This paper argues that human dignity is a sui generis status principle whose function lies in unifying our normative orders. More fully, human dignity denotes a basic status to be preserved in any institution or process; it is a principle demanding determination in different contexts; and it has its most characteristic application where the legal, moral, and political place competing obligations on individuals. The implication of this account is that we should not seek to reduce human dignity to either a (...) legal norm or a legal principle. (shrink)

In his final, incomplete Tractatus Politicus (1677), Spinoza’s account of human power and freedom shifts towards a new, teleological interest in the ‘highest good’ of the state in realising the freedom of its subjects. This development reflects, in part, the growing influence of Aristotle, Machiavelli, Dutch republicanism, and the Dutch post-Rampjaar context after 1672, with significant implications for his view of political power and freedom. It also reflects an expansion of his account of natural right to include independence of mind, (...) a model of autonomy that in turn shapes the infamous sui juris exclusions of his unfinished account of democracy. This article focuses specifically on the Tractatus Politicus, a hitherto under-addressed work in Spinoza’s corpus and one too often considered indistinct from his earlier Tractatus Theologico-Politicus (1670). It argues for a reconsideration of its importance to early modern political thought, particularly regarding the role of the state in realising the freedom and harmony of its subjects through reasonable laws. (shrink)

To study Judicial determinants of the ordered obstetrical and fertility interventions. Nature, corresponding laws, decisions upon the 37 expounded holdings at the Probate, Trial, District, Appellate, and Supreme Courts are studied in 92 published materials identified through the ACOG, RCOG, SOCG portals, and Legal Scholarship Repository. Hearings are held in the US (83.8 %), Canada (10.8 %) and U.K (5.4 %). Of all the hearings reviewed, 27 % concern mentally impaired, 37.8 %-maternal incompetence, and 21.6 % cases are of criminal (...) nature. The Judicial determinants vary from country to country. In Canada, the ordered medical interventions are effected by the child protection legislation, whereas in the US, by court orders. In majority of cases, orders are obtained by dismissing the patriae petitions for involuntary sterilizations of mentally impaired sui juris adults (57 %); coerced obstetrical interventions (33.3 %), fetal custody (50 %); enforcement of surrogacy contracts (62.5 %) in favor of the Common Humanity Benefit clause; and recognizing the rights to inherit in posthumously conceived children (80 %) pursuant to the Social Security Act, Law of obviousness, Law of inherent anticipation, and Intestacy statute. Current study prioritizes two questions: (1) whether it is justified to override the wishes of a competent patient purportedly in her best interests; and (2) whether the patient’s autonomy and competence is an absolute concept. With the law unsettled as to a woman’s right to assent a treatment and contradict her fetus, parties concerned with fetal rights should consider exercising of screening tools on maternal judgmental fitness jointly developed by medical and legal practitioners. Further, given the advances in gamete conservations, states consider enacting legislation in order to safeguard the orderly administration of estates disrupted by claims from posthumously conceived children. A balance must be struck between the child’s right to inherit, the state’s interest, as well as the interests of prior born children. (shrink)

Philosophy & Social Criticism, Volume 48, Issue 6, Page 882-903, July 2022. Indigenous conservation through patrimonialization is the product of political and legal decisions made by a non-indigenous agent: the liberal state, using the law to retain a form of bios. We propose that patrimonialization is the device by which liberal states have processed and integrated indigenous claims into a form of bios ultimately designed to safeguard state legal structures. We argue that, to uphold the rule of law in contexts (...) of struggle and resistance that challenge the very understanding of the law, states respond by wielding the law in the form of the rule by law, that is, pushing the law to the limit to give normative content to the criteria by which the state conducts its affairs, without straying from the individual rights framework. We hold that the rule by law is an operation that defines the patrimonialization of indigenous peoples. It increases their visibility while imposing limits on political action to keep them from becoming sui juris subjects capable of breaching the distinction between zoe and bios. In this article, we try to understand the political–ideological intent of these decisions, the intentions beyond the letter of the law of patrimonialized peoples. (shrink)

Spinoza es un filósofo que, en pleno siglo XVII, propone una reforma no sólo del pensamiento, sino también, por y en virtud de ésta, una respecto del deseo. Este término aparece en Ética tanto con la noción de cupiditas, esencia del hombre, sinónimo de términos como potencia, acción y virtud, pero también con desiderium, cuya traducción más literal es la de deseo, pero que bajo el cuño interpretativo de su obra, ha sido traducida al español con términos como frustración, anhelo, (...) añoranza, nostalgia. Se pretende establecer aquí la distinción entre ambos y situar de modo tentativo las consecuencias ontológicas, éticas y políticas del afecto de desiderium como base para pensar la propiedad como posesión –en su vinculación con el amor- en el marco de la Ética. (shrink)

The “black page” in Spinoza’s Political Treatise has been much discussed and interpreted. These can be roughly divided into three groups: Approaches that see the “black page” as an extension of Spinoza’s theory of the passions and imagination; approaches that maintain that Spinoza excluded women from politics not because of their innate weaknesses but because of their social conditions; approaches that maintain that he excluded women because he saw them as weaker beings, but this contradicts his certain accounts, especially in (...) the Ethics. In this paper, I take the latter view. My contribution is to argue that this contradiction is not unique to the Ethics. I pursue my reading along two lines, one ontological and one political. In the first, I focus on the continuity between the Ethics and the Political Treatise and show that the “black page” is also inconsistent with the ontology and methodology of the Political Treatise itself. In the second, I argue that the exclusion of women also contradicts the concept of the political absolute developed in this last work, since this concept problematizes any kind of exclusion and provides for political stability the strategic principle of increasing the number of decision-makers as much as possible. (shrink)

The Neo‐Darwinian concept of natural selection is plausible when one assumes a straightforward causation of phenotype by genotype. However, such simple 1:1 mapping must now give place to the modern concepts of gene regulatory networks and gene expression noise. Both can, in the absence of genetic mutations, jointly generate a diversity of inheritable randomly occupied phenotypic states that could also serve as a substrate for natural selection. This form of epigenetic dynamics challenges Neo‐Darwinism. It needs to incorporate the non‐linear, stochastic (...) dynamics of gene networks. A first step is to consider the mathematical correspondence between gene regulatory networks and Waddington's metaphoric ‘epigenetic landscape’, which actually represents the quasi‐potential function of global network dynamics. It explains the coexistence of multiple stable phenotypes within one genotype. The landscape's topography with its attractors is shaped by evolution through mutational re‐wiring of regulatory interactions – offering a link between genetic mutation and sudden, broad evolutionary changes. (shrink)

The stunning possibility of “reprogramming” differentiated somatic cells to express a pluripotent stem cell phenotype (iPS, induced pluripotent stem cell) and the “ground state” character of pluripotency reveal fundamental features of cell fate regulation that lie beyond existing paradigms. The rarity of reprogramming events appears to contradict the robustness with which the unfathomably complex phenotype of stem cells can reliably be generated. This apparent paradox, however, is naturally explained by the rugged “epigenetic landscape” with valleys representing “preprogrammed” attractor states that (...) emerge from the dynamical constraints of the gene regulatory network. This article provides a pedagogical primer to the fundamental principles of gene regulatory networks as integrated dynamic systems and reviews recent insights in gene expression noise and fate determination, thereby offering a formal framework that may help us to understand why cell fate reprogramming events are inherently rare and yet so robust. (shrink)

Sui Han geht von der Mehrdeutigkeit des Begriffs des Nichtseienden – die der von Aristoteles in einer berühmten Formulierung festgestellten Mehrdeutigkeit des Seienden teilweise, aber nicht völlig analog ist – und der „Aussageverflechtung von Sein und Nichtsein“ aus. Sie legt dar, dass bei Plotin mit Blick auf sämtliche Seinsebenen vom Einen-Guten bis hinab zur Materie in jeweils unterschiedlichem Sinn sowohl von deren Sein als auch von deren Nichtsein gesprochen werden kann. Diesem unterschiedlichen Sinn jeweils auf die Spur zu kommen, ist (...) das eigentliche Anliegen der Autorin. (shrink)

It will be proved that the Shoenfield cupping conjecture holds in R/M, the quotient of the recursively enumerable degrees modulo the cappable r.e. degrees. Namely, for any [a], [b] ∈ R/M such that [0] $\prec$ [b] $\prec$ [a] there exists [c] ∈ R/M such that [c] $\prec$ [a] and [a] = [b] ∨ [c].

This article by Juri Lotman from the third volume of Trudy po znakovym sistemam (Sign Systems Studies) in 1967, deals with the problem of artistic modelling. The general working questions are whether art displays any characteristic traits that are common for all modelling systems and which could be the specific traits that can distinguish art from other modelling systems. Art is seen as a secondary modelling system, more precisely, as a play-type model, which is characterised simultaneously by practical and conventional (...) behaviour and constant awareness of the possibility of alternate meanings to the one that is currently being perceived. At the same time art has play-like elements but is not the same as play, since play is inherently rule-bound, whereas art is a more flexible model thepurpose of which is truth. Art is a special type of modelling system, since it is on one hand suitable for storing very large amount of complex information, but onthe other hand it can increase the stored information and transform the consumer. (shrink)

Nakba is ignored in Western philosophy encyclopedias, and the notion of genocide is rarely explained. In turn, there is much talk about the Holocaust.

This article, first published in Russian in 1984 in Sign Systems Studies, introduces the concept of semiosphere and describes its principal attributes. Semiosphere is the semiotic space, outside of which semiosis cannot exist. The ensemble of semiotic formations functionally precedes the singular isolated language and becomes a condition for the existence of the latter. Without the semiosphere, language not only does not function, it does not exist. The division between the core and the periphery is a law of the internal (...) organisation of the semiosphere. There exists boundary between the semiosphere and the non- or extra-semiotic space that surrounds it. The semiotic border is represented by the sum of bilingual translatable “filters”, passing through which the text is translated into another language (or languages), situated outside the given semiosphere. The levels of the semiosphere comprise an inter-connected group of semiospheres, each of them being simultaneously both participant in the dialogue (as part of the semiosphere) and the space of dialogue (the semiosphere as a whole). (shrink)

Spontaneous Infra-Slow Fluctuations of the human EEG were discovered 60 years ago when appropriate amplifiers for their recordings were designed. To avoid skin-related artifacts the recording of EEG-ISFs required puncturing the skin under the electrode. In the beginning of the 21st century the interest in EEG-ISFs was renewed with the appearance of commercially available DC-coupled amplified and by observation of ISFs of the blood oxygen level–dependent functional magnetic resonance imaging signal at a similar frequency. The independent components of irregular EEG-ISFs (...) were shown to correlate with BOLD signals which in turn were driven by changes in arousal level measured by galvanic skin response, pupil size and HRV. There is no consensus regarding the temporal organization of EEG-ISFs: some studies emphasize the absence of peaks on EEG-ISFs spectra, some studies report prominent oscillations with frequency around 0.1 or 0.02 Hz, while some emphasize multiple discrete infraslow oscillations. No studies used parameters of EEG-ISFs as neuromarkers to discriminate psychiatric patients from healthy controls. Finally, a set of working hypotheses is suggested that must be tested in future research to solve the enigma of EEG-ISFs. (shrink)

The role of intellectuals in the reconciliation between Latvians and Russians in postcommunist Latvia is analysed in the context of the traditional philosophicalproblem of the social role of philosophers and based on the ideas of Plato, Kant and Foucault. In accordance with Kant's understanding of the political role of philosophers, the main political functions of the intellectuals a repointed out. Despite the important role played by Latvian intellectuals in the so-called "singing revolution," they did not fullill their critical potential in (...) opposition to the mass consciousness after the renewal of independence. Nowadays the establishment of dialogue between Latvian and Russian communities, based on mutual understanding and respect for otherness, is a crucial presupposition for the long-term stability of Latvian society. Whether this dialogue arises is to a great extent a question of moral choice made by intellectuals from both sides. (shrink)

The fateful combination of (i) the Dunning‐Kruger effect (ignorance of one's own ignorance) with (ii) the nonlinear dynamics of the echo‐chamber between reviewers and editors fuels a self‐reinforcing collective delusion system that sometimes spirals uncontrollably away from objectivity and truth. Escape from this subconscious meta‐ignorance is a formidable challenge but if achieved will help correct a central deficit of the peer‐review process that stifles innovation and paradigm shifts.

Should we be worried that the concept of trust is increasingly used when we assess non-human agents and artefacts, say robots and AI systems? Whilst some authors have developed explanations of the concept of trust with a view to accounting for trust in AI systems and other non-agents, others have rejected the idea that we should extend trust in this way. The article advances this debate by bringing insights from conceptual engineering to bear on this issue. After setting up a (...) target concept of trust in terms of four functional desiderata (trust-reliance distinction, explanatory strength, tracking affective responses, and accounting for distrust), I analyze how agential vs. non-agential accounts can satisfy these. A final section investigates how ‘non-ideal’ circumstances—that is, circumstances where the manifest and operative concept use diverge amongst concept users—affect our choice about which rendering of trust is to be preferred. I suggest that some prominent arguments against extending the language of trust to non-agents are not decisive and reflect on an important oversight in the current debate, namely a failure to address how narrower, agent-centred accounts curtail our ability to distrust non-agents. (shrink)

In the tradition of Western medicine that goes back to Hippocrates, we teach medical students to see beyond the disease and to consider the patient as a whole—to take into account the broader context of family, lifestyle, and environmental exposures. For instance, when measuring blood pressure to diagnose hypertension, family history and situational stress must be considered. Moreover, repeated measurements at multiple time points must be performed to avoid a false-positive diagnosis due to temporary fluctuations of blood pressure. The diagnosis (...) then provides, in adherence to standard-of-care guidelines, the indication for antihypertensive therapy. The recommendations have been... (shrink)

[Without a theorising], a man might as well go into a gravel-pit and count the pebbles and describe the colours. How odd it is that anyone should not see that all observation must be for or against some view if it is to be of any service!Recent years have seen a steady shift of funding programs in biomedical research towards data collection, analysis, and management and its computational analysis. A sizable majority of new major funding opportunity announcements call for assembling (...) large sample banks and databases of molecular profiles of diseases or for computational tools for analysis, display, and distribution of the data. Large consortium projects, such as the Cancer Genome Atlas, the UK Biobank (Allen... (shrink)

This paper provides an empirical account of commercial genetic testing in China. Commercial predictive genetic testing has emerged and is developing rapidly in China, but there is no strict and effective governance. This raises a number of serious social and ethical issues as a consequence of the enormous potential market for such tests. The paper demonstrates that the commercialization of genetic testing and the lack of adequate regulation have created an environment in which dubious advertising practices and misleading and unprofessional (...) medical advice are commonplace. The consequences of these ethically problematic activities for the users of predictive tests are unknown. The paper concludes with a bioethical and social science perspective on the ethical governance issues raised by the dissemination and utilization of commercial genetic testing in Chinese society. (shrink)

本书主要内容包括:自序;保持健康心态要努力做到“五个牢记”和“五个淡忘”;感情是团结的“粘合剂”;对人对事不能情绪化;学会包容;增强自我安全意识的基本原则;力戒官气;领导者应有“七气”等。.

November 1936 PREFACE THIS book is, in slightly revised form, a dis sertation presented for the degree of Doctor of Philosophy in Yale University.

It is shown to be consistent that the reals are covered by ℵ1 meagre sets yet there is a Baire class 1 function which cannot be covered by fewer than ℵ2 continuous functions. A new cardinal invariant is introduced which corresponds to the least number of continuous functions required to cover a given function. This is characterized combinatorially. A forcing notion similar to, but not equivalent to, superperfect forcing is introduced.

European Journal of Philosophy, Volume 30, Issue 2, Page 546-564, June 2022.

The project was partially supported by a NSF grant of China. The author was grateful to Professor S. Lempp for his encouragement and suggestion while the author was visiting the Department of Mathematics at the University of Wisconsin.