Polyclonal antibodies raised against the human erythrocyte nucleoside transporter were used to investigate the distribution of the nucleoside transporters in the placenta. Immunoblots of brush-border membranes isolated from the human syncytiotrophoblast revealed a cross-reactive species that co-migrated with the erythrocyte nucleoside transporter as a broad band of apparent M 55,000. In contrast, no labelling was detected in basal membranes containing a similar number of equilibrative nucleoside transporters as assessed by nitrobenzylthioinosine -binding. The absence of cross-reactive epitopes in basal membranes and (...) their presence in brush-border membranes was confirmed by confocal immunofluorescence microscopy. The results suggest that at least two isoforms of the NBMPR-sensitive nucleoside transporter are present in the human placenta. The lumenal surfaces of fetal capillaries, small placental vessels and umbilical vein ware also strongly labelled by the antibody, a finding that suggests that the high fetal-placental adenosine uptake previously reported is due to endothelial transporters. (shrink)

The literature on affective determinants of physical activity is growing rapidly. The present paper aims to provide greater clarity regarding the definition and distinctions among the various affect-related constructs that have been examined in relation to PA. Affective constructs are organized according to the Affect and Health Behavior Framework, including: affective response to PA; incidental affect; affect processing; and affectively charged motivational states. After defining each category of affective construct, we provide examples of relevant research showing how each construct may (...) relate to PA behavior. We conclude each section with a discussion of future directions for research. (shrink)

In this paper, we report on the development and validity of the Professional Decision-Making in Research measure, a vignette-based test that examines decision-making strategies used by investigators when confronted with challenging situations in the context of empirical research. The PDR was administered online with a battery of validity measures to a group of NIH-funded researchers and research trainees who were diverse in terms of age, years of experience, types of research, and race. The PDR demonstrated adequate reliability and parallel form (...) correlation. As hypothesized, the PDR was significantly negatively correlated with narcissism, cynicism, moral disengagement, and compliance disengagement; it was not correlated with socially desirable responding. In regression analysis, the strongest predictors of higher PDR scores were low compliance disengagement, speaking English as a native language, conducting clinical research with human subjects, and low levels of narcissism. Given that the PDR was written at an eighth grade reading level to be suitable for use with English as a second language participants and that only one-fourth of items focused on clinical research, further research into the possible roles of culture and research ethics training across specialties is warranted. This initial validity study demonstrates the potential usefulness of the PDR as an educational outcome assessment measure and a research instrument for studies on professionalism and integrity in research. (shrink)

Furthering our project of applying Plantinga’s epistemology to different world religions, we do a comparative study of Mormonism and Vaiśeṣika Hinduism and analyze whether they can utilize Plantinga’s epistemology in order to claim that their beliefs about God if true are probably warranted. Specifically, we argue that they cannot, as ultimately they are unable to account for the preconditions needed to make for an intelligible cognitive design plan, due to either affirming an infinite regress when it comes to the designers (...) of our cognitive faculties or affirming an infinite number of cosmological cycles in which our faculties are formed. (shrink)

Communication Theories for Everyday Life introduces readers to the complexities of theories in communication studies, mass communication, and public relations, emphasizing their connection to everyday life. Instead of utilizing a "theory-a-day" approach, this text cuts across content areas and clusters related theories, making them easier for readers to process and apply to real-life situations. Communication Theories for Everyday Life also addresses theories in emerging areas and growing fields, such as media research, organizational communication, and computer-mediated communication, while still featuring the (...) traditional theories that always have defined the field. Features: Contextualizes theory with an introductory chapter in each of the main content areas that introduces the theories and research in the field, showing students how the theories developed. Features new theories and subject areas not present in most traditional communication theory textbooks, including new interactive technologies, feminist scholarship, British cultural studies, semiotics, postmodernism, and critical race theory. Emphasizes the application of some theories across many subject areas through headings in the form of questions that encourage students to process material and explore for themselves how theories and content apply to their lives. Uses case-study chapters that demonstrate to students how each subject area would use theory to solve or understand issues in everyday life. Reviews theories for the three main genres of communication - communication studies, mass communication, and public relations - with balanced coverage, examining the unique contributions each area has made to the field of communication as a whole. Page 1 of 1. (shrink)

Few contemporary behaviorists are aware of the importance of George Herbert Mead's contributions to the philosophy of behaviorism. Mead's work on agency and determinism are presented to provide a sample of his ideas on issues that are of significant importance to current debates in behaviorism. His ideas are then compared with Skinner's positions on related issues, revealing significant similarities in their scientific thinking. One major difference between the two behaviorists is identified, and the relative merits of the two different positions (...) are evaluated. If Mead is correct, we can begin to build bridges between the cognitive and the more traditional forms of behaviorism. (shrink)

In the wake of a pilot study that indicated that the experience of medical education appears to Inhibit moral development In medical students, increased attention needs to be given to the structure of medical education and the Influence it has on medical students. Interest in ethics and moral reasoning has become widespread in many aspects of professional and public life. Society has exhibited great interest in the ethical issues confronting physicians today. Considerable effort has been undertaken to train medical students, (...) interns, and residents In how to reason through medical-ethical dilemmas. Media attention has focused on Issues such as abortion, euthanasia, care of severely handicapped infants, organ transplantation, and so forth, producing heated debates in both the professional and lay literature over the morality of the various positions. The curriculum of medical education has paralleled and reflected this general Interest in medical ethics. Most medical schools now offer, and frequently require, course work in ethics. However, further research Is needed to better characterize and understand the relationship of medical education to moral development. (shrink)

This chapter contains section titled: The Good Life: Booze, Pills, Hot and Cold Running Interns? “Be the Best Machines (and Humans) the Universe Has Ever Seen” “Be Ready to Fight or You Dishonor the Reason Why We're Here” “Each of Us Plays a Role. Each Time a Different Role” Notes.

Mealey's data do not support her dichotomous model of primary and secondary sociopathy; this data supports the view that there is a continuum of degrees of sociopathy, from zero to the maximal manifestation. There are multitudes of factors that can contribute to sociopathy and the countless different mixes of them can produce multiple degrees and variations of sociopathic behavior.

If biologists are going to incorporate learning into theories of animal behavior, why not go all the way and incorporate the enormous literatures on Pavlovian conditioning, plus those on operant and observational learning?

In this paper, we report on the development and validity of the Professional Decision-Making in Research measure, a vignette-based test that examines decision-making strategies used by investigators when confronted with challenging situations in the context of empirical research. The PDR was administered online with a battery of validity measures to a group of NIH-funded researchers and research trainees who were diverse in terms of age, years of experience, types of research, and race. The PDR demonstrated adequate reliability and parallel form (...) correlation. As hypothesized, the PDR was significantly negatively correlated with narcissism, cynicism, moral disengagement, and compliance disengagement; it was not correlated with socially desirable responding. In regression analysis, the strongest predictors of higher PDR scores were low compliance disengagement, speaking English as a native language, conducting clinical research with human subjects, and low levels of narcissism. Given that the PDR was written at an eighth grade reading level to be suitable for use with English as a second language participants and that only one-fourth of items focused on clinical research, further research into the possible roles of culture and research ethics training across specialties is warranted. This initial validity study demonstrates the potential usefulness of the PDR as an educational outcome assessment measure and a research instrument for studies on professionalism and integrity in research. (shrink)

State Medical Boards (SMBs) can take severe disciplinary actions (e.g., license revocation or suspension) against physicians who commit egregious wrongdoing in order to protect the public. However, there is noteworthy variability in the extent to which SMBs impose severe disciplinary action. In this manuscript, we present and synthesize a subset of 11 recommendations based on findings from our team’s larger consensus-building project that identified a list of 56 policies and legal provisions SMBs can use to better protect patients from egregious (...) wrongdoing by physicians. (shrink)

Nuffield Council on Bioethics, London * Corresponding author: Nuffield Council on Bioethics, 28 Bedford Square, London WC1B 3JS, UK. Email: hschmidt{at}nuffieldbioethics.org ' + u + '@' + d + ' '//--> Abstract In November 2007, the Nuffield Council on Bioethics published the report Public Health: Ethical Issues . While the report has been welcomed by a wide range of stakeholders, there has also been some criticism. First, it has been suggested that it is not clear why, in developing its ‘stewardship (...) model’, the Council felt the need to go beyond the liberal position developed by John Stuart Mill—what is it that the stewardship model adds? Second, it is suggested that the Report is confused about the concept of paternalism. Third, it is argued that the discussion of the concept of stewardship is lacking in detail and substance. We clarify the Working Party's thinking regarding these three areas, which demonstrates the robustness of the framework set out in the report. CiteULike Connotea Del.icio.us What's this? (shrink)

This paper owes its inspiration to a remark made by Professor M. Rostovtzeff; in a note in his Social and Economic History of the Roman Empire on the widespread social unrest of the first two centuries A.D., having cited other literary authorities such as Dio Chrysostom, Aelius Aristides, etc., he writes: ‘The social problem as such, the cleavage between the poor and the rich, occupies a prominent place in the dialogues of Lucian; he was fully aware of the importance of (...) the problem.’ No one, as far as I know, has attempted to collect and discuss the main passages in Lucian on this topic, and the latest writer on this aspect of Lucian reaches a conclusion quite opposed to Rostovtzeff and one which I believe to be wholly misleading. The aim of this paper is to collect and discuss the main references in Lucian to the social problem interpreting them in the light of Lucian's life and background, and the social and economic conditions of his age. In particular I shall stress the importance of the Cynic tradition as it bears on Lucian's attitude, but shall endeavour to show that this tradition is firmly rooted in practical politics and actual participation in social revolutionary movements and goes far beyond the repetition of mere ethical cliches generally ascribed to it. (shrink)

Let $\mathbf{I}(\mu,K)$ denote the number of nonisomorphic models of power $\mu$ and $\mathbf{IE}(\mu,K)$ the number of nonmutually embeddable models. We define in this paper the notion of a diverse class and use it to prove a number of results. The major result is Theorem B: For any diverse class $K$ and $\mu$ greater than the cardinality of the language of $K$, $\mathbf{IE}(\mu,K) \geq \min(2^\mu,\beth_2).$ From it we deduce both an old result of Shelah, Theorem C: If $T$ is countable and (...) $\lambda_0 > \aleph_0$ then for every $\mu > \aleph_0,\mathbf{IE}(\mu,T) \geq \min(2^\mu,\beth_2)$, and an extension of that result to uncountable languages, Theorem D: If $|T| < 2^\omega,\lambda_0 > |T|$, and $|D(T)| = |T|$ then for $\mu > |T|$, $\mathbf{IE}(\mu,T) \geq \min(2^\mu,\beth_2).$. (shrink)

T. D. Barnes has recently impugned the authenticity of these verses and calls for a defence of their genuineness. Although I agree with Fergus Millar that ‘the problem of the Historia Augusta is one into which sane men refrain from entering’,2 yet I think we can at least counter Barnes's objections. Barnes musters four arguments which he naturally calls ‘quite conclusive’. He first points out that the verses are omitted in the epitome of Dio by Xiphilinus, who is our sole (...) source for Dio here, and claims that it is unlikely that Xiphilinus could have omitted such a ‘striking poem’. This is putting an extraordinarily high value on Xiphilinus, who is quite capable of omitting things of greater moment than five Latin verses which he would presumably have had to translate into Greek; as an epitomator of Dio, he is inferior to Zonaras, and his account of Hadrian's reign is particularly poor. (shrink)

The lymphatic vasculature plays a critical role in the regulation of body fluid volume and immune function. Extensive research into the molecular mechanisms that control blood vessel growth has led to identification of molecules that also regulate development and growth of the lymphatic vessels. This is generating a great deal of interest in the molecular control of the lymphatics in the context of embryogenesis, lymphatic disorders and tumor metastasis. Studies in animal models carried out over the past three years have (...) shown that the soluble protein growth factors, vascular endothelial growth factor (VEGF)‐C and VEGF‐D, and their cognate receptor tyrosine kinase, VEGF receptor‐3 (VEGFR‐3), are critical regulators of lymphangiogenesis. Furthermore, disfunction of VEGFR‐3 has recently been shown to cause lymphedema. The capacity to induce lymphangiogenesis by manipulation of the VEGF‐C/VEGF‐D/VEGFR‐3 signaling pathway offers new opportunities to understand the function of the lymphatic system and to develop novel treatments for lymphatic disorders. BioEssays 24:1030–1040, 2002. © 2002 Wiley‐Periodicals, Inc. (shrink)

Our Book Review Editor, James Keller, invited William Hasker to write a review of the Book by D. Z. Phillips, "The Problem of Evil and the Problem of God" and then in consultation with the Editor-in-Chief invited Phillips to respond. Aware of both their respect for each other and their philosophical differences we planned that Hasker's review and Phillips' response would appear in the same issue of the "International Journal for Philosophy of Religion." Unfortunately that was not to be. Dewi, (...) as he was known to his many friends throughout the world, collapsed at his desk on 25 July, 2006 in the library of his beloved University of Wales, Swansea. Although we were not able to have the review and response appear in the same issue as we had all planned, we are now printing his response to Hasker's review, "D. Z. Phillips's Problems with Evil and with God," which appeared in IJPR, Vol. 61,3. Dewi had completed the review and thanks to the efforts of Helen Baldwin who prepared the manuscript and Dewi's wife, Monica, and family we are able to print it here. Since Dewi was responding to an earlier version of Hasker's review, a few minor editorial changes have been made. Dewi's death is a great loss to the philosophical community and a deep personal loss to his family and friends, but I am confident that he would be pleassed to have this response appear. He might even have a story to tell, a comment that those who knew him well will fully understand. Eugene Thomas Long. (shrink)

This article contends that James Baldwin’s exploration of racism and resistance to it in The Fire Next Time may be put into conversation with Ludwig Wittgenstein’s consideration of fundamental epistemic commitments in On Certainty. Out of this constructive engagement, I argue that white supremacism in the United States may be interpreted as being like a Wittgensteinian grounding or "hinge" commitment and that this viewpoint illuminates some of the ways in which white supremacism may interact with various kinds of religious (...) commitments. This combined analysis depicts the extent to which fundamental commitments about race deeply affect people, including the formation of their ethical and civic values, existential and religious commitments, and range of empathetic capacity and also details similarities between Baldwin and Wittgenstein when it comes to their contentions that there is ethical value in the clarification of language and work on oneself. (shrink)

Due Process is one of the most interesting and conceptually challenging areas of the common law, and in recent years there has been a major revival of interest in the sheer range and applicability of the term. In this major new book, the author of the widely admired Discretionary Powers offers a study of the underlying principles of due process and fair procedures, and sets the discussion within a broad comparative and theoretical framework. In landmark decisions such as Ridge v. (...) Baldwin the courts in Britain and other parts of the Commonwealth have begun to recognize the importance of procedural fairness across a broad spectrum of official powers and decisions. Principles have begun to emerge, and yet the courts have not yet developed an approach which is entirely adequate to the task. In this timely book, the author traces the development of these principles within a framework which includes analysis and critique of legal developments in the major common law jurisdictions, and which relates these developments to similar ideas under both the European Convention on Human Rights and the American Constitution. Original, scholarly and thought-provoking, this major new study will be required reading for lawyers with interests in public law, civil and criminal procedure, civil liberties, legal theory and comparative law. (shrink)

Our Book Review Editor, James Keller, invited William Hasker to write a review of the Book by D.Z. Phillips, The Problem of Evil and the Problem of God and then in consultation with the Editor-in-Chief invited Phillips to respond. Aware of both their respect for each other and their philosophical differences we planned that Hasker’s review and Phillips’ response would appear in the same issue of the International Journal for Philosophy of Religion. Unfortunately that was not to be. Dewi, as (...) he was known to his many friends throughout the world, collapsed at his desk on 25 July, 2006 in the library of his beloved University of Wales, Swansea. Although we were not able to have the review and response appear in the same issue as we had all planned, we are now printing his response to Hasker’s review, “D.Z. Phillips’s Problems with Evil and with God,” which appeared in IJPR, Vol. 61,3. Dewi had completed the review and thanks to the efforts of Helen Baldwin who prepared the manuscript and Dewi’s wife, Monica, and family we are able to print it here. Since Dewi was responding to an earlier version of Hasker’s review, a few minor editorial changes have been made. Dewi’s death is a great loss to the philosophical community and a deep personal loss to his family and friends, but I am confident that he would be pleased to have this response appear. He might even have a story to tell, a comment that those who knew him well will fully understand. Eugene Thomas Long. (shrink)

We extend Morley's Theorem to show that if a theory is κ-p-categorical for some uncountable cardinal κ, it is uncountably categorical. We then discuss ω-p-categoricity and provide examples to show that similar extensions for the Baldwin-Lachlan and Lachlan Theorems are not possible.

Modern cultivation has multiplied the classic sciences into families of fissionable specialities, whose individual methods and objects tend to be communicated less and less to the man of general culture and even to the specialist fellow traveller. One established means of restoring basic communication lies in the periodic exposition by a team of sympathetic experts of the problems, historic personalities and principles of solution of each family, so that concise, accurate reference is readily available both to the serious student and (...) to the enquiring colleague who may wish to grasp a point of research, theory or jargon without having to search for it precariously in the deceptive haystack of selective text-books, monographs and learned papers. This solution, however, is prodigal of resources, material and intellectual—only anguished editors know what toil underlies the serenity of the expert encyclopedia, with its alphabetical reference, succinct scholarship and up-to-date analysis of every minute point at issue. Convinced lovers of wisdom should quail less than others, perhaps, from this herculean task. In fact, while this century has seen some new philosophic dictionaries and a fair representation of philosophic topics in general encyclopedias, no specialised philosophic encyclopedia has appeared to continue the early enterprise of Baldwin’s Dictionary of Philosophy and Psychology and of Hasting’s Encyclopaedia of Religion and Ethics. Now within two years has come the prodigious completion of a meticulous set of four Italian volumes, which survey the whole history and scope of philosophic and cognate science, and present the reviewer with a veritable embarras des richesses. (shrink)