The neurobiology and development of human morality in light of evolution -- More than genes : human inheritances and the moral sense -- The dynamic self : emotions and development -- Moral heritage 1 : engagement of the heart -- Moral heritage 2 : communal imagination -- Undercare and the stress response : early life gone wrong -- The morality that stress promotes : self protective ethics -- Shifting moral mindsets -- Culture and imagination: cooperation or competition? -- Paths to (...) moral wisdom -- Common-self wisdom: fostering a good life for self and others -- The road to human excellence and flourishing. (shrink)

Organoids and specifically human cerebral organoids (HCOs) are one of the most relevant novelties in the field of biomedical research. Grown either from embryonic or induced pluripotent stem cells, HCOs can be used as in vitro three-dimensional models, mimicking the developmental process and organization of the developing human brain. Based on that, and despite their current limitations, it cannot be assumed that they will never at any stage of development manifest some rudimentary form of consciousness. In the absence of behavioral (...) indicators of consciousness, the theoretical neurobiology of consciousness being applied to unresponsive brain-injured patients can be considered with respect to HCOs. In clinical neurology, it is difficult to discern a capacity for consciousness in unresponsive brain-injured patients who provide no behavioral indicators of consciousness. In such scenarios, a validated neurobiological theory of consciousness, which tells us what the neural mechanisms of consciousness are, could be used to identify a capacity for consciousness. Like the unresponsive patients that provide a diagnostic difficulty for neurologists, HCOs provide no behavioral indicators of consciousness. Therefore, this article discusses how three prominent neurobiological theories of consciousness apply to human cerebral organoids. From the perspective of the Temporal Circuit Hypothesis, the Global Neuronal Workspace Theory, and the Integrated Information Theory, we discuss what neuronal structures and functions might indicate that cerebral organoids have a neurobiological capacity to be conscious. (shrink)

Extraversion has two central characteristics: (1) interpersonalengagement, which consists of affiliation (enjoying and valuing close interpersonal bonds, being warm and affectionate) and agency (being socially dominant, enjoying leadership roles, being assertive, being exhibitionistic, and having a sense of potency in accomplishing goals) and (2) impulsivity, which emerges from the interaction of extraversion and a second, independent trait (constraint). Agency is a more general motivational disposition that includes dominance, ambition, mastery, efficacy, and achievement. Positive affect (a combination of positive feelings and (...) motivation) is closely associated with extraversion. Extraversion is accordingly based on positiveincentivemotivation. (shrink)

Efforts to bridge emotion theory with neurobiology can be facilitated by dynamic systems (DS) modeling. DS principles stipulate higher-order wholes emerging from lower-order constituents through bidirectional causal processes cognition relations. I then present a psychological model based on this reconceptualization, identifying trigger, self-amplification, and self-stabilization phases of emotion-appraisal states, leading to consolidating traits. The article goes on to describe neural structures and functions involved in appraisal and emotion, as well as DS mechanisms of integration by which they interact. These mechanisms (...) include nested feedback interactions, global effects of neuromodulation, vertical integration, action-monitoring, and synaptic plasticity, and they are modeled in terms of both functional integration and temporal synchronization. I end by elaborating the psychological model of emotion–appraisal states with reference to neural processes. (shrink)

There continues to be a debate on whether addiction is best understood as a brain disease or a moral condition. This debate, which may influence both the stigma attached to addiction and access to treatment, is often motivated by the question of whether and to what extent we can justly hold addicted individuals responsible for their actions. In fact, there is substantial evidence for a disease model, but the disease model per se does not resolve the question of voluntary control. (...) Recent research at the intersection of neuroscience and psychology suggests that addicted individuals have substantial impairments in cognitive control of behavior, but this "loss of control" is not complete or simple. Possible mechanisms and implications are briefly reviewed. (shrink)

‘Plant neurobiology’ has emerged in recent years as a multidisciplinary endeavor carried out mainly by steady collaboration within the plant sciences. The field proposes a particular approach to the study of plant intelligence by putting forward an integrated view of plant signaling and adaptive behavior. Its objective is to account for the way plants perceive and act in a purposeful manner. But it is not only the plant sciences that constitute plant neurobiology. Resources from philosophy and cognitive science are central (...) to such an interdisciplinary project, if plant neurobiology is to maintain its target well-focused. This manifesto outlines a road map for the establishment and development of a new subject—the Philosophy of Plant Neurobiology—, a new field of research emerging at the intersection of the philosophy of cognitive science and plant neurobiology. The discipline is herewith presented, introducing challenges and novel lines of engagement with the empirical investigation, and providing an explanatory framework and guiding principles that will hopefully ease the integration of research on the quest for plant intelligence. (shrink)

‘Plant neurobiology’ has emerged in recent years as a multidisciplinary endeavor carried out mainly by steady collaboration within the plant sciences. The field proposes a particular approach to the study of plant intelligence by putting forward an integrated view of plant signaling and adaptive behavior. Its objective is to account for the way plants perceive and act in a purposeful manner. But it is not only the plant sciences that constitute plant neurobiology. Resources from philosophy and cognitive science are central (...) to such an interdisciplinary project, if plant neurobiology is to maintain its target well-focused. This manifesto outlines a road map for the establishment and development of a new subject—the Philosophy of Plant Neurobiology—, a new field of research emerging at the intersection of the philosophy of cognitive science and plant neurobiology. The discipline is herewith presented, introducing challenges and novel lines of engagement with the empirical investigation, and providing an explanatory framework and guiding principles that will hopefully ease the integration of research on the quest for plant intelligence. (shrink)

Paul Churchland has recently argued that empirical evidence strongly suggests that perception is penetrable to the beliefs or theories held by individual perceivers (1988). While there has been much discussion of the sorts of psychological cases he presents, little has been said about his arguments from neurology. I offer a critical examination of his claim that certain efferents in the brain are evidence against perceptual encapsulation. I argue that his neurological evidence is inadequate to his philosophical goals, both by itself (...) and taken in concert with his psychological evidence. (shrink)

This book presents a state-of-the-art multidisciplinary perspective on psychological, physiological and computational approaches to understanding the ...

It is common to account for our senses on the basis of our sensory organs. One way of glossing why Aristotle famously counted five senses—and why his count became common sense in the West and elsewhere—is because there are five rather obvious organs of sense. In more modern accounts, this organ criterion of the senses has transformed into a neurobiological criterion; that is to say, part of what it means to be a sense is to have an associated organ with (...) appropriate physiological properties. For example, part of the claim that humans have a sense of vision is that we have a non-vestigial organ (the eye) that has cells (photoreceptors) especially sensitive to the properties of electromagnetic radiation. However, the nature of this “organ criterion” is a point of some contention. Is it a sufficient criterion? Necessary? To be called “vision” need the organ mediating it give rise to “visual experiences”? This chapter will consider the neurobiological criterion as it was originally presented in Aristotle and later reconceptualized in 19th-century neurophysiologist Johannes Müller’s “Law of Specific Nerve Energies.” By understanding the role of neurobiology in these accounts, we will be able to explore the deficiencies of contemporary accounts that downplay neurobiology in differentiating the senses. We will consider one of these accounts in detail: Alva Noë’s recent arguments in favor of an enactive approach to perceptual psychology. (shrink)

Are there neurobiological reasons why we are willing to trust other people and why ‘trust’ and moral values such as ‘care’ play a quite pivotal role in our social lives and the judgements we make, including our social interactions and judgements made in the context of schooling? In pursuing this question, this paper largely agrees with claims made by Patricia Churchland in her 2011 book Braintrust. She believes that moral values are rooted in basic brain circuitry and chemistry, which have (...) been shaped over evolutionary time. However, these naturalistic claims raise important issues, including the standard philosophical objection that they fall victim to the naturalistic and/or deontic fallacies. This paper provides an overview of the neurobiology of trust and examines some of the main objections, in the belief that recognising the neurobiological substrate of care and trust can deepen our appreciation of the role these play in education. (shrink)

Neurobiological models of language need a level of analysis that can account for the typical range of language phenomena. Because linguistically motivated models have been successful in explaining numerous language properties, it is premature to dismiss them as biologically irrelevant. Models attempting to unify neurobiology and linguistics need to be sensitive to both sources of evidence.

_Spiritual practices have been proposed to have many beneficial effects as far as mental health is concerned. The exact neural basis of these effects is slowly coming to light and different imaging techniques have elucidated the neural basis of meditative practices. The evidence though preliminary and based on studies replete with methodological constraints, points toward the involvement of the prefrontal and parietal cortices. The available data on meditation focus on activated frontal attentional network. Neuroimaging studies have shown that meditation results (...) in an activation of the prefrontal cortex, activation of the thalamus and the inhibitory thalamic reticular nucleus and a resultant functional deafferentation of the parietal lobe. The neurochemical change as a result of meditative practices involves all the major neurotransmitter systems. The neurotransmitter changes contribute to the amelioration of anxiety and depressive symptomatology and in part explain the psychotogenic property of meditation. This overview highlights the involvement of multiple neural structures, the neurophysiological and neurochemical alterations observed in meditative practices._. (shrink)

This article focuses on the substantial progress in understanding the psychology and neurobiology of sensory pleasure that has been made over the last decade. The link between pleasure and happiness has a long history in psychology. The growing evidence for the importance of affect in psychology and neuroscience shows a scientific account that involves hedonic pleasures and displeasures. A neurobiological understanding is required of how positive and negative effects are balanced in the brain. The article surveys developments in understanding brain (...) mechanisms of pleasure. It identifies a number of brain regions that are important in the brain's hedonic networks, and speculated on potential interaction with eudaimonic networks. The scientific study of pleasure and affect demonstrates the evolution of emotions and affective expressions, and suggests that these are adaptive responses to environmental situations. (shrink)

Gold & Stoljar pose a dilemma for linguistics should neurobiology win out as the science of mind. The dilemma can be avoided by reestablishing linguistics as an autonomous discipline, rather than a branch of the science of mind. Independent considerations for doing this are presented.

While life in general can be explained by the mechanisms of physics, chemistry and biology, to many scientists and philosophers it appears that when it comes to explaining consciousness, there is what the philosopher Joseph Levine called an “explanatory gap” between the physical brain and subjective experiences. Here we deduce the living and neural features behind primary consciousness within a naturalistic biological framework, identify which animal taxa have these features (the vertebrates, arthropods, and cephalopod molluscs), then reconstruct when consciousness first (...) evolved and consider its adaptive value. We theorize that consciousness is based on all the complex system features of life, plus the even more complex features of elaborate brains. We argue that the main reason why the explanatory gap between the brain and experience has been so refractory to scientific explanation is that it arises from both life and from varied and diverse brains and brain regions, so bridging the gap requires a complex, multifactorial account that includes the great diversity of consciousness, its personal nature that stems from embodied life, and the special neural features that make consciousness unique in nature. (shrink)

Sunstein is right that poorly informed heuristics can influence moral judgment. His case could be strengthened by tightening neurobiologically plausible working definitions regarding what a heuristic is, considering a background moral theory that has more strength in wide reflective equilibrium than “weak consequentialism,” and systematically examining what naturalized virtue theory has to say about the role of heuristics in moral reasoning.

There continues to be a debate on whether addiction is best understood as a brain disease or a moral condition. This debate, which may influence both the stigma attached to addiction and access to treatment, is often motivated by the question of whether and to what extent we can justly hold addicted individuals responsible for their actions. In fact, there is substantial evidence for a disease model, but the disease model per se does not resolve the question of voluntary control. (...) Recent research at the intersection of neuroscience and psychology suggests that addicted individuals have substantial impairments in cognitive control of behavior, but this “loss of control” is not complete or simple. Possible mechanisms and implications are briefly reviewed. (shrink)

This paper outlines the functional capacities of a novel scheme for cognitive representation and computation, and it explores the possible implementation of this scheme in the massively parallel organization of the empirical brain. The suggestion is that the brain represents reality by means of positions in suitably constitutes phase spaces; and the brain performs computations on these representations by means of coordinate transformations from one phase space to another. This scheme may be implemented in the brain in two distinct forms: (...) (1) as a phase-space sandwich, which may explain certain laminar structures, such as cerebral cortex and the superior colliculus; and (2) as a neural matrix, which may explain other structures, such as the beautifully orthogonal architecture of the cerebellum. (shrink)

The neurobiological mechanisms associated with affiliation, that Depue & Collins argue are a central component of extraversion are not specified in their model. In addition, only the involvement of the prefrontal cortex in extraversion is discussed, although recent evidence suggests that activity associated with additional cortical regions may be related to this trait. Finally, the assumption that neurobiological mechanisms underlie or play a causal, and therefore, more fundamental role than psychological constructs in the trait is challenged.

Recent investigations have explored how large-scale systems in the brain operate in the processes of retrieving knowledge for words and concepts. Much of the crucial evidence derives from lesion studies, because word retrieval and concept retrieval can be clearly dissociated in brain-damaged individuals. We discuss these findings from the perspective of our neurobiological framework, which is cited in Pulvermüller's target article.

Our primary goal in this article is to discuss the cross-talk between biological and cultural factors that become manifested in the individual brain development, neural wiring, neurochemical homeostasis, and behavior. We will show that behavioral propensities are the product of both cultural and biological factors and an understanding of these interactive processes can provide deep insights into why people behave the way they do. This interdisciplinary perspective is offered in an effort to generate dialog and empirical work among scholars interested (...) in merging aspects of anthropology and neuroscience, and anticipates that biological and cultural anthropology converge. We discuss new theoretical developments, hypothesis-testing strategies, and cross-disciplinary methods of observation and data collection. We believe that the exigency of integrating anthropology and the neurosciences is indisputable and anthropology's role in an emerging interdisciplinary science of human behavior will be critical because its focus is, and has always been, on human biological and cultural systems. (shrink)

Our self-conception derives mostly from our own experience. We believe ourselves to be conscious, rational, social, ethical, language-using, political agents who possess free will. Yet we know we exist in a universe that consists of mindless, meaningless, unfree, nonrational, brute physical particles. How can we resolve the conflict between these two visions? In _Freedom and Neurobiology_, the philosopher John Searle discusses the possibility of free will within the context of contemporary neurobiology. He begins by explaining the relationship between human reality (...) and the more fundamental reality as described by physics and chemistry. Then he proposes a neurobiological resolution to the problem by demonstrating how various conceptions of free will have different consequences for the neurobiology of consciousness. In the second half of the book, Searle applies his theory of social reality to the problem of political power, explaining the role of language in the formation of our political reality. The institutional structures that organize, empower, and regulate our lives-money, property, marriage, government-consist in the assignment and collective acceptance of certain statuses to objects and people. Whether it is the president of the United States, a twenty-dollar bill, or private property, these entities perform functions as determined by their status in our institutional reality. Searle focuses on the political powers that exist within these systems of status functions and the way in which language constitutes them. Searle argues that consciousness and rationality are crucial to our existence and that they are the result of the biological evolution of our species. He addresses the problem of free will within the context of a neurobiological conception of consciousness and rationality, and he addresses the problem of political power within the context of this analysis. A clear and concise contribution to the free-will debate and the study of cognition, _Freedom and Neurobiology_ is essential reading for students and scholars of the philosophy of mind. (shrink)

This paper employs an interventionist framework to elucidate some issues having to do with explanation in neurobiology and with the differences between mechanistic and non-mechanistic explanations.