Oscillations in cytosolic Ca2+ occur in a wide variety of cells, either spontaneously or as a result of external stimulation. This process is often accompanied by intracellular Ca2+ waves. A number of theoretical models have been proposed to account for the periodic generation and spatial propagation of Ca2+ signals. These models are reviewed and their predictions compared with experimental observations. Models for Ca2+ oscillations can be distinguished according to whether or not they rely on the concomitant, periodic variation in inositol (...) 1,4,5‐trisphosphate. Such a variation, however, is not required in models based on Ca2+‐induced Ca2+ release. When Ca2+diffusion is incorporated into these models, propagating waves of cytosolic Ca2+ arise, with profiles and rates comparable to those seen in the experiments. (shrink)

In photoreceptors of a dark adapted eye, the inward flux of sodium and calcium ions in the outer segment is balanced by the outward flux of potassium ions. But in the presence of light the creation of cyclic guanosine monophosphate in the outer segment decreases. Due to low concentration of cG the channels in the outer segment open relatively less and thus the influx of calcium ion decreases, leading finally to hyperpolarization of the photoreceptors. We have analyzed theoretically (...) the effect of oxidizing iron ions on the photoreceptors. In order to explain the effects of iron-induced oxidative stress, the different molecules and ions involved in phototransduction are quantified leading to a differential equation for calculating the electroretinogram a-wave voltage. The theoretical results are compared with published experimental data. In the presence of light, the iron ions could push outward the similarly charged calcium ions resulting in a small increase in the amount of inward calcium flux. Again, the presence of iron ions generates Reactive Oxygen Species, and ROS could attract the calcium ions which also increases the calcium flux. This will result in a reduction in the amplitude and slope of the a-wave voltage in the electroretinogram. These results are parametrized in terms of calcium ion concentrations. As the amplitude of the a-wave shows how much electrical signal is produced, its reduction indicates reduction in the visual signal. Thus, the increase in iron ions could explain the reduction in the electrical signal due to iron-induced oxidative stress. (shrink)

The discovery of participation of astrocytes as active elements in glutamatergic tripartite synapses (composed by functional units of two neurons and one astrocyte) has led to the construction of models of cognitive functioning in the human brain, focusing on associative learning, sensory integration, conscious processing and memory formation/retrieval. We have modelled human cognitive functions by means of an ensemble of functional units (tripartite synapses) connected by gap junctions that link distributed astrocytes, allowing the formation of intra- and intercellular calcium (...) waves that putatively mediate large-scale cognitive information processing. The model contains a diagram of molecular mechanisms present in tripartite synapses and contributes to explain the physiological bases of cognitive functions. It can be potentially expanded to explain emotional functions and psychiatric phenomena. (shrink)

Intercellular communication (IC) is mediated by gap junctions (GJs) and hemichannels, which consist of proteins. This has been particularly well documented for the connexin (Cx) family. Initially, Cxs were thought to be the only proteins capable of GJ formation in vertebrates. About 10 years ago, however, a new GJ‐forming protein family related to invertebrate innexins (Inxs) was discovered in vertebrates, and named the pannexin (Panx) family. Panxs, which are structurally similar to Cxs, but evolutionarily distinct, have been shown to be (...) co‐expressed with Cxs in vertebrates. Both protein families show distinct properties and have their own particular function. Identification of the mechanisms that control Panx channel gating is a major challenge for future work. In this review, we focus on the specific properties and role of Panxs in normal and pathological conditions. (shrink)

A new theory for basic function in the nervous system has recently been proposed (Dempsher, J., 1979a, 1979b; 1980, 1981). The major basic themes of the new theory are as follows: (1) There are two fundamental units of structure and function, the fibre or conducting mechanism, and the neurocentre, where nervous system function as we know it takes place. (2) The nerve impulse is regarded as a mathematical event. The mathematics is the result of a prescribed fusion of energy and (...) matter. (3) Nervous system function everywhere in the nervous system is mathematical. In the fibre, the prescribed fusion of energy and matter results in a number. In the neurocentre, the prescribed fusion of energy and matter results in a mathematical function. Basic function in the nervous system everywhere requires a transformation of a nerve impulse in the fibre into a nerve impulse in the neurocentre with opposing properties: The nerve impulse in the fibre is confined to the fibre; cannot sum with another nerve impulse; can travel long distances with constant form and velocity; curvature in space and time are not significant features; and it is regarded as a number. On the other hand, the nerve impulse in the neurocentre is confined to the neurocentre; can sum with other nerve impulses; cannot travel long distances - even in a very short distance, it changes form; curvature in space and time is a very significant feature; and it is regarded as a mathematical function.The approach to determine how one form of the nerve impulse is transformed into the other at the input region is based on two of the differences listed above: (1) The nerve impulse in the fibre cannot sum with another nerve impulse in the fibre, whereas in the neurocentre, several nerve impulses sum to form a larger nerve impulse. (2) The nerve impulse in the fibre is regarded as a number, in the neurocentre, it is regarded as a mathematical function. The commonality of (1) and (2) is that the properties defining the nerve impulse in the fibre are associated with the property ofdiscreteness, whereas, the properties defining the nerve impulse in the neurocentre are associated with the property ofcontinuousness. Thus, the basic theme of unification of function at the input region of the neurocentre is the transformation of a phenomenon with the property of discreteness into a phenomenon with the property of continuousness. The solution to this transformation is approached from two directions:biologic andmathematical. In the biologic approach, the unit element of the nerve impulse in the fibre terminations (as.u. as a wave of energy, a spike in the classical theory) fuses with a. calcium-binding protein causing the release of Ca++. The calcium ions then combine with another protein. Associated with the second reaction is a conformational change in the Ca++-protein complex and the unit element in the neurocentre, bs.u., is emitted. Individual bs.u. then fuse with acetylcholine; summation occurs andwave b is emitted. In the mathematical approach, the nerve impulse as a number, is partitioned into two numbers with a precise rule relating these two numbers. One possibility suggested is that the number can be regarded as the value of a trigonometric function. This value then gives rise to an angle with sides related in a ratio or proportionality fashion — a relationship with the property of continuousness, as contrasted with that of a single number, discreteness. Both biologic and mathematical approaches are united so as to suggest that the mathematical (trigonometric) function arose as the result of a fusion of energy (as.u. as a wave of energy) and the calcium-binding protein as matter; following this reaction, bs.u., with opposing properties, is emitted. (shrink)

The complexity of calcium profiles observed in plant cells has led to the realization that specific patterns of calcium propagation (now termed calcium signatures) encode specific information and relay it to downstream elements (effectors) for translation into corresponding cellular responses in higher plants. The concept of calcium signatures is now well established and the tight control of the temporal and spatial characteristics of cytosolic calcium alterations is considered to be responsible for the specificity of various (...) cellular responses, in particular to environment‐induced stresses. To date, three major classes of plant calcium sensors responsible for drought‐stress signal transduction during soil water deficit have been identified. Valuable pieces of the calcium signal‐specificity puzzle are being put together and are illustrated here for the calcium‐mediated signal‐transduction cascades that operate in the responses of higher plants to soil environmental deficits. BioEssays 30:634–641, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

As calcium plays an important role in regulating a great variety of neuronal processes, there is a strong interest to generate gadolinium complexes which can act as calcium-sensors in magnetic resonance imaging (MRI). Here we report a new series of potential CAs based on DO3A, having alkylaminobis(methylenephosphonate) side chains (propyl L1, butyl L2, pentyl L3 or hexyl L4). The high complexation efficiency towards the biologically important metal ions of the aminopolyphosphonic acids could be used for the sensing of (...) the extracellular calcium in the brain. On the other hand the introduction of negatively charged phosphonate groups into common Gd3+-based CAs increases their r1 which is important to improve the MR signal especially in high field magnets. The paramagnetic response of the complexes GdL1-GdL4 to Ca2+ was studied by means of relaxometric titrations. The initial relaxivities of the complexes found to be higher than usually reported for the DO3A type ligands at high field magnets (9.4T). r1 values of 6.92, 7.43, 6.70 and 5.76 mM-1s-1 were determined for GdL1, GdL2, GdL3, and GdL4 respectively. Interestingly complexes exhibit unusual properties in the presence of Ca2+. In contrast to previously reported probes the longitudinal relaxivities decrease upon addition of Ca2+. This is favourable for novel fMRI techniques as it could allow transforming the real in vivo decrease in Ca2+ concentration into a positive contrast during physiological processes. The sensitivity of the complexes towards Ca2+ increases with the extension of the aliphatic side chain. No changes in r1 of GdL1 were found over the whole span of Ca2+ concentration. In the case of GdL2, a moderate decrease of r1 was observed on addition of Ca2+, whereas the r1 of the GdL3 and GdL4 solutions showed a strong dependency on the calcium concentration resulting in the decrease to 66% and 61% of the initial r1 values, respectively. (shrink)

Evidence suggests that the Ca2+/calmodulin-sensitive adenylyl cyclase may play a key role in neural plasticity and learning in Aplysia, Drosophila, and mammals. This dually-regulated enzyme has been proposed as a possible site of stimulus convergence during associative learning. This commentary discusses the evidence that is required to demonstrate that a protein in a second messenger cascade actually functions as a molecular site of associative integration. It also addresses the issue of how a dually-regulated protein could contribute to the temporal pairing (...) requirements of classical conditioning: that relationship between stimuli display both temporal contiguity and predictability. (shrink)

This is a new volume of original essays on the metaphysics of quantum mechanics. The essays address questions such as: What fundamental metaphysics is best motivated by quantum mechanics? What is the ontological status of the wave function? Does quantum mechanics support the existence of any other fundamental entities, e.g. particles? What is the nature of the fundamental space of quantum mechanics? What is the relationship between the fundamental ontology of quantum mechanics and ordinary, macroscopic objects like tables, chairs, (...) and persons? This collection includes a comprehensive introduction with a history of quantum mechanics and the debate over its metaphysical interpretation focusing especially on the main realist alternatives. (shrink)

This is a new volume of original essays on the metaphysics of quantum mechanics. The essays address questions such as: What fundamental metaphysics is best motivated by quantum mechanics? What is the ontological status of the wave function? What is the nature of the fundamental space (or space-time manifold) of quantum mechanics?

The orderly sequence of events that constitutes the cell cycle is carefully regulated. A part of this regulation depends upon the ubiquitous calcium signalling system. Many growth factors utilize the messenger inositol trisphosphate (InsP3) to set up prolonged calcium signals, often organized in an oscillatory pattern. These repetitive calcium spikes require both the entry of external calcium and its release from internal stores. One function of this calcium signal is to activate the immediate early genes (...) responsible for inducing resting cells (G0) to re‐enter the cell cycle. It may also promote the initiation of DNA synthesis at the G1/S transition. Finally, calcium contributes to the completion of the cell cycle by stimulating events at mitosis. The role of calcium in cell proliferation is highlighted by the increasing number of anticancer therapies and immunosuppressant drugs directed towards this calcium signalling pathway. (shrink)

The calpactins are a novel group of proteins associated with the membrane skeleton. The two main forms, calpactin I and II, have been shown to bind to the cytoskeletal proteins actin and spectrin, as well as to anionic phospholipids, which may imply some sort of bridging role. By raising monoclonal antibodies to the heavy and light chains of calpactin I, and to calpactin II, the protein subunits were shown to be coordinately expressed, and the existence of separate calpactin pools hypothesized. (...) Calcium‐binding studies suggest that the calpactins may translate Ca2+ signals into cellular responses at the membrane. Structural studies have revealed two distinct domains and are beginning to throw light on heavy‐‐light chain interaction and cytoskeletal attachment. (shrink)

It is generally argued that if the wave-function in the de Broglie–Bohm theory is a physical field, it must be a field in configuration space. Nevertheless, it is possible to interpret the wave-function as a multi-field in three-dimensional space. This approach hasn’t received the attention yet it really deserves. The aim of this paper is threefold: first, we show that the wave-function is naturally and straightforwardly construed as a multi-field; second, we show why this interpretation is superior (...) to other interpretations discussed in the literature; third, we clarify common misconceptions. (shrink)

The calcium signals regulate the production and secretion of many signaling molecules like inositol trisphosphate ( $$IP_{3}$$ ) and adenosine triphosphate (ATP) in various cells including pancreatic $$\beta$$ -cells. The calcium signaling mechanisms regulating $$IP_{3}$$, ATP and insulin responsible for various functions of $$\beta$$ -cells are still not well understood. Any disturbance in these mechanisms can alter the functions of $$\beta$$ -cells leading to diabetes and metabolic disorders. Therefore, a mathematical model is proposed by incorporating the reaction-diffusion equation (...) for calcium dynamics and a system of first-order differential equations for $$IP_{3}$$, ATP-production and insulin secretion with initial and boundary conditions. The model incorporates the temporal dependence of $$IP_{3}$$ -production and degradation, ATP production and insulin secretion on calcium dynamics in a $$\beta$$ -cell. The piecewise linear finite element method has been used for the spatial dimension and the Crank-Nicolson scheme for the temporal dimension to obtain numerical results. The effect of changes in source influxes and buffers on calcium dynamics and production of $$IP_{3}$$, ATP and insulin levels in a $$\beta$$ -cell has been analyzed. It is concluded that the dysfunction of source influx and buffers can cause significant variations in calcium levels and dysregulation of $$IP_{3}$$, ATP and insulin production, which can lead to various metabolic disorders, diabetes, obesity, etc. The proposed model provides crucial information about the changes in mechanisms of calcium dynamics causing proportionate disturbances in $$IP_3$$, ATP and insulin levels in pancreatic cells, which can be helpful for devising protocols for diagnosis and treatment of various metabolic diseases. (shrink)

Hugh Everett III proposed his relative-state formulation of pure wave mechanics as a solution to the quantum measurement problem. He sought to address the theory’s determinate record and probability problems by showing that, while counterintuitive, pure wave mechanics was nevertheless empirically faithful and hence empirical acceptable. We will consider what Everett meant by empirical faithfulness. The suggestion will be that empirical faithfulness is well understood as a weak variety of empirical adequacy. The thought is that the very idea (...) of empirical adequacy might be renegotiated in the context of a new physical theory given the theory’s other virtues. Everett’s argument for pure wave mechanics provides a concrete example of such a renegotiation. (shrink)

Peter Achinstein (1990, 1991) analyses the scientific debate that took place in the eighteenth and nineteenth centuries concerning the nature of light. He offers a probabilistic account of the methods employed by both particle theorists and wave theorists, and rejects any analysis of this debate in terms of coherence. He characterizes coherence through reference to William Whewell's writings concerning how "consilience of inductions" establishes an acceptable theory (Whewell, 1847) . Achinstein rejects this analysis because of its vagueness and lack (...) of reference to empirical data, concluding that coherence is insufficient to account for the belief change that took place during the wave-particle debate. (shrink)

An increasing number of studies indicate that changes in cytosolic free Ca2+ ([Ca2+]c) mediate specific types of signal transduction in plant cells. Modulation of [Ca2+]c is likely to be achieved through changes in the activity of Ca2+ channels, which catalyse passive influx of Ca2+ to the cytosol from extracellular and intracellular compartments. Voltage‐sensitive Ca2+ channels have been detected in the plasma membranes of algae, where they control membrane electrical properties and cell turgor. These channels are sensitive to 1,4‐dihydropyridines, which in (...) animal cells specifically affect one class of voltage‐regulated plasma membrane Ca2+ channel. Ca2+‐permeable channels with different pharmacological properties have been found in the plasma membrane of higher plants. Recent evidence suggests the existence of two discrete classes of Ca2+ channel co‐resident in the vacuolar membrane (tonoplast) of higher plants. The first is gated by inositol 1,4,5‐trisphosphate, and bears a number of similarities to its animal counterpart which is located in the endoplasmic reticulum (ER). The second tonoplast Ca2+ channel is voltage‐operated. However, the specific roles of these tonoplast channels in signal transduction have yet to be elucidated. (shrink)

Receptor‐mediated stimulation induces massive actin polymerization and cyto‐skeletal reorganization. The activity of a potent actin‐modulating protein, gelsolin, is regulated both by Ca2+ and polyphos‐phoinositides, and it may have a pivotal role in restructuring the actin cytoskeleton in response to agonist stimulation. Structure‐function analysis of gelsolin has (1) indicated that its NH2‐terminal half is primarily responsible for modulating actin filament length and polymerization; and (2) elucidated mechanisms by which Ca2+ and phospholipids may regulate such functions. Gelsolin is functionally and structurally similar (...) to villin, another Ca2+‐activated actin‐severing protein found in microvilli, suggesting that gelsolin may be a prototype of this family of actin‐modulating proteins. A molecular variant of gelsolin is secreted and may be involved in the clearance of actin filaments released during tissue damage. The two forms of gelsolin are encoded by a single gene, and distinct messages are derived by alternative message splicing. (shrink)

The recent detection of gravitational waves by the LIGO team has rightly been hailed as “the crowning achievemen of classical physics”. This detection, which came at the end of a decade-long quest, involved 950 investigators, and cost around one billion US dollars, was the scientific star of the year 2015. What, if any, is the philosophical impact of this scientific breakthrough, which Albert Einstein had anticipated one century earlier? To answer this question we start by examining the central equations of (...) Einstein’s theory of gravitation, also known as general relativity. Subsequently we analyze the special case of a hollow sphere, in an attempt to answer the question of the reality and even materiality of space or, rather, spacetime. As well, the view that gravitation is a manifestation of the curvature of spacetime is discussed, and the reality of gravitational waves is regarded as the coup de grâce to that view. (shrink)

There have been times in the history of ethical theory, especially in this century, when moral realism was down, but it was never out. The appeal of this doctrine for many moral philosophers is apparently so strong that there are always supporters in its corner who seek to resuscitate the view. The attraction is obvious: moral realism purports to provide a precious philosophical good, viz., objectivity and all that this involves, including right answers to (most) moral questions, and the possibility (...) of knowing those answers. In the last decade, moral realism has re-entered the philosophical ring in powerful-looking naturalistic form. ln this paper we provide a dialectical overview: we situate the new wave position itself, and also our objections to it, in the context of the evolving program of philosophical naturalism in 20th century analytic philosophy. We seek to show that although this new contender might initially look like championship material, it succumbs to punches surprisingly similar to those that knocked out the old-fashioned versions of naturalist moral realism. (shrink)

There have been times in the history of ethical theory, especially in this century, when moral realism was down, but it was never out. The appeal of this doctrine for many moral philosophers is apparently so strong that there are always supporters in its corner who seek to resuscitate the view. The attraction is obvious: moral realism purports to provide a precious philosophical good, viz., objectivity and all that this involves, including right answers to (most) moral questions, and the possibility (...) of knowing those answers. In the last decade, moral realism has re-entered the philosophical ring in powerful-looking naturalistic form. ln this paper we provide a dialectical overview: we situate the new wave position itself, and also our objections to it, in the context of the evolving program of philosophical naturalism in 20th century analytic philosophy. We seek to show that although this new contender might initially look like championship material, it succumbs to punches surprisingly similar to those that knocked out the old-fashioned versions of naturalist moral realism. (shrink)

In eukaryotic cells the nucleus and its contents are separated from the cytoplasm by the nuclear envelope. Macromolecules, as well as smaller molecules and ions, can cross the nuclear envelope through the nuclear pore complex. Molecules greater than approx. 60 kDa and containing a nuclear localization signal are actively transported across the nuclear membranes, but there has been little evidence for regulatory mechanisms for smaller molecules and ions. Recently, diffusion across the nuclear envelope has been observed to be regulated by (...) nuclear cisternal Ca2+ concentrations. Following depletion of Ca2+ from the nuclear store by inositol 1,4,5‐trisphosphate or Ca2+ chelators, a fluorescent 10 kDa marker molecule was no longer able to enter the nucleus. Distinct conformational states of the nuclear pore complexes depended on the Ca2+ filling state of the nuclear envelope, supporting the assumption that a switch in the conformation of the nuclear pore complex may control the transport of intermediate‐sized molecules across the nuclear envelope. Thus nuclear Ca2+ stores may regulate the conformational state of the nuclear pore complex, and thereby passive diffusion of molecules between the cytosol and the nucleoplasm. The physiological significance of this finding is currently unknown. (shrink)

A collection of papers to illustrate new waves in Philosophy of Language: -/- "Linguistic Puzzles and Semantic Pretence" by B. Armour-Garb & J. Woodbridge; "Minimal Semantics and the Nature of Psychological Evidence" by E. Borg; "A Naturalistic Approach to the Philosophy of Language" by J. Collins; "In Praise of our Linguistic Intuitions" by A. Everett; "Phenomenal Continua and Secondary Properties" by P. Greenough; "Semantic Oughts in Context" by A. Hattiangadi; "Content Force and Semantic Norms" by M. Kolbel; "Linguistic Competence and (...) Propositional Knowledge" by G. Longworth; "Expressives and Beyond" by S. Predelli; "Analyticity in Externalist Languages" by G. Russell ; "Names as Predicates" by S. Sawyer; "The Epistemic Reading of Counterfactual Conditionals" by K. Schulz; "Introduction, Transmission, and the Foundations of Meaning" by J. Speaks. (shrink)

Calcium storage is one of the functions commonly attributed to the endoplasmic reticulum (ER) in non‐muscle cells. Several recent studies have added support to this concept. Analysis of reticuloplasm, the luminal ER content, has shown that it contains several proteins (reticuloplasmins) which are prospective calcium storage proteins. One of these, calreticulin, is also present in the sarcoplasmic reticulum (SR). In sea urchin eggs, a calsequestrin‐like protein has been clearly localised to the ER. The recent demonstration that the IP3 (...) receptor, which has similarities with the calcium release channel in the SR is also localised in the ER membrane suggests that calcium stored in the ER is important for intracellular signalling. The alternative view, that the physiologically important calcium store is a specialised organelle, the calciosome, is not supported by these observations. Recent evidence also suggests that ER calcium might be important in ER structure and in the retention of the luminal ER proteins. (shrink)

In this paper I offer a normative account of development expertise. Although extending expertise beyond the traditional development experts to include local stakeholders, this normative account aims to delimit legitimate forms of expertise. I label this normative view third wave development expertise. Third wave expertise is distinguished from both the technocratic and the social constructivist views of development expertise. In particular, I discuss the notions of contributory and interactional expertise. Contributory expertise denotes the extent to which a group (...) of agents possesses knowledge which can make a significant contribution to development decision-making, while interactional expertise denotes the extent to which they are able to communicate this knowledge meaningfully. While local stakeholders may possess contributory expertise in matters of their own development, they may lack interactional expertise to communicate this knowledge. Resolving this issue, I argue, requires a mediator who can interact with and between external experts and local stakeholders. (shrink)

I argue that the wave function ontology for quantum mechanics is an undesirable ontology. This ontology holds that the fundamental space in which entities evolve is not three-dimensional, but instead 3N-dimensional, where N is the number of particles standardly thought to exist in three-dimensional space. I show that the state of three-dimensional objects does not supervene on the state of objects in 3N-dimensional space. I also show that the only way to guarantee the existence of the appropriate mental states (...) in the wave function ontology has undesirable metaphysical baggage: either mind/body dualism is true, or circumstances which we take to be logically possible turn out to be logically impossible.“While our theory can be extended formally in a logically consistent way by introducing the concept of a wave in a 3N-dimensional space, it is evident that this procedure is not really acceptable in a physical theory... ” (Bohm 1957, 117). (shrink)

Laudan and Cantor maintain that there exists a methodological gulf between 19th century wave theorists of light, who employed a method of hypothesis, and 18th and 19th century particle theorists, who were inductivists. This paper examines how in fact wave theorists typically argued for their theory, in order to see to what extent their reasoning corresponds to the method of hypothesis or to inductivism in sophisticated versions of these doctrines offered by Whewell and Mill. It also examines how, (...) given the methodology they actually employed, wave theorists could in principle deal with anomalies to their theory, particularly with phenomena, such as dispersion, which their theory could not explain. (shrink)

Recognition memory performance reflects two distinct memory processes: a conscious process of recollection, which allows remembering specific details of a previous event, and familiarity, which emerges in the absence of any conscious information about the context in which the event occurred. Slow wave sleep and rapid eye movement sleep are differentially involved in the consolidation of different types of memory. The study assessed the effects of SWS and REM sleep on recollection, by means of the “remember”/”know” paradigm. Subjects studied (...) three blocks of 12 words before a 3-h retention interval filled with SWS, REM sleep or wakefulness, placed between 3 a.m. and 6 a.m. Afterwards, recognition and recollection were tested. Recollection was higher after a retention interval rich in SWS than after a retention interval rich in REM sleep or filled with wakefulness. The results suggest that SWS facilitates the process of recollection in recognition memory. (shrink)

We report on the simultaneous determination of complementary wave and particle aspects of light in a double-slit type “welcher-weg” experiment beyond the limitations set by Bohr’s Principle of Complementarity. Applying classical logic, we verify the presence of sharp interference in the single photon regime, while reliably maintaining the information about the particular pinhole through which each individual photon had passed. This experiment poses interesting questions on the validity of Complementarity in cases where measurements techniques that avoid Heisenberg’s uncertainty principle (...) and quantum entanglement are employed. We further argue that the application of classical concepts of waves and particles as embodied in Complementarity leads to a logical inconsistency in the interpretation of this experiment. (shrink)

The meaning of the wave function has been a hot topic of debate since the early days of quantum mechanics. Recent years have witnessed a growing interest in this long-standing question. Is the wave function ontic, directly representing a state of reality, or epistemic, merely representing a state of knowledge, or something else? If the wave function is not ontic, then what, if any, is the underlying state of reality? If the wave function is indeed ontic, (...) then exactly what physical state does it represent? In this book, I aim to make sense of the wave function in quantum mechanics and find the ontological content of the theory. The book can be divided into three parts. The first part addresses the question of the nature of the wave function. After giving a comprehensive and critical review of the competing views of the wave function, I present a new argument for the ontic view in terms of protective measurements. In addition, I also analyze the origin of the wave function by deriving the free Schroedinger equation. The second part analyzes the ontological meaning of the wave function. I propose a new ontological interpretation of the wave function in terms of random discontinuous motion of particles, and give two main arguments supporting this interpretation. The third part investigates whether the suggested quantum ontology is complete in accounting for our definite experience and whether it needs to be revised in the relativistic domain. (shrink)

There have been times in the history of ethical theory, especially in this century, when moral realism was down, but it was never out. The appeal of this doctrine for many moral philosophers is apparently so strong that there are always supporters in its corner who seek to resuscitate the view. The attraction is obvious: moral realism purports to provide a precious philosophical good, viz., objectivity and all that this involves, including right answers to (most) moral questions, and the possibility (...) of knowing those answers. In the last decade, moral realism has re-entered the philosophical ring in powerful-looking naturalistic form. ln this paper we provide a dialectical overview: we situate the new wave position itself, and also our objections to it, in the context of the evolving program of philosophical naturalism in 20th century analytic philosophy. We seek to show that although this new contender might initially look like championship material, it succumbs to punches surprisingly similar to those that knocked out the old-fashioned versions of naturalist moral realism. (shrink)

The meaning of the wave function and its evolution are investigated. First, we argue that the wave function in quantum mechanics is a description of random discontinuous motion of particles, and the modulus square of the wave function gives the probability density of the particles being in certain locations in space. Next, we show that the linear non-relativistic evolution of the wave function of an isolated system obeys the free Schrödinger equation due to the requirements of (...) spacetime translation invariance and relativistic invariance. Thirdly, we argue that the random discontinuous motion of particles may lead to a stochastic, nonlinear collapse evolution of the wave function. A discrete model of energy-conserved wavefunction collapse is proposed and shown consistent with existing experiments and our macroscopic experience. Besides, we also give a critical analysis of the de Broglie-Bohm theory, the many-worlds interpretation and other dynamical collapse theories, and briefly discuss the issues of unifying quantum mechanics and relativity. (shrink)

The analysis of long economic cycles allows us to understand long-term worldsystem dynamics, to develop forecasts, to explain crises of the past, as well as the current global economic crisis. The article offers a historical sketch of research on K-waves; it analyzes the nature of Kondratieff waves that are considered as a special form of cyclical dynamics that emerged in the industrial period of the World System history. It offers a historical and theoretical analysis of K-wave dynamics in the (...) World System framework; in particular, it studies the influence of the long wave dynamics on the changes of the world GDP growth rates during the last two centuries. Special attention is paid to the interaction between Kondratieff waves and Juglar cycles. The article is based on substantial statistical data, it extensively employs quantitative analysis, contains numerous tables and diagrams. On the basis of the proposed analysis it offers some forecasts of the world economic development in the next two decades. The article concludes with a section that presents a hypothesis that the change of K-wave upswing and downswing phases correlates significantly with the phases of fluctuations in the relationships between the World-System Core and Periphery, as well as with the World System Core changes. (shrink)

This volume brings together eleven essays by the distinguished philosopher of science, Peter Achinstein. The unifying theme is the nature of the philosophical problems surrounding the postulation of unobservable entities such as light waves, molecules, and electrons. How, if at all, is it possible to confirm scientific hypotheses about "unobservables"? Achinstein examines this question as it arose in actual scientific practice in three nineteenth-century episodes: the debate between particle and wave theorists of light, Maxwell's kinetic theory of gases, and (...) J.J. Thomson's discovery of the electron. The book contains three parts, each devoted to one of these topics, beginning with an essay presenting the historical background of the episode and an introduction to the philosophical issues. There is an illuminating evaluation of various scientific methodologies, including hypothetico-deductivism, inductivism, and the method of independent warrant which combines features of the first two. Achinstein assesses the philosophical validity of both nineteenth-century and modern answers to questions about unobservables, and presents and defends his own solutions. (shrink)

This paper introduces a new theory in temporal ontology, ‘wave theory’, and argues for its attractions over and above existing tensed theories of time.

Although far from unanimous, there seems to be a general consensus that neither mind nor brain can be reduced without remainder to the other. This essay argues that indeed both mind and brain need to be included in a nonreductionistic way in any genuinely integral theory of consciousness. In order to facilitate such integration, this essay presents the results of an extensive cross-cultural literature search on the ‘mind’ side of the equation, suggesting that the mental phenomena that need to be (...) considered in any integral theory include developmental levels or waves of consciousness, developmental lines or streams of consciousness, states of consciousness, and the self . A ‘master template’ of these various phenomena, culled from over one-hundred psychological systems East and West, is presented. It is suggested that this master template represents a general summary of the ‘mind’ side of the brain-mind integration. The essay concludes with reflections on the ‘hard problem', or how the mind-side can be integrated with the brain-side to result a more integral theory of consciousness. (shrink)

In quantum mechanics, the wavefunction predicts probabilities of possible measurement outcomes, but not which individual outcome is realised in each run of an experiment. This suggests that it describes an ensemble of states with different values of a hidden variable. Here, we analyse this idea with reference to currently known theorems and experiments. We argue that the ψ-ontic/epistemic distinction fails to properly identify ensemble interpretations and propose a more useful definition. We then show that all local ψ-ensemble interpretations which reproduce (...) quantum mechanics violate Statistical Independence. Theories with this property are commonly referred to as superdeterministic or retrocausal. Finally, we explain how this interpretation helps make sense of some otherwise puzzling phenomena in quantum mechanics, such as the delayed choice experiment, the Elitzur-Vaidman bomb detector, and the Extended Wigner's Friends Scenario. (shrink)

Presenilin‐1 (PS1) is thought to regulate cell differentiation and survival by modulating the Notch signaling pathway. Mutations in PS1 have been shown to cause early‐onset inherited forms of Alzheimer's disease (AD) by a gain‐of‐function mechanism that alters proteolytic processing of the amyloid precursor protein (APP) resulting in increased production of neurotoxic forms of amyloid β‐peptide. The present article considers a second pathogenic mode of action of PS1 mutations, a defect in cellular calcium signaling characterized by overfilling of endoplasmic reticulum (...) (ER) calcium stores and altered capacitive calcium entry; this abnormality may impair synaptic plasticity and sensitize neurons to apoptosis and excitotoxicity. The calcium signaling defect has also been documented in lymphocytes, suggesting a contribution of immune dysfunction to the pathogenesis of AD. A better understanding of the calcium signaling defect resulting from PS1 mutations may lead to the development of novel preventative and therapeutic strategies for disorders of the nervous and immune systems. BioEssays 23:733–744, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

In quantum mechanics, the wave function of a N-body system is a mathematical function defined in a 3N-dimensional configuration space. We argue that wave function realism implies particle ontology when assuming: (1) the wave function of a N-body system describes N physical entities; (2) each triple of the 3N coordinates of a point in configuration space that relates to one physical entity represents a point in ordinary three-dimensional space. Moreover, the motion of particles is random and discontinuous.

This is an introduction to wave function realism for a compendium on the philosophy of quantum mechanics that will be edited and translated into Portuguese by Raoni Arroyo, entitled Compêndio de Filosofia da Física Quântica. This essay presents the history of wave function realism, its various interpretations, the main arguments that are given for the position, and the main objections that have been raised to it.

Thirteen up-and-coming researchers in the philosophy of mathematics have been invited to write on what they take to be the right philosophical account of mathematics, examining along the way where they think the philosophy of mathematics is and ought to be going. A rich and diverse picture emerges. Some broader tendencies can nevertheless be detected: there is increasing attention to the practice, language and psychology of mathematics, a move to reassess the orthodoxy, as well as inspiration from philosophical logic.

A century after the discovery of quantum mechanics, the meaning of quantum mechanics still remains elusive. This is largely due to the puzzling nature of the wave function, the central object in quantum mechanics. If we are realists about quantum mechanics, how should we understand the wave function? What does it represent? What is its physical meaning? Answering these questions would improve our understanding of what it means to be a realist about quantum mechanics. In this survey article, (...) I review and compare several realist interpretations of the wave function. They fall into three categories: ontological interpretations, nomological interpretations, and the sui generis interpretation. For simplicity, I will focus on non-relativistic quantum mechanics. (shrink)