Die Figur des kynischen Philosophen Diogenes hat nicht nur die Antike und Moderne, sondern gerade auch das Mittelalter und die Frühe Neuzeit in besonderer Weise fasziniert. Dabei erscheint der Kyniker als kritische Figur, über die viele Anekdoten, vor allem aber eine ganze Reihe von Exempelerzählungen berichten. Die verschiedenen Formen dieser Erzählungen und die Poetik des Exemplums stehen denn auch im Zentrum des Interesses des Bandes, der die Rezeptionstraditionen der Diogenesgeschichten darstellt, analysiert und zudem als Quellensammlung ediert. Der Band versucht weiter, (...) die Bedeutung zu verstehen, die der Kyniker als Exempelfigur auch im Blick auf die Moderne von Erasmus bis hin zu Nietzsche, Benjamin und Foucault behält. (shrink)

CRISPR germline editing therapies hold unprecedented potential to eradicate hereditary disorders. However, the prospect of altering the human germline has sparked a debate over the safety, efficacy, and morality of CGETs, triggering a funding moratorium by the NIH. There is an urgent need for practical paths for the evaluation of these capabilities. We propose a model regulatory framework for CGET research, clinical development, and distribution. Our model takes advantage of existing legal and regulatory institutions but adds elevated scrutiny at each (...) stage of CGET development to accommodate the unique technical and ethical challenges posed by germline editing. (shrink)

Transformer-based Pre-Trained Language Models currently dominate the field of Natural Language Inference (NLI). We first survey existing NLI datasets, and we systematize them according to the different kinds of logical inferences that are being distinguished. This shows two gaps in the current dataset landscape, which we propose to address with one dataset that has been developed in argumentative writing research as well as a new one building on syllogistic logic. Throughout, we also explore the promises of ChatGPT. Our results show (...) that our new datasets do pose a challenge to existing methods and models, including ChatGPT, and that tackling this challenge via fine-tuning yields only partly satisfactory results. (shrink)

In his Confessions Jean-Jacques Rousseau tells the story of his life, from the formative experience of his humble childhood in Geneva, through the achievement of international fame as novelist and philosopher in Paris, to his wanderings as an exile, persecuted by governments and alienated from the world of modern civilization. In trying to explain who he was and how he came to be the object of others' admiration and abuse, Rousseau analyses with unique insight the relationship between an elusive but (...) essential inner self and the variety of social identities he was led to adopt. The book vividly illustrates the mixture of moods and motives that underlie the writing of autobiography: defiance and vulnerability, self-exploration and denial, passion, puzzlement, and detachment. Above all, Confessions is Rousseau's search, through every resource of language, to convey what he despairs of putting into words: the personal quality of one's own existence. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:482 HISTORY OF PHILOSOPHY disorder was reLigious men's tendency to find in the Scriptures and their consciences justifications for rebelling against their sovereign. The last half of Leviathan is designed to refute these claims in detail, and this refutation is not merely tacked onto the first parts but is a logical extension of them. The argument for escaping the state of nature is that only through obedience to a (...) common power can man escape the likelihood of an early death. Once that common power is established, and so long as it can carry out its protective function, obedience to it is obligatory. When a man enters civil society, the only right he retains is to defend himself against physical death, and consequently, the only time he is entitled to disobey the sovereign is when the sovereign directly threatens him. Thus excuses for rebellion are reduced to an absolute minimum. In McNeiily's formalization however, the concept of a man's death must be replaced by the formal concept of the frustration of all one's desires. And so "whatevvr [a man] regards as the complete frustration of all his desires... he will be entitled to resist, even if such resistance puts him at war with others, including lawful authority" (p. 193). Now the incredible range of things men have believed essential to avoiding the frustration of all their desires is amply testified to in the history of religious warfare. And clearly, under this formalized interpretation, men would be entitled to rebel over the form of baptism, church government, ministerial costume, prayer, or anything else if they are convinced it is essential to their salvation. It takes little knowledge of history to see that Hobbes's espousing of a theory with such consequences has a low degree of probability indeed. Hobbes complains in Leviathan of Scriptural exegetes who "by casting atoms of Scripture, as dust before men's eyes, make everything more obscure than it is." Rather, he claims, it is "not bare words, but the scope of the writer, that giveth the true light by which any writing is to be interpreted; and they that insist upon single texts, without considering the main design, can derive nothing from them clearly'" (E. W., III, 602). This last would be too harsh to apply to McNeiity's work generally, for his "atoms" are for the most part of considerable worth in themselves. But with regard to our understanding of Hobbes's Leviathan he raises a lot of dust. PAUL J. JOHNSON CalifornM State College, San Bernardino The Enlightenment: An Interpretation. By Peter Gay. VoL I, The Rise ol Modern Paganism. (New York: Alfred A. Knopf, 1966. Pp. xviii+SSS+xv); VoL II, The Science ot Freedom. (New York: Alfred A. Knopf, 1969. Pp. xx+70S+xviii) Le grand int~rSt port~ aux ~tudcs du xvm* si~cle au cours des deux derni~res d6cades et la remise en question des principes critiques encore en vigueur it y a une dizaine d'ann~,s ont fray~ la voie h de nouveaux efforts de synth~se dent la derni~re en date, et non la moins int~ressante, est celle de Peter Gay. Ses deux substantiels volumes sent destines ~ servir de guides ~ une nouvelle g~n~ration d'~tudiants et de chercheurs, ne ffit-ce que pour la bibliographie tr~s d6taill~e et accompagn~ d'obserrations personneUes qui forme un supplement tr~s pr6cieux ~ la Bibliographie de D. C. Cabeen de 1951 et de 1968. Lo travail de Peter Gay inspire confianc~ par BOOK REVIEWS 483 Fampleur des lectures auxquelles il s'est astreint et. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:482 HISTORY OF PHILOSOPHY disorder was reLigious men's tendency to find in the Scriptures and their consciences justifications for rebelling against their sovereign. The last half of Leviathan is designed to refute these claims in detail, and this refutation is not merely tacked onto the first parts but is a logical extension of them. The argument for escaping the state of nature is that only through obedience to a (...) common power can man escape the likelihood of an early death. Once that common power is established, and so long as it can carry out its protective function, obedience to it is obligatory. When a man enters civil society, the only right he retains is to defend himself against physical death, and consequently, the only time he is entitled to disobey the sovereign is when the sovereign directly threatens him. Thus excuses for rebellion are reduced to an absolute minimum. In McNeiily's formalization however, the concept of a man's death must be replaced by the formal concept of the frustration of all one's desires. And so "whatevvr [a man] regards as the complete frustration of all his desires... he will be entitled to resist, even if such resistance puts him at war with others, including lawful authority" (p. 193). Now the incredible range of things men have believed essential to avoiding the frustration of all their desires is amply testified to in the history of religious warfare. And clearly, under this formalized interpretation, men would be entitled to rebel over the form of baptism, church government, ministerial costume, prayer, or anything else if they are convinced it is essential to their salvation. It takes little knowledge of history to see that Hobbes's espousing of a theory with such consequences has a low degree of probability indeed. Hobbes complains in Leviathan of Scriptural exegetes who "by casting atoms of Scripture, as dust before men's eyes, make everything more obscure than it is." Rather, he claims, it is "not bare words, but the scope of the writer, that giveth the true light by which any writing is to be interpreted; and they that insist upon single texts, without considering the main design, can derive nothing from them clearly'" (E. W., III, 602). This last would be too harsh to apply to McNeiity's work generally, for his "atoms" are for the most part of considerable worth in themselves. But with regard to our understanding of Hobbes's Leviathan he raises a lot of dust. PAUL J. JOHNSON CalifornM State College, San Bernardino The Enlightenment: An Interpretation. By Peter Gay. VoL I, The Rise ol Modern Paganism. (New York: Alfred A. Knopf, 1966. Pp. xviii+SSS+xv); VoL II, The Science ot Freedom. (New York: Alfred A. Knopf, 1969. Pp. xx+70S+xviii) Le grand int~rSt port~ aux ~tudcs du xvm* si~cle au cours des deux derni~res d6cades et la remise en question des principes critiques encore en vigueur it y a une dizaine d'ann~,s ont fray~ la voie h de nouveaux efforts de synth~se dent la derni~re en date, et non la moins int~ressante, est celle de Peter Gay. Ses deux substantiels volumes sent destines ~ servir de guides ~ une nouvelle g~n~ration d'~tudiants et de chercheurs, ne ffit-ce que pour la bibliographie tr~s d6taill~e et accompagn~ d'obserrations personneUes qui forme un supplement tr~s pr6cieux ~ la Bibliographie de D. C. Cabeen de 1951 et de 1968. Lo travail de Peter Gay inspire confianc~ par BOOK REVIEWS 483 Fampleur des lectures auxquelles il s'est astreint et. (shrink)

BackgroundBiobanking biospecimens and consent are common practice in paediatric research. We need to explore children and young people’s (CYP) knowledge and perspectives around the use of and consent to biobanking. This will ensure meaningful informed consent can be obtained and improve current consent procedures.MethodsWe designed a survey, in co-production with CYP, collecting demographic data, views on biobanking, and consent using three scenarios: 1) prospective consent, 2) deferred consent, and 3) reconsent and assent at age of capacity. The survey was disseminated (...) via the Young Person’s Advisory Group North England (YPAGne) and participating CYP’s secondary schools. Data were analysed using a qualitative thematic approach by three independent reviewers (including CYP) to identify common themes. Data triangulation occurred independently by a fourth reviewer.ResultsOne hundred two CYP completed the survey. Most were between 16–18 years (63.7%, N = 65) and female (66.7%, N = 68). 72.3% had no prior knowledge of biobanking (N = 73).Acceptability of prospective consent for biobanking was high (91.2%, N = 93) with common themes: ‘altruism’, ‘potential benefits outweigh individual risk’, 'frugality', and ‘(in)convenience’.Deferred consent was also deemed acceptable in the large majority (84.3%, N = 86), with common themes: ‘altruism’, ‘body integrity’ and ‘sample frugality’. 76.5% preferred to reconsent when cognitively mature enough to give assent (N = 78), even if parental consent was previously in place. 79.2% wanted to be informed if their biobanked biospecimen is reused (N = 80).ConclusionProspective and deferred consent acceptability for biobanking is high among CYP in the UK. Altruism, frugality, body integrity, and privacy are the most important themes. Clear communication and justification are paramount to obtain consent. Any CYP with capacity should be part of the consenting procedure, if possible. (shrink)

Algorithms, once obscure objects of technical art, have lately been subject to considerable popular and scholarly scrutiny. What does it mean to adopt the algorithm as an object of analytic attention? What is in view, and out of view, when we focus on the algorithm? Using Niklaus Wirth's 1975 formulation that “algorithms + data structures = programs” as a launching-off point, this paper examines how an algorithmic lens shapes the way in which we might inquire into contemporary digital culture.

Harmonik als Grundlage einer 'erneuerten' Naturwissenschaft -- "Sie haben Augen und sehen nicht-- " -- Hans Waldmann und Niklaus von der Flüeh.

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 487 61oign6 de Locke, qui a fait entrer les math6matiques dans la logique, il est leur successeur attitr6. II a 6pous6 une doctrine pacifiste encore plus imp6rative que celle de Voltaire. N'a-t-il pas lui aussi cherch6 a cultiver son jardin pour en faire un paradis terrestre, et ce n'est certes pas sa faute ni celle de la raison humaine sice paradis s'estompe darts un avenir toujours plus (...) 61oign6 pour n'~tre en d6finitive qu'un mirage. P. Gay qui est ~t sa fa~on un bon disciple de Locke est un pragmatiste plus qu'un rationaliste. Le programme des philosophes n'Stait pas seulement raisonnable, il ~tait pratique. MSme si ceux-ci se sonl: paffois montr6s, ridicules pour avoir m~connu la grande part de l'irrationnel daus l'esprit humain, ils ont du moins le m~rite d'avoir fair appel au bon sens de la collectivit6, ce bon sens qui fondait route la m6thode de Descartes. Pour P. Gay, comme pour les hommes du xvm e sidle, le philosophe est avant tout le sage et le savant, l'homme de bien et le citoyen, tel qu'il est dit daus l'Encyclopddie. C'est le "militaire phflosophe" dont l'auteur est inconnu, le "philosophe ignorant" de Voltaire, le "philosophe sans le savoir" de Sedaine. Une nouvelle conception de l'homme se fait jour, celle d'un 8tre ~ la lois rationnel et sensible. Par derriere de nombreux avatars se retrouve une philosophic g6n~rale commune: celle de Locke et de Condillac, de Hume, d'Helv6tius et de Diderot, celle-l~t m6me qu'E. C.assirer a su mettre en lumi~re en insistant sur son c6t6 formel, et que le philosophe sovi6tique J. Luppol a quelque peu fauss6e par une interpr6tation marxiste et par trop dogrnatique de l'histoire. Elle s'exprime clairement dans le Discours pr~lirninaire de d'Alembert. Le sensationnalisme a promu l'id~e de la souverainet~ de l'esprit critique et par l~t m~me a r6pudi6 la toute-puissance de la Raison. La nouvelle m6thode pr6conis ~e permet une dialectique nouvelle, qui est pr~cis6ment celle de l'homme moderne. EUe entraine une conception diff6rente du monde et de l'homme, une interpretation nouvelle de leurs rapports. La psychologie est amen~e ~ faire ses premiers pas en tant que science; mais c'est une analyse impitoyable du moi profond en marge d'une exploration de la vie sociale et du monde ext~rieur qui a fray6 la voie ~t la modernitY, et nous a donn~ le sentiment de notre libertY. C'est ainsi qu'il convient de faire entrer le Rousseau des Confessions aussi bien que du Contrat social dans la grande famille d~sunie qui fait le sujet du livre de P. Gay. Pour nous, en nous pla~ant ~t un point de rue quelque peu different de celui de notre auteur, et tout en reconnaissant avec lui que le dix-huiti~me si~cle a port~ une atteinte mortelle ~ la m~taphysique, nous croyons pouvoir dire que le dix-huiti~me si~cle n'est pas tant le si~cle qui a reni~ Dieu, mais le si~cle qui s'en est fait une conception plus moderne en le repoussant darts un pass~ lointain et t~n~breux ou en le situant, non sans ivresse, darts un avenir tr~s incertain. R. NIKLAUS Exeter, England La Filosofia Politica di Schelling. By Claudio Cesa. (Bari, Laterza, 1969. Pp. 252. n.p.) Was Schelling an original political philosopher? This does not seem to be the opinion of the author of this very careful research, which is beyond any doubt the 488 HISTORY OF PHILOSOPHY most extensive study of this aspect of Schelling's thought, at least until 1806. However, even if Schelling was not, as it is frequently stated, indifferent to the problems and the vicissitudes of politics, his theoretical thinking on this subject never went beyond temporary systematizations, to be given up, or modified, after a while. The author shows how Schelling, especially in this fieM, was influenced either by his environment in general, or by some personalities he happened to contact: first... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 487 61oign6 de Locke, qui a fait entrer les math6matiques dans la logique, il est leur successeur attitr6. II a 6pous6 une doctrine pacifiste encore plus imp6rative que celle de Voltaire. N'a-t-il pas lui aussi cherch6 a cultiver son jardin pour en faire un paradis terrestre, et ce n'est certes pas sa faute ni celle de la raison humaine sice paradis s'estompe darts un avenir toujours plus (...) 61oign6 pour n'~tre en d6finitive qu'un mirage. P. Gay qui est ~t sa fa~on un bon disciple de Locke est un pragmatiste plus qu'un rationaliste. Le programme des philosophes n'Stait pas seulement raisonnable, il ~tait pratique. MSme si ceux-ci se sonl: paffois montr6s, ridicules pour avoir m~connu la grande part de l'irrationnel daus l'esprit humain, ils ont du moins le m~rite d'avoir fair appel au bon sens de la collectivit6, ce bon sens qui fondait route la m6thode de Descartes. Pour P. Gay, comme pour les hommes du xvm e sidle, le philosophe est avant tout le sage et le savant, l'homme de bien et le citoyen, tel qu'il est dit daus l'Encyclopddie. C'est le "militaire phflosophe" dont l'auteur est inconnu, le "philosophe ignorant" de Voltaire, le "philosophe sans le savoir" de Sedaine. Une nouvelle conception de l'homme se fait jour, celle d'un 8tre ~ la lois rationnel et sensible. Par derriere de nombreux avatars se retrouve une philosophic g6n~rale commune: celle de Locke et de Condillac, de Hume, d'Helv6tius et de Diderot, celle-l~t m6me qu'E. C.assirer a su mettre en lumi~re en insistant sur son c6t6 formel, et que le philosophe sovi6tique J. Luppol a quelque peu fauss6e par une interpr6tation marxiste et par trop dogrnatique de l'histoire. Elle s'exprime clairement dans le Discours pr~lirninaire de d'Alembert. Le sensationnalisme a promu l'id~e de la souverainet~ de l'esprit critique et par l~t m~me a r6pudi6 la toute-puissance de la Raison. La nouvelle m6thode pr6conis ~e permet une dialectique nouvelle, qui est pr~cis6ment celle de l'homme moderne. EUe entraine une conception diff6rente du monde et de l'homme, une interpretation nouvelle de leurs rapports. La psychologie est amen~e ~ faire ses premiers pas en tant que science; mais c'est une analyse impitoyable du moi profond en marge d'une exploration de la vie sociale et du monde ext~rieur qui a fray6 la voie ~t la modernitY, et nous a donn~ le sentiment de notre libertY. C'est ainsi qu'il convient de faire entrer le Rousseau des Confessions aussi bien que du Contrat social dans la grande famille d~sunie qui fait le sujet du livre de P. Gay. Pour nous, en nous pla~ant ~t un point de rue quelque peu different de celui de notre auteur, et tout en reconnaissant avec lui que le dix-huiti~me si~cle a port~ une atteinte mortelle ~ la m~taphysique, nous croyons pouvoir dire que le dix-huiti~me si~cle n'est pas tant le si~cle qui a reni~ Dieu, mais le si~cle qui s'en est fait une conception plus moderne en le repoussant darts un pass~ lointain et t~n~breux ou en le situant, non sans ivresse, darts un avenir tr~s incertain. R. NIKLAUS Exeter, England La Filosofia Politica di Schelling. By Claudio Cesa. (Bari, Laterza, 1969. Pp. 252. n.p.) Was Schelling an original political philosopher? This does not seem to be the opinion of the author of this very careful research, which is beyond any doubt the 488 HISTORY OF PHILOSOPHY most extensive study of this aspect of Schelling's thought, at least until 1806. However, even if Schelling was not, as it is frequently stated, indifferent to the problems and the vicissitudes of politics, his theoretical thinking on this subject never went beyond temporary systematizations, to be given up, or modified, after a while. The author shows how Schelling, especially in this fieM, was influenced either by his environment in general, or by some personalities he happened to contact: first... (shrink)