analogs. In this review, we discuss the evidence for the cellular localization of the biosynthetic steps in this pathway and propose a simplified, consensus version. We also propose variations of the simple pathway to account for its heterogeneity and (...) variability in different cell types and differentiation states. (shrink)

Microfilament interactions with the plasma membranes of animal cells appear to vary with cell type and localization. In the erythrocyte, actin oligomers are associated with the membrane via spectrin and ankyrin. The ends of stress fibers in cultured cells, such as fibroblasts, are attached to the plasma membrane at focal adhesion sites and may involve the protein vinculin as a linking protein. In intestinal brush border microvilli a 110,000 dalton protein links the microfilament bundles to sites on the microvillus. A (...) transmembrane complex containing actin stably associated with a cell surface glycoprotein can be isolated from ascites tumor cell microvilli and can be obtained still associated with microfilaments by gentle extraction and gradient centrifugation of the microvilli. These varied interaction mechanisms are believed to be needed to satisfy the different structural and dynamic requirements of the particular systems. (shrink)

Sound moves us. Nowhere is this more apparent than in our responses to genuine emotional vocalizations, be they heartfelt distress cries or raucous laughter. Here, we present perceptual ratings and a description of a freely available, large database of natural affective vocal sounds from human infants, adults and domestic animals, the Oxford Vocal (OxVoc) Sounds database. This database consists of 173 non-verbal sounds expressing a range of happy, sad, and neutral emotional states. Ratings are presented for the sounds on a (...) range of dimensions from a number of independent participant samples. Perceptions related to valence, including distress, vocalizer mood, and listener mood are presented in Study 1. Perceptions of the arousal of the sound, listener motivation to respond and valence (positive, negative) are presented in Study 2. Perceptions of the emotional content of the stimuli in both Study 1 and 2 were consistent with the predefined categories (e.g., laugh stimuli perceived as positive). While the adult vocalizations received more extreme valence ratings, rated motivation to respond to the sounds was highest for the infant sounds. The major advantages of this database are the inclusion of vocalizations from naturalistic situations, which represent genuine expressions of emotion, and the inclusion of vocalizations from animals and infants, providing comparison stimuli for use in cross-species and developmental studies. The associated website provides a detailed description of the physical properties of each sound stimulus along with cross-category descriptions. (shrink)

I denne teksten blir følgende spørsmål tatt opp til drøfting: Er det å ta medisinsk teknologi i bruk for å selektere et døvt barn mer etisk problematisk enn det motsatte; å bruke teknologien for å sikre seg et hørende barn? På bakgrunn av fire premisser konkluderer jeg med at både seleksjon for døvhet og for hørsel er tilnærmet like etisk problematisk. De fire premissene er 1) at seleksjonskriteriet sykdom eller skade bør erstattes av autentisitetsbetraktninger, 2) at døve og hørende har (...) samme potensial for autentisk livsutfoldelse, selv om det ikke kan avvises at døvhet kjennetegnes ved manglende hørsel, 3) at seleksjon innebærer fravalg av liv som har autentisk potensialitet enten som døv eller hørende, og 4) at dette fravalget involverer en etisk kostnad. Konklusjonen har enkelte andre implikasjoner og en restproblematikk som belyses avslutningsvis. (shrink)

In this article, I foreground the role of relationality in Husserl’s later reflections on ethics and self-constitution, with a particular interest in Husserl’s account of sacrifice. I exposit how Husserl’s account of self-constitution and the conflict of absolute values between competing vocations offers a solution to Brentano’s rendering of the obligation to “choose the best among the ends attainable.” I explore the numerous instances in which Husserl uses the parent-child relation to illustrate the absolute value of our relation to an (...) individual and how this absolute value triumphs over other seemingly rational maxims. Although problematic in several ways, Husserl’s account of motherhood grounds his notion of self-constitution in particular relations with others, rather than in a general category of nation or humanity. I conclude by considering how his emphasis on phenomenological constitution and his approach to value and sacrifice may inform future projects in phenomenological relational ethics. (shrink)

In a promising working note to the Visible and Invisible, Merleau-Ponty proposes that we understand Being according to topological space – relations of proximity, distance, and envelopment – and move away from an image of Being based on homogeneous, inert Euclidean space. With reference to treatments of cross-sensory perception, color-blindness, and the concept of quale or qualia, I seek to rehearse this shift from Euclidean to topological Being by illustrating how modern science confines color itself to a Euclidean model of (...) color space. I discuss “being as Object” in Merleau-Ponty’s later work before showing how color, and indeed all perception, is reduced to being as Object in the form of “quale”. Next, I address discussions in Merleau-Ponty’s work and contemporary research to illustrate how synesthesia and so-called color-blindness are rendered abnormal by this objectified being of color. Merleau-Ponty’s reading of synesthesia follows directly from his rejection of quale, and his use of color perception serves as a rejection of solipsism. With appeal to his proposed topological model of Being, I conclude by recognizing the problematic nature of synesthesia and color-blindness as being ontological, not psychological.Dans une note de travail, à mon sens décisive, du Visible et l’Invisible, Merleau-Ponty propose que l’on comprenne l’Être à partir de l’espace topologique – relations de proximité, distance et enveloppement – allant à l’encontre d’une l’image de l’Être fondée sur un espace euclidien homogène et inerte. En faisant référence aux traitements de la perception synesthésique, au daltonisme et au concept de quale ou qualia, j’essayerai de décrire ce passage de l’Être euclidien à l’Être topologique en montrant que la science moderne finit par confiner la couleur dans un modèle euclidien d’espace-couleur. J’examinerai « l’Être-objet » dans les derniers écrits de Merleau-Ponty avant de montrer comment la couleur, et plus en général la perception, est réduite à être comme un Objet dans la forme d’un « quale ». Ensuite, en examinant les analyses merleau-pontiennes et les recherches contemporaines, je montrerai comment la synesthésie et le daltonisme sont donc considérés comme anormaux à partir de cette objectivation de la couleur. La lecture que Merleau-Ponty donne de la synesthésie est la conséquence directe de son refus du quale, et l’utilisation qu’il fait de la perception des couleurs sert comme un refus du solipsisme. En faisant appel au modèle topologique de l’Être qu’il propose, je conclurai en constatant que la nature problématique de la synesthésie et du daltonisme est ontologique et non pas psychologique.In una nota di lavoro al Visibile e l’invisibile, Merleau-Ponty propone di comprendere l’Essere a partire da uno spazio topologico – secondo le relazioni di prossimità, distanza e avvolgimento – e abbandona l’immagine di un Essere fondato su uno spazio omogeneo, inerte, euclideo. Facendo riferimento ai trattamenti per le percezioni sinestetiche, al daltonismo e al concetto di quale o qualia, si cercherà di provare questo passaggio da un Essere euclideo a uno topologico, illustrando quanto la scienza moderna tenda a ridurre il concetto stesso di colore a un modello euclideo di spazio-colore. Si esaminerà l’“Essere-oggetto” degli ultimi lavori di Merleau-Ponty, mostrando come il colore, e in realtà la percezione tout court, vengano ridotti a oggetto nella forma di “quale”. Infine, si esaminerà l’opera merleau-pontiana e la ricerca contemporanea al fine di illustrare quanto la sinestesia e il daltonismo siano resi anormali da questa oggettivazione dell’essere del colore. L’interpretazione merleau-pontiana della sinestesia deriva proprio dal suo rifiuto del quale, e il suo uso della percezione del colore funge da rifiuto del solipsismo. Ricorrendo al modello topologico di Essere elaborato da Merleau-Ponty, si conclude riconoscendo che il problema della sinestesia e del daltonismo è, a tutti gli effetti, ontologico e non psicologico. (shrink)

DIVBased on a series of lectures delivered in 1840, Thomas Carlyle’s On Heroes, Hero-Worship, and the Heroic in History considers the creation of heroes and the ways they exert heroic leadership. From the divine and prophetic to the poetic to the religious to the political, Carlyle investigates the mysterious qualities that elevate humans to cultural significance. By situating the text in the context of six essays by distinguished scholars that reevaluate both Carlyle’s work and his ideas, David (...) Sorensen and Brent Kinser argue that Carlyle's concept of heroism stresses the hero’s spiritual dimension. In Carlyle’s engagement with various heroic personalities, he dislodges religiosity from religion, myth from history, and truth from “quackery” as he describes the wondrous ways in which these “flowing light-fountains” unlock the heroic potential of ordinary human beings. /div. (shrink)

Neil Tennant and Joseph Salerno have recently attempted to rigorously formalize Michael Dummett's argument for logical revision. Surprisingly, both conclude that Dummett commits elementary logical errors, and hence fails to offer an argument that is even prima facie valid. After explicating the arguments Salerno and Tennant attribute to Dummett, I show how broader attention to Dummett's writings on the theory of meaning allows one to discern, and formalize, a valid argument for logical revision. Then, after correctly providing a rigorous statement (...) of the argument, I am able to delineate four possible anti-Dummettian responses. Following recent work by Stewart Shapiro and Crispin Wright, I conclude that progress in the anti-realist's dialectic requires greater clarity about the key modal notions used in Dummett's proof. (shrink)

Peirce’s system may be identified as one of a family of “organic memory” theories which flourished during the period in which he developed it, especially in the Monist journals which published much of his late work. “Organic memory” theories were vigorously opposed in their own day and are remembered in our own, if at all, only in connection with discredited theories such as racial memory and Lamarckian inheritance. When read in the context of their own time, however, “organic memory” theories (...) stand revealed as among modernity’s first attempts at a still-unrealized, post-nominalist re-foundation of science. Being thus closely related to Peirce’s own project both in time and in spirit, they deserve to be understood on their own terms. The synthesis of these theories in the book Das Gesetz der Serie (1919) by the Austrian biologist Paul Kammerer (1880-1926), a prominent representative of organized Monism's European branch, provides insight into the systematic unity of the various aspects of Peirce's thought, especially the close relationship between pragmatism and what is now called “emergence.”. (shrink)

The neuregulin gene encodes a series of polypeptide growth factors that can influence the growth state of target vertebrate cells in culture. Recently, three studies have explored the in vivo function of the neuregulin signaling system in mice by disrupting the genes encoding the neuregulin ligand(1) and two of its receptors, ErbB2(2) and ErbB4(3). Each of the genes is essential for development, and aberrations in cardiac and neural development are particularly prominent in mutant embryos. The observed defects, together with the (...) localization of expression of the neuregulin signaling components within these tissues, highlight a paracrine mechanism for neuregulin‐mediated intercellular communication. (shrink)

Stimulation of mitogenesis by the epidermal growth factor (EGF) operates through a pathway involving the receptor, the small G‐protein Ras and protein kinases of the MAP kinase cascade. It is proposed that two of the critical steps of that pathway utilize localization of components to the plasma membrane where Ras is located: recruitment of the nucleotide exchange protein Sos to the phosphorylated EGF receptor via a complex with the SH2/SH3‐containing protein Grb2 and recruitment of the protein kinase Raf to activated (...) Ras. Moreover, it is then proposed that Raf associates with the cytoskeleton at the membrane as it is being activated. Other signaling elements, including class I receptor kinases, nonreceptor tyrosine kinases and tyrosine phosphatases, are known to function at specific cellular sites. These observations have led us to propose that localization of signaling components, and particularly sites at membrane‐microfilament interfaces, play critical roles in cellular regulation. (shrink)

ABSTRACT Although Kairos in Greek mythology is often depicted as the winged son of Zeus who grants to those who lay hold of his single lock of hair their once-in-a-lifetime opportunity, in traditional African American culture, particularly when it comes to speech, Kairos is essentially family. Given how much African American speakers depend on seizing the moment to invoke spiritual connections, emit laughter, and profess the truth, Kairos, or what we might call CPT (“Colored People’s Time”), can be summoned almost (...) at will. One of the African American discourses this article will use to illustrate this point is Call and Response, a verbal exchange in which speakers and listeners attune to one another and to the timeliness of an event. Martin Luther King Jr.’s “I Have a Dream” speech was such an event, but it wouldn’t have been so were it not for the timely responding of his favorite gospel singer, Mahalia Jackson. (shrink)

The Protestant ethic — a moral code stressing hard work, rigorous self-discipline, and the organization of one's life in the service of God — was made famous by sociologist and political economist Max Weber. In this brilliant study (his best-known and most controversial), he opposes the Marxist concept of dialectical materialism and its view that change takes place through "the struggle of opposites." Instead, he relates the rise of a capitalist economy to the Puritan determination to work out anxiety over (...) salvation or damnation by performing good deeds — an effort that ultimately discouraged belief in predestination and encouraged capitalism. Weber's classic study has long been required reading in college and advanced high school social studies classrooms. (shrink)

The function of REM, or any other stage of sleep, can currently only be conjectured. A rational evaluation of the role of REM in memory processing requires systematic testing of hypotheses that are optimally derived from a complete synthesis of existing knowledge. Our view is that the large number of studies supporting a relationship between REM-related brain activity and memory is not easily explained away. [Vertes & Eastman].

MUC1 and MUC4 are the two membrane mucins that have been best characterized. Although they have superficially similar structures and have both been shown to provide steric protection of epithelial surfaces, recent studies have also implicated them in cellular signaling. They act by substantially different mechanisms, MUC4 as a receptor ligand and MUC1 as a docking protein for signaling molecules. MUC4 is a novel intramembrane ligand for the receptor tyrosine kinase ErbB2/HER2/Neu, triggering a specific phosphorylation of the ErbB2 in the (...) absence of other ErbB ligands and potentiating phosphorylation and signaling through the ErbB2/ErbB3 heterodimeric receptor complex formed in the presence of neuregulin. In contrast, MUC1 has a highly conserved cytoplasmic tail, which binds β‐catenin, a key component of adherens junctions and a regulator of transcription, in a process that is tightly regulated by MUC1 phosphorylation. The specific localization of these membrane mucins to the apical surfaces of epithelial cells suggests that their signaling functions may be important as sensor mechanisms in response to invasion or damage of epithelia. BioEssays 25:66–71, 2003. © 2002 Wiley Periodicals, Inc. (shrink)

This study examines the history of the psychoanalytic theory of mysticism, starting with the seminal correspondence between Freud and Romain Rolland concerning the concept of "oceanic feeling." Providing a corrective to current views which frame psychoanalysis as pathologizing mysticism, Parsons reveals the existence of three models entertained by Freud and Rolland: the classical reductive, ego-adaptive, and transformational. Then, reconstructing Rolland's personal mysticism through texts and letters unavailable to Freud, Parsons argues that Freud misinterpreted the oceanic feeling. In offering a fresh (...) interpretation of Rolland's mysticism, Parsons constructs a new dialogical approach for psychoanalytic theory of mysticism which integrates culture studies, developmental perspectives, and the deep epistemological and transcendent claims of the mystics. (shrink)

The Walker model raises a number of questions, particularly about the nature of the sleep states involved in consolidation enhancement. While REM sleep, Stage 2 sleep, and Stage 3/4 sleep have been implicated in procedural learning, we still do not understand which types of learning are involved with specific sleep states. Several possible ideas for future research are suggested.

Recent contributions to discussions on paediatric cochlear implantation in Norway indicate two mutually exclusive doctrines prescribing the best course of post-operative support for a child with cochlear implants; bilingually with sign language and spoken language simultaneously or primarily monolingually with speech only. This conflict constitutes an ethical problem for parents responsible for choosing between one of the two alternatives. This article puts forth the precautionary principle as a possible solution to this problem. Although scientific uncertainty exists in the case of (...) both doctrines, there exists a scenario of possible irreversible harm to some of the children habilitated monolingually. An application of the precautionary principle may hence suggest that it is rational to agree on the bilingual approach, at least for the time-being. (shrink)

(Statement of Responsibility) by Timothy S. Huebner.

In this article, I foreground the role of relationality in Husserl’s later reflections on ethics and self-constitution, with a particular interest in Husserl’s account of sacrifice. I exposit how Husserl’s account of self-constitution and the conflict of absolute values between competing vocations offers a solution to Brentano’s rendering of the obligation to “choose the best among the ends attainable.” I explore the numerous instances in which Husserl uses the parent-child relation to illustrate the absolute value of our relation to an (...) individual and how this absolute value triumphs over other seemingly rational maxims. Although problematic in several ways, Husserl’s account of motherhood grounds his notion of self-constitution in particular relations with others, rather than in a general category of nation or humanity. I conclude by considering how his emphasis on phenomenological constitution and his approach to value and sacrifice may inform future projects in phenomenological relational ethics. (shrink)

This text presents an overview of the bioethical debate on pediatric cochlear implants and pays particular attention to the analysis of the Deaf critique of implantation. It dismisses the idea that Deaf concerns are primarily about the upholding of Deaf culture and sign language. Instead it is argued that Deaf skepticism about child rehabilitation after cochlear surgery is well founded. Many Deaf people have lived experiences as subjects undergoing rehabilitation. It is not the cochlear technology in itself they view as (...) problematic, but rather the subsequent rehabilitation process. Because they themselves have experienced what they describe as harmful effects which relate above all to the idea of normalization, they have articulated worries for the new generations of deaf children in need of rehabilitation following cochlear implant surgery. These insights have attracted little attention, but could represent relevant ethical questions of which both practitioners and researchers in the field of implantation might be aware. (shrink)

Dan Marshall and Josh Parsons note, correctly. that the property of being either a cube or accompanied by a cube is incorrectly classified as intrinsic under the definition we have given unless it turns out to be disjunctive. Whether it is disjunctive, under the definition we gave, turns on certain judgements of the relative naturalness of properties. They doubt the judgements of relative naturalness that would classify their property as disjunctive. We disagree. They also suggest that the whole idea of (...) judging relative naturalness is a dubious business. We reply that, like them or not, such judgements cannot easily be avoided. (shrink)

It is tempting to think that Meinong overlooked the "specific/nonspecific" distinction. For example, 'I am looking for a grey horse' may either mean that there is a specific horse I am looking for (e.g. one I lost), or just that I am grey-horse-seeking. The former reading, and not the latter, requires for its truth that there be a grey horse. The purpose of this paper is to investigate whether it is defensible to maintain Meinong's theory here: to take nonspecific reading (...) of any verb concerning a possibly non-existent but incomplete object. This requires essential appeal to the distinction between nuclear and extranuclear properties. Included is a discussion of criticisms of Meinong's own theory, and of the Medieval theory of ampliation, according to which psychological discourse can "ampliate" a term such as 'chimera' so as to stand for one or more things that cannot exist, yet are chimeras. The paper concludes inconclusively. (shrink)

It is tempting to think that Meinong overlooked the "specific/nonspecific" distinction. For example, 'I am looking for a grey horse' may either mean that there is a specific horse I am looking for, or just that I am grey-horse-seeking. The former reading, and not the latter, requires for its truth that there be a grey horse. The purpose of this paper is to investigate whether it is defensible to maintain Meinong's theory here: to take nonspecific reading of any verb concerning (...) a possibly non-existent but incomplete object. This requires essential appeal to the distinction between nuclear and extranuclear properties. Included is a discussion of criticisms of Meinong's own theory, and of the Medieval theory of ampliation, according to which psychological discourse can "ampliate" a term such as 'chimera' so as to stand for one or more things that cannot exist, yet are chimeras. The paper concludes inconclusively. (shrink)